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INDONESIA
Indonesian Journal of Rheumatology
ISSN : 20861435     EISSN : 25811142     DOI : -
Core Subject : Health,
Indonesian Journal of Rheumatology is a peer-reviewed open access journal on rheumatic diseases and connective tissue disorders. This is an official journal of Indonesian Rheumatology Associantion (IRA) and published twice a year since 2009. Our mission is to encourage the development of scientific and medical practice in rheumatic diseases and connective tissue disorders. This journal is self-focused on rheumatic disease and connective tissue disorders in the form of original article (extended and/or concise reports), review articles, editorial letters, leaders, lesson from memorable cases, book reviews, and matter arising. Both in clinical and laboratory including animal studies.
Arjuna Subject : -
Articles 252 Documents
Validation of Modified COPCORD Questionnaire Indonesian Version as Screening Tool for Joint Pain and Musculoskeletal Diseases Muhammad Anshory; Cesarius Singgih Wahono; Handono Kalim; Harun Al Rasyid
Indonesian Journal of Rheumatology Vol. 10 No. 1 (2018): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.818 KB) | DOI: 10.37275/ijr.v10i1.95

Abstract

Background: WHO-ILAR COPCORD Program is a program that aimed to obtain data on joints pain and musculoskeletal diseases in developing countries, one aspect which has not been studied is the ability of COPCORD questionnaire as a screening tool which standardized for  screening  joint pain and musculoskeletal diseases. Objective of this study is to assess the validity of modified COPCORD questionnaire Indonesian version in screening joint pain and musculoskeletal disease compared to examination by rheumatologists.Methods: The initial phase of the research is determining essential points, translation to Indonesian, and back translation. The second stage is testing questionnaires in communities which 100 respondents involved. Dependent variable is the diagnosis of rheumatic diseases and independent variables are pain in less and more than 7 days, high degree pain in less and more than 7 days, history of NSAIDs/Steroids/DMARDs use, and disabilities. Validation test was assessed by calculating the sensitivity, specificity, PPV, NPV, LR+, and ROC curve. Bivariate analysis using Chi Square analysis, and multivariate analysis using logistic regression.Results: The sensitivity test results is best obtained on the question history of NSAIDs/steroids/DMARDs use (100%)  and specificity is best obtained on the question about disability (98%). ROC curve analysis which the results >85% obtained on the question of pain >7 days (90%), high degree pain >7 days (93%), and history of NSAIDs/steroids/DMARDs use (92%).  LR+ to diagnose rheumatic diseases found in all questions. Chi square analysis showed that all questions were significant with p <0.05 and odds ratio (OR) obtained most on high degree pain more than 7 days (OR: 180.167; 95% CI: 38.196-849.834).Conclusion: The modified COPCORD questionnaire Indonesian version has been adapted and can be a good tool in the screening of joint pain and musculoskeletal diseases compared to examination by rheumatologists. Keyword: Validation, Questionnaire, COPCORD
Prevalence of Albuminuria and Associated Factors among Gout Arthritis Patients in Cipto Mangunkusumo Hospital Jeffrey Christian Mahardhika; R.M. Suryo Anggoro
Indonesian Journal of Rheumatology Vol. 10 No. 1 (2018): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.936 KB) | DOI: 10.37275/ijr.v10i1.96

Abstract

Background Gout arthritis associates with many comorbodities such as hyperuricemia, hypertension, hyperglycemia, obesity, and dyslipidemia, which are also factors for the development of/or predisposition factors of chronic kidney diseases (CKD). Albuminuria is a predictor factors for CKD. Screening for albuminuria is needed to be done in patients with high risk of CKD. This research was conducted to examine the prevalence of albuminuria and the associated factors in gout arthritis patients.Methods This research was a cross-sectional study from gout arthritis patients’ medical records in Cipto Mangunkusumo Hospital. We included all gout patients who treated within 2011−2015. Subjects with chronic kidney disease, in kidney replacement therapy, hypertension ≥ 10 years, and diabetes ≥ 5 years were excluded. Albuminuria was determined by urine dipstick result of protein ≥ 1+. Factors associated were age, sex, hyperuricemia, hypertension, stage of hypertension, hyperglycemia, obesity, dyslipidemia, uric acid level, and body mass index (BMI). Data associated with the factors were recorded and the associations were tested with chi square, fisher’s exact, or independent t-test.Results from 54 subjects included in this research, the prevalence of albuminuria was 20.4%. There were no significant associations between all factors and albuminuria tested by chi square and fisher’s exact test. Independent t-test’s results also showed no significant associations between all the factors and albuminuriaConclusion The prevalence of albuminuria in gout arthritis patient was 20.4%. There were no significant associatons between age, sex, hyperuricemia, hypertension, hyperglycemia, obesity, dyslipidemia, uric acid level, and body mass index (BMI) tested with albuminuria in gout arthritis patients in Cipto Mangunkusumo Hospital from 2011−2015.Keywords: Prevalence, Albuminuria, Gout Arthritis, Risk Factors
Management of Salmonella Septic Bursitis in Renal Transplant Recipient Albert Prasetya; Anna Ariane; Bambang Setyohadi
Indonesian Journal of Rheumatology Vol. 10 No. 1 (2018): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (671.134 KB) | DOI: 10.37275/ijr.v10i1.97

Abstract

Salmonella as a causative agent in septic bursitis is considered rare. We report a case of 56 years old male with history of renal transplantation and using mycophenolate mofetil, cyclosporine and methylprednisolone as maintenance, admitted due to 3-week-fever associated with tenderness and swelling on left shoulder. Upon investigation, a diagnosis of septic bursitis was established. Salmonella enteritidis as the definitive causative agent was revealed. He was treated with meropenem 1g IV three times daily and levofloxacin 500 mg IV once a day for 3 weeks, followed by oral ciprofloxacin 500 mg twice a day for 2 weeks and oral metronidazole 500 mg three times a day for 1 week with a total duration of 5 weeks of antibiotics. On the subsequent follow up there was no recurrence episode of fever and the swelling of the left shoulder subsided, no tenderness noted and the patient has no limitation of range of movement. Since immunocompromised state complicates the management, the duration of therapy may twice longer than the typical management of septic bursitis. Salmonella as etiologic agent should be considered as differential in immunocompromised patient with septic bursitis.Keywords: Immunocompromised state, septic bursitis, deep bursae, Salmonella, duration of therapy.
Correlation between Interleukin-6 and E-Selectin as a Marker of Endothelial Dysfunction in Rheumatoid Arthritis Patient without Traditional Cardiovascular Risk Factor Jerry Eddya Putra Boer; Rudy Hidayat; Ika Prasetya Wijaya; Ikhwan Rinaldi
Indonesian Journal of Rheumatology Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.443 KB) | DOI: 10.37275/ijr.v10i2.98

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease which has recently been recognized to manifest as not only intraarticular but also extraarticular symptoms. Cardiovascular events, presented either subclinically or clinically, were discovered more in AR patients. Atherogenic inflammatory mediator in AR including interleukin-6 (IL-6) was thought to be one of nontraditional cardiovascular risk factor contributing to increase the endothelial dysfunction biomarker such as E-Selectin. This study was purposed to determine the correlation between inflammatory mediator and endothelial dysfunction event, especially between IL-6 and E-Selectin, in RA patient without traditional cardiovascular risk factor. A cross-sectional study was performed to 40 RA patients of Rheumatology Clinic of Cipto Mangunkusumo National General Hospital, Indonesia from September to November 2017. Measurement of the level of IL-6 and E-Selectin were performed using enzyme-linked immunosorbent assay (ELISA). Bivariate correlation analysis was performed to determine the correlation between those two biomarkers. The mean age of this study subjects was 44.9 (13.1) years and median of disease duration was 36 months. This study showed weak correlation between IL-6 and E-Selectin level, but not statistically significant.232, p=0.149). There is weak correlation between IL-6 and sE-Selectin in rheumatoid arthritis patient without traditional risk factor cardiovascular Keywords: traditional risk factor cardiovascular, E-Selectin, interleukin-6, pro inflammatory mediator, rheumatoid arthritis
Correlation Between Serum C-Reactive Protein (CRP) and Soluble Cd40 Ligand (sCD40L) with Disease Activity by Modified Rodnan Skin Score (mRSS) in Systemic Sclerosis Patients in Indonesia Widi Palupi Ayu Padmandani; Sumartini Dewi; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.053 KB) | DOI: 10.37275/ijr.v10i2.100

Abstract

Introduction: Systemic Sclerosis (SSc) is a chronic autoimmune disease which presents immunological, endothelial dysfunction, skin and organs fibrosis. The inflammatory process is an important pathophysiology of systemic sclerosis. Disease activity assessment using clinical parameters of Modified Rodnan Skin Score (mRSS) changes and inflammatory laboratory parameters of C-Reactive Protein (CRP), Erytrocyte Sedimentation Rate (ESR) and soluble CD40 ligand. The European Scleroderma Study Group (EscSG) Activity Index uses CRP. CRP is higher sensitivity and specificity than ESR (80% and 91.2%). The study aims to evaluate the correlation between CRP and sCD40L with disease activity by mRSS.Methods: This research was a cross-sectional study, and data of mRSS and sCD40L were obtained from the study, "Blind Clinical Trials Extract Ciplukan Herbs on Clinical Improvement of Skin Disorders, Inflammatory Process, Immunology and Fibrosis in Scleroderma Patients”. CRP examination was done by using the rest samples of the study, conducted in December 2017. Data analysis with Rank-Spearman and Pearson Correlation..Result: There were fifty-eight subjects with mean age 38 ± 11 years old. Most of subjects were female (94.8%) and with a late disease duration > 2 years (74.1 %). Subjects consisted of 35 (60.3%) diffuse SSc and 23 (39.7 %) limited SSc. CRP was measured by Turbidimetric Immunoassay. Median (range) CRP serum was 2.89 (0.16–17.29) mg/L, while the median of sCD40L was 6457 (1018–17976) pg/mL, and the median of mRSS was 17 (4–36). There was no correlation between CRP and sCD40L with mRSS (r = -0.134, p = 0.167; and r = 0.023, p = 0.433).Conclusion: There was no correlation between CRP and sCD40L serum with mRSS in systemic sclerosis patients.
The Correlation Between Disease Activity Assessed by DAS28-ESR and Quality of Life Assessed by SF-36 in Rheumatoid Arthritis Patients Putri Vidyaniati; Rachmat Gunadi Wachjudi; Anna Tjandrawati; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.741 KB) | DOI: 10.37275/ijr.v10i2.101

Abstract

Background Rheumatoid arthritis is the most prevalent form of inflammatory arthritis. One of the key components for its multidimensional outcome is the disease activity, measured by DAS28-ESR. The physical, emotional, and social aspects of RA contribute to the quality of life, and SF-36 questionnaire can be used to measure it. This study aims to ascertain the correlation between the disease activity (DAS28-ESR) and the quality of life (SF-36) in RA patients. Method This study was an analytical, descriptive study with a cross sectional design that took primary data from RA patients undergoing treatment in Rheumatology Clinic of Hasan Sadikin Hospital from February to April 2015. The patient’s data included sex, age, marital status, employment status, educational level, serostatus (RF and Anti-MCV), duration of diagnosis, total number of medications, total number of DMARD, DAS28-ESR scores, and SF-36 scores. The data was analysed with the Shapiro-Wilk normality test, followed by the Rank-Spearman correlation analysis. Result There were 42 subjects, with an average age of 41 ± 12. The ratio between females and males was 20:1, and the majority of subjects (73,8%) had a positive serostatus (RF and/or anti-MCV). The score median of DAS28-ESR was 4,3, with the score median for SF-36 PCS being 39,8 and the score median for SF-36 MCS being 48,2. Based on the the Rank-Spearman analysis (CI of 95%), there was a correlation between DAS28-ESR score and SF-36 PCS score, with the correlation coefficient (r) of -0,577 (p < 0,001), and there was also a correlation between DAS28-ESR score and SF-36 MCS score with r of -0,368 (p = 0,008). Conclusion There was a strong negative correlation between disease activity and physical component of quality of life, and a moderate negative correlation between disease activity and mental component of quality of life, and the two correlations were statistically significant.
Takayasu Arteritis : Diagnostic Approach Malikul Chair; Bambang Setyohadi; RM Suryo Anggoro; Anna Ariane
Indonesian Journal of Rheumatology Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (504.988 KB) | DOI: 10.37275/ijr.v10i2.102

Abstract

Takayasu arteritis (TA) is a systemic, inflammatory large-vessel vasculitis of unknown etiology that most commonly affects women of childbearing age. It involves the aorta and its major branches. The main abnormalities found in this disease are vascular ischemic signs/symptoms including claudication, carotid bruit, weak distal pulsation. Hereby we report a case a 25-year-old unmarried female complained a recurrent left arm pain, worsening when she did her work as a doctor. Formerly, she had experienced intermittent bilateral leg pain for four years with strange sound coming from inside her neck. She was hospitalized half a year ago due to acute limb ischemic and she was diagnosed with TA after the imaging showed multiple stenosis in large arteries including bilateral neck area, shoulder area, abdominal aorta, and right renal artery. The inferior right extremity biopsy showed the histologist result of erythema nodosum appearance. Cuantitative C reactive protein (CRP): 19,8, erythrocyte sedimen rate (ESR): 53. The others laboratory data to exclude differential diagnosis are unremarkable. This report demonstrates the importance of diagnostic approach in rare case of Takayasu’s arteritis patients. Keyword: Diagnostic; Vasculitis, Takayasu Arteritis
Recurrent Rheumatic Fever Patriotika Ismail; Cecep Suryani Sobur; Cyntia Olivia
Indonesian Journal of Rheumatology Vol. 11 No. 2 (2019): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v11i2.103

Abstract

Rheumatic fever (RF) may often be encountered in developing country including in Indonesia. RF is autoimmune disease resulted from Group-A Streptococcus upper respiratory tract infection. RF diagnostic criteria underwent some changes since it was first arranged. Patients with RF episode history have a higher risk to experience recurrence following Group-A Streptococcus pharyngeal infection and need long-term antibiotic prophylaxis to prevent severe disease and RHD. Here we present a case of patient who has RF and RHD history since the age of 10 years old. This case is reported to show recurrent RF management and prophylaxis treatment that can be done next to prevent recurrence of RF in the future.
Mean Platelet Volume on Systemic Lupus Erythematosus Patients with and without Thrombocytopenia in Dr Hasan Sadikin Hospital Bandung: A Descriptive Study Patrick Philo; Laniyati Hamijoyo; Dewi Kartika Turbawaty
Indonesian Journal of Rheumatology Vol. 11 No. 1 (2019): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v11i1.110

Abstract

Abstract Background : The aim of the study is to provide an insight about mean platelet volume (MPV) value in systemic lupus erythematosus (SLE) with and without thrombocytopenia patient. MPV wa expected to be used to determine the cause thrombocytopenia in lupus, so the patient could be treated appropriately. Method : The study design was descriptive categoric, and the data were obtained by using cross-sectional method from patient’s medical record and lab examination result in the period from January 1st 2016 – January 31st 2018. The sampling method are done using total sampling. The inclusion criteria of this study were SLE patients which MPV and platelet count had been examined at the same time, the data used is data that was first discovered in the period of the study. The exclusion criteria were incomplete medical record data, patient with thrombocytosis, and SLE with comorbidity such as thrombotic disease (ischemic stroke and deep vein thrombosis), other high inflammatory overlap diseases (such as rheumatoid arthritis and inflammatory bowel disease), and infection. Result : From 75 patients that match with the inclusion criteria, all patients were female and based on the age of diagnosis, most patients were in age group of 25-34 years old (41,33%). Based on the lab results, group with normal platelet count have 53 data of normal MPV and 12 data of high MPV, while group with thrombocytopenia have 6 data of normal MPV and 4 data of high MPV. Conclusion : Group with normal MPV value and normal platelet count has the largest proportion, while the group with thrombocytopenia in lupus and high MPV value has the lowest proportion.
Correlation of Anxiety Disorder and Quality of Life in Systemic Lupus Erythematosus Patients Kemala Emrizal; Laniyati Hamijoyo; Lynna Lidyana
Indonesian Journal of Rheumatology Vol. 11 No. 1 (2019): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v11i1.111

Abstract

Background: Systemic Lupus Erythematosus (SLE), an autoimmune disease, can cause damage and impairment in the nervous system. Patients who had any manifestation of neurology can be classified as patients with Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). One of the most frequent NPSLE manifestation is anxiety disorder. The presence of anxiety disorder is believed to be correlated with their ability to carry out daily activities. This study aims to see the correlation between anxiety disorder and quality of life (QOL) in patients with SLE. Method: an analitic cross-sectional study was done. The data were collected by distributing validated questionnaires to patients diagnosed with SLE in the outpatient clinic of dr. Hasan Sadikin General Hospital. Quality of life and anxiety disorder was measured using Short From-36 (SF-36) and Zung Self-Rating Anxiety Scale (Zung-SAS), respectively. Normality test was done before correlating the variables using Pearson method. Result: Forty-six SLE patients fitted with the inclusion criteria were participated in the study. The assessment using Zung-SAS showed that 9 (19.56%) correspondents had mild–moderate anxiety, and 1 (2.17%) had severe anxiety. The analysis of SF-36 showed the means of Physical Component Summary (PCS) and Mental Component Summary (MCS) which were 45.18 ± 8.23 and 47.11± 9.78, in order. The correlation test of Zung-SAS with PCS and MCS showed the result of r= -0.651 (p < 0,01) and -0.654 (p < 0,01), respectively. Conclusion: There is a significant negative correlation between anxiety disorder and QOL in patients with SLE. The result of this study showed that the high degree of ones anxiety was in a parallel line with their low level of QOL, so it is important to do an early detection and prevention of anxiety disorder in SLE patients. Keywords: Anxiety disorder, quality of life, Systemic Lupus Erythematosus, Zung Self Rating Anxiety Scale.

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