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INDONESIA
Jurnal Fitofarmaka Indonesia
Published by Universitas Muslim Indonesia
ISSN : 23560398     EISSN : 25412329     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : -
Articles 5 Documents
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Search results for , issue "Vol 8, No 1 (2021): JURNAL FITOFARMAKA INDONESIA" : 5 Documents clear
EFEK HEPATOPROTEKTOR ANDROGRAPHOLIDE TERHADAP AKTIVITAS ALANIN AMINOTRANSFERASE DALAM SERUM Rattus norvegicus JANTAN GALUR WISTAR YANG DIINDUKSI KARBON TETRAKLORIDA Dewinta Putri Utami; Andriani Andriani; Mardhia Mardhia; Virhan Novianry; Mistika Zakiah
Jurnal Fitofarmaka Indonesia Vol 8, No 1 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i1.582

Abstract

Background: Andrographolide is a diterpenoid bioethanol that effectively prevent liver injury by reducing liver oxidative stress response. Method :  The research was randomized experimental design with pretest-posttest design. Thirty male wistar rats was randomly divided into 6 groups, normal control, negative control (0,2 ml CCl4), and positive control (500 mg/kgBW curcumin), dose I (50 mg/kgBW), dose II (100 mg/kgBW), dose III (200 mg/kgBW) given for 8 days and induced by 0,2 ml CCl4 on the first day. Data was analyzed by One-Way Anova test, LSD  Post-Hoc test and paired T test. Results :All groups induced by CCl4 shows elevated of ALT activity. The posttest results shows significant differences of ALT activity between groups (p<0,05). Conclusion :  Andrographolide shows hepatoprotector effect by decrease the activity of ALT in male wistar rats induced by CCl4. The effective dose of andrographolide is 200 mg/kgBW.
Aktivitas Antijamur Ekstrak Etanol Daun Cengkodok (Melastoma malabathricum) Terhadap Pertumbuhan Malassezia furfur Willy Sanjaya; Ambar Rialita; Mahyarudin Mahyarudin
Jurnal Fitofarmaka Indonesia Vol 8, No 1 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i1.614

Abstract

Pityriasis versicolor (PV) is an infection on epidermal layer of skin and the common caused by a type of yeast that live on the skin named Malassezia furfur. The increasing of fungal resistant against antifungal and high reccurence rate after cured in 2 years about 80%, requires alternative treatment that come from plants. Cengkodok leaves (Melastoma malabathricum) is used conventionally as an alternative medicine. Cengkodok leaf produces secondary metabolites which have antifungal activity. The aim of this study was to investigate the antifungal activity of ethanolic extract Melastoma malabathricum leaves (EEMML). Phytochemical screening of EEMML were performed using Thin Layer Chromatography (TLC). Melastoma malabathricum leaves were extracted with maceration method using 96% ethanol. The testing of antifungal activity was determined using disc-diffusion method with the concentration of 5; 20; 50; 100; 250; 500 ppm. Ketoconazole 10 ug/disc and Itraconazole 8ug/disc was used as positive control while negative control used 10% dimethyl sulfoxide (DMSO). EEMML didn’t showed zone of inhibition against Malassezia furfur although 100% concentration extract used. EEMML have no antifungal activity against Malassezia furfur
Isolasi Dan Identifikasi Senyawa Kimia Monoterpen Dari Fraksi Etilasetat Daun Keji Beling (Strobilanthes crispa (L.) Blume) Yang Mempunyai Daya Sitotoksik Lilik Sulastri; Ristanti Mega Lestari; Partomuan Simanjuntak
Jurnal Fitofarmaka Indonesia Vol 8, No 1 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i1.721

Abstract

Isolation and identification one of chemical compound mono-terpene from Keji beling plant (local name) (Strobilanthes crispa) has been done. Extraction was carried out by maceration of the keji beling leaf powder with ethanol 96%, then partitioned with water-ethyl acetate. Ethylacetate extract was isolated and purified by a cytotoxic guide fractionation system with Brine Shrimp Lethality Test (BSLT) on column chromatography (SiO2; n-hexane - ethylacetate = 20 : 1); and preparative Thin Layer Chromatography (TLC) (SiO2; n-hexane - ethylaseate = 10 : 1) which gave one compound in oily form.  Based on identification by infra red spectra and gas chromatography-mass spectra (GC-MS), the compound is a monoterpene D-limone which has a cytotoxic power of 73,11 ppm.
Aktivitas Antiinflamasi Ekstrak Etanolik Daun Arbenan [Duchesnea indica (Jacks.) Focke] Risda Waris; A. Mumtihanah Mursyid
Jurnal Fitofarmaka Indonesia Vol 8, No 1 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i1.722

Abstract

Arbenan leaf is a medicinal plant that used in the healing of inflammation. The content of phenolic compounds, flavonoids, steroids and tannins contained in arbenan plants which play an important role in alternative medicine. Currently, scientific work of phytotherapy is an important alternative route in finding effective natural medicines with minimal side effects. The aim of this study was to determine the phytochemical properties and to determine the anti-inflammatory effect of arbenan leaf [Duchesnea indica (Jacks.) Focke] extract. In this study, nine male Wistar rats were tested in three treatment groups. Group I Na CMC, group II Na diclofenac and group III arbenan leaf extract. Inflammation in rats by inducing 1% carrageenan as much as 0.10 mL. The volume of edema per hour is known from the difference in the volume of the foot at certain hours with the volume of the normal foot. The AUC value of edema volume was calculated by the trapezoid method every one hour and the percen of anti-inflammatory power was calculated. The statistical analysis of the Least Significance Different (LSD) AUC value from the edema volume data showed that the two treatment groups, namely the Na diclofenac and the arbenan leaf extract group, were significantly different from the Na CMC group (P <0.05). So that both treatment groups have anti-inflammatory effects. The results showed that the ethanolik extract of arbenan leaves contained phenolic compounds, flavonoids and tannins. Then the ethanolic extract of arbenan leaves has anti-inflammatory activity of 0.31%.
IDENTIFIKASI SENYAWA BAHAN ALAM SEBAGAI INHBITOR TIROSIN KINASE EGFR: SKRINING IN SILICO BERBASIS FARMAKOFOR DAN MOLECULAR DOCKING Frangky Sangande; Jonly Piere Uneputty
Jurnal Fitofarmaka Indonesia Vol 8, No 1 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i1.539

Abstract

Epidermal growth factor receptor (EGFR) is one of tyrosine kinase that overexpressed in many types of cancer. The ihbiition of EGFR activity has known as a rational target for cancer therapy. However,  several EGFR inhibitors have limitations related to resistance problems or reduced tumor response. Therefore, the effort to develop new inhibitors with greater efficacy is very important to overcome the problems. In the present study, we designed a computational method by combining ligand based pharmacophore modeling and molecular docking for screening the potential natural compounds as EGFR inhibitors. Validation result of ligand based pharmacophore modeling and docking molecular by ROC curves showed that both of these protocols had AUC ≥ 0.7. The Redocking erlotinib to EGFR in our docking protocols gave the RMSD < 2 Å. Therefore, our computational method could be applied for virtual screening. Initial screening based on pharmacophore modeling obtained 86 out of 179.816 compounds that could be mapped with the pharmacophore features.  Further screening through molecular docking showed two compounds had a lower docking score than erlotinib, i.e ZINC00941342 and ZINC72325782. However, by careful analysis of their interaction profiles, only ZINC00941342 which formed hydrogen bonds with Met769, which is known as an EGFR key residue. Additionally, it was also found to form hydrogen with Cys773. Therefore, we recommend ZINC00941342 as a potential EGFR inhibitor.

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