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All Journal Folia Medica Indonesiana Journal of Agromedicine and Medical Sciences Berkala Kedokteran Nusantara Medical Science Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Abdidas Journal of Community Development Hang Tuah Medical Journal Calvaria Medical Journal Prosiding Seminar Nasional Kusuma Prosiding Seminar Nasional COSMIC Kedokteran

I Made Subhawa Harsa

Bagian Ilmu Faal Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya

Author-ID : 5344665

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Effect Administration of Ethanol Extract of Bitter Melon (Momordica Charantia L.) On The Reduction of MDA (Malondialdehyde) Levels Serum in Rats Given a High-Fat Diet Andiani, Andiani; harsa, made subhawa
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Hyperlipidemia is a disease whichthe effect in increased fat levels in the blood. In hyperlipidemia, the condition of high oxidative stress is obtained due to the oxidation process of LDL (Low Density Lipoprotein) in the body, this condition showed by increased of MDA (Malondialdehyde) levels in serum. Bitter melon (Momordica Charantia L.) contains a lot of active ingredients, one of the ingredients of bitter melon that is thought to have antilipidemic effects is flavonoid compounds. This study was experimental study using a randomized posttest only control group design study with a sample size of 30 male white rats (Rattus norvegicus) wistar strain which was divided into 3 groups, namely K1, K2, and K3. In each group, different treatments are given. Negative control group (K1), given standard feed, water ad libitum; Positive control group (K2), given standard feed, high fat feed with a dose of 2.5 ml water ad libitum; The treatment group (K3) was given a standard diet, high-fat feed with a dose of 2.5 ml water ad libitum and extract of bitter melonat a dose of 250 mg / kg BB by orally every morning for 3 weeks. Data analysis using One Way Anova Test. From the results of the test shows the significance of p-value = 0.000 which is <Î± (0.05). The results showed that there was an effect ofÂ administration ethanol extract of bitter melon (Momordica charantia L.) to decrease in serum MDA (malondialdehyde) levels in male white wistar rats (Rattus norvegicus) given a high-fat diet.

The Influence of Giving Tempe Flour Toward the Amount and Morphology of White Male Rat (Rattus norvegicus) Erythrocytes Wistar Strain was Affected by Cigarette Smoke I Made Subhawa Harsa
Berkala Kedokteran Vol 15, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Cigarette smoke was one of free radicals source for the body. Free radical contain in cigarette smoke were hydroxide radicals (•OH). Hydroxide radicals would cause erythrocytes damage. Antioxidants were substances that can prevent free radicals. Now, natural antioxidants source has developed, one of that is tempe, because of it contained antioxidants substances such as carotene, Vitamin E, isoflavon, and factor II antioxidants. This resource was for knowing the influence of giving tempe flour toward the amount and morphology of white male rat (Rattus norvegicus) erythrocytes wistar strain was affected by cigarette smoke. A pure experiment which was used the post test only-control group design method. Sample of the resource was white male rat wistar strain aged of 3-4 month as much 30 rats by the weight around 180-220 gram. The samples divided into 3 groups that were control group (K1), treatment group 1 (K2), and treatment group 2 (K3), each group consists of 10 rats. Control group was not given a special treatment, it only got a standard feed, treatment group 1 got special treatment and it was affected by cigarette smoke, furthermore, treatment group 2 got standard feed, it was affected by cigarette smoke and tempe. Analysis of data used one way anova experiment. The test showed the significance P-value = 0,036 that was <α (0,05). The result showed that there was the influence of giving tempe flour toward the amount and morphology of white male rat (Rattus norvegicus) erythrocytes wistar strain was affected by cigarette smoke. Keywords: cigarette smoke, free radicals, erythrocytes, antioxidants, tempe

Tempe Flour Increase The Amount of Erythrocytes of White Male Rat (Rattus norvegicus) Wistar Strain Induced by Cigarette Smoke I Made Subhawa Harsa
Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i1.9673

Cigarette smoke was one of the free radical sources for the body. Free radical contain in cigarette smoke were hydroxide radicals (•OH). Hydroxide radicals would cause erythrocytes damage. Antioxidants were substances that can prevent free radicals. Now, natural antioxidants source has developed, one of that is tempe because it contains antioxidants substances such as carotene, Vitamin E, isoflavone, and factor II antioxidants. The aim of this study is knowing the influence of giving tempe flour toward the amount of erythrocytes of white male rat (Rattus norvegicus) Wistar strain induced by cigarette smoke. The experiment used a post-test only-control group design method. The samples were white male rats Wistar strain aged of 3 to 4 months as much 30 rats with weight around 180-220 gram. The samples divided into three groups, that were control group (K1), treatment group 1 (K2), and treatment group 2 (K3), each group consists of 10 rats. Control group was not given any treatment, it only got a standard feed, treatment group 1 got treatment and it was induced by cigarette smoke. Furthermore, treatment group 2 got standard feed, it was induced by cigarette smoke and was given tempe. Analysis of data used one-way anova showed the significance p-value = 0,036 that was <α (0,05). The result showed giving tempe flour increase the amounts of erythrocytes of white male rat (Rattus norvegicus) Wistar strain which was induced by cigarette smoke. Keywords: cigarette smoke, free radicals, erythrocytes, antioxidants, tempe

The Relationship Between Clean Water Sources And The Incidence Of Diarrhea In Kampung Baru Resident At Ngagelrejo Wonokromo Surabaya I Made Subhawa Harsa
Journal of Agromedicine and Medical Sciences Vol 5 No 3 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i3.13813

Abstract Water is a good medium for bacterial growth, so that contamination is happening especially if less attention in terms of hygiene and sanitation. The use of bed water sources can increase the risk of diarrhea. Diarrhea is one of the environmentally based disease is a major cause of morbidity and mortality. Kampung Baru village located around Jagir Kali Surabaya Most people are in the middle to low socioeconomic level. The lifestyle of them, also pays less attention to environmental hygiene and sanitation, so that it can cause water pollution which can increase the risk of diarrhea. This study was an observational analytic cross sectional study. Entire study population villagers of Kampung Baru. A sample of 75 respondents drawn with simple random sampling technique. The data used is primary data obtained through the distribution of questionnaires, interviews, and observations. Data analysis using the Spearman rank test with a significance level (α = 0.1). The results showed that 53,3% affected diarrhea and 46,7% didn’t affected (P =0.087, r=0.463). The results showed a medium correlation between the source of water with the incidence of diarrhea in Kampung Baru Resident At Ngagelrejo Wonokromo Surabaya. Keyword : Diarrhae, Water Sanitation

Pemberian Ekstrak Buah Pare dan Diet Tinggi Lemak pada Penurunan Berat Badan Tikus Putih Jantan I MADE SUBHAWA HARSA
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background : Obesity is an energy balance disorder, ketogenic diet can reduce body weight. Bitter melon (Momordica charantia L.) is a type of vegetable material that is often used as an antioxidant, hypocholesterolemia and hypotriglyceridemia drug. Cucurbitasin is a substance produced by bitter melon (Momordica charantia L.) with a bitter taste which causes in decreasing appetite, resulting in a decrease in triglycerides. This is caused by the bioactivity of bitter melon (Momordica charantia L.) which can increase lipid oxidation, which causes the accumulation of decreased fat tissue which can reduce weight. Methods: This research using pre and post test randomized controlled group design with sample size of 30 male white rats (Rattus norvegicus) wistar lines divided into 3 groups, group 1 as negative control group given standard feed, group 2 as positive control group given high-fat diet with a dose of 2.5 ml and group 3 as a treatment group given a high-fat feed with dose of 2.5 ml and extract of bitter melon (Momordica charantia L.) at dose of 37.5 mg / 150 gBB by feeding tube every morning for 28 days. Data were analyzed by T-paired tests. Result: The T-paired test in each group found a significantly different result of p = 0,000. Conclusion: given bitter melon (Momordica charantia L.) extract and high-fat diet can reduce weight in male white rats (Rattus norvegicus). Keywords:Bitter molon extract, high fat feed, weight loss

Efek pemberian ekstrak etanol bawang putih (Allium sativum) sebagai hepatoprotektor pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi parasetamol dosis hepatotoksik Made Subhawa Harsa
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Garlic (Allium sativum) is a plant that known to have various properties that can be used in treatment as a hepatoprotective agent. This study aim was to determine the effect of garlic ethanol extract (Allium sativum) in Wistar strain white male rats (Rattus norvegicus) which was induced by paracetamol in hepatotoxic dose. This research is an experimental study with randomized the post-test only control group design with sample consisted of twenty-four Wistar strain white male rats (Rattus norvegicus). The sample were divided into four groups: control groups, group P1 (given garlic ethanol extract 10 mg/kg), group P2 (ethanol extract of garlic was given 20 mg/kg) and group P3 (given the ethanol extract garlic 30 mg/kg). This study for seventeen days. The entire samples were terminated in order to draw blood to examine SGPT and SGOT. The data of SGPT and SGOT examined by One Way ANOVA. Result showed that there was significant difference in SGPT and SGOT values between groups after given ethanol extract of garlic (Allium sativum) (Î± <0.05). From the analysis we can concluded that garlic ethanol extract (Allium sativum) can be used as a hepatoprotective agent in Wistar strain white male rats (Rattus norvegicus) Â induced by paracetamol in hepatotoxic dose.

Effect Administration of Ethanol Extract of Bitter Melon (Momordica Charantia L.) On The Reduction of MDA (Malondialdehyde) Levels Serum in Rats Given a High-Fat Diet Andiani Andiani; Made Subhawa Harsa
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Hyperlipidemia is a disease whichthe effect in increased fat levels in the blood. In hyperlipidemia, the condition of high oxidative stress is obtained due to the oxidation process of LDL (Low Density Lipoprotein) in the body, this condition showed by increased of MDA (Malondialdehyde) levels in serum. Bitter melon (Momordica Charantia L.) contains a lot of active ingredients, one of the ingredients of bitter melon that is thought to have antilipidemic effects is flavonoid compounds. This study was experimental study using a randomized posttest only control group design study with a sample size of 30 male white rats (Rattus norvegicus) wistar strain which was divided into 3 groups, namely K1, K2, and K3. In each group, different treatments are given. Negative control group (K1), given standard feed, water ad libitum; Positive control group (K2), given standard feed, high fat feed with a dose of 2.5 ml water ad libitum; The treatment group (K3) was given a standard diet, high-fat feed with a dose of 2.5 ml water ad libitum and extract of bitter melonat a dose of 250 mg / kg BB by orally every morning for 3 weeks. Data analysis using One Way Anova Test. From the results of the test shows the significance of p-value = 0.000 which is <α (0.05). The results showed that there was an effect of administration ethanol extract of bitter melon (Momordica charantia L.) to decrease in serum MDA (malondialdehyde) levels in male white wistar rats (Rattus norvegicus) given a high-fat diet.

Efek Pemberian Ekstrak Daun Pegagan (Centella Asiatica) Terhadap Penyembuhan Luka Sayat Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar I Made Subhawa Harsa
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Wound refers to partly damage or loss of body tissue. One way that has been used by the people in helping the process of wound healing is the use of medicinal plants, such as gotu kola (Centella asiatica). Gotu kola (Centella asiatica) is kind of plant that found almost in all territories of Indonesia which functions as a cell revitalizing substance which quickens wound healing those are burnt, skin ulcer and to prevent keloid. This study is aimed to know the effect of giving gotu kola leaf extract (Centella Asiatica) against to the healing of the wound incision on male white rats (Rattus Norvegicus) wistar strain. This study is a pure experimental research using the randomized post test only control group design with the subjects are 30 male white rats (Rattus norvegicus) wistar strain that were divided into 3 groups, namely K1, K2, and K3. The incision wound were made on the back of all white rat in each group with a length of ± 2 cm and a depth of ± 2 mm. The wound in the negative control group (K1) was not given any substance; in the positive control group (K2) was given povidone iodine 10%; and in the treatment group (K3) was given gotu kola leaf extract at a dose of 37,5 mg/150 grBB. The study was done for 10 days. Furthermore, wound observation and monitoring is held. Then the results were processed by using One Way ANOVA. The result study of wound incision healing on male white rats (Rattus norvegicus) wistar strain shows that there is significant difference among the negative control group (K1), the positive control group (K2), and the treatment group (K3) on One Way ANOVA test which significant p-value are 0,027 (p < 0.05). The result of Post-Hoc LSD test also shows a significant differences among the K1 and K3 groups, and K2 and K3 groups which significant p-values are 0,011 and 0,038 (p < 0,05). From these results, it can be concluded that gotu kola leaf extract (Centella asiatica) effective on quickens wound healing of the wound incision on male white rats (Rattus norvegicus) wistar strain.

Potency of Ethanol Extract Celery (Apium graveolens L.) Stalk as Anti-Cholesterol I Made Subhawa Harsa; Andiani Andiani; Harsono Wiradinata; Putu Oky Ari Tania
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 2 (2022): EDISI SEPTEMBER 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Increasing levels of blood cholesterol is one of the risk factors for atherosclerosis. Currently, experts have been trying used herbal medicine as an alternative treatment of atherosclerosis. One of the highlights is the use of celery stalks. Celery is generally used as a flavouring dish. In addition, celery stalks are believed able to reduce cholesterol levels because they contain flavonoids, tannins, and saponins. This study was aim to determine the effect of celery stalk ethanol extract to reduce LDL an increase of HDL level in rats after fed high-fat diet. Randomized Post Test Only Control Group Design was used to measure the HDL and LDL blood serum levels of male Wistar (Rattus norvegicus) rats fed a high-fat diet. This study was used 27 male Wistar rats (Rattus norvegicus) divided into 3 groups; K1 was only given regular feed and water, K2 was given a high-fat diet and water, K3 was given a high-fat diet and celery stalk extract at a dose of 75mg/kg BW/day for 14 days. The data were analysed by ANOVA test and Tukey HSD test. The results of the ANOVA test showed a significance value of p-value of LDL = 0.000 and HDL p-value = 0.536. Celery stalk extract (Apium graviolens L) had an effect on decreasing LDL levels but not on increasing HDL blood serum levels of white Wistar rats (Rattus norvegicus) given high-fat diet.

Effect Of Intaking High-Fat Diet On White Rat’s (Rattus norvegicus)Blood Lipid Profil Made Subawa Harsa
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 3, No 1 (2014): Edisi Maret 2014
Publisher : Universitas Wijaya Kusuma Surabaya

Obesity and metabolic syndrom are characterized by dislipidemia. One of methods that is performed to increase body fat contents is by intaking of high-fat diet. The purpose of this study was to demonstrate the effect of a dietary intake of high-fat on the lipid profile (total cholesterol, HDL, LDL, and triacylglycerol) in white rat (Rattus norvegicus). This research was tested on 30 white rats that were divided into 2 randomized groups, and were treated for 4 weeks. Group 1 (K1) : was treated with standard diet, (K2) : with standard and high-fat diet. The results showed that intaking high-fat diet increases the total cholesterol content, triacylglycerol, LDL cholesterol, and decreases HDL cholesterol content.

Co-Authors Andiani Andiani Andiani Andiani Andiani Andiani, Andiani Andra Agnez Al Aska Arin Nurtya Artaria Tjempakasari, Artaria Aska, Andra Agnez Al Giri, Made Widiantara Harsono Wiradinata Harya Narottama Herliani, Olivia Kartika Ishartadiati Malik, Moch Lukman Ni Putu Intan Mulyasari Noer Kumala Indahsari, Noer Kumala Pudji Lestari Putu Oky Ari Tania Shanty, Ni Putu Chintya Eka Sri Andarini Sulistiawati Sulistiawati Sulistiawati Ummi Maimunah Wiradinata, Harsono Zahiroh, Viky Nauvalia

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