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Paediatrica Indonesiana
Published by Ikatan Dokter Anak Indonesia
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 2,127 Documents
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Serum eosinophilic cationic protein level and hematological parameters in infants with cow's milk protein allergy Erkan Dogan; Eylem Sevinc
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.036 KB) | DOI: 10.14238/pi59.3.2019.119-24

Abstract

Background Various biomarkers have been investigated in the diagnosis of cow's milk protein allergy (CMPA) in infants. To our knowledge, no prior studies have evaluated serum eosinophil cationic protein (sECP), neutrophil-lymphocyte ratio (NLR), and mean platelet volume (MPV) concurrently in infants with CMPA. Objective To compare sECP levels, MPV, and NLR in infants with and without CMPA, as well as to investigate the suitability of these parameters as biomarkers in the diagnosis of CMPA. Methods Fifty-six children with CMPA were compared to 40 healthy, similar to distribution of age and sex normal infants as controls. The serum ECP levels were detected by a chemiluminescence assay. The MPV values were calculated by devices in hemogram parameters. The NLR values were obtained by dividing the neutrophil count by the lymphocyte count. Results The median sECP level in the CMPA group was significantly higher than in the control group (23.5 and 9.27 ng/mL, respectively; P=0.001). However, there were no significant differences between groups with regards to median MPV (8.5 and 8.6 fL, respectively; P=0.149) and median NLR (0.35 and 0.37 respectively; P=0.637). Correlation analysis of sECP level with MPV and NLR in the CMPA group revealed no significant relationships (P>0.05 for both). In the Receiver-operating characteristic (ROC) curve analysis, the optimal cut-off levels to identify CMPA for sECP, MPV, and NLR were 18.4 ng/mL (60.7% sensitivity, 97.5% specificity, and AUC: 0.831), 10.05 fL (54% sensitivity, 77.5% specificity, and AUC: 0.413) and 0.97 (14.3% sensitivity, 50% specificity, and AUC: 0.528), respectively. Conclusions The sECP level and blood eosinophil count are significantly higher in infants with CMPA, but MPV and NLR do not differ between infants with and without CMPA. There are also no significant correlations in the CMPA group between sECP and MPV, as well as sECP and NLR. Serum ECP might be useful as a potential biomarker for diagnosing CMPA.
Relationship between serum ferritin and zinc levels in patients with major thalassemia Hervita Yeni; Finny Fitry Yani; Amirah Zatil Izzah; Gustina Lubis
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.731 KB) | DOI: 10.14238/pi59.3.2019.144-9

Abstract

Background In thalassemia patients, reduced zinc absorption results from increased serum iron due to repeated blood transfusions, increased iron absorption due to ineffective erythropoiesis, and competitive inhibition between iron and zinc in binding to transferrin, a means of transporting both types of minerals in the blood. Few studies have been done to examine zinc levels in thalassemia patients and its relationship with ferritin. Objective To compare serum zinc in thalassemia patients and healthy controls and to assess for a possible correlation between serum ferritin and zinc in thalassemia patients. Methods This cross-sectional study in 68 subjects was done from October 2016 to August 2017. Serum ferritin measured by chemiluminescence immunoassay and serum zinc by inductively coupled plasma mass spectrometry (ICP-MS). Wilcoxon test was used to analyze for differences between serum zinc in thalassemia patients and controls. Spearman’s correlation test was used to analyze for a possible correlation between ferritin and serum zinc in thalassemia patients. Results There were 34 patients with thalassemia and 34 healthy control subjects. The median serum zinc was 119.34 µg/dL (IQR=71.27) in the thalassemia group and 120.08 µg/dL (IQR=26.28) in the control group (P=0.36). There was no significant correlation between serum ferritin and zinc in thalassemic children (r=-0.023; P=0.895). Conclusion There is no significant difference in serum zinc levels between thalassemic children and healthy controls. There is no significant correlation between serum ferritin and zinc in thalassemic children.
UGT1A1 gene polymorphisms and jaundice in Indonesian neonates Rinawati Rohsiswatmo; Radhian Amandito; Andiani Wanda Putri; Nilam Sartika; Amarila Malik
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (390.063 KB) | DOI: 10.14238/pi59.3.2019.150-6

Abstract

Background Uridine diphospho-glucuronocyltransferase 1A1 (UGT1A1) polymorphisms are a risk factor for unconjugated hyperbilirubinemia in neonates. UGT1A1 polymorphisms decrease bilirubin conjugation, thus causing hyperbilirubinemia. A variety of polymorphisms have been reported, with UGT1A1*60 and UGT1A1*6 especially prominent in the Asian population. Hyperbilirubinemia polymorphism studies are lacking in Indonesian populations. Objective To identify UGT1A1*60 and UGT1A1*6 profiles in Indonesian populations of heterogeneous ethnicity. Methods We enrolled 42 jaundiced neonates who were born from January to April 2017 and treated in the Neonatal Intensive Care Unit of our national referral center, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Genetic mutations *60 of exon 1 and *6 of the promoter region were analyzed by polymerase chain reaction – restriction fragment length polymorphism methods, with DraI and AvaII as restriction enzymes, respectively. Clinical data including total serum bilirubin and racial information were obtained by medical records and interviews with parents. Results There were no homozygous mutations of UGT1A1*6, but 4.8% of subjects were heterozygous. As for UGT1A1*60, 4.8% were heterozygous and 95.2% were homozygous. Racial variations were not observed for UGT1A1*60, while Betawi descendents were found to have many heteroygous forms of UGT1A1*6. Conclusion Polymorphisms of the UGT1A1 gene were found in Indonesian neonates. Some ethnicities also showed increased tendency towards its incidence, such as the heterozygous form of UGT1A1*6.
The Behaviour of Health Care Providers in Managing Diarrheal Disease in Palembang City, South Sumatera, Indonesia Rusdi Ismail; Achirul Bakri; Muhammad Nazir; Nancy Pardede
Paediatrica Indonesiana Vol 31 No 5-6 (1991): May - June 1991
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (947.833 KB)

Abstract

A study on knowledge, attitude and practice of health care providers in Palembang had been conducted at the end of 1989 and beginning of 1990. Four approaches were carried out: (1) by recording the help obtained by cases who consulted researchers for further help for the same diarrheal diseases (DD) episode, (2) by studying the medical records of DD cases admitted to three hospitals, (3) by studying prescriptions dispensed by three pharmacies and (4) by focus group discussions. The findings were analysed to evaluate the achievement of the Indonesian Diarrheal Diseases Control Program (CDD). ORT, avoiding antimotility drugs and appropriated feeding have been accepted and practiced by the providers in Palembang. The target of promotion now is to support the acquisition of these behaviours to be if implemented as a routine habit of the providers and as a part of the ongoing system of health care delivery system. Specifically the danger of loperamide promotion to the policy on antimotility must be stressed. Rapid iv rehydration and avoiding surface precipitating agents have been accepted, but are not practiced consistently yet due to practical considerations. It seems that there is no impact at all of CDD towards the rate of antibiotic therapy in DD. Besides intensifying the campaign, enforcing group pressure, maybe we have to elaborate more the perception of health care provider as a practitioner, and conforming the strategy of the CDD campaign towards the findings. Health education had not been practiced effectively yet. Morale and value system of the providers are important for the success of this program. In general the medical-technic aspect of the CDD has been accepted by the providers, but there is still a lot to do in communicating them to be adopted as an effective behaviour.
Umbilical Cord Length and Intra Uterine Wellbeing Erwin Sarwono; Disse W. S.; Oudesluys Murphy; Oosting H.; De Groot C. J.
Paediatrica Indonesiana Vol 31 No 5-6 (1991): May - June 1991
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.255 KB)

Abstract

The length of the umbilical cord was studied in 179 Indonesian newborn determine the normal range of cord length and its influence on the occurrence of intrapartum complications such as meconium stained amniotic fluid, asphyxia and entanglement of the cord around the fetus. The authors also attempted to investigate whether unfavourable intra uterine conditions could influence cord length. Therefore a correlation between cord length, sex, gestational age, birthweight and headcircumference was sought. The mean length of the umbilical cord was 52.2 cm, with a S.D. of 10.2 cm, ranging from 31-100 cm. Male infants had significantly longer umbilical cords than females (p = 0.02). The risk of complications increased parallel with cord length.
Spectrum of Asthma in Child en Visiting the Outpatient Clinic of the Subdivision of Allergy and Immunology Corry S. Matondang
Paediatrica Indonesiana Vol 31 No 5-6 (1991): May - June 1991
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (928.488 KB)

Abstract

A retrospective study on clinical and laboratory findings was conducted in 104 children with asthma visiting the Outpatient Clinic, Subdivision of Allergy and Immunology, Department. of Child Health, Dr. Cipto Mangunkusumo General Hospital, Medical School, University of Indonesia, Jakarta. This study revealed that the proportion of asthma in males was greater than in females with the ratio 1.36: 1. The age ranged from 8 months to 14 years with a mean age of 6.72 years. The majority of the children (70.2%) had the age of onset of asthma under 5 years, and the highest percentage was between 2- 4 years (45.2%). The author thinks that this may be due to the upper respiratory tract infections, which frequently found in that age group of children and may precipitate asthma in certain Individuals. There was no significant correlation between the duration of breast feeding and the age of onset of asthma, without considering strict avoidance of formula or solid food. The majority of the children in this study (95.2%) had positive family history of atopy and 79.80% had family history of asthma. This supports the opinion that asthma is inherited. Thirty nine out of 104 children (37,5%) also suffered from other allergic manifestations and was mostly urticaria. It seems that patients with asthma tend to have other allergic diseases. The percentage of increased serum IgE level in pure asthma was 21.87% While increased eosinophil count 36.1%. The majority of the children in this study (92.8%) showed positive prick test. It seems that normal IgE serum level and normal eosinophil count did not rule out the presence of allergic asthma. The percentage of increased level of serum lgE and peripheral eosinophil count increased with the presence of ascariasis and other allergic manifestations. The majority of the patients tested (64 out of 60 patients) showed positive skin prick test against at least one allergen, the three leading percentages were against house dust (75 %), animal epithelia (70.1 %) and house dust mite (54.7%). lt seems that the majority of our children with asthma were allergic and the most involved allergen was aeroallergen (inhalan).
The Influence of Pyridoxin in the Theatment of Tetanus Neonatorum Dianto Dianto; Immanuel Mustadjab
Paediatrica Indonesiana Vol 31 No 5-6 (1991): May - June 1991
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.316 KB)

Abstract

During a 2-year-period (1988-1990) 31 patients with tetanus neonatorum were recruited for this study. The patients were divided into 2 groups: The first group (15 patients) was treated with ATS injection, oral metronidazole and amoxycillin, and diazepam suppositoria. The second group (16 patients) was treated with the same regimen, as the first group plus pyridoxin injection 100 mg on the first day followed by 25 mg orally on the next days. There was no statistical difference in the two groups concerning the gestation period, sex, severity of the disease (p> 0.05), place of delivery (all at home) and mode of delivery delivered by traditional (midwife/dukun). The mortality of the first group (without pyridoxin) was 60% and the second (with pyridoxin) 37.5% (p < 0.05).
Myotonia Congenita (Thomsen's Disease) Report of Five Cases in a Family Hardiono D. Pusponegoro; Jahja Zacharia; Jimmy Passat
Paediatrica Indonesiana Vol 31 No 5-6 (1991): May - June 1991
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.639 KB) | DOI: 10.14238/pi31.5-6.1991.170-8

Abstract

This report describes 5 out of 8 siblings who were the first cases of myotonia congenital diagnosed in our department. The parents were first cousins. Neither the parents, nor the other family members have myotonia. The affected siblings 4 boys and 1 girl, all showed a very typical myotonia especially after prolonged rest, and it could be worked off with, continuing activity. They had a muscular looking body or a herculean proportion. The diagnosis were based upon family history, clinical findings of percussion myotonia, had grip myotonia, prominent muscular hypertrophy and confirmed by electromyographic examination revealing myotonic discharges. Since there were some junctional impairments, these patients were treated with diphenylhydantoin and then with quinine sulphate, with good results. The patients related parents were much likely to be heterozygous for the same harmful recessive genes, because they had common ancestor. The role of marriage counseling is important in this kind of inherited disease, to prevent the occurrence of this inherited disorder in the next generations.
Nutritional Status in Childhood Thalassaemia at the-Department of Child Health University of North Sumatera Dr. Pirngadi Hospital Medan Ismet Fadil Loebis; Sugiani Sinulingga; Adi Sutjipto
Paediatrica Indonesiana Vol 31 No 5-6 (1991): May - June 1991
Publisher : Indonesian Pediatric Society

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Abstract

A-10 year (June 1979 to May 1989) study on the nutritional status of children with thalassaemia was done. The number of patients was 131; 75 (57.25%) were males and 56 (42. 75%) females. A study on nutritional status by the age group was performed in 123 cases at the first diagnosis. The incidence of malnourished children over 1 year of age was significantly higher than in below 1 year of age cases (p < 0.05).
Neonatal Mortality in Yogyakarta Rural Areas Achmad Surjono
Paediatrica Indonesiana Vol 28 No 5-6 (1988): May - June 1988
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (613.541 KB) | DOI: 10.14238/pi28.5-6.1988.97-104

Abstract

The outcome of neonatal care was studied in three subdistricts rural areas in Yogyakarta Province with a total population of 112075 people. For data collection all pregnancies and deliveries between May 1983 -April 1984 were registered and visited twice during pregnancy, on delivery, 5 days and one month afterwards by trained health cadres. There were 1819 singleton liveborn infants with a neonatal mortality rate of 25.3 o/oo, in which 82.6% of the deaths occurred in the early neonatal period. An amount of 91.5% of the women delivered in their own house and 83.9% were assisted by a traditional birth attendant either trained or untrained. There was still 27.1% of pregnancies which never got any antenatal care. The coverage of tetanus immunization was 75.2% with 1.1 o/oo incidence of tetanus. The incidence of low birth weight infants was 8.1%, of which 19. 7% died before one month of age, I representing 63% of neonatal mortality. The causes of neonatal deaths were as follows: birth asphyxia and hypoxia 56.5%, prematurity/low birth weight 13%, infection/sepsis 13%, diarrhea 8. 7%, tetanus neonatorum 4.4% and others/unknown 4.4%. In rural areas, traditional birth attendants play a key role on assisting labour and taking care of the mothers as well as their newborns up to one month of age. Improvement of health service delivery at all levels of the health care system which includes the traditional birth attendants is needed especially concerning resuscitation of the newborns and the problems of low birthweights.

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