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Buletin Farmatera
Published by Universitas Muhammadiyah Sumatera Utara
ISSN : 2528410X     EISSN : 2528410X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 9, No 3 (2024)" : 5 Documents clear
Effect Of Low Doses of Acetylsalicylic Acid (ASA) On the Histopathological Features of Fibroblasts in The Amniotic Membrane Mourisa, Cut; Suryani, Des
Buletin Farmatera Vol 9, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i3.19907

Abstract

Abstract: Acetylsalicylic acid (ASA) is a drug with several indications such as analgesic, antipyretic, and antithrombotic/antiplatelet. ASA is efficacious as antithrombotic at low doses and used for thrombosis therapy in stroke, antiphospholipid syndrome (APS), pre-eclampsia and eclampsia. However, the administration of ASA made pharmacokinetic interactions that cause a vitamin C deficiency condition. This study aims to determine the effect of low doses of Acetylsalicylic acid (ASA) on the histopathological appearance of fibroblasts on fetal membranes. This study used a cross-sectional design using 54 paraffin membrane blocks as samples processed into histopathological preparations. The case group received low-dose ASA and the control group did not receive low-dose ASA. Histopathological preparations were observed using a microscope to see images / count the number of fibroblast cells. The results showed that there were significant differences between the number of fibroblasts in the case group and the control group with p = 0.001 or p 0.05
Molecular Mechanisms and Effectiveness of Sports On Hypertension Treatment Nasution, Sharlini Desfika; Rahmi, Rahmi
Buletin Farmatera Vol 9, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i3.23362

Abstract

Abstract: Hypertension is a serious global health problem. Exercise is an effective non-pharmacological intervention in the management of hypertension through several molecular mechanisms, including vascular endothelial regulation, oxidative stress modulation, and anti-inflammatory effects. This literature study aims to increase readers' knowledge about the molecular mechanism and effectiveness of exercise in the treatment of hypertension by conducting literature searches in national and international journals published in the last 5 years. The main pathological changes in hypertension are changes in the structure and function of arterial vessels, which are characterized by increased peripheral vascular resistance due to vascular remodelling. Regular aerobic exercise has been shown to increase the activity of antioxidant enzymes, including superoxide dismutase (SOD), which plays an important role in protecting cells from oxidative damage. The frequency and duration of exercise play a key role in the effectiveness of exercise programs to lower blood pressure in hypertensive patients.
Potensi Habbatussauda ( Nigella Sativa ) Terhadap Pencegahan Demensia Alzheimer Arifin, Hasanul
Buletin Farmatera Vol 9, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i3.23405

Abstract

Abstract: Dementia is a progressive and degenerative clinical syndrome, that affects memory, thinking ability, behaviour, emotions and personality that interfere with daily life activities. The aetiology of dementia is linked to the involvement of vascular, inflammatory, oxidative stress and neurotoxicity that causes neurodegenerative brain pathologies that can contribute to cognitive impairment and dementia. Multidomain interventions targeting multiple risk factors for effective prevention including dietary supplements from traditional plants. Nigella sativa (NS) is a traditional plant native to the Mediterranean Area and Southwest Asia that has long been used to maintain human health. Nigella Sativa has a significant content of thymoquinone (TQ) as a bioactive element of 30-48% of the total NS compounds. Several in vitro and in vivo preclinical studies and clinical trials that are still limited to non-dementia humans show that TQ has a positive effect on cognitive impairment through oxidative stress control mechanisms, vascular health, anti-inflammatory, maintenance of nerve cell integrity and improvement of neurotrophic regulatory factors which are promising in preventing cognitive decline. Nigella sativa serves as a potential dietary supplement to prevent the progression of Alzheimer's disease but requires long-term investigation and follow-up research to test safety and toxicity and compare its effectiveness at different stages of dementia such as Alzheimer's disease.
Prevalence of Allergies Due to Paracetamol Use in Children: A Literature Study Hariaji, Ilham
Buletin Farmatera Vol 9, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i3.23436

Abstract

Abstract: Paracetamol is an antipyretic and analgesic drug that is often used to relieve fever and pain in children. Although considered safe, the use of paracetamol in children can cause allergic reactions. This study aims to assess the prevalence of allergies due to the use of paracetamol in children. This Literature Review identifies and analyzes articles published in the last five years, using databases such as PubMed, Scopus, and Google Scholar. The included studies were studies with cohort, cross-sectional, and case-control designs that assessed the association between paracetamol use and allergic reactions in children. Of the 23 articles that met the inclusion criteria, it was found that the prevalence of allergies due to paracetamol use in children varied between 0.1% and 6.5%. Some of the factors that play a role in increasing the risk of allergies are the history of allergies in the family and the influence of environmental factors. In addition, frequently reported types of allergies include urticaria, eczema, and anaphylactic reactions. The results of this review suggest that although the prevalence of paracetamol allergy in children is relatively low, special attention is still needed, especially in children with a history of allergies or certain medical conditions. Proper management and further understanding of the pathogenesis of paracetamol allergy in children need to be done. Allergies due to paracetamol use in children, although rare, should remain a medical concern. Further research is needed to identify clearer risk factors and to develop guidelines for the use of paracetamol in children who have allergic predispositions.
Pengaruh Blue Light Filter Pada Smartphone Terhadap Tingkat Kelelahan Mata Mahasiswa Fakultas Kedokteran Universitas Muhammadiyah Sumatera Utara Savista, Taya Elsa; Adilah, Rifkah
Buletin Farmatera Vol 9, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i3.23375

Abstract

Abstract: The use of smartphones in the digital era like today is increasingly intense in daily life. Not only teenagers and adults, smartphones are also widely used by children, toddlers, and even babies.  Blue light filters on smartphones are believed to reduce visual disturbances that occur due to long-term smartphone use. The purpose of this study is to analyze the effect of a blue light filter on the level of eye fatigue of students of the Faculty of Medicine, University of Muhammadiyah North Sumatra (FK UMSU). This research is quasi-experimental with a pre-posttest design. A total of 154 FK UMSU students were divided into 2 groups, the Blue Light Filter Group (BLF) and the Non-Blue Light Filter Group (Non-BLF) with the same number (n1 = n2 = 77). Each group filled out a VFS (Visual Fatigue Scale) questionnaire before and after working on the visual task. The data were analyzed using the Mann-Whitney and Wilcoxon tests. The results showed that the post-test score of the level of eye fatigue in the Non-BLF group was significantly higher than that of the BLF group (P 0.001). There was a significant difference between the pre-test and post-test results of the Non-BLF Group (P 0.001), while the pre-test and post-test results of the BLF Group showed a difference but not significant (P = 0.860). This study shows that the use of blue light filters affects the level of eye fatigue. 

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