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All Journal Journal of Agromedicine and Medical Sciences Berkala Kedokteran Majalah Kedokteran Universa Medicina SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat Prosiding Konferensi Nasional PKM-CSR Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) Jurnal Pengabdian Masyarakat Formosa (JPMF) Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Fish Scientiae : Jurnal Ilmu-Ilmu Perikanan dan Kelautan Jurnal Pengabdian Masyarakat Bestari (JPMB) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Asian Journal of Community Services (AJCS) Homeostasis: Jurnal Mahasiswa Pendidikan Dokter JOURNAL OF WETLANDS ENVIRONMENTAL MANAGEMENT
Isnaini Isnaini
Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Lambung Mangkurat Kalimantan Selatan
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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THE EFFECT OF LONG EXPOSURE OF UV RADIATION ON ERYTHEMA AND MELANIN INDEX Isnaini Isnaini; Ika Kustiyah Oktaviyanti; Eko Suhartono
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.725 KB) | DOI: 10.20527/jbk.v18i1.11829

Abstract

UV radiation are divided into 3, namely UV A (400 – 315 nm), UV B (315-280 nm), UV C (280 – 100 nm). UV C radiation have the greatest effect on skin damage compared to UV A and UV B. UV radiation can reach the earth's surface, that can cause burning of the skin with signs such as redness of the skin (erythema), pain, blistering and peeling of the skin. Until now there has been no research on the effect of long exposure of UV C radiation on the erythema and melanin index, so aim this research is know about the effect of long exposure of UV C radiation on the erythema and melanine index. This research was conducted by giving exposure to rat that had been shaved with variations in exposure time, namely 5 minutes, 10 minutes, 15 minutes and 20 minutes. The skin that has been exposed with UV radiation will be photographed for color analysis using a chromometer. The results showed that exposure of UV radiation for 10 minutes caused the greatest increase in the melanin and erythema index
Aktivitas Larvisida Minyak Atsiri Rimpang Kunyit Putih (Curcuma zedoaria) terhadap Larva Aedes aegypti Roselina Panghiyangani; Isnaini; Dodo T. Suarnella
Majalah Kedokteran UKI Vol. 27 No. 3 (2010): JULI-SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Rimpang kunyit putih (Curcuma zedoaria) mempunyai zat aktif berupa minyak atsiri yang selama ini diduga berpotensi sebagai larvisida. Penelitian ini merupakan penelitian eksperimental yang bertujuan untuk mengetahui daya bunuh minyak atsiri rimpang kunyit putih terhadap larva Ae. aegypti instar IV. Variasi konsentrasi yang digunakan adalah 15,2 ppm, 30,3 ppm, 60,5 ppm, 121 ppm, 242 ppm serta kontrol positif (temefos 1%) dan kontrol negatif (CMC Na 1%) dengan empat kali replikasi untuk tiap perlakuan. Minyak atsiri didapatkan melalui metode destilasi uap. Hasil pengamatan selama 24 jam untuk menguji aktivitas minyak atsiri sebagai larvisida diuji dengan Anava, diperoleh nilai p = 0,000, artinya terdapat perbedaan jumlah kematian larva yang bermakna pada dua kelompok. Analisis Post-Hoc (LSD) menunjukkan ada perbedaan jumlah kematian larva antara perlakuan pada kelompok kontrol positif dengan semua perlakuan pada berbagai tingkat konsentrasi minyak atsiri rimpang kunyit putih (p<0,05). Demikian juga perlakuan pada kelompok kontrol negatif, terdapat perbedaan bermakna dengan semua perlakuan pada berbagai tingkat konsentrasi minyak atsiri rimpang kunyit putih (p<0,05). Hasil uji analisis probit menunjukkan bahwa pada konsentrasi 54,5 ppm mengakibatkan kematian 50% populasi larva uji. Kesimpulannya bahwa minyak atsiri rimpang kunyit putih berpotensi sebagi larvisida nyamuk Ae. aegypti. Kata kunci: minyak atsiri rimpang kunyit putih, larva Ae. aegypti Abstract White turmeric (Curcuma zedoaria) has an active substance in the form of volatile oils that have been alleged potential as larvacide. This was an experimental study aimed to determine the white turmeric rhizome volatile oils’ activity against the in star 4 larvae Aedes aegypti. The concentrations used were 15.2 ppm, 30.3 ppm, 60.5 ppm, 121 ppm, 242 ppm. Furthermore, a positive control (temefos 1%) and negative control (CMC Na 1%) with 4 times replication for each treatment were applied. White turmeric volatile oil was obtained by steam distillation method. The observation for 24 hours to test the volatile oils’ activity as larvicide were tested with Anava. The p value = 0.000 was obtained, which means at least there was difference of larvae mortality in the two groups. The results post-hoc analysis (LSD) showed that there were differences in the number of dead larvae between the treatments in the positive control group to all various levels treatment of white turmeric rhizome volatile oil concentration (p<0.05). Then, the treatment of negative control group showed significant differences in all various levels treatment of white turmeric rhizome essential oil concentration (p<0.05). Probit analysis of the test results showed that white turmeric rhizome volatile oil at the concentration of 54.5 ppm could result in the death of 50% population of test larvae. It could be concluded that the white turmeric volatile oil could be used as potential larvicide to eradicate Ae. aegypti mosquito. Hence, to destroy the dengue hemorrhagic fever disease vector. Keywords: white turmeric rhizome essential oil, Ae. aegypti larvae
Antibacterial and Antifungal Activity of Galam (Melaleuca cajuputi subsp. Cumingiana (Turcz.) Barlow) Extract against E. coli bacteria and C. albicans fungi Isnaini Isnaini; Agung Biworo; Husnul Khatimah; Khusnan Mustofa Gufron; Shafa Rahmani Puteri
Journal of Agromedicine and Medical Sciences Vol 7 No 2 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i2.23467

Abstract

Galam (Melaleuca cajuputi subsp. Cumingiana (Turcz.) Barlow) is a peat swamp forest plant. This plant is used to treat respiratory diseases, colitis, sore throat, itchy skin, diarrhea, and dizziness. This study aimed to analyze the antibacterial and antifungal activity of the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow flowers and fruit against Escherichia coli and Candida albicans bacteria. This research is a pretest-posttest research with control group design and consists of 3 stages of research. The first stage is the phytochemical screening test, the second stage determines the minimum inhibitory concentration (MIC) and the third determines the minimum bactericidal concentration (MBC). The results showed that the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow flowers and fruit contained terpenoids, flavonoids, phenols, saponins, quinones, steroids, tannins, while alkaloid compounds only found in the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow fruit. The MIC and MBC values ​​of M. cajuputi subsp. Cumingiana (Turcz.) Barlow flower methanol extract against E. coli were 1.67 and 2.083 mg/mL, respectively, while the MIC and MBC values ​​of the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow flower against C. albicans were 3.125 and 25 mg/mL. The MIC and MBC values ​​of the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow fruit against E. coli have same value were 3.334 mg/mL, while the MIC and MBC values ​​of the methanol extract of M. cajuputi subsp. Cumingiana (Turcz.) Barlow fruit against C. albicans were 3.125 and 12.5 mg/mL, respectively. Keywords: Galam antibacterial, antifungal, Escherichia coli, Candida albicans
EDUKASI REMAJA SADAR GIZI UNTUK PENCEGAHAN KEKURANGAN ENERGI KRONIK (KEK) DALAM MENURUNKAN ANGKA KEMATIAN IBU (AKI) DI WILAYAH LAHAN BASAH Fakhriyah Fakhriyah; Isnaini Isnaini; Meitria Syahadatina Noor; Andini Octaviana Putri; Lisa Fitriani; Muhammad Hashfi Abdurrahman; Ranindy Qadrinnisa
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 5, No 1 (2021): Desember
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v5i1.5764

Abstract

ABSTRAKKekurangan Energi Kronik (KEK) pada remaja putri/wanita adalah suatu kondisi di mana remaja putri/wanita mengalami kekurangan gizi (kalori dan protein) yang berlangsung lama atau menahun. Berdasarkan hasil Riskesdas 2018 angka kejadian KEK pada remaja putri sebesar 33,5 %. Data Riskesdas Kalimantan Selatan angka KEK paling banyak pada kategori usia remaja (15-19 tahun)  yaitu sebanyak 41,24% pada wanita hamil dan 38,27%  pada wanita yang tidak hamil. Berdasarkan survei pendahuluan terdapat 58,3 % remaja di Kecamatan Aluh-aluh mengalami KEK. Mitra sasaran kegiatan PKM adalah siswi SMAN 1 Aluh-aluh. Berdasarkan hasil survei dan diskusi dengan mitra, ada beberapa masalah yang dihadapi oleh mitra, yaitu mereka tidak pernah melakukan pemantauan status gizi dan rendahnya pengetahuan terhadap makanan dengan gizi seimbang. Metode pelaksanaan pengabdian adalah dengan memberikan edukasi remaja sadar gizi secara daring dengan cara diskusi menggunakan media ebooklet tentang gizi seimbang dan KEK. Berdasarkan hasil evaluasi terdapat peningkatan pengetahuan siswi SMAN 1  Aluh-aluh tentang gizi seimbang dan KEK. Sebanyak 62 % meningkat, 20% menurun dan 18% tetap. Rekomendasi kepada pihak sekolah adalah melaksanakan kegiatan edukasi tentang gizi seimbang dan KEK secara berkala untuk meningkatkan pengetahuan remaja dan dapat mengaplikasikannya dalam rangka mencegah terjadi KEK. Kata kunci: edukasi; pemberdayaan; siswi SMAN 1 Aluh-aluh; gizi seimbang; KEK; booklet.  ABSTRACTChronic Energy Deficiency (CED) in adolescent girls/women are young women/women who experience malnutrition (calories and protein) that lasts for a long time or are chronic. Based on the results of the 2018 Riskesdas, the incidence of CED in adolescent girls is 33.5%. Data from Riskesdas South Kalimantan has the highest number of CED in the category of adolescents (15-19 years) as many as 41.24% in pregnant women and 38.27% in women who are not pregnant. Based on the preliminary survey, there were 58.3% of adolescents in Aluh-aluh District experienced CED. The target partners of PKM activities are students of SMAN 1 Aluh-aluh. Based on the survey results and discussions with partners, there are several problems faced by partners, namely they have never monitored their nutritional status and have low knowledge of balanced nutrition. The method of implementing the service is to provide nutrition-aware youth education online by means of discussions using ebooklet media about balanced nutrition and CED and online quizzes about balanced nutrition. Based on the results of the evaluation, there was an increase in the knowledge of SMAN 1 Aluh-aluh students about balanced nutrition and CED. A total of 62% increased, 20% decreased and 18% remained. Recommendations to the school are to carry out educational activities about balanced nutrition and CED on a regular basis to increase adolescent knowledge and be able to apply it in order to prevent CED from occurring. Keywords: education; empowerment; students of SMAN 1 Aluh-aluh; balanced nutrition; CED; booklet.
Potential of turmeric rhizome essential oils against Aedes aegypti larvae Roselina Panghiyangani; Leni Marlinae; Isnaini Isnaini; Fauzi Rahman
Universa Medicina Vol. 31 No. 1 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.20-26

Abstract

BACKGROUNDDengue hemorrhagic fever (DHF) has long been a serious health problem in Indonesia, including Kalimantan (Borneo), as is evident from the increased case fatality rate in Banjarbaru city. Synthetic chemical insecticides have frequently been used to eradicate mosquitoes, but are toxic to the body and resistance of adult and larvae mosquito Aedes aegypti has been reported. The present study aims to assess the effect of essential oils of turmeric rhizomes (Curcuma domestica Val) against Aedes aegypti larvaeMethodsThis was an experimental study of post test one group design, performed in two phases, using Aedes aegypti larvae as test organisms. In the first phase, laboratory-reared larvae were used for calculation of the LC50 and LC90, while in the second phase the test organisms were larvae taken from 75 buildings that had been designated based on a preliminary survey in four sub-districts in Banjarbaru city with a high incidence of dengue cases. Probit analysis of was used to calculate LC50 and LC90, and the Kruskal-Wallis test to determine the larvicidal potency of turmeric rhizome essential oils. ResultsThis study demonstrates that turmeric rhizome essential oils effectively killed laboratory-reared Aedes aegypti larvae at an LC50 of 9.239 ppm and an LC90 of 13.565 ppm. The effectiveness of the essential oils of turmeric rhizomes (Curcuma domestica Val.) for killing Aedes aegypti larvae in residential areas was 68%.ConclusionTurmeric (Curcuma domestica Val.) rhizome essential oils can kill Aedes aegypti larvae, are environment friendly and can be used for the control of mosquitoes.
Peningkatan Pengetahuan Guru Dan Siswa Sekolah Dasar Di Sungai Kuin Selatan Banjarmasin Tentang Sediaan Tanaman Obat Untuk Mencegah Penyakit Yang Ditularkan Lewat Tangan Dan Air Sungai Isnaini Isnaini; Lia Yulia Budiarti; Lena Rosida
Prosiding Konferensi Nasional Pengabdian Kepada Masyarakat dan Corporate Social Responsibility (PKM-CSR) Vol 1 (2018): Prosiding PKM-CSR Konferensi Nasional Pengabdian kepada Masyarakat dan Corporate Socia
Publisher : Asosiasi Sinergi Pengabdi dan Pemberdaya Indonesia (ASPPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.642 KB)

Abstract

Kebiasaan masyarakat menggunakan air sungai untuk mandi dan aktivitas rutin dalam tumah tangga, secara tidak langsung dapat menimbulkan penyakit infeksi pada saluran pencernaan yang ditularkan melalui air sungai dan tangan. Risiko penyakit infeksi yang ditularkan dari tangan dan air lebih banyak dialami anak-anak usia sekolah dasar. Ada beberapa cara sediaan tanaman obat yang dapat dibuat secara sederhana oleh masyarakat mencegah dan mengatasi suatu infeksi. Penerapan pengetahuan pada usia sekolah dasar yang merupakan masa pembentukan karakter dapat memberikan pemahaman yang lebih baik. Tujuan kegiatan ini adalah memberikan pengetahuan dan terbentuknya perilaku mitra/sasaran tuntuk memahami cara pembuatan dan penyediaan sediaan obat pencegah infeksi dan sediaan antiseptik tangan secara sederhana dengan menggunakan perlatan sederhana. Mitra sasaran pada kegiatan ini adalah para guru dan siswa-siswa sekolah dasar Kuin Selatan 5 dan 6 yang mayoritas bertempat tinggal di sekitar bantaran sungai Kuin Banjarmasin. Metode yang digunakan adalah penyuluhan tentang penyakit infeksi yang ditularkan lewat tangan dan air sungai serta penyuluhan dan demonstrasi tentang cara membuat sediaan tanaman obat dan antiseptik tangan secara sederhana. Kegiatan dilaksanakan pada bulan Mei - Juli 2018. Evaluasi kegiatan didapat dari hasil pre dan post tes kuisioner. Hasil dari kegiatan pengabdian ini adanya peningkatan pengetahuan dan perilaku mitra/ sasaran lebih dari target pencapai 75% yaitu: mengenal jenis infeksi yang ditularkan lewat tangan dan air sungai, mengenal jenis tanaman obat dilingkungan, mengenal jenis sediaan tanaman obat pencegah infeksi dan antiseptik tangan, memahami cara pembuatan sediaan tanaman secara sederhana.
PERBANDINGAN JENIS KELAMIN (SEX RATIO) DAN PARAMETER PERTUMBUHAN IKAN SELUANG EKOR MERAH (Rasbora Lateristriata, Blkr 1854) DI WILAYAH HULU SUNGAI BARITO KALIMANTAN SELATAN, INDONESIA Iriansyah Iriansyah; Erwin Rosadi; Isnaini Isnaini
Fish Scientiae Vol 6 No 2 (2016): Issue December-Fish Scientiae Journal
Publisher : Faculty of Fisheries and Marine Resources of Lambung Mangkurat University-South Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.098 KB)

Abstract

The purpose of this study is to analyze the biological parameters of the fish resources Seluang red tail (R. lateristriata) the fish sex ratio parameter (sex ratio) and the parameters of the population dynamics of the growth parameters of fish resources Seluang red tail (R. lateristriata) in the upstream region of the Barito River in South Kalimantan Indonesia. Methods of data collection are done by collecting samples at fish landing sites and fishing operations and held for 2 (two) months with a fixed time interval decision namely1 (one) week. The sex ratio of fish in the analysis by using chi-square analysis of the end.The growth parameters were analyzed fish-Walford Plot method, while theoretically Agefish when a width equal to 0 (t0) was performed using empirical equations Pauly (1984).The expected outcome of this research is the availability of scientific data related to thesex ratio comparison of fish and fish growth parameters Seluang red tail (R. lateristriata)in the upstream region of the Barito River in South Kalimantan. Comparison of the gender (sex ratio) Seluang fish red tail (R. lateristriata) of malesand females in the upstream region of the Barito River in South Kalimantan is 2: 1. Condition population dynamics parameters in the Barito river R. lateristriata South Kalimantan covering the theoretically maximum length parameter ( length infinity/108.15 mm, coefficient of growth (per unit time / K) of 0.350/ year, the parameters of thetheoretical age at the time of a length equal to zero (t0) of -0.14.
Uji Toksisitas Ekstrak Metanol Kulit Kayu dan Daun Galam dengan Metode BSLT Ahmad Danial Rizkillah Az Zamzami; Isnaini Isnaini; Alfi Yasmina
Homeostasis Vol 4, No 1 (2021)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.291 KB)

Abstract

Abstract: Galam (Malaleuca cajuputi subs. Cuimingiana [Turcz.] Barlow) contains phenolic compounds, flavonoids, alkaloids, tannins, steroids, and terpenoids, which are assumed to have toxic properties. Each part of the plant contains different compounds that might affect its biological activity. This study aimed to analyze the toxicity of the methanol extracts of galam leaves and tree bark with brine shrimp lethality test (BSLT). This research was experimental, and the samples used were the methanol extracts of galam leaves and tree bark with concentrations of 10, 100, 200, 500, and 1000 ppm. Toxicity was assessed with BSLT, and LC50 was analyzed using probit analysis. The results showed that the LC50 value for galam leaves methanol extract was 141.86 (110.77-177.07) ppm and for galam tree bark methanol extract was 610.50 (495.03-745.36) ppm. It can be concluded that galam leaves and tree bark methanol extracts was classified as toxic, with the methanol extract of galam leaves having a higher toxicity than the methanol extract of galam tree bark. Keywords: toxicity, galam, Malaleuca cajuputi, brine shrimp lethality test Abstrak: Tanaman galam (Malaleuca cajuputi subs. Cuimingiana [Turcz.] Barlow) mengandung steroid, fenol, alkaloid, terpenoid, tanin, dan flavonoid yang diduga memiliki sifat toksisitas. Bagian-bagian tanaman memiliki senyawa-senyawa yang berbeda, yang dapat mempengaruhi aktivitas biologisnya. Penelitian ini memiliki tujuan dalam menganalisa toksisitas ekstrak metanol kulit kayu dan daun galam dengan metode brine shrimp lethality test (BSLT). Penelitian ini adalah penelitian eksperimental laboratorik. Sampel yang digunakan adalah ekstrak metanol kulit kayu dan daun galam dengan konsentrasi 10, 100, 200, 500, dan 1000 ppm. Toksisitas dinilai dengan menggunakan metode BSLT dan dinyatakan dengan LC50. LC50 dianalisis menggunakan analisa probit. Hasil penelitian ini menunjukkan nilai LC50 untuk ekstrak metanol daun galam sebesar 141, 86 (110,77-177,07) ppm dan untuk ekstrak metanol kulit kayu galam sebesar 610,50 (495,03-745,36) ppm. Dengan demikian, daun dan kulit kayu galam diklasifikasikan sebagai toksik, dengan ekstrak metanol daun galam mempunyai toksisitas lebih besar daripada ekstrak metanol kulit kayu galam. Kata-kata kunci: toksisitas, galam, Malaleuca cajuputi, brine shrimp lethality test
Pengetahuan Masyarakat Mengenai Penyakit Kecacingan di Desa Sungai Madang Kecamatan Sungai Tabuk Kab Banjar Kalimantan Selatan isnaini isnaini; Lisda Hayatie; Zulfa Emelda
Jurnal Pengabdian ILUNG (Inovasi Lahan Basah Unggul) Vol 2, No 2 (2022)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ilung.v2i2.5842

Abstract

Sungai Madang Village is a village located on the banks of the Tabuk river. This village is located in Sungai Tabuk District, Banjar Regency, South Kalimantan. The location of the village which is on the edge of the river and the many tributaries that surround the village of Sungai Madang make this village at risk of worm disease. This study aims to determine the level of public knowledge of helminthiasis and the use of worm medicine. The method used is the interview technique. The data obtained will be described. The profile of respondents as much as 31.25% are early elderly, 81.25% are women and 93.75% are married. The results of the survey show that 75% of respondents do not know about helminthiasis and they cannot mention the characteristics of helminthiasis. Profile of respondents who know about helminthiasis and they can mention the characteristics of helminthiasis 90.91% Women, 45.45% early elderly and 100% married. The number of respondents who have never used deworming medication is the same as the number of respondents who have used deworming medication, which is 46.9%. Meanwhile, the profile of respondents who have used deworming medication 93.33% are married, 80% are women, 40% are early adults. The conclusion is the community in Sungai Madang Village still have low knowledge about helminthiasis and the use of worm medicine.Keywords: knowledge level, helminthiasis, Sungai Madang, worm medicine
Antioxidant and Antiproliferative Activities of Methanol Extract from Melaleuca cajuputi subsp. Cumingiana [Turcz.] Fruit Isnaini Isnaini; Rosinta Dewi Achmadiyah; Gelvia Awaeh; Husnul Khatimah; Alfi Yasmina
Jurnal Sains dan Terapan Kimia Vol 17, No 1 (2023)
Publisher : Program Studi Kimia, Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jstk.v17i1.13055

Abstract

Melaleuca cajuputi subsp. Cumingiana [Turcz.] Barlow (M. cajuputi) is a plant that is easily found in Banjarmasin. M. cajuputi contains phytochemical compounds in the form of polyphenols including flavonoids, quinons, saponins, and alkaloids that are thought to have antioxidant and antiproliferation activities. The aim of this research was to find out analyze antioxidant and antiproliferation activity of M. cajuputi fruit methanol extract. The antioxidant activity was tested using the DPPH method. The activities were observed in IC50 and were measured using the UV-VIS spectrophotometer at a wavelength of 517 nm. To test the antiproliferation, true experimental with post-test was applied in this research.  Animal used in this study were 30 mature zebras (length > 2.5 cm) which were grouped into 4, namely the negative control group (DMSO 0.05%), the methanol extract group of M. cajuputi with concentrations of 18.5 ppm, 37 ppm and 74 ppm. The bound variable in this study was antiproliferation activity in the tail of an amputated fish. Data analysis was measured by one-way ANOVA and Post-Hoc Tukey HSD tests. Phytochemical results obtained the presence of phenol compounds, cuinons, flavonoids, alkaloids, saponins, tannins, steroids and terpenoids. Methanol extract of Melaleuca cajuputi subsp Cumingiana [Turcz.] Barlow fruit was at IC50 of 15.50 ppm (95% CI 8.31- 32.72).  The antiproliferation activity of zebrafish tails increased in the administration of fruit extract Melaleuca cajuputi subsp. Cumingiana [Turcz.] Barlow in consentration of 74 ppm (p<0.05), both on day 4 and day 8 of measurement when compared to negative controls. It can be concluded that methanol extract of Melaleuca cajuputi subsp Cumingiana [Turcz.] Barlow fruit has antiproliferative activity against the growth of amputated zebrafish tails.
Co-Authors Agung Biworo Ahmad Danial Rizkillah Az Zamzami Alfi Yasmina Andi Azizah M Budiarman Andifa Anugerah Putra Andini Octaviana Putri Asnawati Asnawati Asnawati Asnawati Azma Rosida Azma Rosida Bhisma Ridho Romadhon Dinda Rohama Dodo T. Suarnella Dwi Setyohadi Eko Suhartono Ellanda Permata Derlin Emmi Erliyanti Erida Widyamala Erida Wydiamala Erwin Rosadi Fahdyanoor Fakhriyah Fakhriyah Fauzi Rahman Gelvia Awaeh Gusti Nadya Nurzahida Hendra Wana Nur'amin Hilma Wardatina Ika Kustiyah Oktaviyanti Ika Novitasari Iriansyah Iriansyah Jeniar Atmadela Kartika Veranisa Putri Khansa Khafiya ‘Ibaadurrahmaan Khansa Khafiyya 'Ibadurrahman Khatimah, Husnul Khusnan Mustofa Gufron Lena Rosida Leni Marlinae Lia Yulia Budiarti Lia Yulia Budiarti Lia Yulia Budiarti Lia Yulia Budiarti Lisa Fitriani Lisda Hayatie, Lisda Meitria Syahadatina Noor Muhammad Hashfi Abdurrahman Nabilla Azzahra Ariady Nabilla Azzahra Ariady Nida Nurkhalishah Nor Admi Zayanti Nur Azmina Aisyah Nur Salsabila Apriliani Risma Putri Panghiyangani, Roselina Rahma Yuliani Ranindy Qadrinnisa Risma Yulfa Riyani Risma Yulfa Riyani Rosinta Dewi Achmadiyah Shafa Rahmani Puteri Sukses Hadi Wahyuni Wahyuni Yafi Fahmi Zahra Aprillita Zulfa Emelda