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Paediatrica Indonesiana

paediatrica-indonesiana
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Published by Ikatan Dokter Anak Indonesia

ISSN : 00309311 EISSN : 2338476X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.

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Articles 2,114 Documents

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Evaluation of Bio M pylori serologic test and C-13 urea breath test for H. pylori infection in children with recurrent abdominal pain: a pilot study Mira Dewita; Badriul Hegar Syarif; Sudigdo Sastroasmoro
Paediatrica Indonesiana Vol 50 No 2 (2010): March 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi50.2.2010.101-104

Background Diagnosing Helicobacter pylori infection in childrenis still a problem. Urea breath test is the gold standard for noninvasivediagnostic test, but it is expensive and not available inmost hospitals. The Bio M Pylori serologic test has good diagnosticvalue in adults, less expensive and more practical, but had neverbeen evaluated in children.Objective To determine the prevalence of H. pylori infection andthe diagnostic accuracy of Bio M Pylori serologic test in childrenwith recurrent abdominal pain.Methods This study was conducted in May - June 2009. Childrenaged 12-15 years with recurrent abdominal pain were examinedwith urea breath test and the Bio M Pylori serologic test.Sensitivity, specificity, area under the curve (AUC), predictivevalues, and likelihood ratios were calculated for the Bio M Pyloriserologic test.Results Most subjects aged 13 years (83%). Girls outnumberedboys, and most were undernourished. The prevalence ofH. pyloriinfection detected by urea breath test and Bio M Pylori serologictest was 8% and 52%, respectively. The Bio M Pylori serologictest had sensitivity and specificity of 100% and 53%, respectively.Area under the curve (AUC) was 0.764. Positive and negativepredictive values were 16 and 100%, whereas positive andnegative likelihood ratios are 2.12 and 0. The overall accuracyof this test is 5 7%Conclusions The Bio M Pylori serologic test has high sensitivityvalue (100%). This diagnostic kit can be considered as a goodpre-endoscopic screening tool in children with recurrentabdominal pain caused by H. pylori infection.

Oral Rehydration on Infants and Children in the Dr. Hasan Sadikin General Hospital, Bandung Djoeanda P; Wyati Donhuijsen
Paediatrica Indonesiana Vol 19 No 3-4 (1979): March - April 1979
Publisher : Indonesian Pediatric Society

Fifty-nine out of one hundred and fifty-jour patients with gastroenteritis and dehydration admitted between April and September 1975 to the Department of Child Health, Dr. Hasan Sadikin General Hospital, were treated with oral glucose electrolyte solution and studied.Twenty-nine patients (group I) were treated with P.3.M. formula and thirty patients (group II) with Hirschhorn formula. In both groups no significant differences were noted in grades of volume depletion which ranged between 5 to 10%, with a peak incidence of 8%. Rehydration was excellent in 41 (69.6%), good in 14 (23.7%) and poor in 4 patients (6.7%). No significant differences were found between both groups. The mean weight gain after rehydration was 4.5% (of the initial weight) in group I and 4.49% in group II (no significant differences). In the study of Hirchhorn et al. (1975) the mean weight gain was about 3%. Fifty-four patients (91.5%) had a recognized pathogen in their stool. In general, the result of oral rehydration in this study was satisfactory; statistically the treatment with both oral glucose electrolyte solutions gave the same good results.

Magnitude and influencing factors of parasomnia in schoolchildren Choudhury Habibur Rasul; Khan Golam Mostafa; Nitya Nanda Baruri; Jakia Sultana
Paediatrica Indonesiana Vol 53 No 6 (2013): November 2013
Publisher : Indonesian Pediatric Society

Background Parasomnias are undesirable events occurring inthe sleep-wake transition period. Several predisposing factors arereported to induce parasomnia in preschool children.Objective To es timate the magnitude of parasomnia in schoolchildren and to evaluate its relationship with possible predisposingfactors .Methods Five hundred children aged 5- 16 years from a boys'school and a girls' school in Khulna City, Ban gladesh, wererandomly selected for the study conducted fromJuly to December2011. The survey was don e in two steps: self-administeredquestionnaire and clinical interviews of affected students andtheir parents. Apart from demographic features, questionnairesincluded details of perinatal and personal fac tors as well asfamilial and socioeconomic factors . The diagnoses of variantsof parasomnias was based on the criteria for category-basedclassification by the American Academy of Sleep Medicine.Results Seven hundred thir teen filled questionnaires revealedparasomnia in 187 (26.2%) children. Most parasomnias wereaccompanied by other sleep disorders, in which 23 (12.3%) havingprimary dyssomnias including 18 (9.3%) obstructive sleep apnea,and 10 (5.3%) parasomnias with hypersomnias . Nightmares(7. 4%) were highest among the parasomnias fo llowed by nocturnalenuresis (4.1 %) and sleep terrors (3 .4%). More girls experiencedparasomnias than boys (107 /360 vs . 80/353, respectively;P= 0.039) . Perinatal factors such as problems during pregnancy(17 .1 %) or eventful delivery (25. 7%), and socioeconomic factorssuch as familial disharmony (11.8%) and low socioeconomiclevel(3 1.6%) had positive associations with parasomnia.Conclusion One-quarter of school children experience parasomnia.We found perinatal factors particularly problem duringpregnancy, and socioeconomic factors particularly familialdisharmony have significant influences on this condition.

Molecular analyses in Indonesian individuals with intellectual disability and microcephaly Farmaditya EP Mundhofir; Rahajeng N Tunjungputri; Willy M Nillesen; Bregje WM van Bon; Martina Ruiterkamp-Versteeg; Tri I Winarni; Ben CJ Hamel; Helger G Yntema; Sultana MH Faradz
Paediatrica Indonesiana Vol 53 No 2 (2013): March 2013
Publisher : Indonesian Pediatric Society

Background Intellectual disability (ID) often coincides with anabnormal head circumference (HC). Since the HC is a reflectionof brain size, abnormalities in HC may be a sign of a brain anomaly.Although microcephaly is often secondary to ID, hereditary(autosomal recessive) forms of primary microcephaly (MCPH)exist that result in ID.Objective To investigate mutations in MCPH genes in patientswith ID and microcephaly.Methods From a population of 527 Indonesian individuals withID, 48 patients with microcephaly (9.1 %) were selected. Thesepatients were previously found to be normal upon conventionalkaryotyping, fragile X mental retardation 1 (FMRl) gene analysis,subtelomeric deletion, and duplication multiplex ligationdependentprobe amplification (MLPA). Sanger sequencing forabnormal spindle-like microcephaly-associated (ASPM) and WDrepeat domain 62 (WDR62) was performed in all 48 subjects, whilesequencing for microcephalin (MCPHl), cyclin-dependent kinase5 (CDK5) regulatory subunit-associated protein 2 (CD5KRAP2) ,centromere protein} (CENPJ), and SCUfALl interrupting locus(STIL) was conducted in only the subjects with an orbitofrontalcortex (OFC) below -4 SD.Results In all genes investigated, 66 single nucleotide polymorphisms(SNPs) and 15 unclassified variants which were predictedas unlikely to be pathogenic (lN2), were identified. Possiblepathogenic variants (lN3) were identified in ASPM. However,since none of the patients harboured compound heterozygouslikely pathogenic mutations, no molecular MCPH diagnosis couldbe established. Interestingly, one of the patients harboured thesame variants as her unaffected monozygotic twin sister, indicatingthat our cohort included a discordant twin.Conclusions This study is the first to investigate for possible geneticcauses ofMCPH in the Indonesian population. The absenceof causative pathogenic mutations in the MCPH genes tested may originate from several factors. The identification of UV2and UV3 variants as well as the absence of causative pathogenicmutations calls for further investigations.

Neurocysticercosis M Arimbawa; I Komang Kari; N S Laksminingsih
Paediatrica Indonesiana Vol 44 No 4 (2004): July 2004
Publisher : Indonesian Pediatric Society

In this paper we report a case of NCC in an 11-year old Balinese boy.

Relationship between protein energy malnutrition and social maturity in children aged 1-2 years Nurhayati Nurhayati; Soetjiningsih Soetjiningsih; I Ketut G. Suandi
Paediatrica Indonesiana Vol 42 No 11-12 (2002): November 2002
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi42.6.2002.261-7

Background Protein energy malnutrition (PEM) affects physical, psychological, and social development.Objective To investigate the relationship between PEM and social maturity in children aged 1-2 years.Methods We carried out a cross-sectional study at Child Health Outpatient Clinic, Sanglah Hospital, betweenApril-September 2000. We included children living with their parents, with no handicap or chronically ill condition. Data were collected by using structured questionnaires. Nutritional status was determined based on WHO-NCHS standard, while social maturity was measured by Vineland social maturity scale.Results Of the 200 subjects analyzed, the mean age was 16.9 months (SD 3.8), body weight 10.2 kg (SD 1.7) and social quotient (SQ) score 94.3(SD 10.6). There was a significant correlation between SQ and PEM (B-7.5, CI 95%-10.6;-4.3, p<0.001) parents' occupation (B4.9, CI 95% 2.2-7.7, P<0.001) and mothers' education (B4.2,CI 95% 1.0-7.4, P<0.001).Conclusion This study revealed that the more severe the PEM, the lower the SQ, while the better the education and occupation, the higher the SQ was.

Intraperitoneal Fluid Therapy in Children Harden Noerasid; Pitono Soeparto; Bing Rudyanto; Sugeng Sugijanto; Abdul Hamid; A. Saraswati
Paediatrica Indonesiana Vol 15 No 7-8 (1975): July - August 1975
Publisher : Indonesian Pediatric Society

The administration of intraperitoneal fluid to 56 children, with gastroenteritis and dehydration, admitted to the Department of Child Health Dr. Soetomo Hospital, was discussed. The authors especially considered the practical aspects and the danger arising from the administration of intraperitoneal fluids. Although none of the patients died, some did show restlessness, meteorism, a raised leucocyte-count and a small rise in body temperature. The authors are of the opinion that the administration of intraperitoneal fluids is not free of danger and it should be reserved for emergency situation only.

The Sick Child Initiative James Tulloch
Paediatrica Indonesiana Vol 37 No 9-10 (1997): September - October 1997
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi37.9-10.1997.189-92

Every year some L2 million children die before they reach their fifth birthday, many of them during the first year of life. Seven in every 10 of these child deaths are due to diarrhea, pneumonia, measles, malaria, or malnutrition - and often to a combination of these conditions (see Table 1). In addition to this substantial mortality, these con-ditions typically account for three out of four sick children seeking care at a health facility. Every day, millions of parents seek health care for their children, taking them to hospitals, health centers, pharmacists, community health care providers and traditional healers.

Perinatal factors associated with autistic spectrum disorder Asri Yuniastuti; Tunjung Wibowo; Djauhar Ismail
Paediatrica Indonesiana Vol 54 No 3 (2014): May 2014
Publisher : Indonesian Pediatric Society

Background The prevalence of autistic spectrum disorder(ASD) has increased in recent decades. The definitive causesof ASD have yet to be recognized. Howevei; it is believed thatboth genetic and non-genetic, as well as perinatal and post natalfactors influence ASD. Previous studies have shown inconsistentfindings.Objectives To assess for prematurity, birth weight, asphyxia,mode of delivery, bleeding during pregnancy, parental age andeducation, as prognostic factors for ASD.Methods We conducted a cross sectional study at schools forautistic children in Yogyakarta between February 2011 to October2012. The inclusion criteria were children with and without ASD,whose parents consented to participate in this study. Childrenwith genetic abnormalities or who planned to move away duringthe study period were excluded. A total of 48 subjects with ASDand 96 subjects without ASD were involved in this study. Datawere obtained by direct interview using questionnaires. Logisticregression analysis was performed to examine the hypoth esis.Results Multivariate analysis showed that prematurity was nota significant prognostic factor (RR 2.73; 95%CI 0.3 to 15.7) forASD. Howevei; children born by Caesarean section were 5.4 timesmore likely to have ASD (RR 5.4; 95%CI 1.3 to 22.8) comparedto those who were delivered vaginally or by vacuum extraction.Moreovet; asphyxia was also a significant prognostic factor forASD (RR 8.7; 95%CI 1.9 to 38.6) .Conclusion Prematurity is not a risk factor for ASD. Asphyxiaand Caesarean birth should be considered as potential confoundersin this study.

Prognostic factors of epilepsy in patients with neonatal seizures history Banani Sidiq; Elisabeth S. Herini; Tunjung Wibowo
Paediatrica Indonesiana Vol 53 No 4 (2013): July 2013
Publisher : Indonesian Pediatric Society

Background Seizures in neonates are often associated withneurological disorders in early life, including epilepsy. Severalpossible prognostic factors may influence the development ofepilepsy in these patients.Objective To evaluate prognostic factors that may influence theoccurrence of epilepsy in the first two years of life in patients witha history of neonatal seizures.Methods We performed a cohort retrospective study on patientswith neonatal se izures in Sardjito Hospital during 2004-2009.Prognostic factors observed were gender, family history ofepilepsy, neonatal hypoglycemia, assisted labor, hypoxic ischemicencephalopathy, preterm infant delivery, and epileptic state.Results Hypoxic ischemic encephalopathy and epileptic stateincreased the risk of epilepsy (HR 5.8; 95%CI 1.63 to 20.43 andHR 6.3; 95%CI 2 .0 to 19. 70, respectively). Assisted labor, pretermdelivery, neonatal hypoglycemia, family history of epilepsy, andgender did not increase the risk of epilepsy in the first two yearsof life.Conclusion Hypoxic ischemic encephalopathy and epileptic statein neonates presenting with seizures are the prognostic factors tobe epileptic children during the first two years of life.

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