Garuda - Garba Rujukan Digital

Pengaruh Intervensi Terhadap Pengetahuan Farmasis Remaja Tentang Swamedikasi Yunita, Erma; Qonitah, Fadilah; Khasanah, Kharismatul; Zulbayu, L.M. Andi; Mistriyani, Mistriyani; Pratama, Nofran Putra; Jannah, Nurul; Sayakti, Putri Indah; Wulandari, Septi; Nur, Syamsu; Hertiani, Triana
Journal of Community Engagement and Empowerment Vol 1, No 1 (2019)
Publisher : Institut Ilmu Kesehatah Bhakti Wiyata Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar

Latar Belakang: Farmasis remaja memiliki peran dalam pembangunan kesehatan. Salah satu kegiatan yang dilakukan adalah penerapan swamedikasi. Tujuan: Pentingnya peran farmasis remaja dalam swamedikasi mendorong dilakukannya kegiatan pengabdian dengan tema pengenalan peran farmasis remaja dalam swamedikasi. Metode: Peserta diberikan pretest dan selanjutnya diberi intervensi berupa materi umum terkait swamedikasi, diskusi dan praktek swamedikasi bersama tutor. Media yang digunakan berupa materi dalam bentuk power point, modul dan alat peraga. Kegiatan diakhiri dengan melakukan posttest pada peserta yang sama. Hasil: Hasil pretest menunjukan bahwa hanya 14 peserta (20,29%) yang memiliki pengetahuan baik, sedangkan 50 peserta (72,46%) berpengetahuan cukup dan 5 peserta (7,25%) memiliki pengetahuan kurang. Nilai rata-rata hasil pretest adalah 57,10. Setelah diberi intervensi, hasil posttest menunjukan bahwa 66 peserta (95,65%) memiliki pengetahuan baik, sedangkan hanya sejumlah 3 peserta (4,35%) yang masih memiliki pengetahuan cukup. Nilai rata-rata posttes adalah 85,60. Kesimpulan: Adanya peningkatan nilai ini menunjukkan bahwa pemberian intervensi dalam program pengenalan farmasis remaja dalam swamedikasi yang diberikan dapat meningkatkan pengetahuan siswa SMK Pelita Bangsa Yogyakarta tentang swamedikasi. Perlu dilakukan penelitian sejenis dengan jangka waktu antara pretest dengan posttest lebih dari 1 bulan.

Peningkatan Pengetahuan Penggunaan Obat dan Pengenalan Peran Apoteker Dalam Swamedikasi di SMK Kesehatan Pelita Bangsa Yogyakarta Nofran Putra Pratama; Niken Larasati; Kurnia Rahayu Purnama Sari; Sugiyono
The Journal of Innovation in Community Empowerment Vol 1 No 1 (2019): JICE
Publisher : Journal of Innovation in Community Empowerment

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.938 KB)

Peningkatan pembangunan kesehatan menjadi prioritas utama sebagai tolak ukur kemajuan suatu negara. Apoteker adalah salah satu agen tenaga kesehatan yang memiliki peran dalam pembangunan kesehatan, salah satunya dengan melakukan swamedikasi. Kegiatan swamedikasi merupakan suatu tindakan pemilihan obat (tanpa resep dokter) untuk mengatasi penyakit atau gejala penyakit. Poin-poin penting dalam swamedikasi perlu disampaikan kepada masyarakat sehingga dapat terwujud swamedikasi yang aman, rasional, efektif, dan terjangkau. Mengacu pada keterangan di atas maka perlu dilakukan kegiatan pengabdian kepada masyarakat dengan tujuan untuk meningkatkan pengetahuan masyarakat mengenai peran apoteker dalam swamedikasi. Keseluruhan kegiatan terdiri atas empat tahapan yaitu persiapan, pelaksanaan, evaluasi, dan penyelesaian laporan. Tahapan persiapan terdiri dari observasi lapangan, pengumpulan bahan, penyusunan proposal, dan persiapan materi. Tahap pelaksanaan kegiatan yaitu pretest, ceramah, praktik dan diskusi. Tahapan evaluasi meliputi postest, pengisian kuisioner, dan penyusunan laporan. Sasaran kegiatan ini adalah siswa SMK Kesehatan Pelita Bangsa, Desa Ngestiharjo, Kecamatan Kasihan, Kabupaten Bantul, Daerah Istimewa Yogyakarta sebanyak 50 siswa (kelas X). Acara pengabdian kepada masyarakat ini berjalan dengan baik terbukti dengan banyaknya peserta yang aktif bertanya mengenai materi yang disampaikan. Hasil dari kegiatan ini adalah terjadi peningkatan pengetahuan peserta terhadap peran apoteker dalam swamedikasi dari 54,93% menjadi 84,13%.

Acute toxicity study of Andrographis paniculata (Burm.f) Ness herbs and Gynura procumbens (Merr) leaves extracts combination Kurnia Rahayu Purnomo Sari; Nofran Putra Pratama; Nadia Husna
Jurnal Ilmiah Farmasi Vol. 16 No. 1 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss1.art5

AbstractBackground: Development of medical plants as an alternative treatment needs support in terms of scientific evidence to increase public confidence to ensure the safety of its use. Recent research on Andrographis paniculata (Burm. f) Ness and Gynura procumbens (Lour.) Merr showed that the combination of these extracts has a potential to be developed into antihyperglycemic agent and there’s no any potential toxicity for each extract.Objective: The aim of this study was to evaluate the acute toxicity level of these two extracts combination. From this research, it is expected that information can be obtained regarding the safety of extracts to support the further development of the extract combination. Method: The method that used in this research is based on OECD 423. Observation was intensively done to animal behavior 4 h after acute exposure and continued up to 14 days after acute exposure to evaluate whether there were animal died. After the 15 days, all the animals were sacrificed and the vital organ was isolated for histological study.Results: The results showed that the exposure of these combination didn’t caused any to toxicity symptoms and there’s no animals died. Histological study on hepar showed that there’s no mayor damage in the hepar even after exposure of 2000 mg/kgBW dose.Conclusion: The combination of ethanol extract of A. paniculata herbs and G. procumbens leaves was categorized as unclassified (>2000 mg/kgBW) in term of toxicity levels based on Globally Harmonized Classification System.Keywords: Andrographis paniculata (Burm.f) Ness, Gynura procumbens (Lour.) Merr, acute toxicityIntisariLatar belakang: Pengembangan tanaman obat sebagai alternatif pengobatan perlu dukungan dari segi scientific evidence untuk meningkatkan kepercayaan masyarakat dan menjamin keamanan penggunaannya. Penelitian terbaru tentang sambiloto dan sambung nyawa menunjukkan bahwa kombinasi ekstrak tersebut berpotensi untuk dikembangkan menjadi agen antihiperglikemia dan dibutuhkan pemastian keamanannya.Tujuan: Penelitian bertujuan untuk mengevaluasi potensi ketoksikan secara akut kombinasi ekstrak larut etanol herba sambiloto dan daun sambung nyawa.Metode: Metode yang digunakan pada penelitian ini mengacu pada panduan OECD 423. Pengamatan yang dilakukan termasuk pada tingkah laku hewan uji tikus betina galur Wistar berjumlah 15 ekor, secara intensif terhadap gejala toksisitas selama 4 jam awal setelah paparan sediaan uji kemudian dilanjutkan hingga 14 hari pasca paparan untuk melihat ada/tidaknya hewan uji yang mati. Pada hari ke-15, seluruh hewan uji dikorbankan dan dibedah untuk diisolasi, ditimbang organ vitalnya dan dilakukan pengamatan histologi. Hasil: Hasil penelitian menunjukkan bahwa kombinasi ekstrak tersebut tidak menyebabkan gejala toksik terhadap hewan uji dan tidak ada satupun hewan uji yang mati. Hasil histopatologi organ hepar menunjukkan bahwa kombinasi ekstrak ini tidak menunjukkan efek berbahaya pada organ hepar hewan uji yang telah diberi paparan akut dengan dosis 2000 mg/kgBB. Kesimpulan: Ketoksikan kombinasi ekstrak larut etanol herba sambiloto dan daun sambung nyawa masuk dalam kategori unclassified (>2000mg/kgBB) menurut Globally Harmonized Classification System.Kata kunci : Andrographis paniculata (Burm.f) Ness, Gynura procumbens (Lour.) Merr, toksisitas akut

PENGARUH PEMBERIAN GEL BINAHONG TERHADAP PENYEMBUHAN LUKA SAYAT Deby Zulkarnain Rahadian Syah; Nofran Putra Pratama
MEDIA ILMU KESEHATAN Vol 9 No 3 (2020): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v9i3.699

Background: Effective wound healing will reduce the costs incurred for treatment. Wound assessment, action and selection of treatment are carried out based on conditions and problems. Today's society prefers to do treatment by utilizing natural resources only on incision wounds given binahong leaves. Objective: Produces a binahong gel composition that heals cuts and minimizes infection in the incision. Methods: This research is included in inferential quantitative with parametric data. The mean difference test was then performed, followed by a paired t-test. Results: Administration of Na CMC On day 10 the mean wound closed was 18.83 cm with a standard deviation of 1.15. The administration of 1% binahong gel obtained an average wound healing area of 19.54 cm with a standard deviation of 0.18. The administration of 5% binahomg gel on the 6th day only showed wound healing with a T test value of 0.004 but on day 8 there was no additional wound closure with an average wound healing area of 6.36. The administration of 7.5% gel was known until the 10th day indicating that there was no wound healing. Giving Povidone iodine is known to be on the 8th day showing wound healing with an average wound healing of 6.65 cm. Conclusion: The 1% binahong gel was more effective in accelerating the healing of cuts in rats compared to the 5% and 7.5% binahong gel.

Effect of Andrographis paniculata (Burm.f) Ness Herbs and Gynura Procumbens (Merr) Leaves Extracts Combination in Free-Radical Scavenging Activity Kurnia Rahayu Purnomo Sari; Nofran Putra Pratama; Margaretha Kurniasari
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Development of medical plants as an alternative treatment needs support in terms of scientific evidence to increase public confidence in its efficacy and to ensure the safety of its use. Recent research on Andrographis paniculata (Burm.f) Ness dan Gynura procumbens (Lour.) Merr show that the combination of these two extracts has a potential to be developed into antihyperglycemic agent, through the mechanism of action as an antioxidant. The aim of this study was to evaluate the antioxidant effect of these two extracts combination. Extraction was done by maceration method. Testing of free radical capture activity was carried out by the DPPH method. The results of the antioxidant activity test showed that the combination of soluble ethanol extract of A. paniculata herbs and G. procumbens leaves 50:50 had the best IC50 value of 91.418 µg/mL, the combination of soluble ethanol extract 75:25 had IC50 value 117,059 µg/mL, and the combination combination of soluble ethanol extract 25:75 had the weakest IC50 of 142,277 µg/mL. The three comparisons of the combination were weaker in antioxidant activity compared to the standard vitamin C which had IC50 3,546 µg/mL. Statistical analysis using one-way ANOVA obtained significant differences in antioxidant activity of the three comparison groups.

Acute Toxicity Study of the Combination of Azadirachta indica A. Juss. and Gynura procumbens (Lour.) Merr. Leave Extracts Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari; Ririn Irma Marliana
Journal of Fundamental and Applied Pharmaceutical Science Vol 1, No 2 (2021): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v1i2.9868

Azadirachta indica A.Juss. and Gynura procumbens (Merr.) are medicinal herbs widely used in traditional medicine. Recent research on the combination of these two plants showed aggressive antioxidant activity. The combination results can improve insulin and beta-cell morphology and can increase insulin expression. The variety of activities performed is the basis for conducting acute toxicity tests on the ethanol extract of Azadirachta Indica A. Juss. and Gynura procumbens (Lour.) Merr. to increase public confidence in its efficacy and ensure the safety of its use. The acute toxicity test on the ethanol extract of Azadirachta Indica A. Juss. and Gynura procumbens (Lour.) Merr. was carried out on female Wistar rats by following the 423 procedures of OECD (Organization for Economic Cooperation and Development) Guideline with five groups of experimental animals, namely normal treatment, aquadest solvent treatment and 0.5 Na-CMC 0.5%, a separate treatment of the ethanol extract of Azadirachta Indica A. Juss., a separate treatment of the ethanol extract of Gynura procumbens (Lour.) Merr., and combination treatment of the ethanol extract of Azadirachta Indica A. Juss. and leaves of Gynura procumbens (Lour.) Merr. Furthermore, it was proceeded by observing the liver of the experimental animals histopathologically. The acute toxicity test results utilizing the 423 procedures of the OECD did not confirm any death or signs of toxicity in the experimental animals, and histopathological observations did not show any major histopathological damage. Based on these results, according to Globally Harmonized Classification System (GHS), the combination of the ethanol extract of Azadirachta Indica A. Juss. and Gynura procumbens (Lour.) Merr. is included in the unclassified category 2,000 mg/kg BW.

FORMULATION OF CHEWABLE TABLET PREPARATIONS FROM THE COMBINATION OF Azadirachta Indica A. Juss. AND Gynura Procumbens (Merr.) Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari; Endah Kurniawati
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.5918

Azadirachta indica A. Juss. and Gynura procumbens (Merr.) are one type of potential medicinal plants because they have various properties. One of the properties of these two plants is as an antioxidant. The combination of the two plants has a strong category of antioxidant activity, does not cause death and physical changes in test animals. This study aimed to make an antioxidant chewable Tablet containing a combination of Azadirachta indica A. Juss. and Gynura procumbens (Merr.) extract with a variation of mannitol-sorbitol as a filler. This variation has the advantage of covering the bitter taste of the active substance so that it is expected to provide a pleasant taste and is easy to swallow. The extract obtained was formulated into chewable Tablets with variations of mannitol-sorbitol (90%:10%), (80%:20%), and (70%:30%). The method used is wet granulation. The granules obtained were tested for their physical properties, namely flow velocity, angle of repose, and compressibility. The physical properties of the Tablets tested included uniformity of weight, size, hardness, friability, disintegration time, quality of taste, shape, and odor. Based on the test results of the physical properties of the granules, the three formulas met the requirements. While the physical properties of Tablets that do not meet the criteria are uniformity of size and disintegration time. This research concludes that the extracts of Azadirachta indica A. Juss. and Gynura procumbens (Merr.) be formulated into chewable Tablets where formula two with variations of mannitol:sorbitol (80:20%) is the best formula by fulfilling 9 of 11 requirements

Analisis fitokimia dan kromatografi lapis tipis ekstrak etanol daun rosella (Hibiscus sabdariffa L.) Tira Risa Oktapiya; Nofran Putra Pratama; Nur'aini Purnamaningsih
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.181

Rosella (Hibiscus sabdariffa L) is a plant belonging to the Malvaceae family. This plant is widely used as herbal medicine. Rosella leaves have many compounds that can function as antioxidants and antibacterials. As a crude material for traditional medicine, it is necessary to know the content of secondary metabolites contained in rosella leaves both quantitatively and qualitatively as one of the standardization parameters. The objective of this study was to determine the content of secondary metabolites contained in the ethanolic extract of rosella leaves through phytochemical analysis and Thin Layer Chromatography. Rosella leaf extraction was carried out by maceration method using 70% ethanol as solvent. Testing the content of secondary metabolites in the ethanolic extract of rosella leaves was carried out by phytochemical screening. Furthermore, the TLC test was carried out to confirm the presence of a positive group of compounds on phytochemical screening. Phytochemical screening from rosella leaves extract revealed the presence of alkaloids, flavonoids, saponins and tannins. The TLC system used in this study was able to separate the phytochemical content and gave positive results confirming the phytochemical screening results. The eluent used was chloroform:methanol:acetic acid with a ratio of 14:2:1 obtained spots with an Rf of 0.737 which is similar to the Rf standard of quercetin which is 0.762.

Aktivitas antioksidan ekstrak etanol daun Sonchus arvensis L. Rochmy Istikharah; Khittah Dea Annisa Annisa; Nofran Putra Pratama; Hady Anshory Tamhid
Jurnal Ilmiah Farmasi Vol. 11 No. 2 (2015): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Intisari Penelitian terhadap ekstrak air dan ekstrak metanol daun Sonchus arvensis L. atau tempuyung telah terbukti mempunyai khasiat sebagai antioksidan. Salah satunya diduga karena kandungan flavonoidnya. Etanol merupakan pelarut yang paling sering digunakan dalam proses ekstraksi dan mempunyai kemampuan yang baik dalam mengekstraksi flavonoid. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol daun S. arvensis sebagai antioksidan dengan metode DPPH (1,1-diphenyl-2-picrylhydrazyl) dan metode ABTS (2,2’-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid). Ekstrak daun S. arvensis diperoleh melalui proses maserasi dengan etanol 70%. Uji aktivitas antioksidan dilakukan dengan menggunakan DPPH dan ABTS sebagai sumber radikal bebas terhadap seri kadar ekstrak sehingga dapat dihitung nilai IC50 melalui perhitungan PROBIT. Seri kadar vitamin C digunakan sebagai kontrol positif. Hasil uji peredaman radikal bebas menunjukkan nilai IC50 S. arvensis sebesar 138,26 µg/mL terhadap ABTS dan 64,97 µg/mL terhadap DPPH. Ekstrak etanol daun S. arvensis yang diuji mempunyai aktivitas antioksidan. Kata kunci : Sonchus arvensis, antioksidan, ABTS, DPPH

Peningkatan Pengetahuan Penggunaan Obat dan Pengenalan Peran Apoteker Dalam Swamedikasi di SMK Kesehatan Pelita Bangsa Yogyakarta Nofran Putra Pratama; Niken Larasati; Kurnia Rahayu Purnama Sari; Sugiyono
The Journal of Innovation in Community Empowerment Vol 1 No 1 (2019): Journal of Innovation in Community Empowerment (JICE)
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jice.v1i1.205

Peningkatan pembangunan kesehatan menjadi prioritas utama sebagai tolak ukur kemajuan suatu negara. Apoteker adalah salah satu agen tenaga kesehatan yang memiliki peran dalam pembangunan kesehatan, salah satunya dengan melakukan swamedikasi. Kegiatan swamedikasi merupakan suatu tindakan pemilihan obat (tanpa resep dokter) untuk mengatasi penyakit atau gejala penyakit. Poin-poin penting dalam swamedikasi perlu disampaikan kepada masyarakat sehingga dapat terwujud swamedikasi yang aman, rasional, efektif, dan terjangkau. Mengacu pada keterangan di atas maka perlu dilakukan kegiatan pengabdian kepada masyarakat dengan tujuan untuk meningkatkan pengetahuan masyarakat mengenai peran apoteker dalam swamedikasi. Keseluruhan kegiatan terdiri atas empat tahapan yaitu persiapan, pelaksanaan, evaluasi, dan penyelesaian laporan. Tahapan persiapan terdiri dari observasi lapangan, pengumpulan bahan, penyusunan proposal, dan persiapan materi. Tahap pelaksanaan kegiatan yaitu pretest, ceramah, praktik dan diskusi. Tahapan evaluasi meliputi postest, pengisian kuisioner, dan penyusunan laporan. Sasaran kegiatan ini adalah siswa SMK Kesehatan Pelita Bangsa, Desa Ngestiharjo, Kecamatan Kasihan, Kabupaten Bantul, Daerah Istimewa Yogyakarta sebanyak 50 siswa (kelas X). Acara pengabdian kepada masyarakat ini berjalan dengan baik terbukti dengan banyaknya peserta yang aktif bertanya mengenai materi yang disampaikan. Hasil dari kegiatan ini adalah terjadi peningkatan pengetahuan peserta terhadap peran apoteker dalam swamedikasi dari 54,93% menjadi 84,13%.

Title

Found 36 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 36 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 36 Documents
Search