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Jurnal Fitofarmaka Indonesia
Published by Universitas Muslim Indonesia
ISSN : 23560398     EISSN : 25412329     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : -
Articles 6 Documents
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Search results for , issue "Vol 1, No 2 (2014): JURNAL FITOFARMAKA INDONESIA" : 6 Documents clear
PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN BAWANG MEKAH (Eleutherine Americana Merr.) TERHADAP KADAR MALONDIALDEHYDE TIKUS WISTAR (Rattus norvegicus) JANTAN PASCA PAPARAN ASAP ROKOK Melda Mery Andiriyani; Eka Kartika Untari; Sri Wahdaningsih
Jurnal Fitofarmaka Indonesia Vol 1, No 2 (2014): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.344 KB) | DOI: 10.33096/jffi.v1i2.189

Abstract

Malondialdehyde (MDA) is a biomarker of lipid peroxidation that is closely correlated with level of oxidative stress. The aim of this study was to know ethanol extract activities from E. americana leaves against blood plasma MDA in male Wistar rats exposed by cigarette smoke using tiobarbituric acid test. The simplicia extracted by maseration using 70% ethanol. Twenty four rats were divided into six groups, i.e. : a normal group, an exposed cigarette smoke (negative) control group, a positive control group and three treatment groups. One normal group received carboxyl methyl cellulose and another groups exposed cigarette smoke during 14 days. Positive control group received vitamin E (18mg/kg BW), and another groups received ethanol extract of E. americana leaves doses 180; 90; 45mg/kg BW, respectively. The MDA level was analysed by spectrophotometer UV-Visible in 532,2 nm. The MDA level statically analysis by Kruskal-Wallis test and following by Mann-Whitney test. The mean MDA levels of normal group, negative control group, positive control group and groups received ethanol extract of E. americana leaves doses 180; 90; 45mg/kg BW were 0,11±0,09; 13,74±2,84; 0,06±0,03; 10,88±2,19; 0,13±0,03; 0,03±0,02 ppm. The mean MDA levels of groups received ethanol extract of E. americana leaves doses at 180; 90mg/kg BW significantly (p<0,05) lower than negative control group. These results show the beneficial effect of ethanol extract of E. americana leaves in the MDA level reducing on the rats that exposed by cigarette.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN BAWANG MEKAH (Eleutherine americana Merr.) TERHADAP GAMBARAN HISTOPATOLOGI PARU TIKUS (Rattus norvegicus) WISTAR JANTAN PASCA PAPARAN ASAP ROKOK Hafidzah Ramadhaniyah Al Idrus; Iswahyudi Iswahyudi; Sri Wahdaningsih
Jurnal Fitofarmaka Indonesia Vol 1, No 2 (2014): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.361 KB) | DOI: 10.33096/jffi.v1i2.190

Abstract

Exposure to cigarette smoke is one of the exogenous free radicals. Exposure to cigarette smoke is associated with lung inflammation, oxidative stress and lipid peroxidation. Compounds that can inhibit the oxidation reaction by binding free radicals known as antioxidants. Eleutherine americana Merr. leaves has an antioxidant activity in invitro study. The aim of this work was to study E.americana leaves as a natural antioxidant that reduce the level of lung damage from exposure to cigarette smoke in male wistar rats and study effective dose of E.americana leaves to reduce the level of lung damage.  The leaves of E.americana extracted by maceration method for 6 days using ethanol 70%. Rats were divided into six groups of four animals each : exposed to ambient air (GroupA), exposed to cigarette smoke (Group B), exposed to cigarette smoke and treated with ethanol extract of E.americana leaves at dose 45mg/kg bw, 90mg/kg bw, 180mg/kg bw (Group C,D,E), exposed to cigarette smoke and treated with vitamin E dose 18mg/kg bb(Group F). All rats were treated for 14 days using 3 cigarettes non filtered each day by using a smoking chamber. After 14 days rats were killed. Right lungs were removed for histopathology. The results showed that dose 45mg/kg bw, 90mg/kg bw, 180mg/kg bw can reduce the level of lung damage to the enlarge of alveolar, thickening of the alveolar wall and inflammatory cell infiltration. Dose 180mg/kg bw as an effective dose to reduce the level of lung damage that compare to normal control.
UJI AKTIVITAS ANTIBAKTERI FRAKSI n-HEKSAN KULIT BUAH NAGA MERAH (Hylocereus polyrhizus Britton & Rose) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923 Sri Amalia; Sri Wahdaningsih; Eka Kartika Untari
Jurnal Fitofarmaka Indonesia Vol 1, No 2 (2014): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.312 KB) | DOI: 10.33096/jffi.v1i2.191

Abstract

Inappropiate antibiotic use was one of the main reason that caused pathogenic microorganism resistance, leads to ineffective treatment. One of those resistance bacteria is Staphylococcus aureus. The research for discovering new antibiotics can help with this issue. The peel of red dragon fruit (Hylocereus polyrhizus) is one of the plants that has antibacterial compounds. The aim of this research is to prove and determine the minimum inhibitory concentration (MIC) value of n-hexane fraction of red dragon fruit’s peel againts Staphylococcus aureus ATCC 25923. The peel was maserated with chloroform, then fractinated by n-hexane. Futhermore, the antibacterial properties of the fraction was tested using Disc Diffusion (Kirby-Bauer) methode with 40, 20 dan 10 mg/mL concentrations. Ampisilin used as control positive. Based on the phytochemical screening of the fraction, the n-hexane fraction of the dragon fruit’s peel contain triterphenoid, steroid and alkaloid. Clear zones produced by 40 mg/mL is 12,80 mm and for 20 mg/mL is 11,17 mm. Wherea concentration 10 mg/mL didn’t show any inhibitory zone. According to this reasearch, the MIC value of the fraction is  20 mg/mL.
PENELUSURAN ZAT TOKSIK SARANG SEMUT ACEH (Mymercodia sp) DENGAN METODE BST TERHADAP LARVA UDANG Artemia salina Frengki Frengki; Cut Gina Indriyani
Jurnal Fitofarmaka Indonesia Vol 1, No 2 (2014): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.311 KB) | DOI: 10.33096/jffi.v1i2.187

Abstract

The Myrmecodia species as medicinal plants find Papua Island and Sumatera Island like Aceh forest.It is a member of Rubiaceae family and lives as ephyphyte on other plants. Local peoples in Aceh province boiled the tubers parts of myrmecodia species to treat inflammation, rheumatic,cancer and other diseases. Meanwhile, there is still limited scientific evidence to proof the efficacy of myrmecodia species.  The dried simplicia was extracted using maceration technique, then partitioned usingn-hexane, chloroform and n-buthanol solvent. Toxicity test was  done by the Brine Shrimp Lethality Test (BST) methodat four concentration levels, i.e: 1000, 500, 250, 125 and 6.5 ppm. The result of the research showed that n-buthanol, chloroform and n-hexan of Myrmecodia sphad acute toxicity by LC50 value 97.72 ppm, 262.02 ppm and 223.87 ppm respectively. Analysis Infrared spectrum of buthanol extract showed some functional groups. like hydroxy, aether and aromatic ring.
DAYA TOLAK INFUSA DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) TERHADAP PELETAKAN TELUR NYAMUK Aedes spp Anggie Cahyadi; Sri Wahdaningsih; Diana Natalia
Jurnal Fitofarmaka Indonesia Vol 1, No 2 (2014): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.336 KB) | DOI: 10.33096/jffi.v1i2.192

Abstract

Aedes spp larval resistance against chemical insecticide has been reported in many country. The new methods that can be used to control the mosquito populations as a dengue fever vector and alternative compound which is safe for environtment and can’t cause the resistance need to be found. Pandan leaves have aromatic fragrant that can be expected as a oviposition deterrent effect against Aeses spp mosquito. To know oviposition deterrent effects and optimum consentration of pandan leaves (Pandanus amaryllifolius Roxb.) infusa against Aedes spp. This research was an experimental research using six groups of concentration. There was 0 mL/L (control), 3 mL/L, 3,5 mL/L, 4 mL/L, 4,5 mL/L and 5 mL/L. Every groups would be repeated by fourth. Ovitraps with different concentration of pandan leaves infusa placed at research location. The mosquito eggs that caught at the ovitrap would be counting and identifying in the laboratorium. Data was analyzed using One Way Anova test via computer program SPSS 19.0 and then continued by LSD test with 95% confidence level. The repellency percentage at 3 mL/L concentration is 30.35%; 3,5 mL/L is 55.35%; 4 mL/L is 65.17%; 4,5 mL/L is 82.14% and 5 mL/L is 100% with significancy value is 0,000 (p<0,05).
PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN BUAS-BUAS (Premna cordifolia. LINN) TERHADAP KADAR MDA TIKUS WISTAR JANTAN PASCA PAPARAN ASAP ROKOK Asri Adyttia; Eka Kartika Untari; Sri Wahdaningsih
Jurnal Fitofarmaka Indonesia Vol 1, No 2 (2014): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.344 KB) | DOI: 10.33096/jffi.v1i2.188

Abstract

Free radical from cigarrete smoke can cause lipid peroxidation that could lead to tissue damage. Tissue damage can be identified by increased levels of MDA (Malondialdehyde). Leavesof buas-buas (Premna cordifolia. Linn) has an antioxidant activity in invitro study. This study aimed to analyze the effect of P. cordifolia leaves extract on the levels of malondialdehyde (MDA) after exposure to cigarette smoke. The simplicia extracted by maseration using 70% ethanol. Twenty four  wistar strain of Rattus novergicus were divided into six groups , i.e. : normal group without any treatment, positive control group with cigarette smoke exposure and vitamin e treatment, negative control groupwith only cigarette smoke exposure, treatment groupwith cigarette smoke exposure and ethanolic extract from P. cordifolialeaves with doses 200; 400; 600 mg/kg of body weight/day. All rats were treated for 14 days using 3 cigarette non filetered each day. After 14 days, plasma MDA was measured in this research. Measurement of plasma MDA are using Spectrophotometer UV-Vis in 532.2 nm. MDA level in this study was analyzed by the Kruskal-Wallis and Mann-Whitney test. The result showed that plasma MDA level of groupreceived ethanol extract of P. cordifolia leaves doses at 600 mg/kg of body weight/day significantly (p<0.05)lower than negative control group and not significantly differ (p<0.05) to normal group and positive control group.

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