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Majalah Farmaseutik

majalahfarmaseutik
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Published by Universitas Gadjah Mada

ISSN : 1410590x EISSN : 26140063 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Majalah Farmaseutic accepts submission concerning in particular fields such as pharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmacology, and social pharmacy.

Arjuna Subject : -

Articles 5 Documents

Search results for , issue "Vol 15 No 1, (2019)" : 5 Documents clear

Effect of Andrographis paniculata (Burm.f) Ness Herbs and Gynura Procumbens (Merr) Leaves Extracts Combination in Free-Radical Scavenging Activity Kurnia Rahayu Purnomo Sari; Nofran Putra Pratama; Margaretha Kurniasari
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Development of medical plants as an alternative treatment needs support in terms of scientific evidence to increase public confidence in its efficacy and to ensure the safety of its use. Recent research on Andrographis paniculata (Burm.f) Ness dan Gynura procumbens (Lour.) Merr show that the combination of these two extracts has a potential to be developed into antihyperglycemic agent, through the mechanism of action as an antioxidant. The aim of this study was to evaluate the antioxidant effect of these two extracts combination. Extraction was done by maceration method. Testing of free radical capture activity was carried out by the DPPH method. The results of the antioxidant activity test showed that the combination of soluble ethanol extract of A. paniculata herbs and G. procumbens leaves 50:50 had the best IC50 value of 91.418 µg/mL, the combination of soluble ethanol extract 75:25 had IC50 value 117,059 µg/mL, and the combination combination of soluble ethanol extract 25:75 had the weakest IC50 of 142,277 µg/mL. The three comparisons of the combination were weaker in antioxidant activity compared to the standard vitamin C which had IC50 3,546 µg/mL. Statistical analysis using one-way ANOVA obtained significant differences in antioxidant activity of the three comparison groups.

Effect of Forms of Pharmaceutical Preparations on Antibacterial Activity of Red Betel Oil (Piper crocatum Ruiz & Pav.) Marchaban Marchaban; Anisa Ragil Handayani; Elsa Putri Kartika; Sudarsono Sudarsono
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The Red Sirih Essential Oil (RSEO) which be obtained from red betel leaf (Piper crocatum Ruiz & Pav.) by water and vapour distillation has potential as antibacterial activity. Formulation of an active pharmaceutical ingredient to become a pharmaceutical dosage form can generally modify their activity. The aim of the study is to proof the influence of dosage forms to the activity of RSEO. The study was done by formulating the RSEO to become emulsion, microemulsion and solubilisation dosage forms, and then, their antibacterial activity againt Escherichia coli ATCC 25922 by microdilution method of 1.25% using ELISA reader at 570 nm. The results showed that formulation reduced antibacterial activity. The raw RSEO had a Bacterial Growth Inhibition (BGI) of 66.59%, whereas microemulsion had 49.58%, emulsion had 17.45%, and solubilisation had 0% of BGI, that mean lost its antibacterial activity.

Antifungal Cream Preparation of Galangal Rhizome Extract (Alpinia galanga L.) Rety Setyawaty; Feriadi Feriadi; Dewanto Dewanto
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Cream is a semi-solid emulsion dosage form of both water-in-oil (W/O) or oil in water (O/W) type containing one or more dissolved or dispersed ingredients in the corresponding base material (containing no less than 60% water). Cream is usually used as emollient or containing active pharmaceutical ingredients on the skin (Ansel, 2008). The advantage of cream are the application practicallity, water washeability, and the easiness to spread evenly. In this research, we formulated cream containing rhizome Galangal rhizome. According to Darmono (2008), Galangal rhizome has various properties such as antifungal and antibacterial activities. Galangal rhizome contains 1-asetoksikhavikol asetat (ACA). ACA is an antifungal. ACA has good solubility in 70% ethanol. We maserated Galangal rhizome (Alpinia galangal L.) to extract ACA from the simplicia. As for the cream base, we use hidrophilic base containing emulgators stearic acid and triethanolamine, with glycerin as humectant. During the optimization, we chose three formulas, formula 1 (10% stearic acid , 2% triethanolamin, 5% glycerin, and 0.01% vitamin E), formula 2 (15% stearic acid , 3% triethanolamin, 10% glycerin, and 0.05% vitamin E), and formula 3 (20% stearic acid, 4% triethanolamin, 7.5% glycerin, and 0.09% vitamin E). We used the bases to contain 10% of the extract. The results show that formula 1, formula 2, and formula 3 had typical smell of Galangal rhizome, brown color, and thick consistency. All formulas are homogenous. Formula 1 the best stability. We conclude that Galangal rhizome (Alpinia galanga L.) can be formulated in cream form with our formula 1 had the best stability among others.

Evaluation of Peptic Ulcer Medication Use in Patients with Peptic Ulcer at Inpatient Installation RSUD Sultan Syarif Mohamad Alkadrie Novi Yana Santika; Rise Desnita; Muhammad Akib Yuswar
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Peptic ulcer is an upper gastrointestinal tract disease caused by hypersecretion of acids and pepsin of gastric mucosa. Peptic ulcer disease can be caused by several factors such as smoking, fast food, alcoholic beverages, NSAIDs and Helycobacter pylori. The purpose of this research was to obtain the distribution of antiulcer and itsrationality on peptic ulcer inpatients at the RSUD Sultan Syarif Mohamad Alkadrie Pontianak. This study is a descriptive observational study with cross sectional design. Data from medical record collected retrospectively. This research using medical record peptic ulcer inpatients from January to December in 2017. The samples used were 34 of 44 patients who met the inclusion criteria. Based on results, the distribution of anti ulcer were omeprazole (2.94%), pantoprazole (73.53%), lansoprazole (26.47%), ranitidine 5.89%, 58.82% antacids and 85.29% sucralfat. The result of rationality evaluation on criteriaof appropriate indication (100%);appropriate drug (55.88%); appropriate patient (97.06%); and appropriate (61.76%). Overall,the rationality of treatment that meets all four rational treatment criterias was 78.68%.

Formulation of Orally Disintegrating Tablet from Nifedipin-β-siklodekstrin Inclusion Complex using Kneading Method Nur Aini Purnamasari; Pratama Anggi Saputra
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Nifedipine is widely used for managing hypertension. The challenges of developing nifedipine oral preparation are its low solubility and unpleasant taste. The purpose of developing the Oral Disintegrating Tablet (ODT) dosage form from the Nifedipine-β-cyclodextrin inclusion complex is to increase the solubility of nifedipine and mask the unpleasant taste of the drug. Specific target: use of a superdisintegrant combination to increase the solubility of nifedipine and mask the bitter taste. The method used in the formation of Nifedipine inclusion complex with β-cyclodextrin was kneading method. Making ODT was done by direct pressing method. Characterization of nifedipine-β-cyclodextrin inclusion complex was analyzed by FTIR and DSC. ODT was tested for the physical properties of the tablet and its solution. Test results for ODT physical properties were analyzed and compared with the literature. Data obtained from the dissolution test results calculated the concentration of the active substance dissolved at 20 minutes (Q20). The results showed that the formation of the Nifedipine-β-cyclodextrin inclusion complex increased solubility and masked the bitter taste. The combination of superdisintegrant Ac-Di-Sol-Crosspovidon accelerated the disintegration and dissolution time and improve the taste of Nifedipine ODT.

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