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INDONESIA
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian
Published by Universitas Muhammadiyah Prof. Dr. Hamka
ISSN : 20866968     EISSN : 26219816     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is an national journal published by Faculty of Pharmacy and Science University of Muhammadiyah Prof. DR. HAMKA. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is aimed at being a medium for research results dissemination and scientific paper exchanges on the pharmaceutical field among academics, practitioners, regulators, and public. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is issued two times annually, i.e., in April, and October.The Editor receives rigorous research manuscripts that have not been offered for publication elsewhere. Since its first issue published in 2010. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian has become a CrossRef Member since 2019. Therefore, all articles published by Farmasains: Jurnal Ilmiah Ilmu Kefarmasian will have unique DOI number with p-ISSN 2086-6968 dan e-ISSN 2621-9816
Arjuna Subject : -
Articles 241 Documents
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Pengaruh Minyak Sacha Inchi (Plukenetia volubilis L.) terhadap Kadar MDA Plasma Tikus Wistar Diinduksi Klorpirifos Rahayu, Putri; Tajudin, Tatang; Pertiwi, Yuniariana
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 13 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v13i1.20756

Abstract

The use of chlorpyrifos remains prevalent in Indonesia, and excessive exposure can trigger oxidative stress, as indicated by increased Malondialdehyde (MDA) levels. Sacha inchi oil (Plukenetia volubilis L.) contains antioxidant compounds that may mitigate oxidative stress. This study investigated the effect of sacha inchi oil on plasma MDA concentrations, Body Weight (BW), and clinical parameters in male Wistar rats exposed to chlorpyrifos. Thirty rats were allocated to five groups (n=6 per group): a normal control, a negative control (chlorpyrifos 10 mg/kg BW/day), and three treatment groups receiving sacha inchi oil orally at doses of 1, 2, and 4 mL/kg BW/day for 28 days. Plasma MDA levels were measured using the TBARS method with spectrophotometric detection at 532 nm, and data were analysed by One-Way ANOVA followed by Tukey’s HSD test. Chlorpyrifos exposure increased MDA levels (18.83 nmol/mL) compared with the normal control, whereas sacha inchi oil reduced MDA levels in a dose-dependent manner to 11.32, 8.98, and 3.90 nmol/mL (p<0.05). Supplementation promoted BW gain and ameliorated clinical manifestations, including lethargy, alopecia, and increased respiratory rate, with no mortality observed in treated groups. Sacha inchi oil exhibited protective effects against chlorpyrifos-induced oxidative stress, demonstrating maximal efficacy at 4 mL/kg BW/day.

Page 25 of 25 | Total Record : 241

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