cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
japr.editor@gmail.com
Editorial Address
Plot No. 105/42, Opposite electricity sub station, Changorabhata, Raipur (Chhattisgarh), India 492001
Location
,
INDONESIA
Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 16 Documents
 1   2 
Search results for , issue "Vol. 12 No. 1 (2024)" : 16 Documents clear
Enhancement of curcumin's physicochemical properties by developing its eutectic mixtures Ahlawat, Sunita; Budhwar, Vikas; Choudhary, Manjusha
Journal of Applied Pharmaceutical Research Vol. 12 No. 1 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.1.71.81

Abstract

Background: Curcumin is a compound obtained from the rhizomes of Curcuma Longa. It has various pharmacological properties like anti-inflammatory, anti-oxidant, anti-hyperlipidemic, etc. However, it also has some limitations that restrict its use as a medicine. Material and method: In the present study, a eutectic mixture of curcumin and glycine (35% and 65%) was prepared to improve its dissolution rate and photostability, characterized by DSC, FTIR, and XRD studies. Result and discussion: After 40 minutes, the eutectic mixture dissolved 10-fold more than the parent drug. The photostability studies were conducted according to ICH Q1B guidelines; after the seventh day of accelerated photostability studies, curcumin-glycine eutectic mixtures showed 36% degradation, 34% less than pure curcumin. Conclusion: The present study revealed that the physicochemical properties of BCS class II drugs can be improved by forming an eutectic mixture.
Clinical investigations to calculate nuchal translucency using F-LNET Chaudhari, Kalyani; Oza, Shruti
Journal of Applied Pharmaceutical Research Vol. 12 No. 1 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.1.59.64

Abstract

Background: According to ongoing research, assessing nuchal translucency (NT) in ultrasound pictures can help to identify fetal development that deviates from the norm. The chance of chromosomal abnormalities in a newborn is predicted by the nuchal translucency (NT) width in ultrasound sonography pictures performed on the child between 11 and 14 weeks of gestation. Method: Deeply learned convolutional networks have recently significantly improved NT region detection performance. This paper discusses a novel approach to learning a cutting-edge NT Region identification algorithm. To address the difficulty of improving the accuracy of NT recognition in various lighting and posture conditions, a Framework Learning Network (F-LNET) is employed. Discussion: The limitations of the current NT estimating technique include findings that are unpredictable and intra-personal, inter-personal, and inter-variation restrictions. On the other hand, existing solutions have a high processing overhead and are, hence, unsuitable for rapid NT limiting and localization, which is critical for reliable recognition. However, current methods could be better for quick NT limiting and localization, which is essential for trustworthy identification schemes because of their significant processing overhead. The suggested automated clinical finding approach, which computes the error between human and automated measurements, is very beneficial to both doctors and society at large. Conclusion: The suggested way reduces the error to 0.42, whereas the error of other methods ranges from 0.8 to 1.1.
Preparation of herbal hair oil exploring the therapeutic benefits of herbs and its evaluation Dhiraj Baishya; Ananta Choudhury; Himangshu Deka; Nurjamal Hoque; Rosamund Jyrwa; Jahnabi Sarmah
Journal of Applied Pharmaceutical Research Vol. 12 No. 1 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.1.116.127

Abstract

Background: Herbal cosmetics, particularly herbal hair oils, have gained popularity due to their perceived efficacy and minimal adverse effects. This study aimed to formulate and evaluate herbal hair oils for promoting hair growth. Methodology: Various herbal extracts, including Coconut, Curry leaves, Amla, Fenugreek, and Onion, were prepared and incorporated into virgin Coconut oil. Phytochemical screening, total flavonoid content, organoleptic evaluation, chemical analysis (acid value, saponification value, specific gravity), stability studies, antioxidant assay (DPPH), antimicrobial assay, sensitivity studies, and in-vivo hair growth activity were conducted. Results: Organoleptic evaluation revealed characteristic odors and colors across formulations. Chemical analysis showed acceptable values for acid value (0.68 - 1.86 mg KOH/g), saponification value (117.87 - 224.27 mg KOH/g), and specific gravity (0.865 - 0.933 g/cm^3). Stability studies over 45 days demonstrated consistent physicochemical properties. The DPPH assay indicated dose-dependent antioxidant activity, with inhibition ranging from 13.8% to 66.5%. Antimicrobial assay showed inhibition zones ranging from 6 mm to 20 mm against Staphylococcus aureus. Sensitivity studies exhibited no adverse reactions. In-vivo hair growth activity demonstrated significant improvements compared to controls. Discussion: The formulated herbal hair oils exhibited promising physicochemical properties, antioxidant activity, antimicrobial efficacy, safety, and hair growth promotion in animal models. These findings suggest their potential as natural remedies for hair care. Conclusion: Herbal hair oils formulated in this study show significant potential for promoting hair growth and addressing hair-related concerns. Whereas, formulation F3 shown significant efficacy across multiple parameters among the formulations. Further research and clinical trials are warranted to validate their efficacy and safety for human use.
Cinnamomum impressinervium meisn.: antioxidant and antimicrobial activities Bhatia, Lovkesh; Sharma, Amit; Kalra, Rishu; Kumar, Varun
Journal of Applied Pharmaceutical Research Vol. 12 No. 1 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.1.100.107

Abstract

Background: The Cinnamomum impressinervium (CI) Meisn. Tree, which belongs to the Lauraceae family and is endemic to India, is also called Assameses or Tejiya. Numerous pharmacological properties of this plant, including anti-tumor, anti-inflammatory, and antioxidant properties, have been demonstrated. Materials and method: This study examines the phytochemical profile of the leaf using qualitative and quantitative methods. Following the phytochemical analysis of the leaf, the antioxidant efficacy for scavenging free radicals (ABTS and DPPH) was measured. Using the agar well diffusion method, the antibacterial potential of the crude extract and its fractions (aqueous, methanolic, n-hexane, and chloroform) was investigated against six gram-negative, three gram-positive, and one fungal strain. Result and discussion: Antioxidant activities of various extracts viz: aqueous, hexane, chloroform, and ethanol were prepared and subjected to antioxidant and antimicrobial activities. Through qualitative analysis, several alkaloids, steroids, and flavones were identified. In the DPPH and ABTS assays, the aqueous extract had the most potent antioxidant activity, with IC50 values of 123.83±0.42 and 57.86±0.85 μg/mL, respectively. DNA nicking assay is a qualitative analysis that shows DNA protection from free radicals. All the extracts towards B. atropheous showed best inhibition activity but a maximum zone of inhibition was shown by aqueous extracts measuring 40 mm. Aqueous and methanolic extracts are completely inactive towards S. typhi. Conclusion: This study revealed the antioxidant and antimicrobial efficacy of various extracts of Cinnamomum impressinervium Meisn. Leaves In this paper, the antibacterial activity of leaf extracts from Cinnamomum impressinervium Meisn. were studied. The evaluated extracts showed varied levels of inhibitory zones against every tested bacterium.
Assessment of hepatoprotective and nephroprotective effects of Vitis vinifera leaf extract on carbon tetrachloride induced toxicity in rats Kumar, Ashok; Pragi; Sharma, Amit; Kumar, Varun
Journal of Applied Pharmaceutical Research Vol. 12 No. 1 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.1.82.92

Abstract

Background: Vitis vinifera is known for its antimicrobial activity; however, the hepatoprotective activity of aqueous extracts of aerial parts has also been reported, but the nephroprotective and hepatoprotective activity of ethanolic extracts have not yet been evaluated. Objective: To evaluate Vitis vinifera's hepatoprotective and nephroprotective activities against CCl4-induced toxicity in rats. Methods: Two doses of ethanolic extract of Vitis vinifera (100 and 200 mg/kg/day) were evaluated and compared with silymarin 100 mg/kg. Biochemical blood parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Gamma-glutamyltranspeptidase (GGT), bilirubin, urea, uric acid, total protein and creatinine, and histopathologic changes of liver and kidney were studied and evaluated. Results: Vitis vinifera reduced the elevated blood levels of ALT, AST, ALP, urea, and creatinine, with the ethanol extract to 200 mg/kg/day being more effective. The histopathologic evaluation suggested that Vitis vinifera decreased hepatic and renal necrosis induced by CCl4. The more significant dose resulted in reductions in AST, ALT, GGT, ALP, and bilirubin of 54, 27, 56, 36, and 17%, respectively. Ethanolic extract 200 mg/kg/day also shows a reduction in elevated levels of Creatinine, Urea, Uric Acid, and Total Protein by 61%, 58%, 29%, and 9%, respectively. Conclusion: Hepatoprotective and nephroprotective activities of ethanol extract of Vitis vinifera were demonstrated, with ethanol extract to 200 mg/kg/day being the most effective. This presents scientific evidence for using medicinal plants such as Vitis vinifera in managing liver and kidney disorders.
Evaluation of toxicity studies of Sesbania grandiflora leaves extracts in Wistar albino rats Sharma, Sharad; Semwal, Bhupesh Chander; Mazumder, Avijit
Journal of Applied Pharmaceutical Research Vol. 12 No. 1 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.1.42.51

Abstract

Objective: Sesbania grandiflora is a well-known medicinal plant belonging to the family Fabaceae, and it is used to treat several disorders. The current investigation aims to analyze the negative consequences of short and long-term administration of hydroalcoholic extract of S. grandiflora leaf in experimental animals.  Materials and Methods:  Acute and subacute toxicity were the two phases in which the entire examination was completed. In phase first, acute toxicity was performed at the dose of (2000, mg/kg) and adverse effect was recorded. However, in sub-acute toxicity the effect of different doses of (1000, 2000 and 5000 mg/kg) were studied for twenty-eight days. Animals were euthanized on the last day of the investigation, and selected internal body organs and samples of the blood were taken from each animal for histological, biochemical, and haematological analysis.  Results:  The result of the current investigation showed that the LD50 of S. grandiflora was observed more than 2000 mg/kg, Furthermore, experimental animals did not experience any mortality or alterations in their behavioral patterns when S. grandiflora was administered repeatedly at 1000, 2000, and 5000 mg/kg or in a single dose of 2000 mg/kg.   Besides this, S. grandiflora also did not significantly modify any of the biochemical or haematological markers, or the histological analyses of selected organs. Conclusion: The results of the above research revealed that the orally administration of S. grandiflora extract did not exhibit any apparent harmful effects in experimental animals. Hence, S. grandiflora could be regarded as a safe and can be used for the therapeutic purpose in human being.

Page 2 of 2 | Total Record : 16

 1   2 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol. 13 No. 4 (2025) Vol. 13 No. 3 (2025) Vol. 13 No. 2 (2025) Vol. 13 No. 1 (2025) Vol. 12 No. 6 (2024) Vol. 12 No. 5 (2024) Vol. 12 No. 4 (2024) Vol. 12 No. 3 (2024) Vol. 12 No. 2 (2024) Vol. 12 No. 1 (2024) Vol. 11 No. 5 (2023) Vol. 11 No. 4 (2023) Vol. 11 No. 3 (2023) Vol. 11 No. 2 (2023) Vol. 11 No. 1 (2023) Vol. 10 No. 4 (2022) Vol. 10 No. 3 (2022) Vol. 10 No. 2 (2022) Vol. 10 No. 1 (2022) Vol. 9 No. 4 (2021) Vol. 9 No. 3 (2021) Vol. 9 No. 2 (2021) Vol. 9 No. 1 (2021) Vol. 8 No. 4 (2020) Vol. 8 No. 3 (2020) Vol. 8 No. 2 (2020) Vol. 8 No. 1 (2020) Vol. 7 No. 4 (2019) Vol 7 No 3 (2019) Vol. 7 No. 3 (2019) Vol 7 No 2 (2019) Vol. 7 No. 2 (2019) Vol 7 No 1 (2019) Vol. 7 No. 1 (2019) Vol 6 No 4 (2018) Vol. 6 No. 4 (2018) Vol 6 No 3 (2018) Vol. 6 No. 3 (2018) Vol. 6 No. 2 (2018) Vol 6 No 2 (2018) Vol. 6 No. 1 (2018) Vol 6 No 1 (2018) Vol 5 No 4 (2017) Vol. 5 No. 4 (2017) Vol 5 No 3 (2017) Vol. 5 No. 3 (2017) Vol 5 No 2 (2017) Vol. 5 No. 2 (2017) Vol 5 No 1 (2017) Vol. 5 No. 1 (2017) Vol. 4 No. 4 (2016) Vol 4 No 4 (2016) Vol. 4 No. 3 (2016) Vol 4 No 3 (2016) Vol. 4 No. 2 (2016) Vol 4 No 2 (2016) Vol. 4 No. 1 (2016) Vol 4 No 1 (2016) Vol. 3 No. 4 (2015) Vol 3 No 4 (2015) Vol 3 No 3 (2015) Vol. 3 No. 3 (2015) Vol. 3 No. 2 (2015) Vol 3 No 2 (2015) Vol 3 No 1 (2015) Vol. 3 No. 1 (2015) Vol. 2 No. 4 (2014) Vol 2 No 4 (2014) Vol. 2 No. 3 (2014) Vol 2 No 3 (2014) Vol 2 No 2 (2014) Vol. 2 No. 2 (2014) Vol. 2 No. 1 (2014) Vol 2 No 1 (2014) Vol. 1 No. 1 (2013) Vol 1 No 1 (2013) More Issue