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INDONESIA
Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 4 Documents
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Search results for , issue "Vol. 31 No. 1 (2012)" : 4 Documents clear
Screening for prostate cancer: what are the benefits ? Murad Lesmana
Universa Medicina Vol. 31 No. 1 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.1-3

Abstract

In men of advanced age, the epithelial cells of the prostate gland undergo substantial stress-associated changes that may result in DNA damage. The aging prostate gland acquires several cancer cell foci originating from special clonal transformation. Most of these foci never develop into clinically detectable cancer.
Ethanolic extract of Anredera cordifolia (Ten.) Steenis leaves improved wound healing in guinea pigs Isnatin Miladiyah; Bayu Rizky Prabowo
Universa Medicina Vol. 31 No. 1 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.4-11

Abstract

BACKGROUNDWound healing is a normal biological process in response to skin injury. Anredera cordifolia (Ten.) Steenis is used  traditionally to treat various diseases, including skin disease, hypertension, inflammation and gout. The aim of this study was to evaluate the wound healing activity of the leaves of binahong or Anredera cordifolia (Ten.) Steenis in guinea pigs. Methods Thirty guinea pigs (1.5-2 kg, 3-4 months old) were randomly divided into 5 groups. Group I was given distilled water (negative control), group II was treated with povidone iodine 10% (positive control), while groups III-V were treated with ethanolic extract of binahong leaves at concentrations of 10%, 20%, and 40%, respectively. Before treatment, a 2 cm long excision wound was made on each animal. All interventions were given by the topical route, twice daily for 15 days. At the end of 15th day, the wound lengths in each group were measured and compared to baseline wound lengths. Data were analyzed with one-way Anova to compare wound healing activity between groups. ResultsThis study showed that groups treated with ethanolic extract of binahong leaves at concentrations of 20% and 40% experienced better wound healing activity than negative and positive controls. There were significant differences (p=0.000) between treatments and negative and positive controls. ConclusionsThis research has succesfully show significance of the Binahong leaf extract has a potential for wound healing in guinea pig.
Protective effect of Brassica oleracea var. botrytis L. against theophylline-induced hepatocellular abnormalities in rats Endang Sri Sunarsih; Lukman Hakim; Sugiyanto Sugiyanto; Sumantri Sumantri
Universa Medicina Vol. 31 No. 1 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.12-19

Abstract

BackgroundIndole and its derivatives, such as indole acetic acid are active constituents of cauliflower (Brassica oleracea var. botrytis L.) with are known to function as plant growth hormones. Drug metabolism mainly occurs in the liver, so that the possibility of damage to this organ is considerable. The purpose of this study was to evaluate the effect of cauliflower extract on alanine transaminase (ALT) levels and on the hepatocyte morphology induced by theophylline in Wistar rats.MethodsTwenty Wistar rats were divided randomly into four groups. Group I was given only theophylline 20 mg/kg BW. Groups II, III, and IV were given cauliflower extract 200 g/kg BW, for 5, 10, 15 days, and on the last day were given theophylline 20 mg/kg BW. On days 5, 10, and 15 the animals were terminated, their livers taken and observed for microscopic appearance, while blood samples were taken for measuring ALT levels.ResultsCauliflower affected a reduction in ALT levels, mean serum ALT concentration in rats given cauliflower for 5 days (109.86 ± 2.20 IU/L was significant higher compared to rats given cauliflower for 15 days (71.58 ± 3.17 IU/L) (p=0.000). Mean values of histopathologic liver cells in rats given cauliflower for 15 days (1.17 ± 0.01) significant lower compared to rats given cauliflower for 5 days (1.45 ± 0.06) (p=0.000).ConclusionSCauliflower extract reduced the level of ALT and improved the microscopic appearance of hepatic cells in the rats. Cauliflower extract could lead to the development of potent anti-tumor agents for hepatic cancer treatment.
Potential of turmeric rhizome essential oils against Aedes aegypti larvae Roselina Panghiyangani; Leni Marlinae; Isnaini Isnaini; Fauzi Rahman
Universa Medicina Vol. 31 No. 1 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.20-26

Abstract

BACKGROUNDDengue hemorrhagic fever (DHF) has long been a serious health problem in Indonesia, including Kalimantan (Borneo), as is evident from the increased case fatality rate in Banjarbaru city. Synthetic chemical insecticides have frequently been used to eradicate mosquitoes, but are toxic to the body and resistance of adult and larvae mosquito Aedes aegypti has been reported. The present study aims to assess the effect of essential oils of turmeric rhizomes (Curcuma domestica Val) against Aedes aegypti larvaeMethodsThis was an experimental study of post test one group design, performed in two phases, using Aedes aegypti larvae as test organisms. In the first phase, laboratory-reared larvae were used for calculation of the LC50 and LC90, while in the second phase the test organisms were larvae taken from 75 buildings that had been designated based on a preliminary survey in four sub-districts in Banjarbaru city with a high incidence of dengue cases. Probit analysis of was used to calculate LC50 and LC90, and the Kruskal-Wallis test to determine the larvicidal potency of turmeric rhizome essential oils. ResultsThis study demonstrates that turmeric rhizome essential oils effectively killed laboratory-reared Aedes aegypti larvae at an LC50 of 9.239 ppm and an LC90 of 13.565 ppm. The effectiveness of the essential oils of turmeric rhizomes (Curcuma domestica Val.) for killing Aedes aegypti larvae in residential areas was 68%.ConclusionTurmeric (Curcuma domestica Val.) rhizome essential oils can kill Aedes aegypti larvae, are environment friendly and can be used for the control of mosquitoes.

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