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<![CDATA[Environmental Conditions and Sincerity affects Cortisol and ?-Endorphins Plasma Levels in Young Healthy Subjects Undergoing Dawood’s Fast ]]>
<![CDATA[Indri Ngesti Rahayu]]>;
<![CDATA[Bambang Purwanto]]>;
<![CDATA[Moh. Ali Azis]]>;
<![CDATA[M. Yogiarto]]>;
<![CDATA[Aryati]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
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DOI: 10.37506/ijfmt.v15i2.14761
<![CDATA[Background: Prevention of Coronary Heart Disease by identifying risk factors facilitates the planning ofprevention interventions. The prevalence of non-communicable disease (NCD) increases with one of therisk factors for NCD being an unbalanced diet. Dawood’s fasting is one of the sunnah fastings that can bedone at any time except at times that are forbidden to fast. This fast is a combination model of TRF and ADF(modified ADF = MADF).Objective: To prove that MADF for six consecutive weeks can increase levels of the hormone ?-endorphinsand reduce levels of the hormone cortisol in peripheral blood circulation.Materials and Methods: Quasi-experimental research with a comparative design of a non-equivalentcontrol group with a population of PP students. Hidayatullah Surabaya with the purposive sampling methoduntil the number of samples required was met as many as 34 people and divided into two groups, namelycontrol and MADF treatment for six consecutive weeks. Sampling was carried out at the pre-test, at the endof the third week for the middle and at the post-test. All subjects in both groups received the same nutritiontwice a day for 42 days. The subject gets spiritual motivation from competent resource persons to givespiritual spark twice.Result: Dawood’s fasting (MADF) for six consecutive weeks did not cause significant differences comparedto control on cortisol and ?-endorphins (p> 0.05). However, Dawood’s fasting (MADF) for six consecutiveweeks decreased the mean values of cortisol levels due to the effect of fasting, although there was also asignificant difference in the control group. Meanwhile the ?-endorphins mean values was increased at themiddle of study, and then decreased at the end of the study, with a significant difference in the both groupbefore and after treatment.Conclusion: There was no difference in cortisol and ?-endorphins levels in healthy young adult subjectsundergoing Dawood’s fast due to the influence of the same environmental conditions and a change in thesincerity of the subjects.]]>
<![CDATA[Ekstrak Kulit Pisang Kepok (Musa paradisiaca) Menurunkan Kadar AST pada Tikus Putih yang Diinduksi Diet Tinggi Lemak ]]>
<![CDATA[STEFANUS DJONI HUSODO]]>;
<![CDATA[ASAMI RIETTA KUMALA]]>;
<![CDATA[INDRI NGESTI RAHAYU]]>
<![CDATA[ HANG TUAH MEDICAL JOURNAL Vol 18 No 2 (2021): Hang Tuah Medical Journal ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/htmj.v18i2.122
<![CDATA[ABSTRACT Background. Non-alcoholic fatty liver disease (NAFLD) is closely related to the incidence of obesity and dyslipidemia. Increased levels of Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) are the most frequently performed liver function tests that can be used as a benchmark for suspicion of NAFLD. Banana peels contain flavonoids and phenolics which are antioxidants that can function as hepatoprotectors. Aim. Proving the effect of Kepok banana peel extract on AST and ALT of Wistar rats induced high fat diet. Method. experimental study with a post-test only control group design, with four treatment groups. There is negative control group only given four weeks standard diet (K-), positive control group only given four weeks high-fat diet (K+), and two treatment group where the rats were given two weeks high-fat diet then were given two weeks high-fat diet plus Kepok banana peel extract at a dose of 200 mg/kg BW (K1) and 400 mg/kg BW (K2). Result. the highest mean AST levels were in the negative control group and the lowest was the K2 group. Meanwhile, the highest mean of ALT was in the positive control group and the lowest was the K2 group. Based on the Kruskal Wallis test, the significance of the AST variable was not different (p>0,05), but the ALT variable was significantly different (p<0,05). Significant differences from the Mann Whitney-U test (p<0,05) were obtained between the negative control group and the positive control, the negative control group with K2 and the positive control group with the K2 group). Conclusion. The administration of Kepok banana peel extract (Musa paradisiaca formatypica) showed a significant decrease in ALT levels in Wistar strain white rats induced by a high-fat diet, but it was not significant for AST levels]]>
<![CDATA[Effects of Morning’s Prayer Routines in The Congregation on Random Blood Sugar Levels of Elderly at Al Wahyu Mosque Rungkut Surabaya ]]>
<![CDATA[Indri Ngesti Rahayu]]>;
<![CDATA[Lani Diana]]>;
<![CDATA[R. Varidianto Yudo Tjahjono]]>
<![CDATA[ Oceana Biomedicina Journal Vol 4 No 2 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 2 ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/obj.v4i2.12
<![CDATA[Background: Increased health problems in the elderly occur because of the aging process that causes many changes in their body. One of the changes istheincrease in blood glucose more than normal and at risk of diabetes mellitus. Morning prayer can be a religious coping and regular physical activity that lowers blood sugar levels. Objective: to analyze the effect of the morning prayer routines in the congregation on random blood sugar levels of the elderly at Al-Wahyu Mosque Rungkut Surabaya. Method:This study was an observational analytic study with a cross-sectional design using 30 respondents. The group studied was the congregation of the morning prayers of the Al Wahyu MosqueRungkut Surabaya which was over 45-year-old which undergoes random blood sugar levels measurement. Results:The Independent t-testmethodshowedthat the value of signification was 0,000 (p<0,05) which means that there is the influence of the morning prayer’s routines in the congregation on random blood sugar levels of the elderly at Al-Wahyu Mosque Rungkut Surabaya. Conclusion:Elderly people who routinely carry out the morning prayer routines in the congregation have lower blood sugar levels than elderly people who are not routine.]]>
<![CDATA[The Effect of Patin Fish Oil Extract on LDL Cholesterol Levels Rattus norvegicus was Induced by Alloxan ]]>
<![CDATA[Salsabila Yumna Fathony]]>;
<![CDATA[Fitri Handajani]]>;
<![CDATA[Indri Ngesti Rahayu]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 2 (2022): SEPTEMBER 2022 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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DOI: 10.30742/jikw.v11i2.1877
<![CDATA[Diabetes mellitus is a chronic hyperglycemic syndrome that can be accompanied by lipid metabolism disorders. Alloxan is a diabetogenic agent that is associated with an increase in LDL cholesterol levels. Patin fish contain omega-3 and oleic acid, which can potentially reduce or control LDL cholesterol levels. This study aims to determine the effect of Patin fish (Pangasius hypothalmus) oil extract on LDL cholesterol levels of alloxan-induced Rattus norvegicus. The method of this study is the post-test-only control group design. Twenty-seven experimental animals were divided into 3 groups; (1) the 1st group was without treatment, (2) 2nd group was induced with 150 mg/kg BW alloxan on the 7th day; (3) 3rd group was induced with 150 mg/kg BW alloxan on the 7th day and given the Patin fish oil extract at a dose of 73 mg/kg BW on the 10th day for 14 days. Blood samples were taken on the 24th day to determine LDL cholesterol levels. The results of the One-Way ANOVA test showed a significant mean difference, p=0,001 (p<a). The results of the Post-Hoc LSD test showed a meant difference between the 1st group and the 2nd control group p=0,001 (p<a); 2nd group and 3rd group p=0,026 (p<a); between the 1st group and the 3rd group p=0,015 (p<a). Giving alloxan 150 mg/kg BW can significantly increase LDL cholesterol levels of Rattus norvegicus and administration of Patin fish oil extract 73 mg/kg BW can significantly reduce LDL cholesterol levels of Rattus norvegicus.]]>
<![CDATA[Effect of Spirulina Platensis on Liver Malondialdehyde Levels of Male White Rat Induced by High Dose Paracetamol ]]>
<![CDATA[Anggilia Vanny]]>;
<![CDATA[Sihning E. J. Tehupuring]]>;
<![CDATA[Indri Ngesti Rahayu]]>;
<![CDATA[Roostantia Indrawati]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 12, No 2 (2023): September 2023 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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DOI: 10.30742/jikw.v12i2.2700
<![CDATA[Paracetamol is widely used in therapy, yet it becomes hepatotoxic agent in a high dose using. The CYP450 enzyme metabolizes a small portion of paracetamol to a reactive substance, NAPQI. High dose of paracetamol causes an extensive increase in NAPQI levels. NAPQI then binds to hepatocytes conditions of oxidative stress. Spirulina platensis contains C-phycocyanin, flavonoids, and phenolics that inhibit lipid peroxidation and reduce oxidative stress. This study aims to determine the effect of Spirulina platensis on MDA levels in the liver tissue of male Wistar rats induced by high dose of paracetamol. This research was experimental with a Randomized Post-test Only Control Group design using 24 white male rats divided into three groups; negative control group (G-), positive control group (G+) was given paracetamol at a dose of 1,250 mg/kg on the 8th day, and treatment group (Gt) was given an amount of Spirulina platensis extract 360 mg/kg BW/day for ten days from 1st until 10th day and paracetamol at a single dose of 1,250 mg/kg BW on the 8th. At the 10th day of the treatment, all groups were terminated for liver tissue collection. TBA test was used to calculate MDA levels. Statistical tests analyzed the results of the data. This statistical tests by SPSS software: MDA levels in the treatment group did not significantly differ (p = 0.144) compared to the negative control group. There was a significant difference of liver tissue MDA levels in the treatment group (p = 0.016) compared to the positive control group. This study concludes that administering Spirulina platensis at a dose of 360 mg/kg/day for ten days can help prevent on increase in tissue MDA levels and maintain liver conditions close to their original state.]]>
<![CDATA[PENURUNAN KADAR MDA TIKUS PUTIH JANTAN DENGAN PEMBERIAN DIET TINGGI LEMAK DAN EKSTRAK BIJI MAHONI ]]>
<![CDATA[Indri Ngesti Rahayu]]>;
<![CDATA[Asami Rieta Kumala]]>
<![CDATA[ Surabaya Biomedical Journal Vol 1 No 1 (2021): September ]]>
Publisher : <![CDATA[Fakultas Kedokteran, Universitas Hang Tuah ]]>
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DOI: 10.30649/sbj.v1i1.7
<![CDATA[Masyarakat modern saat ini mengalami perubahan gaya hidup yang mengakibatkan perubahan pada pola konsumsi makanan menjadi pola makanan yang tinggi lemak jenuh, tinggi gula dan rendah serat. Hal tersebut sering berakibat tingginya asupan makanan yang berkolesterol tunggi kemudian ditambah dengan seringnya frekuensi makan serta konsumsi sayur dan buah yang rendah, akan berpotensi menyebabkan kegemukan. stroke, aterosklerosis dan penyakit jantung koroner (PJK) memiliki faktor risiko paling besar menjadi penyakit serius di masyarakat yaitu hiperlipidemia sehingga diduga menjadi penyebab kesakitan dan kematian di negara adidaya dan berkembang. Membuktikan pengaruh ekstrak biji mahoni terhadap kadar MDA plasma tikus putih jantan galur wistar yang diberikan diet tinggi lemak. 32 ekor tikus dikelompokkan dalam kelompok kontrol negatif yang diberikan diet standart, kontrol positif yang diberikan diet tinggi lemak dan perlakuan yang mendapatkan diet tinggi lemak bersama ekstrak biji mahoni dengan dosis 100 mg/ kgBB dan 200 mg/kgBB. Diet tinggi lemak dikonsumsi tikus selama 14 hari dan pada hari ke 15 pada kelompok perlakuan ditambahkan ekstrak biji mahoni dengan dosis 100 mg/ kgBB dan 200 mg/kgBB Derajat stres oksidatif diukur dengan menggunakan indikator malondialdehyde (MDA). Kelompok kontrol negatif menunjukkan kadar MDA 78,5±16,92 µg/ml. Kelompok kontrol positif menunjukkan kadar MDA 97,17±26,559 µg/ml. Kelompok perlakuan yang mendapatkan diet tinggi lemak dan ekstrak biji mahoni dengan dosis 100 mg/kgBB, kadar MDAnya 65,25±24,126 µg/ml dan yang mendapatkan diet tinggi lemak dan ekstrak biji mahoni dosis 200 mg/kgBB 82±22,836 µg/ml. Uji ANOVA tidak mendapatkan hasil dengan perbedaan yang bermakna (p=0,151).]]>
<![CDATA[Perbedaan Derajat Keparahan Akne Vulgaris berdasarkan Pemakaian Alphadan Beta Hydroxy Acid ]]>
<![CDATA[LAKSMITA SEKAR ANGGRAENI]]>;
<![CDATA[RIETTA KUMALA, ASAMI]]>;
<![CDATA[NGESTI RAHAYU, IINDRI]]>
<![CDATA[ Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal ]]>
Publisher : <![CDATA[Universitas Hang Tuah ]]>
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DOI: 10.30649/htmj.v21i1.237
<![CDATA[Background : Indonesia has a tropical climate that gets very strong sun exposure. With extreme weather conditions, various skin problems can be seen, one of which is acne vulgaris. Topical therapy is the preferred choice for the treatment of mild to moderate acne and is also helpful for the treatment of severe acne, such as alpha hydroxy acids and beta hydroxy acids (AHAs and BHAs). Objective : To determine the differences in the severity of acne vulgaris based on the use of alpha hydroxy acid and beta hydroxy acid (AHA and BHA) in 6th semester students of the Hang Tuah University Faculty of Medicine. Methods: An analytic observational method in a cross sectional study with a simple random sampling method. The study was conducted from April to December using 58 samples by distributing questionnaires through the google form link. Results : The Mann-Whitney U statistical test between users and non-users of alpha hydroxy acid and beta hydroxy acid (AHA and BHA) showed a significance 0,068. So there was no difference in the two groups. Conclusion : The most classification of acne vulgaris severity is mild in female students who use and do not use alpha hydroxy acid and beta hydroxy acid (AHA and BHA). Keywords : AHA and BHA, Acne Vulgaris, Facial Skin.]]>
<![CDATA[Identification of Bioactive Compounds from Pedada Fruit Extract (Sonneratia Caseolaris) to Prevent Stunting ]]>
<![CDATA[Damayanti, Azarine Ahnafia]]>;
<![CDATA[Diarsvitri, Wienta]]>;
<![CDATA[Nefertiti, Eva Pravitasari]]>;
<![CDATA[Rahayu, Indri Ngesti]]>
<![CDATA[ Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 1 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan ]]>
Publisher : <![CDATA[Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT ]]>
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DOI: 10.33533/jpm.v18i1.7491
<![CDATA[Stunting is a problem that still cannot be resolved throughout the world, especially in Indonesia. Children who are malnourished show high levels of blood oxidative stress biomarkers as well as inhibition in growth. To understand prevention of stunting, research was conducted using pedada fruit (Sonneratia caseolaris) which is a mangrove plant taken at the Wonorejo Magrove Ecotourism, Rungkut District, Surabaya City, East Java. The results of the research were used to reveal that there are bioactive compounds in pedada fruit extract to prevent stunting. This research used One Shot Experimental Study. The variables studied used primary data from screening of phenolic and flavonoid antioxidant metabolite compounds at the FK UHT Pharmacy Laboratory and screening for Cu, Fe, Zn mineral content at the UPT East Java Nutrition Laboratory. Result: Based on the results of qualitative phytochemical screening, pedada fruit contained phytochemical compounds, namely phenolics and flavonoids. Mineral screening of pedada fruit was carried out using the Atomic Absorption Spectrophotometry (AAS) method. Pedada fruit extract contained zinc (Zn) of 1.057 mg, while copper (Cu) and iron (Fe) of 0 mg.]]>
<![CDATA[The Effect Of Dawood's Fasting In Removing Total Blood Cholesterol Levels In Surabaya Hidayatullah Islamic Boarding School’s Student ]]>
<![CDATA[Rahayu, Indri Ngesti]]>;
<![CDATA[Wijayanti, Ni Luh Putu Ratih]]>;
<![CDATA[Purwaningsari, Diah]]>;
<![CDATA[Komalasari, Intan]]>;
<![CDATA[Dagradi, Eric Mayo]]>
<![CDATA[ Jurnal Medis Islam Internasional Vol 3 No 1 (2021): December ]]>
Publisher : <![CDATA[UNUSA Press ]]>
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DOI: 10.33086/iimj.v3i1.2445
<![CDATA[Background: Hypercholesterolemia is a risk factor for causing death at a young age. The World Health Organization reported in 2002 that 4.4 million deaths were caused by hypercholesterolemia, or 7.9% of the total number of deaths at a young age. Hypercholesterolemia is a condition in which cholesterol levels in the body exceed normal levels. One way that can be done to prevent hypercholesterolemia is to control diet, namely by fasting. Dawood’s fasting is one of the obligatory fasts of Islamwhich is done with one-day fasting and one-day not. Objective: This study aims to determine the effect of Dawood’s fasting in reducing total blood cholesterol levels in Hidayatullah Islamic Boarding School students in Surabaya.Methods: This study was designed with a quasi-experimental study research method using a comparative pre-test post-test non-equivalent control group design. The sample in this study was divided into two groups, namely one control group and one treatment group from the sample selected by purposive sampling. The population studied were students of the Hidayatullah Islamic Boarding School in Surabaya. Result: The results of statistical analysis using the Wilcoxon signed-rank test showed an effect of Dawood’s fasting in reducing total blood cholesterol levels in Hidayatullah Islamic Boarding School students in Surabaya.Conclusion: From research result that has been done, it can be concluded that there is an effect of Dawood’s fasting in reducing total blood cholesterol levels in Hidayatullah Islamic Boarding School students in Surabaya. Keywords: Dawood’s fasting, total blood cholesterol.]]>
<![CDATA[PENGARUH PUASA INTERMITEN MENGGUNAKAN METODE PUASA DAUD TERHADAP KADAR SGOT TIKUS PUTIH (Rattus norvegicus) ALIRAN WISTAR YANG DIINDUKSI PARACETAMOL ]]>
<![CDATA[Dagradi, Eric Mayo]]>;
<![CDATA[Sukmana, Judya]]>;
<![CDATA[Rahayu, Indri Ngesti]]>
<![CDATA[ Surabaya Biomedical Journal Vol 2 No 1 (2022): September ]]>
Publisher : <![CDATA[Fakultas Kedokteran, Universitas Hang Tuah ]]>
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DOI: 10.30649/sbj.v2i1.43
<![CDATA[Background: Intermittent fasting is done with one day of fasting and one day of eating as usual so that it can reduce oxidative stress, inhibit apoptosis and tissue damage which will reduce degenerative diseases. Fasting can activate SIRT1 and SIRT3 to prevent apoptosis by decreasing reactive oxygen species and inhibiting the mitochondrial permeability transition pore component. The accumulation of free radicals is one of the mechanisms that play a role in liver damage so that the SGOT enzyme present in the liver cells will leave and enter the blood circulation, so that the number of these enzymes in the blood increases. Objective : To prove that there was a decrease in the levels of SGOT (Serum Glutamic Oxaloacetic Transaminase) in male white rats (Ratus norvegicus) of the wistar strain which were fasted intermittently by the Daud fasting method after being induced by Paracetamol. Method : The research design used is a laboratory experimental research type where the method used is randomized the post only control group design. The experimental animals used were white rats (Rattus norvegicus) wistar strain 2-3 months old with an initial body weight of 150-200gr as many as 32 tails. During the fasting treatment, the research subjects were not given diet and drinking, while the non-fasting subjects were given a standard diet and drank regularly were divided into four groups, namely negative control with a water probe that was filtered for 10 days and 1ml of 1% CMC-Na, positive control with a probe. filtered water for 10 days and induction of paracetamol 400mg/kgBW, treatment 1 with standard diet and induction of paracetamol and treatment 2 with intermittent fasting and induction of paracetamol. Results: The results of this study indicate that One-Way ANOVA test obtained p value = 0.384. (p > 0.05) then H0 was accepted, there was no significant difference between the SGOT levels of the experimental animal group that was given a standard diet, the experimental animal group that was given intermittent fasting, the experimental animal group that was given a standard diet and paracetamol and the experimental animal group that was given intermittent fasting and paracetamol treatment. Conclusion: There is no effect of intermittent fasting with the Dawood fasting method on decreasing SGOT levels in male white rats (Rattus norvegicus) Wistar strain induced by paracetamol. Keywords: intermittent fasting, SGOT, paracetamol]]>
