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INDONESIA
Jurnal Kimia Terapan Indonesia
Published by Lembaga Ilmu Pengetahuan Indonesia
ISSN : 08532788     EISSN : 25277669     DOI : -
Core Subject : Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology
Arjuna Subject : -
Articles 8 Documents
 1 
Search results for , issue "Vol 16, No 1 (2014)" : 8 Documents clear
ISOLASI SENYAWA ANTIOKSIDAN DALAM EKSTRAK HEKSANA KULIT BATANG MANGGIS HUTAN (Garcinia bancana Miq.) Sri Hartati; Masrukhan Masrukhan; Herry Cahyana
Jurnal Kimia Terapan Indonesia Vol 16, No 1 (2014)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3178.138 KB) | DOI: 10.14203/jkti.v16i1.4

Abstract

Antioksidan adalah suatu senyawa yang dapat menangkap radikal bebas. Salah satu sumber anti oksidan alami adalah dari tumbuh-tumbuhan. Dalam usaha pencarian antioksidan baru, telah dilakukan identifikasi senyawa antioksidan dari ekstrak n-heksana kulit batang Garcinia bancana Miq dengan metode 1,1-difenil-2-pikrilhidrazil (DPPH). Metode isolasi dilakukan dengan cara  kombinasi kromatografi (Kromatografi kolom vacum, kromatografi kolom gravitasi, kromatografi lapis tipis  sentrifugal dan kromatografi lempeng tipis)  Penentuan struktur molekul berdasarkan analisis data spektroskopi UV-VIS, IR, LC-MS, NMR proton dan karbon. Dari  hasil isolasi didapatkan suatu senyawa isoprenil bezofenon dengan bobot molekul 466,22 dan  rumus molekul C28H34O6 dengan nama IUPAC 3-(3,4-dihidroksibenzoil)-4-hidroksi-8-8-dimetil-1,7-bis(3-metilbut-2enil) bisiklo (3.3.1) non-3-ene-2,9-dione atau disebut bacanone yang diduga senyawa baru. Dari proses isolasi juga ditemukan senyawa atsiri b- caryophyllene, α-humulene dan b-cadinene serta stigmasterol. Hasil uji aktivitas antioksidan ekstrak n-heksana dan hasil isolat murni menunjukkan IC50 berturut-turut 17,78 ppm dan 12,79 ppm dimana pembanding kuersetin adalah 9,90 ppm.Kata kunci:  Garcinia bancana, antioksidan, DPPH, 3-(3,4-dihidroksibenzoil)-4-hidroksi-8-8-dimetil-1,7-bis(3-metilbut-2enil)bisiklo(3.3.1)no-3-ene-2,9-dione, bacanone. Antioxidants are compounds that can capture free radicals. One source of natural antioxidant is from plants. On searching  for new antioxidant, identification of antioxidant compound of the n-hexane extract of the stem bark of Garciniabancana Miq was done by  1.1-diphenyl-2-pikrilhidrazil (DPPH) method. Isolation active compound were done by combination of chromatographic methods (Flash column chromatography, gravitation column chromatography, cetrifugal thin layer chromatography and thin layer chromatography) .Determination of molecular structure by analysis spectroscopic data of UV-VIS, IR, LC-MS, NMR proton and carbon.Isolation results were      isophrenyl bezophenon with molecular weight 466.22 and the molecular formula is C28H34O6 IUPAC name 3 - (3,4-dihydroxybenzoil)-4-hydroxy-8-8-dimethyl-1,7-bis (3-methylbut-2enyl) bicyclo (3.3.1) non-3-ene-2,9-dione or named bacanone wich is suspected as a new compound. From the isolation were also found of known volatile compounds b - caryophyllene, α-humulene and b-cadinene and stigmasterol. The test results of antioxidant activity of  n-hexane extract and pure compound  showed IC50 respectively 17.78 ppm and 12.79 ppm which comparison with  quercetin is 9.90 ppm. Key words :  Garcinia bancana Miq., antioxidant, DPPH, 3-(3,4-dihydroxybenzoil)-4-hidroxy-8-8-dimethyl-1,7-bis (3-methylbut-2enil)bisiklo(3.3.1)no-3-ene-2,9-dione, bacanone.
KANDUNGAN INULIN DARI UMBI DAHLIASp YANG DITANAM PADA JENIS TANAH VERTISOL, INCEPTISOL DAN ANDISOL Yetti Mulyati Iskandar; Sri Pudjiraharti; Diah Ratnaningrum
Jurnal Kimia Terapan Indonesia Vol 16, No 1 (2014)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1668.861 KB) | DOI: 10.14203/jkti.v16i1.5

Abstract

Tujuan dari penelitian ini adalah menentukan kandungan inulin dari umbi Dahlia sp yang ditanam didaerah sejuk seperti Cianjur, Lembang dan Sukabumi pada jenis tanah yang berbeda dalam rangka rencana produksi di Jawa Barat. Inulin adalah oligosacharida yang terjadi secara alami dengan komposisi gabungan fruktooligosacharida dari  oligomer  dengan  derajat polimerisasi yang berbeda. Umbi dahlia dari  bunga berwarna ungu, merah, kuning dan putih yang ditanam di tiga lokasi digunakan sebagai sumber inulin. Metode ekstraksi yang digunakan yaitu cara ekstraksi berdasarkan kelarutan inulin dalam air pada suhu 800 C dan pengendapan dilakukan dengan etanol 30%. Hasil penelitian menunjukkan kadar inulin dari umbi bunga warna merah yang ditanam pada tanah Inceptisols (Sukabumi) memiliki kadar inulin tertinggi yaitu sebesar 17,99%, gula total 19.13%, karbohidrat 8.02%, kadar abu 0,15% sementara kadar inulin terendah pada jenis tanah Vertisols (Cianjur) yaitu 14.90%, gula total 26.61%, karbohidrat 8.66% kadar abu 0.17% sementara jenis tanahAndisols (Lembang) menghasilkan inulin dengan  kadar inulin 11.84%, gula total 12.48%, karbohidrat 9.38% dan kadar abu 0.09%. Kata kunci :Umbidahlia , inulin, vertisols inceptisols, andisols, karbohidrat The objectives of this research were to  measure inulin content of Dahlia sp tubers widely planted in cool area such as Cianjur, Lembang and Sukabumi at different soil type in order to produce inulin in West Java. Inulin is a naturally occurring fructooligosaccharide composed of a mixture of oligomers of varying degrees of polymerization. Dahlia tuber of flower such as violet, red, yellow and white colour was planted on different location used as the source for inulin. The extraction methods was used base on inulin dissolve in water at 800 C and precipitation was carried out by using ethanol 30%.The results indicated that inulin powder of red flower was planted on inceptisols ( Sukabumi) has the highest level of inulin that was 17.99%, total glucose 19.13%, carbohydrate 8.02%, ash 0.15% .The lowest  inulin content was detected in vertisols type ( Cianjur) as much as  14.90%, total glucose 26.61%, carbohydrate 8.66%, ash 0.17% meanwhile  andisols type has inulin concentration 11.84%, total glucose 12.84%, carbohydrate 9.38% and ash 0.09%. Key words:Dahlia tuber, inulin, vertisols inceptisols, andisols, and carbohydrat
SINTESIS DAN KARAKTERISASI NANOFIBER KOMPOSIT Zn-PVDF KOPOLIMER Yelfira Sari; Muhamad Nasir; Chandra Risdian; Syukri Syukri
Jurnal Kimia Terapan Indonesia Vol 16, No 1 (2014)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1669.821 KB) | DOI: 10.14203/jkti.v16i1.1

Abstract

Sintesis nanofiber komposit Zn-PVDF kopolimer dengan metoda elektrospinning telah berhasil dilakukan. Proses pembuatan nanofiber komposit serta  morfologi yang terbentuk dipengaruhi oleh penambahan Zn-asetat dengan perubahan diameter rata-rata serat dari 357,13 nm menjadi 777,24 nm. Analisis FTIR menunjukkan bahwa struktur kristal nanofiber komposit Zn-PVDF kopolimer didominasi oleh strukturβ-phase, dengan bilangan gelombang 1190,08 cm-1 dan 487,99 cm-1 untuk struktur α-phase dan 1404,18 cm-1; 1280,73 cm-1; 1074,35 cm-1; 881,47 cm-1; dan 840,96 cm-1 untuk struktur β-phase.Kata kunci :nanofiber komposit, Zn-PVDF kopolimer komposit, elektrospinning,kristal struktur, morfologi, diameter fiber The fabrication of Zn-PVDF copolymer nanofiber composite has been investigated in this research study by using electrospinning method. Fabrication and morphology of nanofiber composite is influenced by the addition of Zn-acetate. The average diameter of nanofiber composites increase with an addition of Zn-acetate, from 357,13 to 777,24nm. FTIRanalysisshowedthat thecrystalstructure ofPVDFnanofiberis dominatedby β-phase , thewave number 1190,08 cm-1 and 487,99 cm-1 for α-phase structure and 1404,18cm-1; 1280,73cm-1; 1074,35cm-1; 881,47cm-1and840,96cm-1 for β-phase structure respectively.Key words : nanofiber composite, Zn-PVDF copolymer composite, electrospinning, crystal structure,  morphology, fiber diameter
SINTESIS, UJI AKTIVITAS SITOTOKSIK IN VITRO DAN MOLECULAR DOCKING SENYAWA 1-(4-KLOROBENZOIL)-1,3-DIMETILUREA Dian Agung Pangaribowo; Siswandono Siswandono; Bambang Tri Purwanto
Jurnal Kimia Terapan Indonesia Vol 16, No 1 (2014)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1134.674 KB) | DOI: 10.14203/jkti.v16i1.6

Abstract

Senyawa 1-(4-klorobenzoil)-1,3-dimetilurea telah dirancang, disintesis, diidentifikasi struktur, dan diuji aktivitas sitotoksik secara in vitro. Simulasi docking dilakukan dengan memposisikan senyawa ke dalam sisi aktif reseptor Checkpoint kinase 1 (Chk1) untuk menentukan model pengikatan ligan reseptor. Sintesis 1-(4-klorobenzoil)-1,3-dimetilurea dilakukan lewat reaksi asilasi antara 1,3-dimetilurea dan 4-klorobenzoil klorida. Kemurnian produk hasil sintesis ditentukan dengan metode Kromatografi Lapis Tipis (KLT).Identifikasi struktur dilakukan dengan spektrofotometer UV, FT-IR dan spektrometer NMR. Hasil uji antiproliferatif menunjukkan bahwa senyawa 1-(4-klorobenzoil)-1,3-dimetilurea memiliki aktivitas sitotoksik terhadap sel HeLa yang lebih baik dibandingkan dengan kontrol positif yaitu hidroksiurea. Senyawa 1-(4-klorobenzoil)-1,3-dimetilurea dengan potensi aktivitas sitotoksik ini dapat menjadi agen antikanker yang potensial. Kata kunci: 1-(4-klorobenzoil)-1,3-dimetilurea, molecular docking, sintesis, aktivitas sitotoksik, hidroksiurea A novel 1-(4-chlorobenzoyl)-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to position this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-(4-chlorobenzoyl)-1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and 4-chlorobenzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography. Structure identification was performed by UV spectrophotometer, FT-IR and NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control, hydroxyurea. This compound with potent cytotoxic activity might be a potential anticancer agent. Keywords: 1-(4-chlorobenzoyl)-1,3-dimethylurea, molecular docking, synthesis, cytotoxic activity
MELACAK PELAKU TERORISME MELALUI PENENTUAN KANDUNGAN KATION DAN ANION DALAM SAMPEL HASIL PENCUCIAN TELAPAK TANGAN PELAKU DENGAN TEKNIK KROMATOGRAFI ION Muhammad Amin
Jurnal Kimia Terapan Indonesia Vol 16, No 1 (2014)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4091.738 KB) | DOI: 10.14203/jkti.v16i1.2

Abstract

Telah dilakukan analisis kandungan kation (Na+, NH4+, K+, Mg2+ dan Ca2+) dan anion (NO2−,Cl−, ClO3−, NO3−, and SO42−)menggunakan instrumen kromatografi ion terhadap 80 sampel yang berasal dari hasil pencucian telapak tangan penjual petasan/kembang api dan hasil pencucian telapak tangan orang yang diketahui tidak memegang sampel petasan/kembang api sebelumnya. Petasan, kembang api dan korek api adalah 3 jenis bahan kimia yang berpotensi digunakan sebagai bahan peledak. sejumlah5 mM asam tartrate digunakan sebagai eluen untuk pemisahan kelima jenis kation menggunakan kolom penukar-ion kation dan 1 mM asam trimellitik digunakan sebagai eluen untuk pemisahan kelima jenis anion menggunakan kolom penukar-ion anion. Hasil analisis menunjukkan bahwa konsentrasi beberapa kation (Na+, NH4+ dan K+) pada sampel hasil pencucian telapak tangan penjual petasan/kembang api meningkat 2–3x lipat dari sampel hasil pencucian telapak tangan yang tidak memegang sampel. Ion K+ adalah kation penyusun utama dalam ketiga sampel. Ion NO3− adalah anion penyusun utama untuk sampel petasan dan kembang api, dan ion ClO3− adalah anion penyusun utama korek api. Terlihat bahwa instrumen analisis kromatografi ion dapat menjadi alternatif utama dalam membantu dan menyiapkan data analisis kandungan kation dan anion dalam 3 jenis sampel di atas untuk maksud melacak pelaku terorisme.Kata kunci : Kromatografi ion, Pelaku teroris, Telapak tangan, Kation, Anion The analysis of cations (Na+, NH4+, K+, Mg2+ and Ca2+) and anion (NO2–, Cl–, ClO3–, NO3– and SO42–) have been done using ion chromatography method for 80 samples from palm washing of the seller of firecrackers/fireworks, the palm washing known that the person did not touch/hold the sample previously and potentially explosive simulation sample. Firecracker, fireworks, and matches are 3 types of chemicals used as simulation that could potentially be used as explosives. When 5 mM tartaric acid and 1 mM trimellitic acid were used as the eluents, 5 cations and 5 anions could be separated on the cation-exchange column and anion-exchange column, respectively. The analysis results showed that the concentrations of Na+, NH4+, and K+ ions in samples of hands washing from the sellers increased 2-3x comparedto those did not hold the samples previously. K+ ion is the main cation contained in the three types of samples. NO3–ion is the main anion contained in firecracker and fireworks while ClO3− ion is the main anion contained in matches sample. It was concluded that ion chromatography method as an analytical instrument may be a good alternative to prepare the initial data and content analysis of cations and anions in the above three types of samples for counterterrorism purposes. Keywords: Ion chromatography, Terrorist, Palm washing, Cations, Anions
SEPARATION OF SAVORY FRACTION FROM AUTOLYSATE OF KIDNEY BEAN (Phaseolus vulgaris L.) FERMENTED BY Rhizopus sp-PL19 THROUGH CROSS-FLOW MICROFILTRATION (CFMF) MEMBRANE MODULE Aspiyanto Aspiyanto; Agustine Susilowati; Yati Maryati
Jurnal Kimia Terapan Indonesia Vol 16, No 1 (2014)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2613.123 KB) | DOI: 10.14203/jkti.v16i1.7

Abstract

Separation of savory fraction from autolysate of kidney bean (Phaseolus vulgaris L.) fermented by Rhizopus sp.-PL19 as potential seasoning agent was performed using cross-flow microfiltration (CFMF) technique in module scale. The goal of this experiment was to find out the effect of pressure and time on performance of MF membrane, and compositions of retentate and permeate. The result of experiment showed that separation and/or purification using CFMF technique gave permeate as savory fraction with better clearness and sharper aroma than retentate, but retentate had better composition than permeate. During separation increased total protein, dissolved protein and salt concentrations, but decreased total solid, reducing sugar and fat concentrations in permeate at pressure of 2 and 4 bar. Based on N-Amino concentration in permeate, the optimum condition of separation was reached at pump motor frequency of 10 Hz and room temperature with  pressure of 2 and 4 bar for 10 minutes. This condition produced permeate with fluxes of 51.11 and 52.55 L/m2.hour, and concentrations of N-Amino of 5.50 and 9.80 mg/mL, dissolved protein of 1.01 and 0.97 mg/mL, total protein of 4.85 and 12.10 % (dry weight), reducing sugar of 55.75 and 53.75 mg/mL, salt of 1.16 and 1.06 %, fat of 0.41 and 0.65 %, and total solids of 7.82 and 6.35 %, respectively. Keywords : Autolysate, kidney bean (Phaseolus vulgaris L.), Rhizopus sp.-PL19, cross-flow microfiltration (CFMF), permeate, retentate.  Pemisahan fraksi gurih dari autolisat kacang merah (Phaseolus vulgaris L.) terfermentasi oleh Rhizopus sp.-PL19 sebagai bahan seasoning potensial dilakukan menggunakan teknik mikrofiltrasi cross-flow (MFCF) pada modul.Penelitian bertujuan untuk mencari pengaruh tekanan dan waktu pemisahan terhadap kinerja membran mikrofiltrasi (MF) dan komposisi dalam retentat dan permeat. Hasil penelitian menunjukan bahwa pemisahan dan/atau pemurnian menggunakan teknik MFCF memberikan permeat sebagai fraksi gurih savory dengan kejernihan lebih baik dan aroma lebih tajam daripada retentat, tetapi retentat memiliki komposisi lebih baik daripada permeat. Pemisahan dengan waktu lama menaikkan konsentrasi total protein, protein terlarut dan garam, namun mengurangi konsentrasi total padatan, gula pereduksi dan lemak dalam permeat pada tekanan 2 dan 4 bar. Berdasarkan konsentrasi N-Amino dalam permeat, kondisi optimum pada pemisahan dicapai dibawah frekuensi motor pompa 10 Hz dan suhu ruang dengan tekanan 2 dan 4 bar selama 10 menit. Kondisi ini menghasilkan permeat dengan fluks masing-masing 51,11 dan 52,55 L/m2.jam serta konsentrasi N-Amino of 5,50 dan 9,80 mg/mL, protein terlarut 1,01 dan 0,97 mg/mL, total protein  4,85 dan 12,10 % (berat kering), gula pereduksi 55,75 dan 53,75 mg/mL, garam 1,16 dan 1,06 %, lemak 0,41 dan 0,65 % serta total padatan 7,82 dan 6,35 %. Kata kunci : Autolisat, kacang merah (Phaseolus vulgaris L.), Rhizopus sp.-PL19, mikrofiltrasi cross-flow (CFMF), permeat, retentat.
DEVELOPMENT AND VALIDATION OF A TLC DENSITOMETRIC METHOD FOR DETERMINATION OF GLIMEPIRIDE IN TABLETS Yuni Retnaningtyas; Lestyo Wulandiri; Gabriella F Punu
Jurnal Kimia Terapan Indonesia Vol 16, No 1 (2014)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2015.449 KB) | DOI: 10.14203/jkti.v16i1.3

Abstract

A simple and valid TLC method has been developed for the determination of glimepiride in tablet formulation. After extraction of the analyte with a mixture of methanol and ammonia 0,2M (1:1, v/v), the extracts were spotted on precoated TLC silica gel F254 plates, which were developed with a mixture of toluene:methanol:ethyl acetate (75:20:5, v/v/v). Quantitative evaluation was performed by measuring the absorbance reflectance of the analyte spots at 238 nm. The method was validated for specificity, linearity, accuracy and precision. Good linearity was achieved in the concentration range 100–800 ng/spot. The RSD of repeatability and intermediate precision were found to be less than 2%, whereas the mean of the recovery data was 100-101%. The detection limit and quantification limit were 22 and 74 ng/spot, respectively. The method is specific, linear, precise, and accurate; it can be used for the routine quality control testing of marketed formulations.Keywords: glimepiride, TLC densitometric, validation of pharmaceutical methods, pharmaceutical analysis, antidiabetic drug Sebuah metode Kromatografi Lapis Tipis (KLT) yang sederhana dan valid telah dikembangkan untuk penentuan glimepiride dalam sediaan tablet. Setelah analit dalam sampel diekstraksi dengan campuran metanol dan amonia 0,2 M (1:1,v/v), ekstrak yang terlihat pada lempeng silika gel F254, yang dikembangkan dengan campuran toluen : metanol : etil asetat (75:20:5, v/v/v). Evaluasi kuantitatif dilakukan dengan mengukur reflektansi absorbansi noda analit pada panjang gelombang 238 nm.Metode ini divalidasi meliputi spesifisitas, linearitas, akurasi dan presisi.Linearitas yang baik dicapai pada rentang konsentrasi 100-800 ng / spot. RSD pengulangan dan presisi intermediate menunjukkan nilai kurang dari 2 %, sedangkan rata-rata data recovery adalah 100-101 % .Batas deteksi dan batas kuantifikasi adalah 22 dan 74 ng / noda.Metode ini spesifik, linear, tepat, dan akurat, bisa digunakan untuk pengujian kontrol kualitas rutin tablet glimepirid dipasarkan. Kata Kunci: glimepiride, TLC densitometric, validation of pharmaceutical methods, pharmaceutical analysis, antidiabetic drug
ANALISIS, IDENTIFIKASI PRECURSOR DAN HASIL DEGRADASI SENYAWA SENJATA KIMIA MENGGUNAKAN TEKNIK GAS CHROMATOGRAPHY MASS SPECTROMETRY– ELECTRON IONISASI (GCMS-EI) Evita Boes
Jurnal Kimia Terapan Indonesia Vol 16, No 1 (2014)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2375.902 KB) | DOI: 10.14203/jkti.v16i1.8

Abstract

Telah dilakukan analisis, identifikasi precursor dan hasil degradasi senyawa senjata kimia  diethyl methylphosphonat (DEMP), methyl phosphonic acid (MPA) dalam sampel air dan  dimethyl methyl phosphonat (DMMP), ethyl phosphonic acid (EPA) dalam sampel tanah. Contoh yang dianalisa merupakan contoh senyawa tributilphosphat  (TBP)  40 ug/mL dan poliethilene glycol  56,24 ug/mL ditambahkan sebagai background dan sampel tanah kering yang berpasir. Identifikasi dilakukan dengan  metode  kromatografi gas spektrometri massa - elektron ionisani (GCMS-EI). Ekstraksi fasa organik  pada pH netral, sililasi dari fasa air yang diuapkan,  di mana triethylamine/methanol-sililasi dan  kation exchange-sililasi digunakan untuk ekstraksi senyawa - senyawa precursor dan hasil degradasi sebelum diinjeksikan ke GCMS. Dari hasil analisis diperoleh  waktu retensi  8,9 dan 10,97  menit  masing - masing untuk  diethyl methylphosphonat dan bis(trimethylsilyl) methylphosphonate dalam sampel air sedangkan dalam sampel tanah  6,62 dan 12,06 menit untuk dimethyl methylphosphonat  dan bis(trimethylsilyl) ethylphosphonate. Total Ion Chromatography (TIC) yang dihasilkan dari GCMS dievaluasi dengan menggunakan    Library Data Base NIST (National Institute of Standards and Technology), dan AMDIS (Automated Mass Spectral Deconvolution and Identification System). Spektrum yang dihasilkan memberikan nilai base peak pada m/z = 97  untuk  diethyl methylphosphonate , m/z = 225 untuk  bis(trimethylsilyl) methylphosphonate, m/z = 94 untukdimethyl methylphosphonate dan m/z = 239 untuk bis(trimethylsilyl) ethylphosphonate sedangkan  retention index (RI) yang dihitung digunakan untuk  mengonfirmasi masing-masing senyawa precursorKata kunci : precursor, degradsi senyawa senjata kimia, base peak , waktu retensi,  Total Ion KromatografiAnalysis, precursoridentification have been done and  degradation compoundsof chemical weapon diethyl methylphosphonat , methyl phosphonic acid in water matrices, dimethyl methylphosphonat and ethyl phosphonic acidin soil samples. Water used for extracting those  compounds was an example of simulation that contain tributilphosphat  (TBP)  40 ug/mL and poliethylene glycol  56,24 ug/mL which added as a background and  dry sandy soil samples. Identification was done  by using Gas Chromatographic Mass Spectrometry – Electron Ionization (GCMS-EI) method. Neutral organic extraction, evaporated water - silylation, triethylamine/methanol-silylation and cation exchanged-silylation were performed to extract the precursor’s compounds from the samples, before being analyzed by gas chromatography mass spectrometry .The result of the analysis by  Gas Chromatographic  Mass Spectrometry  method showed that the retention time (in min) was 8,9 and 10,97 for diethyl methylphosphonat and bis(trimethylsilyl) methylphosphonate in the water sample , while the retention time in soil sample was 6,62 and  12,06 for dimethyl methylphosphonat and bis(trimethylsilyl) ethylphosphonate . The result of Total Ion Chromatography (TIC) from GCMS was evaluated using NIST (National Institute of Standards and Technology) database library and AMDIS (Automated Mass Spectral Deconvolution and Identification System). The spectrum’s result gave the value of base peak, which are m/z = 97for diethyl methylphosphonat, m/z= 225 for bis(trimethylsilyl) methylphosphonate , m/z = 94 for dimethyl methylphosphonat and m/z = 239 for bis(trimethylsilyl) ethylphosphonate. On the other hand, the retention indice (RI) calculation was used to get the confirmation of each compounds of precursors. Key word : precursor, degradation of chemical weapon,  base peak, retention time, totalion chromatography.

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