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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 7 Documents

Search results for , issue "Vol 14, No 2 (2017)" : 7 Documents clear

ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF AVOCADO SEED (Persea americana Mill.) Caecilia Desi Kristanti; Fransisca Puspa Jelita Simanjuntak; Ni Kadek Pramita Anggara Dewi; Skolastika Venita Tianri; Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

The purpose of this research is to evaluate the anti-inflammatory and analgesic activities of infusion and methanolic extract from avocado seeds. The anti-inflammatory activity was determined using carrageenan-induced paw edema in mice. The analgesic activity was assessed using acetic acid stimuli to induce peripheral pain in mice. Results of this research showed that both all level doses of infusion and methanolic extract of avocado seeds have a significant reduction on the mice paw edema. All level doses of methanolic extract of avocado seeds have a significant reduction on the number of abdominal writhes induced by acetic acid, but only the lowest dose of infusion showed a significant reduction. Our findings suggest that avocado seeds contains potential anti-inflammatory and analgesic compounds which support its traditional use. Further phytochemical studies are required to determine the active compounds are actually responsible for such properties.

THERAPY ADHERENCE OF 40-75 Y.O. HYPERTENSION RESPONDENTS USING MORISKY INSTRUMENT IN NGEMPLAK, SLEMAN, DIY (STUDY ON AGE, DEMOGRAPHY, SOCIAL, AND LIFE-STYLE FACTORS) Jasmine, Millatina; Oktawati, Nurjati Dwi; Damasari, Puspa Raras; Suhadi, Rita
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

Hypertension is systolic blood pressure (SBP) ?140mmHg and/or diastolic blood pessure (DBP) ?90mmHg. The risk factors of hypertension consist of age, life-style, demographic, and social factors. The risk factors have a significant association with antihypertension adherence. Adherence is the suitability of patient behavior to the prescribers recommendations. Morisky instrument can be used to measure the level of hypertension therapy adherence. The aims of this study were to assess respondents profile and therapy adherence based on age, life-style, demographic, social factors among the subjects in Ngemplak, Sleman, Daerah Istimewa Yogyakarta (DIY). Total respondents were 63 respondents. The observational study was done with cross-sectional design. Technique for determining the location used random sampling, data were collected by door to door in the villages of Morangan, Jimat, and Jelapan. Data analysis used chi square with 95% confidence level. There were 23.8% good adherent and 76.2% poor adherent subjects to antihypertensive medication. There was no significant difference between age, life-style, demographic, and social factors to the level of hypertension therapy adherence. However, it was found that controlled blood pressure (p-value0.01) were significantly associated with therapy adherence. This study also found that SBP at age 60-75 years and 40-59 years was significantly different (p-value 0.05).

CORRELATION BETWEEN ANTHROPOMETRIC MEASUREMENTS AND RISK OF ANEMIA AMONG RURAL COMMUNITY IN CANGKRINGAN, SLEMAN Dita Maria Virginia; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

Anemia has been detected on various age groups. Measurement of hemoglobin (Hb) levels is a standard for deciding anemia conditions. The measurement requires certain costs, medical professional, and is invasive. People in rural areas need an economical, easy and simple examination to identify the risk of anemia. Anthropometric measurement is expected to be an appropriate measurement model for rural communities. The objective of the study is to obtain the best anthropometric measurement predictors for detecting anemia in rural communities. This was an observational study using a cross-sectional design. The inclusion criteria of the subjects of the study were residents of Cangkringan, who were between 40 and 60 years old. The subjects were chosen using random sampling cluster technique. The sample size was 100 respondents and was taken based on cluster. Descriptive analysis was used to determine the prevalence of anemia. Analysis the difference in proportion was conducted using Mann-Whitney. Correlation analysis was performed to determine the relationship between Hb levels and anthropometric measurements by using Spearman. The results showed that only 5% of the subjects are in the status of anemia based on their Hb levels. There is a significant difference between Hb levels in the normal and obese groups based on the waist hip circumference ratios (WHR) (p = 0.002). The waist circumference has a weak correlation (r = 0.238, p = 0.017) and WR has a moderate correlation (r = 0.483, p = 0.000) with Hb levels. The results of this study are not appropriate in which central obese patients should be more at risk of anemia. This study concludes that there is a significant positive moderate correlation between anthropometry, which is the waist circumference parameters and WHR, to the Hb levels in rural communities.

OPTIMIZATION OF MIXING TEMPERATURE AND SONICATION DURATION IN LIPOSOME PREPARATION Dina Christin Ayuning Putri; Rini Dwiastuti; Marchaban Marchaban; Akhmad Kharis Nugroho
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

Liposomes are a delivery system used in pharmaceutical products and cosmetics. Liposomes have many advantages such as increase stability and efficacy, can be targeted to reduce toxicity and increase accumulation at the target site and are biocompatible. Preparation of liposomes can be done by conventional or new methods which are still being developed. Conventional methods often require a long time and organic solvents which may be toxic. Heating (Mozafari method) is one of the new methods developed in the manufacture of liposomes without organic solvents. Mixing temperature can affect the physical properties of liposomes. The particle size has become one of the important physical properties because it affects the absorption of the drug. Sonication is an easy method of choice in reducing the size of liposomes. Optimization of mixing temperature and duration of sonication in liposomes preparation using new heating methods and sonication were performed by factorial design with 2 factors and 3-levels to obtain optimal liposome size. Data were analyzed with two-way ANOVA. The results showed that both mixing temperature and sonication duration significantly affect liposome size, but the interaction was not statistically significant. Data analysis also showed that mixing temperature, sonication, and their interaction do not affect the polydispersity index of liposome. Results showed the optimum mixing temperature and sonication duration that can produce liposomes with size below 100 nm is at 60C for 30 minutes.

CRITICAL APPRAISAL OF EFFECTIVENESS OF ORAL FINGOLIMOD ON RELAPSING MULTIPLE SCLEROSIS Rizaldy Taslim Pinzon; Rosa De Lima Renita Sanyasi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

Oral fingolimod has been recently accepted as a treatment for relapsing Multiple Sclerosis (MS) by the Indonesian Food and Drug Administration. The number of MS patients is increasing in Indonesia. There is a critical need of systematically reviewing the new medication for both efficacy and safety. This review aimed to appraise the clinical evidences of oral fingolimod for the effective treatment of relapsing MS. We searched in Pubmed database. We limited our search to only articles that were in full text, published within the last 10 years, and in English. We used the Jadad scale to measure the quality of the evidences. We only found 3 trials, all conducted with randomized and double blind design. The three trials were: the FREEDOMS I, FREEDOMS II, and TRANSFORMS studies. The FREEDOMS studies compared with placebo, and the TRANSFORMS study compared with injectable interferon. All of the studies have good quality in methodology (Jadad scale 3). The results of the three studies showed the benefit of oral fingolimod in reducing MS relapse compared with placebo with relative risk reduction range from 48% to 54%, and also in reducing new lesions in T2 brain MRI with relative risk reduction range from 35% to 74%. Our critical appraisal found that oral fingolimod improved clinical outcomes. The availability of oral fingolimod in Indonesia makes it one of the options in treatment of MS relapse in Indonesia and has been demonstrated to be effective and safe with relatively small risk.

VIRTUAL SCREENING CAMPAIGNS ON ISOFLAVONES TO DISCOVER POTENT CYCLOOXYGENASE-2 INHIBITORS Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

By employing recently published structure-based virtual screening (SBVS) to identify potent cyclooxygenase-2 (COX-2) inhibitors, all isoflavones collected by ZINC15 database were virtually screened. There were 3371 isoflavones in ZINC15 database and 1356 compounds out of them met the Lipinskis rule of 5. Notably, only 3 isoflavones out of those 1356 compounds were identified as potent COX-2 inhibitors.

CORRELATION ANALYSIS BETWEEN THE SERVICE QUALITY, CUSTOMER SATISFACTION, AND CUSTOMER LOYALTY OF VIVA GENERIK PHARMACY IN SEMARANG Eva Monica; Basu Swastha Dharmmesta; Suci Paramitasari Syahlani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

Today, pharmacy service has become more developed along with the enhancement of society awareness of the importance of health. Therefore, as one of the health service facilities, pharmacy is required not only to give priority on product prices and varieties but also to provide qualified service for the patients. Viva Generik pharmacy as a new comer should have the ability to understand the situation and should have the competitive advantage. This study used a survey method. Data were collected with a purposive sampling method using the instrument of closed questionnaires. The questionnaires were tested for the validity and the reliability to 40 respondents who were the consumers of Viva Generik pharmacy. Questionnaires were given to 150 respondents, then were analyzed using qualitative descriptive statistics to identify the respondents characteristic. Quantitative analysis was used to identify the quality of the service and to see the correlation between service quality, satisfaction, and customer loyalty of Viva Generik pharmacy. As a result, Viva Generik pharmacys consumers tended to agree that the quality of service given by Viva Generik pharmacy was good. Simultaneously, service quality variables gave a positive impact to the customer satisfaction and the customer loyalty. It was just the tangible dimension that gave the significant impact on the customer satisfaction and customer loyalty. It was also disclosed that the customer satisfaction brought a significant impact on the customer loyalty to Viva Generik pharmacy.

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Florentinus Dika Octa Riswanto

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editorial.jpsc@usd.ac.id

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editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

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Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Florentinus Dika Octa Riswanto

Contact Email editorial.jpsc@usd.ac.id

Phone -

Journal Mail Official editorial.jpsc@usd.ac.id

Editorial Address Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

Phone
-

Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA