cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
japr.editor@gmail.com
Editorial Address
Plot No. 105/42, Opposite electricity sub station, Changorabhata, Raipur (Chhattisgarh), India 492001
Location
,
INDONESIA
Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 17 Documents
 1   2 
Search results for , issue "Vol. 13 No. 1 (2025)" : 17 Documents clear
Designing a sustained-release solid oral formulation for overactive bladder treatment: a quality by design approach Sharma, Neeraj; Bhatia, Daksh; Shambhakar, Sharda; Solanki, Pavitra
Journal of Applied Pharmaceutical Research Vol. 13 No. 1 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i1.820

Abstract

Background: Mirabegron, a first-in-class β3-adrenergic agonist used for managing overactive bladder (OAB), is well-documented in the literature. However, its low oral permeability results in poor bioavailability, limiting patient compliance and tolerability. To address this, the present study focuses on developing a sustained-release (SR) tablet of mirabegron with enhanced oral effectiveness. In this research, mirabegron was combined with polyethylene oxide to improve permeability and formulated as an HPC-loaded SR tablet, promising improved bioavailability and anti-OAB efficacy. Methods: Tablet design and optimization were carried out using the Box-Behnken Design (Design Expert® 12 software) to refine formulation parameters. The study aimed to create a commercially viable SR tablet with improved intestinal permeability, bioavailability, and clinical acceptance. Results: The optimized formulation showed a 34.8% increase in bioavailability compared to the marketed tablet. In vivo pharmacokinetic studies demonstrated a 31.77% increase in plasma concentration over the marketed formulation. Conclusion: The developed formulation is safe and effective, offering improved therapeutic potential for treating overactive bladder. This work represents a significant advancement in OAB management and highlights the commercial viability of the emerging mirabegron SR tablet in meeting current therapeutic needs.
Fabrication of levofloxacin-loaded ph-sensitive eudragit polymeric floating microballoon biomaterial for gastroretentive drug delivery Prakash, Manivasakam; Nallasamy, Venkateswaramurthy; Venkatachalam, Senthil
Journal of Applied Pharmaceutical Research Vol. 13 No. 1 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i1.829

Abstract

Background: The design of improved biomaterials for medication administration is vital in overcoming problems associated with standard therapy for Helicobacter pylori (H. pylori)-induced stomach ulcers. This study aims to develop and characterize floating biomaterial of levofloxacin microballoon biomaterials based on a fluoroquinolone-benzoxazine system conjugated with methylated piperazine and carboxylic acid groups, strategically designed for prolonged gastric delivery. Methodology: Using the emulsion solvent diffusion method, thirteen preparations were developed by different polymer ratios (pH-sensitive Eudragit RS-100 and Ethyl Cellulose), stirring speeds, and temperatures. Results and Discussion: In the buoyancy study simulated gastric fluid (pH 1.2), the best formulation (F9) shows superior encapsulation efficiency (90.2%) and sustained drug release profile (91.2% over 8 hours) that increases its effectiveness against H. pylori. FTIR and SEM analyses conducted during characterization studies verified the drug stability and the spherical microballoon morphology, with a particle size of 81.2 µm. Levofloxacin-loaded microballoon biomaterials provide a unique gastro-retentive delivery system that improves patient compliance, reduces off-target effects, and maintains effective drug concentrations at the infection site, thereby strengthening the therapeutic efficacy of levofloxacin against H. pylori. Conclusion: This creative method offers a viable substitute for traditional therapies for stomach ulcers and is consistent with the overarching objectives of targeted delivery systems and structure-based drug development.
Novel coumarin chalcone derivatives: synthesis, docking, and antimicrobial evaluation Kumari, Sumita; Sharma, Amit; Yadav, Sonia
Journal of Applied Pharmaceutical Research Vol. 13 No. 1 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i1.838

Abstract

Background: This study synthesized and evaluated a series of coumarin chalcones for their antimicrobial efficacy against microbial and fungal strains. Methodology: Ten new coumarin chalcones were prepared by Claisen- Schmidt condensation by using 4-hydroxy coumarin as a precursor and followed by refluxing obtained intermediate (3-(4-aminophenyl)-3-oxo prop-1-enyl)-4-hydroxy-2H-chromen-one) with substituted aromatic benzaldehyde in the presence of piperidine as a catalyst. IR, 1HNMR, 13CNMR, and GCMS characterized all synthesized compounds. The agar well diffusion method assessed these compounds for antimicrobial activity against various bacterial and fungal strains such as E. coli, P. aeruginosa, B. subtills, S. aureus, and C. albicans. Zone inhibition was measured for each compound (10µL) against all strains. Results and Discussion: The study showed that derivatives 4c, 4e, 4f, and 4g showed strong potential for inhibition towards various fungal and microbial strains. The inhibition zone for 4c and 4e was emerged as 5.48±0.448, 7.02±0.332, 5.62±0.321, 6.81±0.021, 7.72±0.421 and 5.13±0.179, 6.76±0.511, 4.24±0.273, 4.64±0.231, 5.48±0.049 while compound 4f and 4g showed 5.40±0.420, 6.69±0.168, 5.71±0.245, 5.28±0.042, 7.09±0.175, and 4.94±0.814, 6.58±.0160, 6.01±0.455, 6.61±0.021, 6.91±0.414 mm, respectively. Between -7.1 to -10.2Kcal/mol is the range of docking score of derivatives by interactions of DNA gyrase and compounds analyzed. Here, compound 4g exhibited the highest DNA gyrase inhibition, and compound 4c exhibited a strong inhibition with docking scores of -10.2 kcal/mol and -9.8 kcal/mol, respectively. Conclusion: The findings of this work contribute to a better understanding the potential of synthesised compounds as drug candidate against microbial infections through ADMET study.
Characterization and cytotoxicity evaluation of Ixora coccinea-derived iron oxide microparticles for biomedical applications Bharathy, Pavithra; Jayaprakash, Silpa; Allen Christopher M; Rajini prem G; Punniyakoti Veeraveedu Thanikachalam
Journal of Applied Pharmaceutical Research Vol. 13 No. 1 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i1.870

Abstract

Background: This study aimed to synthesise and characterise iron oxide microparticles (IOMPs) using Ixora coccinea flower extracts and evaluate their antioxidant, anti-inflammatory, cytotoxic, and antidiabetic activities. Methodology: IOMPs were synthesised using Ixora coccinea flower extract and characterised using XRD, UV-Vis, EDAX APEX, and SEM. Bioactivity evaluations included anti-inflammatory and antioxidant activities via egg albumin, BSA, and DPPH assays; cytotoxicity through Brine Shrimp Lethality and zebrafish embryonic toxicity assays at 5, 10, 20, 40, and 80 μg/ml; and antidiabetic activity via alpha-amylase and alpha-glucosidase inhibition. Results: Fe₂O₃MPs demonstrated potent anti-inflammatory (83% protein denaturation inhibition at 50 μg/ml), antioxidant (94.26% inhibition at 50 μg/ml), and antidiabetic (86% α-amylase and 84% α-glucosidase inhibition at 50 μg/ml) properties, surpassing diclofenac sodium and ascorbic acid. Cytotoxicity tests revealed low toxicity, with LC50 values of 80.5 μg/ml (Brine Shrimp) and 82.4 μg/ml (zebrafish). Discussion: This study presents an eco-friendly synthesis of Fe₂O₃ microparticles using Ixora coccinea extract as a reducing and stabilising agent. These microparticles hold promise for biomedical applications, including drug delivery, MRI contrast enhancement, and hyperthermia treatment. Further research must optimise the synthesis process and assess the in vivo biocompatibility and therapeutic efficacy. Conclusion: This study addresses the need for eco-friendly nanoparticles. Conventional iron oxide microparticle synthesis uses toxic chemicals, but Ixora coccinea flower extract offers a sustainable alternative. Evaluating Fe₂O₃MPs' cytotoxicity and bioactivity provides insights into biomedical applications, supporting future investigations that link nanotechnology and therapeutics.
Ethnobotanical survey of medicinal plants for bone fracture treatment in Lingmoo, Sikkim Chettri, Bhumika; Khar, Tiewlasubon Uriah; Bhutia, Sonam
Journal of Applied Pharmaceutical Research Vol. 13 No. 1 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i1.909

Abstract

Background: This study documents the use of herbal plants by traditional healers in Lingmoo, Namchi district, Sikkim, to treat bone fractures. Methodology: The methodology used were survey-based, pre-structured questionnaire, field investigation and face to face interaction with one traditional healer. We have recorded about 29 ethno-medicinal plants naturally available in the selected area. Results: According to the survey results, a total of 29 numbers of ethnomedicinal plant species belonging to 23 different families (Rosaceae topped the list) were identified and summarized in Table 1. The study revealed that herbs (48%) are mainly used, followed by trees (24%), climbers (17%), and shrubs (11%). In case of frequency of use, these plants were highly cited during the interview: rivularis, Kaempferia rotunda, Viscum articulatum, Urtica dioica, Curcuma longa, Lepidium sativum, Beaumontia grandiflora, Bergenia ciliate, and Laportea bulbifera. The parts used were roots, stem barks, whole plants, and seeds. The most commonly used preparation was paste. According to gender-wise comparison, males (60%), females (25%), and children (15%) were getting the treatment. Out of 29 plant species, 12 species are abundant and, 1 is in threatened condition; only 3 species are cultivated in present days. Conclusion: Documentation of local plants used by a specific traditional healer will benefit the sustainable use of indigenous medicinal plant practices. It will also provide preliminary information for future biological resource management and research development, which will eventually help in the conservation of ethnomedicinal plants and the advancement of such ideas.
Novel microwave-assisted solid dispersion technology enhances piroxicam dissolution and therapeutic efficacy: an in vitro and in vivo study Kumar, Charit; Nanda, Arun
Journal of Applied Pharmaceutical Research Vol. 13 No. 1 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i1.921

Abstract

Background: Piroxicam (PRX), a nonsteroidal anti-inflammatory drug, exhibits poor aqueous solubility, limiting its therapeutic efficacy. Enhancing solubility can directly improve bioavailability and therapeutic effectiveness. This study explores the development of a new solid dispersion (SD) system of PRX using polyvinylpyrrolidone (PVP K30) as a carrier by MW-assisted method. Methods: The involvement of microwave (MW) in the solvent evaporation method is a newer concept aimed at enhancing the solubility and in vivo bioavailability of PRX. Various ratios of PRX: PVPK30 (1:5, 1:7, 1:9, and 1:11 w/w) were evaluated using conventional and MW-assisted solvent evaporation methods and conducted in vitro dissolution studies. Results: The optimized MW-assisted formulation (1:7 w/w) exhibited 94.69±0.24% drug release in 15 minutes, showing a 5.37-fold increase compared to pure PRX (17.63%) and surpassing the marketed drug release (90.82±0.39%). Fourier Transform Infrared, Differential Scanning Calorimetry, Thermogravimetric analysis, Scanning Electron Microscopy, and powdered X-ray diffraction authenticated the OF. In vivo studies demonstrated significant enhancements (p<0.0001) compared to control. The anti-inflammatory activity showed increased paw oedema inhibition (44.4±0.4%) compared to control and pure PRX (35.37±0.3%). The analgesic activity of OF demonstrated improved pain response time (10.6±0.8 seconds) compared to control (4.2±0.5 seconds) and pure PRX (8.1±0.7 seconds). Conclusion: The SD developed via the MW-assisted drug formulation technique significantly enhances the solubility, bioavailability, and therapeutic efficacy of PRX, offering a potential strategy to improve clinical outcomes for similar drugs with solubility challenges.
Isolation and characterization of cellulose derived from prominent agricultural waste (Sugarcane bagasse) and its utilization in various biomedical field Sharma, Manoj Kumar; Diwan, Anupama; Sardana , Satish; Yadav, Narender; Gupta, Tanya; Kumawat , Mukesh Kumar
Journal of Applied Pharmaceutical Research Vol. 13 No. 1 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i1.942

Abstract

Background: Agricultural waste clearance and reutilization is a significant problem today. Objective: Successful extraction and purification of cellulose and its derivatives (methylcellulose) from agri-waste and pollution. This is an innovative polymer (cellulose & its derivatives) that can be used in pharmaceutical and technical applications in an eco-friendly manner. Aim: Isolate and characterize cellulose derived from prominent agricultural waste (sugarcane bagasse) and its utilization in various biomedical fields. Method: Eco-friendly Soxhlet extraction utilizing organic solvents was employed to give a high yield of cellulose. Further, the obtained cellulose was bleached and transformed into ester derivatives, such as methylcellulose, to analyze their properties. Result: This study’s primary goal is to concentrate on the production of cellulose and its extraction from different agricultural waste & its characterization. The cellulose isolated from different biomass was comparatively evaluated for its varied properties and was found suitable for use in the pharmaceutical industry or technical dimensions. Conclusion: Agri waste has significant potential and sources for value-based products. Here, successful extraction and derivatization of the cellulose from the sugarcane were done. These extracted celluloses were further subjected to various pharmacopeial, micromeritics, and physiochemical properties assessments, including advanced characterization to evaluate and validate the properties of the products, which signifies more efficient, green extraction and pharmacopeial utilization.

Page 2 of 2 | Total Record : 17

 1   2 

Filter by Year

2025 2025


Reset
Filter By Issues
All Issue Vol. 13 No. 4 (2025) Vol. 13 No. 3 (2025) Vol. 13 No. 2 (2025) Vol. 13 No. 1 (2025) Vol. 12 No. 6 (2024) Vol. 12 No. 5 (2024) Vol. 12 No. 4 (2024) Vol. 12 No. 3 (2024) Vol. 12 No. 2 (2024) Vol. 12 No. 1 (2024) Vol. 11 No. 5 (2023) Vol. 11 No. 4 (2023) Vol. 11 No. 3 (2023) Vol. 11 No. 2 (2023) Vol. 11 No. 1 (2023) Vol. 10 No. 4 (2022) Vol. 10 No. 3 (2022) Vol. 10 No. 2 (2022) Vol. 10 No. 1 (2022) Vol. 9 No. 4 (2021) Vol. 9 No. 3 (2021) Vol. 9 No. 2 (2021) Vol. 9 No. 1 (2021) Vol. 8 No. 4 (2020) Vol. 8 No. 3 (2020) Vol. 8 No. 2 (2020) Vol. 8 No. 1 (2020) Vol. 7 No. 4 (2019) Vol. 7 No. 3 (2019) Vol 7 No 3 (2019) Vol. 7 No. 2 (2019) Vol 7 No 2 (2019) Vol. 7 No. 1 (2019) Vol 7 No 1 (2019) Vol. 6 No. 4 (2018) Vol 6 No 4 (2018) Vol. 6 No. 3 (2018) Vol 6 No 3 (2018) Vol. 6 No. 2 (2018) Vol 6 No 2 (2018) Vol. 6 No. 1 (2018) Vol 6 No 1 (2018) Vol 5 No 4 (2017) Vol. 5 No. 4 (2017) Vol 5 No 3 (2017) Vol. 5 No. 3 (2017) Vol 5 No 2 (2017) Vol. 5 No. 2 (2017) Vol. 5 No. 1 (2017) Vol 5 No 1 (2017) Vol 4 No 4 (2016) Vol. 4 No. 4 (2016) Vol. 4 No. 3 (2016) Vol 4 No 3 (2016) Vol. 4 No. 2 (2016) Vol 4 No 2 (2016) Vol. 4 No. 1 (2016) Vol 4 No 1 (2016) Vol. 3 No. 4 (2015) Vol 3 No 4 (2015) Vol. 3 No. 3 (2015) Vol 3 No 3 (2015) Vol 3 No 2 (2015) Vol. 3 No. 2 (2015) Vol. 3 No. 1 (2015) Vol 3 No 1 (2015) Vol. 2 No. 4 (2014) Vol 2 No 4 (2014) Vol 2 No 3 (2014) Vol. 2 No. 3 (2014) Vol. 2 No. 2 (2014) Vol 2 No 2 (2014) Vol. 2 No. 1 (2014) Vol 2 No 1 (2014) Vol 1 No 1 (2013) Vol. 1 No. 1 (2013) More Issue