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Pharmacy Study Program, Faculty of Mathematics and Natural Science, Sam Ratulangi University, Manado, North Sulawesi, Indonesia, 95115
Location
Kota manado,
Sulawesi utara
INDONESIA
PHARMACON
Published by Universitas Sam Ratulangi
ISSN : 23022493     EISSN : 27214923     DOI : 10.35799
Core Subject : Health,
Medicine & Pharmacology
Pharmacon is the journal published by Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Indonesia (P-ISSN: 2302-2493 E-ISSN: 2721-4923). Pharmacon was established in 2012 and published four times a year. Pharmacon is an open access journal and has been indexed by main indexing Google Scholar, GARUDA, Crossref.
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Articles 24 Documents
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Search results for , issue "Vol 2, No 3 (2013): pharmacon" : 24 Documents clear
STUDI KARAKTERISTIK DAN PENGGUNAAN OBAT PADA PENDERITA HEPATITIS B DI RUMAH SAKIT PEMERINTAH KOTA MANADO PERIODE JANUARI 2011 – DESEMBER 2012 Luntungan, Lady zha-zha; Fatimawali, Fatimawali; Bodhi, Widdhi
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2381

Abstract

ABSTRACTHepatitis B is a disease caused by the virus called hepatitis B wich characterized by aninflammation that occurs in organs such as the liver. The transmission of Hepatitis B is higherthan the transmission of the HIV virus. This study aimed to investigate the characteristics anduse of the drug in hepatitis B patients in the Government Hospital in Manado. This researchis a descriptive study based on retrospective data collection for 2 years survey from January2011 to December 2012. The respondent of this research involve of 70 patients with HepatitisB medical record. The results showed that based on group age, responden with age group 46-65 has the highest percentage by 31 patients (44.3%), based on gender, males have thehighest percentage of total of 47 patients (67.1%), based on the duration of treatment, thehighest percentage is shown by the patient with 1 day threatment as 21 patients (30%). Basedon therapeutic treatment this research divided it into 2 kind of threatment. The first us singleagent therapy Hepamax consist of 27 patients (38.6%) The second therapy is combinationbetween Hepamax and Curcuma wich consist of 9 patients (12.9%). This research conductedbased on 100% oral route of medicine threatment.Keywords: Hepatitis B, Hepatitis B medicine, Singel Therapy, Combination Therapy
PENGARUH PENYULUHAN PENGGUNAAN ANTIBIOTIKA TERHADAP TINGKAT PENGETAHUAN MASYARAKAT DI KOTA MANADO Wowiling, Chalvy; Goenawi, Lily Ranti; Citraningtyas, Gayatri
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2327

Abstract

ABSTRACTThe high number of inappropriate of antibiotics in community due to lack of knowledgeabout the use of antibiotics may lead the increasing of antibiotic resistance. This study aimedto measure the people’s knowledge before and after following health education and analyzethe effect of health education of antibiotic administration to community knowledge. This is apre-experimental study in community with one group pretest-posttest design using aquestionnaire. Result of this study show the number of respondent with lack of knowledgebefore the education is 53,3% decrease after education which is 17,3%, number of respondentwith quite good increase from 37,3% become 42,7%, and respondent with good knowledgeincrease from 9,3% become 40%. Mean of knowledge score after following health education70,53 is higher than before following health education 55,53, so H1 is accepted withsignificant value 0.000 (p<0,05). Health education can increase public knowledge aboutantibiotic administration.Keywords : antibiotic, health education , people of Manado City
DAYA REDUKSI MERKURI ISOLAT BAKTERI YANG DIISOLASI DARI URINE PASIEN DI PUSKESMAS BAHU MANADO Fatimawali, Fatimawali
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.3896

Abstract

The aim of this research was to analyze mercury reduction power from patient urine with teeth amalgam which used for mercury detoxification. The research was descriptive which isolate 5 samples of patient urine from Bahu PUSKESMAS. Bacteria were grow in a media wich consist of 5, 10, 20, 40 and 60 ppm of HgCl2. Bacteria which grow in the highest concentration of mercury were identified and tested it reduction power against HgCl2. The result shows that there were 3 isolates which bacteria can grow with HgCl2 60 ppm namely Isolate U1.3, U3.1, and U3.3. Identification result found that isolate U1.3 and U3.1 were positive gram bacteria, rod, and motil, although U3.3 was negative gram bacteria, rod and not motil. Result of mercury reduction shows that in 24 hours, the three isolates reduce 100% mercury in nutrient broth, it concluded that isolates were highly resistant mecury bacteria. It can be used to detoxify mercury.   Key words : mercury reduction, urine, PUSKESMAS
ANALISIS ZAT PEWARNA RHODAMIN B PADA KERUPUK YANG BEREDAR DI KOTA MANADO Dawile, Sherly; Fatimawali, Fatimawali; Wehantouw, Frenly
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2386

Abstract

ABSTRACTRhodamine B dye in the form of a crystalline powder green or reddish purple, odorless, anddissolves easily in bright red solution berfluoresan as textile dyes. Rhodamine B is still nofood products were found to contain rhodamine B dye such as crackers, sauces, ice and otherpastries. The purpose of this study is to investigate and determine the levels of rhodamine Bon crackers circulating in the city of Manado. Sampling sites crackers are 4 market in the cityof Manado is Tuminting Market, Market Paal 2, Market Market Bersehati 45 and 45.Samples with ammonia to soak interesting rhodamine B dye using wool yarn, followed byidentification using thin layer chromatography (TLC) and then in detection with UV light 254nm and 366 nm. The reading levels of rhodamine B using UV-Vis spectrophotometry. Theresults showed that of the ten samples tested with three times obtained one positive samplecontaining rhodamine B with an average concentration value of rhodamine B in a sample of45 markets in the sword of 0.28 mg/ml. Based on these results, some crackers circulating inManado City Market unsafe consumed.Keywords: Rhodamine B, Crackers, spectrophotometry and Thin Layer Chromatography
Formulasi Salep Ekstrak Etanol Daun Tapak Kuda (Ipomoea pes-caprae) Dan Uji Efektivitasnya Terhadap Luka Terbuka Pada Punggung Kelinci Muthalib, Eka Mulya; Fatimawali, Fatimawali; Edy, Hosea Jaya
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2384

Abstract

ABSTRACTPalm horse weevil contains medicinal properties that are useful in the process of woundhealing. The purpose of this study is to to examine formulate an ointment of palm horse(Ipomoea pes-caprae (L) Sweet) weevil extract and to test the ointment to heal open woundon the skin of rabbits. This study is experimental descriptive in the laboratory. Palm horseweevil extracts used in the manufactured of ointment formulation 10%, 15 % and 20 %. Theresults showed that the palm horse weevil formulation meets the ointment test requirementaccording, making ointment formulation using cassava tuber extract used as 5 rabbits.Divided into 5 treatment gropus, namely, test the ointment treatment group, negative controlgroup (basic ointment) and positive control group (chloramphenicol ointment). Observed thehealing effects for 7 days. The results showed that from day-1 to day-7 observations burnssuffered diminution in diameter. It was concluded that concentration of 10 % cassava extractontment has healing effect and increasing the concentration of 15 % and 20 % containedshowed more effective and speed up the healing process.Keywords : Extract leaf palm horse , ointment, wound healing, rabbit.
UJI AKTIVITAS ANTIOKSIDAN DARI AMPAS HASIL PENGOLAHAN SAGU (Metroxylon sagu Rottb) Talapessy, Selvian; Suryanto, Edi; Yudistira, Adithya
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2373

Abstract

ABSTRACTThe study aimed to determine the phenolic content and antioxidant activity of sago wasteprocessing results. Results of processing sago pulp esxtraction was conducted using 1 x 24hour maceration using solvents ethanol with a concentration of 20, 40, 60 and 80%. Phenoliccontent was determined by Folin Ciocalteu method and determination of antioxidant activityusing the DPPH free radical scavengers. The results showed that the extract with the solventconcentration of 40% has a higher total phenolic 83,26 μg/mL followed by solvent extractconcentration of 20, 60 and 80% respectively 70,01; 60,58; 22,04 μg/mL. extract with 60%solvent concentration has free radical scavengers activity the highest of 82,75% followed byconcentration of solvent extracts 80, 20 and 60% are respectively 80,45; 76,62; 62,83%.These results suggest that the processing of sago pulp extract contains phenolic antioxidantsand can be potentially as.Keywords : pulp extract sago precessing results, phenolic compend, antioxidants.
UJI FITOKIMA DAN AKTIVITAS ANALGESIK EKSTRAK ETANOL TANAMAN KUCING-KUCINGAN (Acalypha indica L.) PADA TIKUS PUTIH BETINA GALUR WISTAR (Rattus norvegicus L) Wemay, Miranti Aike; Fatimawali, Fatimawali; Wehantouw, Frenly
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2314

Abstract

ABSTRACTThis research aims to determine the phytochemical compounds and testing the analgesiceffects of ethanol extract of kucing-kucingan plant (Acalypha indica Linn.). Phytochemicaltesting conducted according to Harbone methods and analgesic activity of rats reaction timeis determined based on the thermal response after giving the ethanol extract of A indica L.This study used 20 female Wistar rats were divided into a treatment group was given 0,035mg / kg extract of leaves, stems and roots, negative control receive aquadest and positivecontrol using aspirin. Reaction time data were analyzed using One Way ANOVA followed byDuncan's test multipe Range Test. The results showed that the ethanol extract of A.indica L.contains alkaloids and saponins in the extract while the third type of flavonoid and tanninfound only in leaf extracts. Testing the analgesic activity of ethanol extract A. indica L.showed that the leaf extract gave the highest reaction time of 3.16 seconds, and stem and rootextracts followed by 1.72 seconds and 2.85 seconds. Reaction time in rats given leaf extractA.indica L. did not give significantly different with aspirin group (P> 0:05).Keywords : Phytochemical testing, analgesic, ethanol extract of kucing-kucingan (A.indicaL.).ABSTRAKPenelitian ini bertujuan untuk mengetahui senyawa fitokimia dan menguji efek analgetik
UJI EFEK HEPATOPROTEKTOR EKSTRAK ETANOL DAUN BENALU LANGSAT (Dendrophthoe petandra (L.) Miq.) terhadap KADAR MALONDIALDEHID (MDA) pada HATI TIKUS PUTIH JANTAN GALUR WISTAR yang DIINDUKSI KARBON TETRAKLORIDA (CCl4) Tristanti, Irma; Fatimawali, Fatimawali; Bodhi, Widdhi
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2383

Abstract

ABSTRACTLeaves of Langsat parasite (Dendrophthoe petandra (L.) Miq.) contains flavonoids. Theobjective of this research was to examine hepatoprotector effect of leave extract from langsatparasite on white male rats induced with CCl4. Treatment was conducted for 8 days to 13 rats,which group I (P1) were administered with EDBL 35mg/KgBB,group II (P2) wereadministered with EDBL 70mg/KgBB,group III (K+) were administered withCurcuma81mg/KgBB orally. Group IV (K-) and V (KP) were administered with aquadestad libitum.At 8th day, all groups except (KP) were induced with CCl4 1mL/KgBB intraperitoneally.Eighteen hours after inducing time, all rats in every group were sacrafied to take its liver.Rats liver were analyzed using TBARS (Thiobarbituric Acid Reactive Subtance) method tocalculate MDA (Malondialdehid) level that were the end product of lipid peroxidation in ratsliver.MDA content of P1 were 2,715μM, P2 were 2,080μM, K+ were 1,708μM, and K- were3,413μM. Data analysis using SPSS ver.20 by One-Way ANOVA and Duncan Multiple RangeTest.Keywords : leave of Langsat parasite, hepatoprotector effect,CCl4, MDA
ANALISIS FITOKIMIA DAN UJI AKTIVITAS ANTIOKSIDAN DARI GETAH KULIT BUAH PISANG GOROHO (Musa acuminate (L.)) Kurniawan, Juliana Christie; Suryanto, Edi; Yudistira, Adithya
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2330

Abstract

ABSTRACTThe objectives of this research was to analyze the phytochemical content and antioxidantactivity from goroho’s sap peel. Sample preparation was cut from the banana tier, then havebeen cut to the both base of goroho’s peel and the fresh sap collected into the petri dish. Theextraction method was maceration used 20, 40, 60 and 80% ethanol concentration.Phytochemical screening carried out by analysis of alkaloid, flavonoid, saponin, steroid,terpenoid and tannin. Determination of antioxidant activity performed by DPPH free radicalscavengers. The phytochemical analysis results was goroho’s sap peel contain flavonoid,saponin and tannin. Ethanol extract of goroho’s sap peel with 80% concentration 100 μg/mLhad the highest antioxidant activity. Results of this research concluded that phenolic extractsof goroho’s sap peel has the ability both as an antioxidant to DPPH free radicals.Keywords: Banana sap peel goroho, phytochemical, antioxidant activity
STUDI PENGGUNAAN ANTIMALARIA PADA PENDERITA MALARIA DI INSTALASI RAWAT INAP BLU RSUP Prof. Dr. R. D. KANDOU MANADO PERIODE JANUARI 2013-MEI 2013 Rumagit, Novia Akwila; Tjitrosantoso, Heedy; Wiyono, Weny I
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2376

Abstract

ABSTRACTMalaria is parasite infectious diseases group of Plasmodium which live in human red bloodcell and can be transmitted by a female Anopheles bites. Malaria were classified as one of themost dangerous infectious diseases which cause death. In North Sulawesi, malaria is anendemic diseases because it’s a tropical area, and so susceptible to this disease. Treatment ofmalaria is to obtain clinical and parasitologic recovery. The objectives of this research wereto find out the characteristic of malaria and the use of antimalaria drugs on patient withmalaria. This research is a descriptive survey with retrospective sampling on 68 medicalrecord of patient with malaria treatment. Obtained data shows that there are three variant ofmalaria, falciparum malaria (66,2%), vivax malaria (26,5%), mixed malaria (7,4%).Artesunat-amodiakuin-primakuin in an ACT (Artemisinin Combination Treatment) thatmostly used as malaria drug.Keywords: Plasmodium, red blood cell, malaria, antimalaria

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