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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol. 8 No. 4 (2020)" : 5 Documents clear
A review on global threat corona virus disease: COVID-19 Barbhuiya, Samia begam; Vicky Bareh; Caroline Malsawmtluangi; Parikshit Das
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.10.15

Abstract

Corona virus disease is a kind of viral disease caused by Severe Acute Respiratory Syndrome- CoV 2, which is first witnessed in Wuhan city, China and it can be transmit from human to human. Coronavirus size ranges from (65-125 nm) in diameter and contain a single stranded RNA as nucleic acid material, size ranging from 26 to 32 kbps in length. The sub group of coronaviruses family is Alpha (α) Beta (β) Gama (γ) and delta (δ) coronavirus. Coronavirus disease is a kind of respiratory disease which mainly affects the lower respiratory tract of human body. Initially interferon α normalisation, broad spectrum antibiotic and antiviral drugs was used to reduce the viral load. There may be different kind of mode of transmission of this virus for example Respiratory transmission, Aerosol transmission, Contact transmission and Hospital acquired transmission. There is a well explained safety measures is provided to inhibit the COVID-19 spread which should be followed properly. There are some testing processes also developed to determine the presence of this virus. Till now not even a single vaccine is developed for the treatment of this COVID-19 but more than 12 countries across the globe are undergoing trial for more than 150 vaccine candidates.
Quality of life in total knee replacement (TKR) patients – A review M. Ranga Priya; M. Karthika; Meril Lucy Shibu; B. Kowsalya; Lini Jacob
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.16.23

Abstract

Worldwide, severe pain and disability are caused to patients by Osteoarthritis, which is a common condition of the joints. A need for knee replacement had become a great option for patients when conventional treatment fails in granting appropriate relief in them, especially in elderly patients. Like all joint replacement surgeries, a total knee replacement procedure is also a quite painful and risky procedure that requires sufficient postoperative rehabilitation and therapies to prevent further complications. Post-surgical pain had a great influence on the patients' quality of life and a need to measure pain intensity had become a basic requirement. Measuring pain intensity can be done using traditional pain scales like a visual analogue scale (VAS), and a numerical rating scale (NRS). A risk assessment and predictor tool (RAPT) determines the discharge accuracy in patients. The WOMAC scale which is the abbreviated form of the questionnaire for checking the health status of the patients known as the Western Ontario and McMaster University Osteoarthritis Index.  This questionnaire is used to assess the quality of life of the osteoarthritis patients after a surgery for the total knee replacement. The results of the assessment show that pain had become a significant factor in the reduction in quality of life. In conclusion, a well-designed multimodal analgesic regimen should be incorporated into the patient's rehabilitation care, which in turn will intensify the patient's quality of life, lessen the hospital stay, and minimize the socio-economic burden
In vitro anti-oxidation activity studies of the whole plant (except flower) of Thunbergia coccinea Damanbhalang Rynjah; Sumit Das
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.45.49

Abstract

An in vitro study of the methanolic extract of the whole plant (except flower) of Thunbergia coccinea was performed to check the anti-oxidant activity by different methods (Reducing power assay, TBA and DPPH scavenging assay) and before starting the study, the plant was extracted by Soxhlet apparatus using methanol as solvent and the marc was evaporated kept under desiccator. From the literature survey it was found that the plant contain flavonoids and tannins which are non-enzymatic antioxidants responsible for scavenging free radicals as reported and based on this, the study for antioxidant was carried out. The methanolic extract of the plant Thunbergia coccinea shows promising result in antioxidant studies when in comparison with the standard (Ascorbic acid). Thus further studies like in vivo evaluation can be performed in the mere future.
Analytical method development and validation for simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug by simultaneous equation method Choudhary, Amit; Sinha, Manish; Amar Deep Ankalgi; Goyal, Kamya; Devi, Arti
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.24.32

Abstract

The purpose of the research is to establish a fast, accurate, precise, and low-cost UV-Visible spectrophotometry method for the quantitative simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug. The UV-Visible method employed was a simultaneous equation method. Ethanol was used as a solvent and therefore the absorption maxima (λ max) was found to be 229 nm and 209 nm for mefloquine hydrochloride and artemether. The linearity ranges of both drugs were 1-6 μg/mL and 100 – 350 μg/mL with a regression coefficient r2 ≥ 0.998 respectively. The method was validated for different parameters according to International Conference on Harmonization ICH Q2B guidelines. The average recovery for mefloquine hydrochloride was found to be 100 per cent and artemether 99.3 per cent. The method was also found precise and robust with a per cent relative standard deviation of less than 2. All the parameters result obtained within the limits. Therefore, the proposed method for the accurate quantitation of mefloquine hydrochloride and artemether in the bulk drug was successfully implemented.
Synthesis and characterization of 5-aryl-1,3,4-oxadiazole-2(3h)thione derivatives Pathak, Shailesh; Sharma, Sharad; Pathak, Vinay; Prasad, Mahesh
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.50.61

Abstract

1,3,4-oxadiazoles represent a class of heterocyclic five membered compounds it contain two nitrogen and one oxygen of great importance in Pharmaceutical chemistry. This nucleus show four isomeric forms 1,2,4-oxadiazole,1,3,4-oxadiazole, 1,2,5-oxadiazole, and 1,2,3-oxadiazole. This nucleus has various biological activity such as antioxidant, antimicrobial, antifungal, antitumor, antidepressant, anticancer, analgesic etc.  have been reported. A series of 1,3,4-oxadiazoles-2(3H)thione derivative has been synthesized in four steps and the derivative were characterized by FTIR spectral analysis. This article explain the different biological activities associated with 1,3,4-oxadiazole five membered ring are useful for researchers across the world working on this nucleus.

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