Sintesis Senyawa Turunan Amoksilin Dan Uji Aktivitas Antibakterinya Terhadap Bakteri Salmonella typhi

Hadi Barru Hakam Fajar Siddiq (Akademi Farmasi Jember)
Dewi Rashati (Akademi Farmasi Jember)
Dewi Riskha Nurmalasari (Akademi Farmasi Jember)

MPI (Media Pharmaceutica Indonesiana)
Vol. 2 No. 2 (2018): DECEMBER

The synthesis of amoxicillin derivate has been done by reacting amoxicillin with 4-t-butylbenzoil chloride. The product was characterized by organoleptic test, melting point determination, TLC, UV/Vis Spectrophotometry, and FTIR Spectrophotometry. Antibacterial activity of amoxicillin derivative against Salmonella typhi were tested using dilution method. Result showed that the product has characteristic as follow: light yellow powder, bitter bite, melting point of 132 °C, Rf value of 0.86, pH value of 7.7, maximum wavelength (uv) of 286 nm. Moreover, FTIR spectra of amoxicillin derivate exhibited peaks at 3271 cm-1 (-NH amine), 2962 cm-1 (-CH aromatic), 1633 cm-1 (-C=O ketone), and other. Antibacterial test showed that amoxicillin derivate was unable to form a clear zone around the disc paper. Amoxicillin derivate cannot be used for the treatment of Salmonella typhi.