Ika Prasetya Wijaya
Divisi Kardiologi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta

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The Influence of Direct Reading Thinking Activity (DRTA) Strategy and Know-Want to Know-Learned (KWL) Strategy on Reading Comprehension Skills Wijaya, Prasetya Andika; sutarto, Joko; Zulaeha, Ida
Journal of Primary Education Vol 10 No 3 (2021): September 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jpe.v10i3.44381

Abstract

Reading skills become important role to support his success in the academic field as well as in his daily life. Therefore, for effective learning to be needed the right reading strategy. The aims of this study was to analyze the influence of using the KWL strategy and the DRTA strategy on the reading comprehension skills of fourth grade students. The research design used is a quantitative model in the form of Quasy Experimental Design with a comparative approach. The data collection techniques in this study are test and non-test techniques. The non-test technique in this study used the methods of observation, documentation, and questionnaires. The main indicator measured in this study was comprehension reading skills, which were measured using rubric assessments. The data analysis technique used a prerequisite test, as well as N-gain test, and independent sample t test. The analysis used is comparative analysis, which compares the effectiveness of KWL strategy and DRTA strategy. Based on the results of the study, the DRTA strategy had a positive effect on students' reading comprehension skills by 73.8%, while the KWL strategy also has 64.2%. The DRTA strategy has a positive effect on the reading comprehension results of students by 71.9% and while the KWL strategy has 63.4%. Reading comprehension skills by applying the DRTA strategy obtained an average of 85.6 while the KWL strategy obtained an average of 74.7. It can be concluded that the DRTA strategy has more a positive effect on reading comprehension skills than KWL strategy.
Correlation between Interleukin-6 and E-Selectin as a Marker of Endothelial Dysfunction in Rheumatoid Arthritis Patient without Traditional Cardiovascular Risk Factor Jerry Eddya Putra Boer; Rudy Hidayat; Ika Prasetya Wijaya; Ikhwan Rinaldi
Indonesian Journal of Rheumatology Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.443 KB) | DOI: 10.37275/ijr.v10i2.98

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease which has recently been recognized to manifest as not only intraarticular but also extraarticular symptoms. Cardiovascular events, presented either subclinically or clinically, were discovered more in AR patients. Atherogenic inflammatory mediator in AR including interleukin-6 (IL-6) was thought to be one of nontraditional cardiovascular risk factor contributing to increase the endothelial dysfunction biomarker such as E-Selectin. This study was purposed to determine the correlation between inflammatory mediator and endothelial dysfunction event, especially between IL-6 and E-Selectin, in RA patient without traditional cardiovascular risk factor. A cross-sectional study was performed to 40 RA patients of Rheumatology Clinic of Cipto Mangunkusumo National General Hospital, Indonesia from September to November 2017. Measurement of the level of IL-6 and E-Selectin were performed using enzyme-linked immunosorbent assay (ELISA). Bivariate correlation analysis was performed to determine the correlation between those two biomarkers. The mean age of this study subjects was 44.9 (13.1) years and median of disease duration was 36 months. This study showed weak correlation between IL-6 and E-Selectin level, but not statistically significant.232, p=0.149). There is weak correlation between IL-6 and sE-Selectin in rheumatoid arthritis patient without traditional risk factor cardiovascular Keywords: traditional risk factor cardiovascular, E-Selectin, interleukin-6, pro inflammatory mediator, rheumatoid arthritis
Pengaruh Fungsi Ginjal Sebelum Intervensi Koroner Perkutan Primer Terhadap Perbedaan Kesintasan 30 Hari Pasien Infark Miokard Elevasi Segmen ST Fahmi Razi Darkuthni; Sally Aman Nasution; Aida Lydia; Murdani Abdullah; Dono Antono; Cleopas Martin Rumende; Maruhum Bonar Hasiholan Marbun; Hamzah Shatri; Arif Mansjoer; Ika Prasetya Wijaya; Lusiani Lusiani
eJournal Kedokteran Indonesia Vol 10, No. 3 - Desember 2022
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.10.195.204-11

Abstract

Penyakit jantung koroner merupakan penyebab kematian penyakit kardiovaskular utama di Indonesia. Revaskularisasi fase akut secara mekanis maupun farmakologis merupakan tatalaksana utama pada STEMI. Mortalitas paska revaskularisasi masih tinggi. Salah satu faktor penting yang memengaruhi kesintasan pasien STEMI adalah fungsi ginjal. Gangguan fungsi ginjal yang dicerminkan dengan estimated glomerulus filtration rate (eGFR) < 60 diketahui berhubungan dengan perfusi miokard yang buruk paska IKP primer. Penelitian ini bertujuan untuk memberikan gambaran karakteristik pasien STEMI yang menjalani IKP primer berdasarkan fungsi ginjal sebelum IKP dan menganalisa perbedaaan kesintasan dalam 30 hari pasien STEMI-IKP primer berdasarkan fungsi ginjal sebelum IKP. Metode studi observasional kohort retrospektif dan pengukuran fungsi ginjal dikelompokkan berdasarkan eGFR dengan rumus CKD-EPI menjadi dua yaitu eGFR < 60 dan eGFR ≥ 60. IKP primer dilakukan pada 211 pasien STEMI. Insiden mortalitas eGFR < 60 sebesar 14,7%, sedangkan dengan eGFR ≥ 60 sebesar 4,4%. Perbedaan kesintasan pasien STEMI-IKP antar-kelompok eGFR (p < 0,05) dengan crude HR (IK95%) 3,433 (1,269-9,284). Tidak terdapat perbedaan kesintasan pasien STEMI-IKP antar-kelompok eGFR setelah di-adjusted. Mortalitas dalam 30 hari pada kelompok eGFR < 60 lebih tinggi dibandingkan dengan kelompok eGFR ≥ 60. Kata kunci: infark miokard akut, intervensi koroner perkutan, fungsi ginjal, mortalitas.
Value of Heart Rate Variability, Neutrophil-Lymphocyte Ratio and Quality of Life of Patients with Depressive Symptoms in Acute Myocardial Infarction Shatri, Hamzah; Adli, Mizanul; Muhadi, Muhadi; Abdullah, Murdani; Irawan, Cosphiadi; Putranto, Rudi; Koesnoe, Sukamto; Wijaya, Ika Prasetya
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 4
Publisher : UI Scholars Hub

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Introduction. Major depression criteria can be found in more than 20% of coronary heart patients and more than 30% acute coronary syndrome patients have significant depressive symptoms. Several studies have shown that reduction of hearth rate variability (HRV) and enhancement of neutrophil lymphocyte ratio (NLR) can cause enhancement of morbidity and mortality in myocardial infarction patients. On the other hand, depression can cause reduction of HRV, enhancement of NLR and reduction of quality of life. This study aimed to determine differences in HRV, NLR and quality of life between acute myocardial infarction (AMI) patients with depressive symptoms and AMI patients without depressive symptoms. Methods. A cross-sectional study was conducted among AMI patients who were treated during the period of March to July 2021 at the Intensive Cardiac Care Unit (ICCU) Cipto Mangunkusumo Hospital Jakarta. Samples were taken consecutively until the amount of sample is met. Data were analyzed using unp aired T test. Results. There was a total of 46 subjects AMI patients in this study, ten subjects with depressive symptoms and 36 subjects without depressive symptoms. From the analysis, it was found that AMI patients with depressive symptoms had lower standard deviation normal to normal (SDNN) average (p=0.447), lower low frequency/high frequency (LF/HF) (p=0.323), and higher NLR average (p=0.438) than AMI patients without depressive symptom, although it was not statistically significant. Analysis showed that the mean value of SF36 total scores (p<0.001), physical function domain scores (p<0.001), energy domain scores (p<0.001), mental health domain scores (p<0.001), social function domain scores (p=0.028), bodily pain domain scores (p=0.002), and general health domain scores (p=0.002) were lower in AMI patients with depressive symptoms. Conclusion. AMI patients with depressive symptoms had lower SDNN, lower LF/HF, and higher NLR than AMI patients without depressive symptoms, although it was not statistically significant. AMI patients with depressive symptoms significantly have lower quality of life than AMI patients without depressive symptoms.
The Impact of “CODE STEMI” Program Implementation on Door to Balloon Time and Major Adverse Cardiac Events of Patients with ST Elevation Myocardial Infarction Funay, Prijander L B; Wijaya, Ika Prasetya; Ginanjar, Eka; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 4
Publisher : UI Scholars Hub

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Abstract

Introduction. Delay in the management of ST Elevation Myocardial Infarction (STEMI) patients is a cause of high mortality and the incidence of major adverse cardiac events (MACE). Efforts that can be made in health facilities with primary percutaneous coronary intervention (PCI) capability are achieving timely reperfusion of STEMI patients. Various strategies were carried out to achieve timely reperfusion including implementation the CODE STEMI program. This study aimed to determine the effect of the implementation of the CODE STEMI program on Door to Balloon Time (D2BT) and MACE of STEMI patients undergoing primary PCI. Methods. This was a retrospective cohort study conducted among STEMI patients undergoing primary PCI before the application of the CODE STEMI program (2015-2016) and after the application of the CODE STEMI program (2017-2018). Data were obtained from patients’ medical record. Analysis was performed quantitatively by Mann Whitney test for D2BT and chi square for MACE. Results. There were 111 patients in the non-CODE STEMI group and 144 patients in the CODE STEMI group. D2BT decreased significantly 110 minutes from 275 (99-2356) minutes in the non-CODE STEMI group to 165 (67-1165) minutes in the CODE STEMI group (p < 0.001). Analysis in both group (CODE STEMI vs. non-CODE STEMI) showed as follows: MACE events (48.4% vs 51.6%; p = 0.120), heart failure (46.6% vs 42%; p = 0.288), cardiogenic shock (27% vs 19.4%; p = 0.152), arrhythmia (12.6% vs 6.2%; p = 0.079), stroke (4.5% vs 5.6%; p = 0.705), and mortality rate (7.2% vs 3.5%; p = 0.179) which were similar between the two groups. The incidence of reinfarction (4.5% vs 0.7%; p = 0.047) and repeated PCI (2.7% vs 0.0%; p = 0.047) were significantly reduced in the CODE STEMI group. Conclusions. The CODE STEMI program reduces D2BT. The CODE STEMI program did not reduce the overall MACE incidence but reduced the incidence of reinfarction and repeated PCI of STEMI patients undergoing primary PCI
Determinant Factors and Added Value of Osteoprotegerin (OPG) to Detect Carotid Intima-Media Thickness (CIMT) in Type 2 Diabetes Mellitus Patient Tedjasaputra, Shirly Elisa; Yunir, Em; Wijaya, Ika Prasetya; Setiati, Siti
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 2
Publisher : UI Scholars Hub

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The Role of Duke Treadmill Score as a Predictor of CoronaryArtery Disease in Patients with Positive Treadmill Test Results Ikhsan, Muhammad; Nasution, Sally Aman; Wijaya, Ika Prasetya; Rumende, Cleopas Martin
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
Publisher : UI Scholars Hub

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Introduction. Coronary Artery Disease (CAD) is one of the disease entity that leading cause of morbidity and mortality in worldwide. Treadmill test is part of the diagnostic modality which readily available to assess possibility of narrowing coronary artery and guiding us whether we need for the further investigation. Despite of that, treadmill test has limitation in diagnostic accuracy. Duke Treadmill Score (DTS) was also tested as a diagnostic score, and shown to predict significant CAD better than the ST-segment response alone. Methods. This is a cross-sectional study performed in adult patients with stable CAD that underwent treadmill test and coronary angiography in outward patient clinic of the Integrated Cardiac Service in Cipto Mangunkusumo Hospital between January 2011 and December 2013. Results. A total of 103 patients in this study, thirty nine patients (37,9 %) had significant CAD in coronary angiography. Briefly, mean age was 54,71 years and 55 patients (53,4 %) were females. The most common CAD risk factor was hypertension (51,5 %). A mean of DTS score was -3.53, which mostly categorized as intermediate risk (89,3 %). Based on DTS results, cut-off point was determined by using Receiver Operator Curve (ROC) method, in which value of -8,85 considering as a cut-off point. Sensitivity and specificity value of DTS were 28 % (CI 95 %: 17 % to 44 %), and 95 % (CI 95 %: 87 % to 98 %). Positive and negative predictive value were 79 % (CI 95 %: 52 % to 92 %) and 69 % (CI 95 %: 58 % to 77 %). Positive and negative likelihood ratio were 6.02 and 0.75. Conclusions. DTS has a good performance in predicting significant CAD at cut-off point -8,85 in patients with positive treadmill test.
Depression in Heart Failure: Psychosomatic Approachv Putranto, Rudi; Shatri, Hamzah; Wijaya, Ika Prasetya; Faisal, Edward
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 3
Publisher : UI Scholars Hub

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Depression is a common condition in heart failure (HF) and is considered a risk factor for cardiovascular disease. Depression disorder in patients with heart disease paradigmatically defines a psychosomatic-somatopsychic challenge to any health delivery. However, despite the devastating effects of depression, it is often underdiagnosed and receives little attention in heart failure patients. This review provides an extensive overview of HF regarding epidemiology, disease pathophysiology, diagnosis, and management from the latest literature. Based on the literature review, the prevalence of depression in heart failure in Indonesian patients was 5.3-42%. Psychological stress experienced by people suffering from depression can cause dysregulation in the sympathetic nervous system and hypothalamic–pituitary–adrenal (HPA) axis. This mechanism, in turn, has some deleterious downstream effects, including the development of hypertension, left ventricular hypertrophy, coronary vasoconstriction, endothelial dysfunction, platelet activation, and the production of pro-inflammatory cytokines. The Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5), published by the American Psychiatric Association, is used to diagnose depression in patients with HF. Meanwhile, the Patient Health Questionnaire (PHQ)-2 and PHQ-9 are commonly used as screening tools for depression in patients with HF. The Biopsychosocial-spiritual model as a psychosomatic approach have might reduce or prevent depression and thus improve quality of life and other outcomes. Evidence reveals that both psychotherapeutic treatment (e.g., cognitivebehavioral therapy) and pharmacologic treatment (e.g., use of the selective serotonin reuptake inhibitor sertraline) are safe and effective in managing depression in patients with cardiovascular disease. In conclusion, the review of articles in this paper shows that there is a high prevalence of depression in heart failure, but it is often not recognized by doctors, there is a relationship between psychosomatic, and heart failure, non-pharmacological interventions such as psychotherapy and pharmacological therapy have benefits. Future research is needed to create evidence-based evaluations and treatment algorithms tailored to the specific needs of the target population.
Hyper-IgE Syndrome with Bullous Pemphigoid and EsophagealStricture Budiyani, Laras; Idayu, Adeputri Tanesha; Wijaya, Ika Prasetya; Widhani, Alvina
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
Publisher : UI Scholars Hub

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Laras
The Role of Hydration and N-Acetyl Cysteine Combination in 48Hours Contrast-Induced Nephropaty after Percutaneous CoronaryIntervention in Stage Three Chronic Kidney Disease Patients Simatupang, Lydia D; Susalit, Endang; Wijaya, Ika Prasetya
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 3
Publisher : UI Scholars Hub

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Introduction. Contrast Induced Nephropathy (CIN) after percutaneous coronary intervention (PCI) is common in stage 3 chronic kidney disease (CKD) patients. While there is no cure for CIN and some cases are fatal for the kidney or even life, it is preventable. Eventhough controversial, hydration and N-Acetyl Cysteine (NAC) are modalities to prevent CIN. Not having a certain guideline to prevent CIN in Integrated Cardiac Services (ICS) Cipto Mangunkusumo Hospital for PCI patients generates interest to study it. Methods. A prospective cohort is conducted to evaluate plasma creatinine before and 48 hours after PCI, meanwhile recording whom is given combined hydration and NAC and which not. Results. 43,4% of stage 3 CKD patients are given hydration and NAC, and incidence of CIN occurred in 5.26% patients all belonging to the non hydration and NAC group. Attributable risk is 100% means CIN can be prevented with hydration and NAC. Conclusions. Hydation and NAC is indicated to be protective against CIN in stage 3 CKD patients undergoing PCI.