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Jurnal Ilmiah Kedokteran Wijaya Kusuma

JIKW
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Published by Universitas Wijaya Kusuma Surabaya

ISSN : 19782071 EISSN : 25805967 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.

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Articles 12 Documents

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Search results for , issue "Vol 9, No 1 (2020): MARET 2020 available online since April 2020" : 12 Documents clear

Mekanisme Escape dan Respon Imun innate terhadap Candida albicans Putu Oky ari Tania
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Candidiasis is an infection caused by fungal Candida albicans. The incidence of candidiasis is pretty high in Indonesia. Candida albicans develop their pathogenicity by several ways so that it can invade and escape from the immune system. The host’s immune system must always be vigilant to recognized antigen through various receptors, activation of the transduction pathway and activation of various immune cells. But as organisms that struggle to survive, Candida also develops mechanisms to escape the immune response. There are so many articles have written the immune response against candidiasis, this review aims to understand more and updating information about the biological processes of pathogenicity of fungi and the mechanism of Candida albicans in escaping immune responses, the role of each innate molecule and immune cell, and clinical aspect to Candida albicans infections. We already facing the big challenges against therapy of fungal infection, so by understanding the escape mechanism of Candida albicans, it is possible to developed antifungal or Candida vaccine in the future, therefore the incidence of candidiasis can be suppressed.

Efek Pemberian Ekstrak Daun Pegagan (Centella Asiatica) Terhadap Penyembuhan Luka Sayat Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar I Made Subhawa Harsa
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Wound refers to partly damage or loss of body tissue. One way that has been used by the people in helping the process of wound healing is the use of medicinal plants, such as gotu kola (Centella asiatica). Gotu kola (Centella asiatica) is kind of plant that found almost in all territories of Indonesia which functions as a cell revitalizing substance which quickens wound healing those are burnt, skin ulcer and to prevent keloid. This study is aimed to know the effect of giving gotu kola leaf extract (Centella Asiatica) against to the healing of the wound incision on male white rats (Rattus Norvegicus) wistar strain. This study is a pure experimental research using the randomized post test only control group design with the subjects are 30 male white rats (Rattus norvegicus) wistar strain that were divided into 3 groups, namely K1, K2, and K3. The incision wound were made on the back of all white rat in each group with a length of ± 2 cm and a depth of ± 2 mm. The wound in the negative control group (K1) was not given any substance; in the positive control group (K2) was given povidone iodine 10%; and in the treatment group (K3) was given gotu kola leaf extract at a dose of 37,5 mg/150 grBB. The study was done for 10 days. Furthermore, wound observation and monitoring is held. Then the results were processed by using One Way ANOVA. The result study of wound incision healing on male white rats (Rattus norvegicus) wistar strain shows that there is significant difference among the negative control group (K1), the positive control group (K2), and the treatment group (K3) on One Way ANOVA test which significant p-value are 0,027 (p < 0.05). The result of Post-Hoc LSD test also shows a significant differences among the K1 and K3 groups, and K2 and K3 groups which significant p-values are 0,011 and 0,038 (p < 0,05). From these results, it can be concluded that gotu kola leaf extract (Centella asiatica) effective on quickens wound healing of the wound incision on male white rats (Rattus norvegicus) wistar strain.

A Meta-Analysis of the Ultimate Effect of Mesenchymal Stem / Stromal Cell in Tumor Animal Models Pratika Yuhyi Hernanda
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Several studies have reported the Mesenchymal Stem Cell (MSC) triggered and inhibited tumor growth. We therefore performed a systematic review and meta-analysis of experimental studies evaluating the effects of MSC on tumors. Method: We collected the relevant studies by searching ProQuest, PubMed Publisher, and GoogleScholar. A meta-analysis was performed for the outcome measure: tumor volume and tumor weight. The search resulted in 440 references, of which 22 could be included in the meta-analysis. Of these 22 experiments, 18 (40%) showed a significant decrease of tumor growth and 27 (60%) experiments showed a significant increase of tumor growth. The engineered MSC and the late phase of MSC injection have a significant contribution to tumor inhibition effect. The meta-analysis showed that there are no significant effect of mesenchymal stem cell therapy to the tumor animal volume (SMD-0.23[-0.55, 0.09]; n=15), and to the tumor animal weight (SMD -0.19 [-0.77,0.39]; n=7). Conclusion: MSC appears to have a relative dependent effect in animal models.

Cover Volume 9 Nomer 1 Edisi Maret 2020 Putu oky ari tania
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Puasa Selama Kebuntingan terhadap jumlah sel neuron Cereberum dan Cerebellum Rattus norvegicus Baru Lahir Ucik Nurul Hidayati; Hermanto Tri Joewono; Muhammad Miftahussurur; Agus Sulistyono; Martono Tri Utomo; Sulistiawati Sulistiawati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Fasting by pregnant women causes increasing neurons in the brain. An increasing number of neuron cells will speed up information processing, so it is expected to increasing intelligence. The purpose of this study was to analyze the effect of fasting during pregnancy on the number of new cells of the cerebrum neuron and the newly born Rattus norvegicus cerebellum. The research design was true experimental laboratory posttest only with control group design. Pregnant Rattus norvegicus samples consisted of 3 groups and 1 control group with a total sample of 32 divided by 4; Xo control group without fast treatment, fasting X1 group in 1st trimester (2 days), fasting X2 group in 2nd trimester (2 days), fasting group X3 at TM 3 (2 days). Data analysis using Shapiro – Wilk normality test, followed by ANOVA test and using SPSS for Windows 23 software. The results of statistical analysis showed no significant difference in the number of cerebrum neuron cells in the four groups P = 0.210 (p> 0.05) and there were significant differences in the number of cerebrum neuron cells in the four groups P = 0.032 (p <0.05). The conclusion of this study is there was no difference in the number of neuron cells in cerebrum and cerebellum of Rattus norvegicus newborn in the fasting mother 2 days during trimester I, II dan III of pregnancy. There was a difference in the number of neuron cells in the new cerebellum of Rattus norvegicus fasting for 2 days during trimester III of pregnancy, and there were differences the effect of the number of neuron cell in cerebellum of Rattus norvegicus in all groups.

Perbedaan Jumlah Sel Neuron Cerebrum dan Cerebellum Mus musculus pada Kehamilan Remaja dan Dewasa Tri Purwanti; Widjiati Widjiati; Muhammad Miftahussurur
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Teenage pregnancy contributes to emotional stress higher than adult women Pregnancy in adolescents will trigger negative thoughts and feelings of fear that become the root cause of stress reactions. The onset of stress will trigger the occurrence of Axis HPA activity and the release of corticotrophin releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus, then stimulate the production of adrenencorticotropic hormone (ACTH) by the anterior pituitary gland. ACTH will stimulate glucocorticoids (cortisol) from the adrenal gland cortex to increase the production of CRH in the placenta and give an effect of increasing cortisol in the maternal, as well as the amount of cortisol in the fetus will also increase because it follows the blood placenta barrier. This affects the growth and development of the fetal brain, so that the process of proliferation and differentiation, migration, organization and synaptogenesis and myelination in brain cells. The growth of the brain decreases which affects the number of neuron cells. This study aims to analyze the differences in the number of neuron cells in the cerebrum and cerebellum Mus musculus newly born in adolescent and adult pregnancy. The division of the study group consisted of two groups, namely the adolescent and adult pregnancy groups each of 16 individuals. Taking the examination sample is by taking each of the 3 children from the parent with the heaviest, medium and lowest weights. Then the Mus musculus children were sacrificed by anesthesia and decapitation, then Hematoxilin-Eosin preparations were made from the child's brain. The next step is to examine Hematoxilin-Eosin to calculate the number of neuron cells in the cerebrum and cerebellum with the analysis of the Independent T test showing significant differences between the control and treatment groups with a value of p = 0,000 (p <0.05). Then the analysis of the number of brain neuron cells using the Mann Whitney test showed a difference that the control group was higher than the adolescent group.

Efek Proteksi dari Terapi Oksigen Hiperbarik terhadap Ekspresi Bcl-2 Miometrium Rattus norvegicus Bunting yang Terinfeksi oleh Tachyzoite Toxoplasma gondii Arif Rahman Nurdianto; Aryati Aryati; Mohammad Guritno Suryokusumo; Mufasirin Mufasirin
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i1.730

Hyperbaric Oxygen Therapy (HBOT) can increase oxygen delivery to tissues and stimulate the formation of H2O2 as a secondary messenger for phosphorylation of nuclear factor kappa beta (NF-kB) which plays an important role in the transcription of the anti apoptotic gene. This study aimed to determine the effects of Hyperbaric Oxygen Therapy (HBOT) in enhancing the expressions of Bcl-2 in the myometrium of pregnant rats infected by Toxoplasma gondii. This study was an experimental study with a randomized control group of post-test only and designed by 37 pregnant Rattus norvegicus Sprague Dawley. Randomly, the rats were divided into four groups. Group A is infected pregnant rats that exposed by 10 sessions of HBOT 2.4 ATA in 3x30 minutes. Group B is non-infected pregnant rats and exposed by 10 sessions of HBOT 2.4 ATA in 3x30 minutes. Group C is infected pregnant rats without any exposure. Group D is non-infected pregnant rats without any exposure. Each infected pregnant rat was given a 103 tachyzoite of T.gondii by intraperitoneal injection. Bcl-2 expressions were measured through immunohistochemistry. All data were analyzed using ANOVA test through SPSS 21 program application. There was a significant difference in Bcl-2 expression between Group A and Group C because p<α (p<0.017). HBOT can increase the expression of Bcl-2 from infected and not infected rat myometrium, in the provision of HBOT 2.4 ATA for 3x30 minutes, twice a day for 5 days.

Gambaran Penggunaan Obat Anti Epilepsi (OAE) pada Penderita Epilepsi Berdasarkan Tipe Kejang di Poli Saraf Rumkital DR. Ramelan Surabaya Eric Hartono Tedyanto; Laurawati Chandra; Olivia Mahardhani Adam
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i1.748

Epilepsy is a disorder of the central nervous system (CNS) characterized by attacks (seizures, fit, attack, spell) spontaneous (unprovoked) and periodically. The main treatment of epilepsy is with antiepileptic drugs. It was used the descriptive study design by using secondary data which taken at Medical Record Installation of Dr. Ramelan Naval Hospital Surabaya from September-November 2018. The results showed that the percentage of focal seizures is 41%, seizures general is 36% and unclassified seizures is 23%. From 61 samples, the percentage of anti-epileptic drugs used are phenytoin (31.1%), valproic acid (21.3%) and carbamazepine (4.9%) as a monotherapy. While 42.7% were treated with polytherapy that the combination of phenytoin, valproic acid, carbamazepine and benzodiazepines. Focal seizure that dominate with 41%, the general seizure is 36% and unclassified seizures is 23%. Anti-epileptic drugs that are widely used class of phenytoin, valproic acid and carbamazepine as monotherapy and the combination of phenytoin, valproic acid, carbamazepine and benzodiazepines as polytherapy.

Kata Pengantar-Daftar Isi Edisi Maret 2020 masfufatun masfufatun
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i1.842

Uji Zona Hambat Kombinasi Ekstrak Bawang Putih (Allium sativum) dan Buah Mengkudu (Morinda citrifolia) terhadap Bakteri Escherichia coli R Abyseka Prayogo; Dorta Simamora
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i1.700

Escherichia coli bacteria is the most common cause of gastroenteritis (diarrhea), urinary tract infections (UTI), food poisoning, and other clinical problems such as neonatal miningitis. Garlic (Allium sativum) and Noni fruit (Morinda citrifolia) are plants that have antimicrobial properties, which can be used against bacteria such as E. Coli. This study was conducted to determine the inhibition zone combination of garlic extract (Allium sativum) and Noni fruit (Morinda citrifolia) against gram negative bacteria E. Coli. The research was conducted at the Laboratory of Microbiology at the Faculty of Medicine, University of Wijaya Kusuma Surabaya, and has been ethically feasible. This study was divided into 4 groups with replications 6 times each; group P0 (sterile distilled water), P1 (50% garlic + 25% noni fruit), P2 (50% garlic + 50% noni fruit), P3 (50% garlic + 75% noni fruit). Data were analyzed using One-way ANOVA test. The analysis results showed that the average diameter of the inhibition zone formed was the largest in group P1 (10.7 mm) and the smallest in group P0 (0 mm), while in P2 (9.89 mm), and P3 (9.77 mm). Based on the analysis test, the higher the concentration of noni fruit given to the extract combination resulted in the smaller diameter of the inhibition zone. This occurs due to the combination of garlic and Noni fruit has an antagonistic effect that depend on bacterial species, temperature, pH, chemical structure, chemical reactions, and concentrations or doses of antimicrobial compounds. The results also showed that there was no significant difference between group P1 and group P2, group P1 with group P3 and group P2 with group P3 showing p-value> 0.005.

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Jawa timur

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