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Jurnal Ilmiah Kedokteran Wijaya Kusuma
Published by Universitas Wijaya Kusuma Surabaya
ISSN : 19782071     EISSN : 25805967     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.
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Articles 13 Documents
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Search results for , issue "Vol 12, No 2 (2023): September 2023" : 13 Documents clear
The Relationship of Fever Onset with NS1 Examination Results, IgM, and IgG in Dengue Hemorrhagic Fever Patients Engla Merizka; Assha Luthfianie Alifah; Sri Wahyuni Handayani; Aninda Dinar Widiantari; Farida Murtiani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 12, No 2 (2023): September 2023
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v12i2.2645

Abstract

Fever onset represents the average number of days from the beginning of fever symptoms to the time when IgM and IgG examinations are conducted. Determining the right timing for these examinations can significantly impact their accuracy. In November 2021, there was a notable surge in cases of Dengue Hemorrhagic Fever at the Karawang Health Center, Sukabumi. This study aimed to investigate the relationship between the duration of fever and the results of dengue antigen and antibody tests. The research employed a descriptive analysis with a cross-sectional approach, and a sample of 50 individuals was gathered through consecutive sampling. The data was then analyzed using the Chi-Square test. The study revealed a positive correlation between the duration of fever and the outcomes of the NS1 and IgG Dengue examinations (p<0.05), highlighting the significance of timing when conducting these tests. NS1 was predominantly detected within the first three days of fever, while IgG showed reactivity after more than five days of fever. These findings underscore the importance of timing when conducting these tests and interpreting their results.
Effect of Spirulina Platensis on Liver Malondialdehyde Levels of Male White Rat Induced by High Dose Paracetamol Anggilia Vanny; Sihning E. J. Tehupuring; Indri Ngesti Rahayu; Roostantia Indrawati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 12, No 2 (2023): September 2023
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v12i2.2700

Abstract

Paracetamol is widely used in therapy, yet it becomes hepatotoxic agent in a high dose using. The CYP450 enzyme metabolizes a small portion of paracetamol to a reactive substance, NAPQI. High dose of paracetamol causes an extensive increase in NAPQI levels. NAPQI then binds to hepatocytes conditions of oxidative stress. Spirulina platensis contains C-phycocyanin, flavonoids, and phenolics that inhibit lipid peroxidation and reduce oxidative stress. This study aims to determine the effect of Spirulina platensis on MDA levels in the liver tissue of male Wistar rats induced by high dose of paracetamol. This research was experimental with a Randomized Post-test Only Control Group design using 24 white male rats divided into three groups; negative control group (G-), positive control group (G+) was given paracetamol at a dose of 1,250 mg/kg on the 8th day, and treatment group (Gt) was given an amount of Spirulina platensis extract 360 mg/kg BW/day for ten days from 1st until 10th day and paracetamol at a single dose of 1,250 mg/kg BW on the 8th. At the 10th day of the treatment, all groups were terminated for liver tissue collection. TBA test was used to calculate MDA levels. Statistical tests analyzed the results of the data. This statistical tests by SPSS software: MDA levels in the treatment group did not significantly differ (p = 0.144) compared to the negative control group. There was a significant difference of liver tissue MDA levels in the treatment group (p = 0.016) compared to the positive control group.  This study concludes that administering Spirulina platensis at a dose of 360 mg/kg/day for ten days can help prevent on increase in tissue MDA levels and maintain liver conditions close to their original state.
Profile of The Use of Antihypertension Drug and Blood Pressure Evaluation at Gresik Hospital Prada Marwah Al kamilah; Lusiani Tjandra; Meivy Isnoviana; Ibrahim Njoto
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 12, No 2 (2023): September 2023
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v12i2.2974

Abstract

A potentially fatal non-communicable disease is hypertension. Important organs like the brain, heart, kidneys, retina, big blood vessels (aorta), and peripheral blood vessels are in danger for harm as a result. Heart attacks and even death can result from hypertension. By avoiding and managing risk factors like smoking, sedentary lifestyles, a lack of fruits and vegetables, and obesity, it is crucial to work towards lowering the risk of hypertension. This study's objectives were to assess blood pressure and establish the profile of antihypertensive medicine use. Methods: Data for this retrospective analysis were gathered based on information from patient pharmacy records and medical records. Results: 33.7% hypertension sufferers aged 65-74 years, 62.2% women and 37.8% men, 38.9% The beta-blocker drug group with the drug that is often used Bisoprolol dose of 2.5 mg as much as 26.9 %, 88% in tablet dosage form, which is used in combination form with the rule of using once a day and 64.3% controlled hypertension. This is a retrospective study that obtained data based on medical record information and patient pharmacy data. Conclusion: Hypertension patients are usually aged between 65-74 years, mostly female. Antihypertensive drugs that are often used are in the beta blocker class which is a Bisoprolol dose of 2.5 mg in tablet, used in a single dose or/and combination. Sixty-four point three percent (64.3%) of patients have controlled hypertension.

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