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All Journal MPI (Media Pharmaceutica Indonesiana) Journal of Islamic Pharmacy The Indonesian Biomedical Journal Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Ilmiah Farmasi Akademi Farmasi Jember Ensiklopedia Research and Community Service Review Dental Agromedis

Dewi Riskha Nurmalasari

Akademi Farmasi Jember

Author-ID : 3069575

Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Electrical & Electronics Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Articles

Sintesis Senyawa Turunan Amoksilin Dan Uji Aktivitas Antibakterinya Terhadap Bakteri Salmonella typhi Hadi Barru Hakam Fajar Siddiq; Dewi Rashati; Dewi Riskha Nurmalasari
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

The synthesis of amoxicillin derivate has been done by reacting amoxicillin with 4-t-butylbenzoil chloride. The product was characterized by organoleptic test, melting point determination, TLC, UV/Vis Spectrophotometry, and FTIR Spectrophotometry. Antibacterial activity of amoxicillin derivative against Salmonella typhi were tested using dilution method. Result showed that the product has characteristic as follow: light yellow powder, bitter bite, melting point of 132 °C, Rf value of 0.86, pH value of 7.7, maximum wavelength (uv) of 286 nm. Moreover, FTIR spectra of amoxicillin derivate exhibited peaks at 3271 cm-1 (-NH amine), 2962 cm-1 (-CH aromatic), 1633 cm-1 (-C=O ketone), and other. Antibacterial test showed that amoxicillin derivate was unable to form a clear zone around the disc paper. Amoxicillin derivate cannot be used for the treatment of Salmonella typhi.

PEMISAHAN PROTEIN DALAM DARAH PENDERITA DIABETES MELLITUS TIPE 2 UNTUK PENGEMBANGAN MOLEKUL BIOMARKER Dewi Riskha Nurmalasari
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 4, No 2 (2021): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Diabetes mellitus (DM) is a disorder of the chronic metabolic system due to insufficiency of insulin function. DM is classified into two main categories, type 1 and type 2. The purpose of this study was to separate proteins using the SDS-PAGE method to determine the potential protein profile as a biomarker contained in the blood of type 2 DM patients, so that the results of the analysis can be used as an indicator of early detection of type 2 DM. This research is a true experimental research. The samples of this study were the blood of 20 patients with type 2 DM in Sukorejo Bangsalsari Village and the blood of 5 patients who non DM in Sukorejo Bangsalsari Village. sampling technique was randomized controlled trial, after the blood collection process, blood serum was then prepared at the Molecular Biology Laboratory, FMIPA UNEJ, then protein analysis was performed using the 1D-gel electrophoresis (SDS-PAGE) method. The results of protein characterization using SDS-PAGE analysis with blood serum of type 2 DM patients and serum of healthy people (non-patients) as negative controls, obtained protein bands that are less specific to potential targets, because the results of running are still not good, so it is not possible to know the biomarker protein profile in the blood of patients with type 2 DM in Sukorejo Bangsalsari Village, and the results of this analysis still cannot be used as an indicator for early detection of type 2 diabetes mellitus. Analysis of potential proteins profile as biomarkers using SDS-PAGE analysis has revealed three bands which had molecular weights of 28, 45 and 235 kDa. Keywords: Diabetes mellitus, Biomarker, SDS-PAGE

FORMULASI DAN UJI MUTU FISIK SABUN PADAT EKSTRAK DAUN PEPAYA (Carica papaya L.) 30% SEBAGAI ANTIJERAWAT Dewi Riskha Nurmalasari
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 5, No 1 (2022): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Acne is a skin disease caused by Propiniobacterium acne, and Staphylococcus aureus. To treat acne needed anti acne. In this reseacrh using medicinal plants as anti acne. These plants are efficious for anti acne. The genus Carica reported to contain papain enzym compounds. One type of plant has an anti acne activity with papain. Papain leaves (Carica papaya L) obtained from farmers Umbulrejo Umbulsari Jember. The papaya leavesis extracted with etanol 97%. Papaya leavest extract then made a solid soap, with 30% concentration of extract papaya leaves. The active inggredience is extract papaya leaves, NaOH as basa, oleum rosae as corigen odoris, and distilled water as a solvent. In this reseacrh, several physical quality tests of solid soap were carried out. The results of organoleptis test is this soap has a hard shape, the colours is light green, and the scent of soap smell rosae oil. The test results are recorded on the data collection sheet. Average of pH test showed 11, that entered in the range. The results of water content have an average of 8.2%, it shows that the soap meets the demand. The next test is the free fatty acid test results from the test that is 0.87%, the sign the results enter the range. Keywords: Papaya leaves, Solid soap, Physical quality test

Pengaruh Variasi Konsentrasi Gliserin Terhadap Sifat Fisik Paper Soap Ekstrak Daun Nangka (Artocarpus heterophyllus Lam.) Mikhania Christiningtyas Eryani; Dewi Riskha Nurmalasari; Siti Rohmah Fadilah
Journal of Islamic Pharmacy Vol 7, No 2 (2022): J. Islamic. Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i2.17664

Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi gliserin sebagai plasticizer terhadap sifat fisik sediaan paper soap ekstrak daun nangka (Artocarpus heterophyllus Lam.). Konsentrasi gliserin yang digunakan adalah 7,5% (F1), 15% (F2), dan 22,5% (F3). Sifat fisik yang diteliti meliputi organoleptis (warna, bau, bentuk, kelengketan), pH, tinggi busa, kadar air, dan waktu tercuci. Hasil penelitian menunjukkan bahwa perubahan konsentrasi gliserin memberikan pengaruh terhadap sifat fisik organoleptis bentuk, kadar air, dan waktu tercuci sediaan paper soap dan tidak mempengaruhi organoleptis warna, bau, kelengketan, pH, dan tinggi busa sediaan paper soap. Formula dengan konsentrasi gliserin 22,5% memberikan karakteristik fisik terbaik.

PENGARUH VARIASI KONSENTRASI KOH TERHADAP SIFAT FISIK SABUN CAIR EKSTRAK DAUN PEPAYA (Carica papaya L.) Dewi Riskha Nurmalasari
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 6, No 1 (2023): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53864/jifakfar.v6i1.122

Acne is a skin disease disorder that is often experienced by some people, excess oil on the skin can cause infection and inflammation caused by the development of acne bacteria such as Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes. The purpose of this study was to determine the effect of variations in KOH concentration on the physical properties of papaya leaf extract liquid soap preparations (Carica papaya L.). The research design used was a pre-experimental research design with one group post-design, using research objects as many as 3 sample treatment groups (variations in KOH concentration 14%; 16%; 18%) as sample research objects. The results of organoleptic tests show that variations in KOH concentration affect the physical properties of organoleptic, texture, and aroma. The homogeneity test results of the three formulas show homogeneous results. The results of the pH test using statistical tests using the One Way ANOVA method obtained a significant value of 0.000 (p-value 0.05). The viscosity test results using the One Way ANOVA method obtained a significant value of 0.000 (p value0.05). The results of the foam height test using the One Way ANOVA method obtained a significant value of 0.006 (p value0.05). Based on the research that has been done, it can be concluded that KOH affects the physical properties of soap, namely organoleptic tests, pH, viscosity, and foam height. Keywords: Liquid Soap, Potassium Hydroxide, Physical Properties

PENGARUH VARIASI KONSENTRASI SETIL ALKOHOL SEBAGAI EMULSIFYING AGENT PADA SEDIAAN LOTION EKSTRAK LIDAH BUAYA (Aloe vera (L.) Burm. f) Nurmalasari, Dewi Riskha; Mardani, Alya Eka Dhyra; Eryani, Mikhania Christiningtyas
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 12 No 2 (2023): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v12i2.192

Lotion is a liquid emulsion consisting of an aqueous phase and an oil phase that is stabilized by an emulsifying agent and contains one or more active ingredients. The use of cetyl alcohol as an emulsifying agent was selected because of its properties as a softener, emulsifier, and absorbing water. Cetyl alcohol can increase the stability of the consistency and improve the texture. This study aims to determine the effect of concentration variations in cetyl alcohol on the physical properties of aloe vera extract lotion. The research design used in this study is a pre-experimental preparation formula lotion that was divided into 3 sample groups with different concentrations of cetyl alcohol, namely (2%), (3%), and (4%). Then the sample will be tested for physical properties including organoleptic tests (color, texture, flavor), pH test, spreadability test, and viscosity test, homogeneity test. The research results showed that variations in cetyl alcohol concentrations affected the physical properties of the preparations organoleptic texture, and viscosity. Lotion preparations do not affect organoleptic color, flavor, pH, and homogeneity. Formulation with concentration variation of 3% cetyl alcohol had good physical properties and met the criteria including organoleptic testing with a milky white color, slightly viscous texture, strong jasmine flower flavor, pH value of 7.16 ± 0.34, spreadability value 6.99cm ± 0.18, viscosity value 31.6 dPas ± 2.88, and homogeneous. Keywords: lotion, cetyl alcohol, Aloe vera

PENGETAHUAN MASYARAKAT TENTANG BEYOND USE DATE (BUD) PADA PENGGUNAAN OBAT TETES MATA Rossetyowati, Diyan Ajeng; Nurmalasari, Dewi Riskha; Rohma, Tamara Aisa
Ensiklopedia Research and Community Service Review Vol 4, No 1 (2024): Vol. 4 No. 1 Oktober 2024
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/err.v4i1.3019

Eye drops are sterile preparations in the form of solutions or suspensions used by dripping on the mucous membranes and eyelids. Eye drops should not used more than one month after the lid is opened. Beyond Use Date (BUD) is the time limit for the use of a medicinal product after it has been compounded or prepared or after its primary packaging has been opened or tampered with. This study aimed to determine the description of public knowledge about Beyond Use Date (BUD) in eye drops. This is a descriptive quantitative study. Sample collected by non probability with consecutive sampling method. There are 66 respondents from Gebang Poreng, Jember, who had met the inclusion criteria. Data was obtained by distributing questionnaires filled out by the respondents. Based on the results of the study it can be concluded the respondent's knowledge is included in fewer categories with a percentage is 54,88%.Keywords: Eye drops, Beyond Use Date

Pelatihan Pemastian Mutu Bahan Baku Tanaman Obat dan Pembuatan Produk Jamu Sebagai Upaya Pengembangan Program Desa Rempah di Desa Gombengsari Nurmalasari, Dewi Riskha; Nuraini, Fathiyah Rizki; Handojo, Kukuh Judy; Maulani, Dyan; Dwijayanti, Anies Rahman
Dental Agromedis Vol. 3 No. 1 (2025): Mei
Publisher : Fakultas Kedokteran Gigi, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/da.v3i1.5970

Medicinal plants in Indonesia consist of various species that have similar morphological structures that are difficult to distinguish from one another. In terms of ensuring the safety of using a medicinal plant, quality assurance and quality control are needed. Good quality medicinal plants can be obtained by standardizing medicinal plant raw materials, standardizing production processes, traditional medicinal products, distribution methods, and effective dosages. Gombengsari is part of Banyuwangi Regency. The main commodities in the area are coffee and other plantation commodities such as coconut, cloves, and medicinal plants. The purpose of the community service program is to provide education and training to our Community Service Partners, namely POKMAS Sumberwaru Maju, on how to ensure the quality of medicinal plant raw materials, as well as an effort to develop the Spice Village Program (Toga Village) in Gombengsari. The stages of the activity include: pretest, education or counseling, training in making herbal drinks, posttests, and assisting in the production of herbal products. The results of this counseling and training activity, as well as the mentoring that we have done, have a positive and beneficial impact on the group. This can be seen from the group actively practicing the knowledge that we have taught to the group team. This community service activity is planned to continue with a different theme, but still on interrelated material in Gombengsari Village.Keywords: Medicinal plants, traditional medicinal products, quality assurance

T118N Substitution of Hepatitis B X Protein Reduces Colony Formation of HepG2 Cells Artarini, Anita; Nurmalasari, Dewi Riskha; Permanasari, Silmi Citra; Riani, Catur; Tjandrawinata, Raymond Rubianto; Retnoningrum, Debbie Soefie
The Indonesian Biomedical Journal Vol 15, No 1 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i1.2095

BACKGROUND: The acute Hepatitis B virus (HBV) infection usually ceases before six months, but chronic infection that lasts for more than six months might develop into liver cirrhosis and hepatocellular carcinoma (HCC). Viral particle load, HBV genotypes and association to the HBV x (HBx) gene mutations are the probable factors related to HCC occurrence. The mutation which leads to HBx T118N was found as the second most common HBx mutation in Indonesia, as compared to the known cancer-related HBx K130M/V131I mutant. However, the effect of T118N mutation and its combination with K130M/V131I on human hepatoma cells has not been elucidated well. Hence, this study was conducted to dissect the role of HBx T118N and its mutant combination in colony formation, as compared to the wild type HBx and cancer-related HBx K130M/V131I.METHODS: In this study, the genes encoding wild type HBx, HBx T118N, and HBx K130M/V131I mutations were obtained as synthetic gene. Meanwhile, the gene encoding HBx T118N/K130M/V131I mutations was successfully generated using site-directed mutagenesis. The optimum condition for colony formation assays was determined through Zeocin sensitivity test of HepG2 cells.RESULTS: Selection of HepG2 cells using Zeocin was determined at 200 µg/mL. Colony formation assays performed upon expression of HBx T118N and HBx T118N/K130M/V131I mutant proteins showed reduced colony numbers as compared to the expression of wild type HBx, similar to the effect from HBx K130M/V131I mutant expression.CONCLUSION: The HBx T118N and HBx T118N/K130M/V131I mutation caused less colony formation of HepG2 cells, similar to the K130/M131I mutation. This indicates a possible role of the T118N mutation in liver cancer development.KEYWORDS: colony formation assay, hepatitis B virus, HBx, T118N, K130M/V131I

Co-Authors ARTARINI, ANITA CATUR RIANI DEBBIE SOEFIE RETNONINGRUM Diyan Ajeng Rossetyowati Dwijayanti, Anies Rahman Eryani, Mikhania Christiningtyas Hadi Barru Hakam Fajar Siddiq Handojo, Kukuh Judy Mardani, Alya Eka Dhyra Maulani, Dyan Nuraini, Fathiyah Rizki Permanasari, Silmi Citra Rashati, Dewi Raymond R. Tjandrawinata Rohma, Tamara Aisa Siti Rohmah Fadilah

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