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Paediatrica Indonesiana

paediatrica-indonesiana
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Published by Ikatan Dokter Anak Indonesia

ISSN : 00309311 EISSN : 2338476X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.

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Articles 2,127 Documents

134 135 136 137 138

Perinatal Mortality and Morbidity at Dr. Pirngadi Hospital Medan 1985-1986 Guslihan D. Tjipta; Dachrul Aldy; Noersida Raid; Baren Ratur Sembiring
Paediatrica Indonesiana Vol 29 No 5-6 (1989): May - June 1989
Publisher : Indonesian Pediatric Society

A retrospective study was conducted on babies born during January 1985 to December 1986 at Dr. Pirngadi Hospital Medan. The aim of this study was to evaluate perinatal mortality and morbidity, and various possible factors related to the subject matter.The main results can be summarized as follows : There were 7102 deliveries during the study period consisting of 999 babies weighing less than 2500 gram and 6103 with body weight of 2500 gram or more. Perinatal mortality rate was 563.56 o/oo in the first group and 78.49 o/oo in the second while the avera/ mortality rate was 146.72 o/oo.Rate of perinatal demise was high in babies born from mothers in the age groups of below 20 and above 35 years, namely 681 .82 o/oo and 202.19 o/oo. It was also high among primiparae (165.67 o/oo) and more so among grandmultiparae (246.46 o/oo).There were 1966 (30.49%) ill newborn babies with asphyxia neonatorum accounting for 44.91%, infection 30.42% and respiratory problems 9.21% of the main causes of illness, while respiratory problems (40.05%) and injection (28.68%) constituted the main causes of death .We concluded that the rate of perinatal mortality and morbidity is still high at this hospital. Quality of prenatal and neonatal care with extensive public health education is necessary to be enhanced for the reduction of perinatal mortality and morbidity.

Cerebrospinal Fluid Lactic Dehydrogenase Activity in Children with Acute Lymphoblastic Leukemia Treated for Cranial Prophylaxis Musa Kazim Caglar; Gonul Hicsonmez; Nurten Renda
Paediatrica Indonesiana Vol 29 No 5-6 (1989): May - June 1989
Publisher : Indonesian Pediatric Society

Total lactic dehydrogenase (TLDH) activity in cerebrospinal fluid (CSF) has been prospectively studied in order to determine whether it could be a biochemical marker for brain damage due to cranial prophylaxis in children with acute lymphob/atic leukemia (ALL). TLDH activity has been measured in 15 patients before prophylaxis, in 15 patients after the prophylaxis which consisted of cranial radiotherapy (2400 rads) and intrathecal methotrexate (0.5 mg/kg-dose, 5 doses), in 8 patients after radiotherapy alone (2400 rads) and in 9 patients after intrathecal methotrexate (0.5 mg!kg-dose, 5 doses) alone. TLDH activity in CSF of combined prophylaxis group has been found to be higher than the ones before study (p < 0.05). There were insignificant elevations of TLDH activity in the other two groups (p > 0.05; p > 0.05). This result indicated combined cranial prophylaxis seemed to be more toxic than the other prophylaxis regimens when they were used alone.

Acute Mediastinitis Toto Andriono; I. G. N. Susanta; Makmuri Makmuri; Gunadi Santosa
Paediatrica Indonesiana Vol 29 No 5-6 (1989): May - June 1989
Publisher : Indonesian Pediatric Society

Mediastiniti is not a new disease, however, the occurrence was rare especially in children. Focal infection which considered to be insignificant, can result in diffuse dissemmation involving mediastinum leading to fatal condition. This paper reported a case of mediastinitis with very critical condition. Fast and accurate diagnosis as well as adequate antibiotic treatment saved the patient without surgical intervention.

New Perspectives in the Nutrition of Premature and Low Birth Weight Infants Ursula Wachtel
Paediatrica Indonesiana Vol 29 No 5-6 (1989): May - June 1989
Publisher : Indonesian Pediatric Society

Everybody in this audience is well aware of the fact that in about the last two decades great advances have been made in fetal and neonatal medicine. Due to the recently gained knowledge in fetal biology as well as in neonatal biochemistry, physiology and pathophysiology a much better understanding of special dietary needs in prematurity and infancy has been achieved. Based on sound scientific background completely new feeding regimens are used today, which have not even been thought of about 20 or 30 years ago and which in turn have considerably contributed to the development of so-called "foods for special dietary purposes."

Case report discussion of management of pink tetralogy of Fallot in VACTERL association Bayushi Eka Putra; Toto Wisnu Hendrarto
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

Tetralogy of Fallot (TOF) and VACTERL are considered rare entities requiring medical attention with regards to diagnosis and management. When TOF is associated with VACTERL association, case management might differ from a simple case of TOF. Tetralogy of Fallot (TOF) is defined as a complex congenital cardiac abnormality characterized by ventricular septal defect, right outflow tract obstruction, right ventricular hypertrophy, and overriding aorta.1 The term was coined in 1888 by Fallot of Marseilles, even though the defect had been described in 1673 by Steno of Denmark. The entity was then studied extensively to deliver better care management through medical and surgical approaches.2

Conjunctival Diphtheria Syahrir Pasaribu
Paediatrica Indonesiana Vol 33 No 5-6 (1993): May - June 1993
Publisher : Indonesian Pediatric Society

Three cases of conjunctival diphteria in 3 siblings of one family with the ages of 7 months, 6 and 8 years bad been reported. These children bad never obtained complete D1P immunization, one of them bad been once immunized with D1P. General signs encountered were conjunctival hyperemia, ocular secretion and palpebral edema. A relationship between length of ailment with appearance of clinical symptom and severity of the disease was noted. Myocarditis as a complication was found in one case. Treatment in this series consisted of intravenous anti diphtheria serum (ADS) and intramuscular procain penicillin.

Hyperventilation in Children with Dengue Hemorrhagic Fever (DHF) Kasim Y. A.; Anky Tri Rini K. E.; Sumarmo S. P. S.
Paediatrica Indonesiana Vol 31 No 9-10 (1991): September - October 1991
Publisher : Indonesian Pediatric Society

Many studies of Dengue Hemorrhagic Fever (DHF) have been done but only a few revealed the respiratory status. Respiratory problems arise. because of plasma leakage through the 'damaged capillaries, causing lung edema and in turn result in hypoxemia. This later on will be compensated by a hyperventilation state. During a 6-month-period (May to September 1988), two aspects were studied in 85 patients hospitalized with DHF. First, the ventilatory pattern and second, the result of giving oxygen support in improving the respiratory disturbance, in this case alveolar hyperventilation. The incidence of alveolar hyperventilation in DHF grade II (DHF II) and Dengue Shock Syndrome (DSS) differed significantly. Hypoxemia occurred in DHF II and DSS with no significant differences. The difference of the incidence of metabolic acidosis in DHF II and DSS were significant. In DHF II patients having had hyperventilation state, oxygen therapy decreased respiration rate significantly and increased the PaC02 though not significantly.

A five-year review of children with neuroblastoma at Dr. Sardjito General Hospital, Yogyakarta, Indonesia Sutaryo Sutaryo; Scolastika Dita Kristian
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

Background Neuroblastoma is the third most common tumor in children, after leukemia and retinoblastoma. The disease presents with a wide range of symptoms. Objective To assess the clinical profiles of children with neuroblastoma at Dr. Sardjito General Hospital from 2012-2016. Methods A retrospective review of all children with neuroblastoma under 18 years of age in the Childrenâ€™s Ward of Dr. Sardjito General Hospital, Yogyakarta from 2012-2016. Patients diagnosed and treated in other hospitals were excluded. Data were taken from the Yogyakarta Pediatric Cancer Registry (YPCR) and medical records. Outcomes were assessed by patient status: alive, died, or lost to follow-up. Results A total of 40 subjects were included in this study. Six (15.0%) patients were diagnosed at <1 year of age, 26 (65.0%) patients at 1 to <5 years of age, 6 (15.0%) patients at 5 to <10 years of age, and 2 (5.0%) patients at â‰¥10 years of age. The male to female ratio was 1.5:1. Four (10.0%) patients had stage IV-S, 34 (85.0 %) patients had stage IV, and 2 (5.0 %) patients had stage II/III of the disease. Proptosis (40.0%) and abdominal mass (35.0%) were the most common chief complaints. Eight (20.0%) patients were alive at the end of observation, 15 (37.5%) died, and 17 (42.5%) were lost to follow-up. The deaths were mostly caused by sepsis. Conclusion Most patients are diagnosed at the age of 1 to <5 years, with a median age of 3 years. Proptosis is the most common chief complaint. Most patients present in stage IV. Overall survival rate is very low. The high numbers of lost to follow-up should be noted.

Highly active antiretroviral therapy and left ventricular diastolic function in children with human immunodeficiency virus infection Ni Made Ayu Agustini; Eka Gunawijaya; Ni Putu Venny Kartika Yantie; Ketut Dewi Kumara Wati; Komang Ayu Witarini; Hendra Santoso
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

Background In the past, cardiovascular involvement did not seem to be a common complication of HIV, but in recent years it has been described more frequently. With the advent of highly active antiretroviral therapy (HAART), the symptoms of cardiac disease has changed, as the number of HIV-infected patients with abnormal diastolic parameters has increased significantly, often presenting as symptomatic rather than asymptomatic. Objective To analyze for a possible correlation between HAART duration and left ventricular diastolic function in HIV-infected children. Methods This cross-sectional study was conducted from December 2016 to December 2017 at the Cardiology and Allergy-Immunology Division/Department of Child Health, Universitas Udayana Medical School/Sanglah Hospital, Denpasar, Bali. Subjects with HAART were collected using a consecutive sampling method. The following data were recorded for each subject: age, sex, current stage of HIV, CD4+ level, as well as HAART regimen and duration of use. Transthoracic echocardiography was performed for tissue doppler imaging (TDI) of diastolic function. Spearmanâ€™s test was used to analyze the strength of correlation based on normality test results. Results This study involved 53 subjects, 21 of whom had impaired diastolic function. There was no correlation between HAART duration and diastolic function in children with HIV infection (r= -0.03; P=0.82). Conclusion Diastolic dysfunction is found in children under HAART treatment, but there is no correlation between HAART treatment duration and diastolic dysfunction.

Serum S100B and intelligence in children with Down syndrome Nurul Noviarisa; Eva Chundrayetti; Gustina Lubis
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

Background Down syndrome is characterized by physical and mental retardation and caused by chromosome 21 (Hsa21) abnormalities. The S100B is a protein that is overproduced in Down syndrome due to overexpression of chromosome 21 genes. Comorbidities caused by S100B in Down syndrome are cognitive deterioration and early onset of dementia. Objective To assess for a possible association between S100B protein and intelligence levels in children with Down syndrome. Method This cross-sectional study included students in a special needs school in Padang, West Sumatera, who had the characteristic clinical features of Down syndrome and trisomy 21 by chromosome analysis. Examination of S100B levels was carried out using an enzyme-linked immunosorbent assay (ELISA) method. Intelligence quotient (IQ) was measured using the 4th edition of the Wechlser Intelligence Scale for Children (WISC-IV) method. Results A total of 39 children with Down syndrome participated in the study. There were 25 children with mild mental retardation and 15 children with moderate-severe mental retardation. The mean S100B levels were not significantly different between groups [479.1 (SD 204) pg/mL in the mild mental retardation group and 458.7 (SD 158) pg/mL in the moderate-severe mental retardation group; P > 0.05]. The mean S100B level was significantly higher in subjects aged â‰¤ 10 years than in those aged > 10 years [566.9 (SD 210.0) pg/mL and 434.4 (SD 167.2) pg/mL, respectively (P<0.05)]. Conclusion There is no association between S100B and intelligence levels in children with Down syndrome. There is a significant association between higher S100B levels and younger age in children with Down syndrome.

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