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INDONESIA
Indonesian Journal of Obstetrics & Gynecology Science
Published by Universitas Padjadjaran
ISSN : 2615496X     EISSN : 2615496X     DOI : -
Core Subject : Health,
Health Professions Public Health
OBGYNIA (Indonesian Journal of Obstetrics & Gynecology Science ) adalah jurnal dalam bidang ilmu Obstetri & Ginekologi yang diterbitkan resmi oleh Departemen Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran. OBGYNIA menerbitkan artikel penelitian tentang kemajuan ilmiah, manajemen klinis pasien, teknik bedah, kemajuan pengobatan dan evaluasi pelayanan, manajemen serta pengobatan dalam bidang obstetri & ginekologi.
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Search results for , issue "Volume 6 Nomor 2 Juli 2023" : 20 Documents clear
Manajemen Jangka Panjang Endometriosis: Dapatkah Progestin Menjadi Andalan? Hartanto Bayuaji
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.527

Abstract

Latar belakang: pada tahun 2014 The Practice Committee of The American Society of Reproductive Medicine menyebutkan bahwa endometriosis merupakan penyakit kronis yang memerlukan penanganan jangka panjang dengan titik berat pada terapi medikamentosa. Progestin merupakan modalitas terapi yang berpotensi digunakan dalam jangka panjang. Dienogest merupakan progestin turunan 19-nortestosteron dengan pengaruh pada endometrium dan antiinflamasi yang kuat merupakan pilihan untuk terapi jangka panjang endometriosis.Metode: telaah pustaka.Hasil: dalam manajemen endometriosis, progestin digunakan dalam terapi jangka panjang serta untuk mencegah rekurensi. Penggunaan dienogest jangka panjang menurunkan skor visual analogue scale secara bermakna dari beberapa penelitian. Analisis efektivitas-biaya menunjukkan profil penghematan biaya yang lebih baik pada dienogest dibandingkan goserelin. Rekurensi endometriosis pasca operasi menurun secara bermakna pada wanita yang mendapat terapi dienogest. Dalam suatu network meta-analysis diketahui bahwa kombinasi agonis GnRH + dienogest diharapkan menjadi pilihan terbaik pencegahan rekurensi. Dari dua penelitian dengan subjek wanita Asia, efek samping dienogest terjadi pada sekitar 13,27% - 31,5% subjek dan umumnya bersifat ringan. Perubahan pola perdarahan uterus merupakan hal yang sering disampaikan subjek. Kepadatan mineral tulang mengalami penurunan pada pemberian dienogest namun mengingat pentingnya pencegahan rekurensi dan menghindari operasi ulang, keputusan penggunaan dienogest sebaiknya tidak hanya didasarkan pada hal ini saja. Simpulan: data menunjukkan bahwa dalam konsep terapi jangka panjang, progestin merupakan modalitas yang amat penting. Dienogest merupakan salah satu pilihan untuk manajemen jangka panjang endometriosis. Pengawasan penggunaan progestin harus selalu diperhatikan untuk mengupayakan diperolehnya hasil yang optimal.The Long Term Management Of Endometriosis: are Progestins the Reliable Choice?AbstractBackground: in 2014, The Practice Committee of The American Society of Reproductive Medicine stated that endometriosis should be viewed as a chronic disease that requires a lifelong management, with focus on progestins. Dienogest, a 19-nortestosterone derivative, is a progestin compound with strong endometrium effects and antiinflammatory property that may become an option in long term management of endometriosis.Method: literature reviewResults: progestins might be applied in both long term management and prevention of recurrence of endometriosis. The significant reduction of visual analogue scale score were found in several study. The cost-effectiveness analysis reveals better cost-saving profile of dienogest when compared with goserelin. Women who received postoperative dienogest treatment have reduced incidence of recurrence. In one network meta-analysis study, the GnRH agonist + dienogest combination revealed the best option for preventing recurrence. The adverse effects of dienogest from 2 Asian studies range from 13.27% - 31.5%, mostly mild cases. Changes in uterine bleeding pattern were the most common reported side effects. The bone mineral density decreased after dienogest treatment, however, considering the benefit of dienogest for preventing recurrence and repeated operation, the use of dienogest should not be solely based on bone mineral density changes.Conclusion: progestin is the important mainstay of long term therapi in endometriosis. Dienogest is an option in long term management of endometriosis. However, monitoring of their usage should be an important aspects to ensure optimal outcomes are achieved.Key words: bleeding pattern, bone mineral density, dienogest, endometriosis, long term management, progestins.
Hubungan Ekspresi Cyclooxygenase-2 (Cox-2) dengan Invasi Limfovaskuler, Infiltrasi Sel Radang dan Stadium Kanker Serviks Andi Ahmed Onterio; Syahrul Rauf; Nugraha Utama Pelupessy; Rina Masadah; Isharyah Sunarno; Nasrudin Andi Mappaware; Sharvianty Arifuddin
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.478

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan Ekspresi COX-2 dengan Lymphovascular Space Invasion (LVSI), Infiltrasi sel radang dan stadium kanker serviks. Metode: Penelitian ini menggunakan desain cross sectional di Rumah Sakit Pendidikan Tinggi Negeri Universitas Hasanuddin. Pengambilan sampel menggunakan teknik total sampling dengan data pemeriksaan kadar COX-2 pada 50 hasil biopsi dan hasil operasi pada kasus kasus kanker serviks melalui pemeriksaan immunohistokimia. Data dianalisis dengan uji chi-square dengan tingkat kepercayaan 95%. Hasil: Hasil penelitian diperoleh ada hubungan signifikan antara eskpresi COX-2 dan stadium kanker serviks dengan nilai p<0,05. Ekspresi COX-2 tidak berhubungan signifikan dengan Lymphovascular Space Invasion dan infiltrasi sel radang dengan nilai p>0,05. Ekspresi COX-2 juga tidak berhubungan signifikan dengan paritas, pendidikan, pekerjaan, penggunaan kontrasepsi oral kombinasi ≥5 tahun, mitra seksual, dan riwayat merokok dengan nilai p>0,05. Kesimpulan: Berdasarkan hasil penelitian dapat disimpulkan bahwa semakin tinggi stadium kanker serviks maka semakin tinggi ekspresi COX-2, sehingga pemeriksaan ekspresi COX-2 dapat dijadikan sebagai pertanda keganasan pada serviks, selain itu ditemukan LVSI dan infiltrasi sel radang tidak memiliki pengaruh terhadap ekspresi COX-2.The Correlation Cyclooxygenase-2 (Cox-2) Expression and Lymphovascular Invasion, Inflammatory Cell Infiltration and Cervical Cancer StageAbstractObjective: This study is objected to find out the correlation between COX-2 expression and Lymphovascular Space Invasion, inflammatory cell inflation and cervical cancer stage. Method: This study uses cross sectional design at educational hospital of Hasanuddin University. COX-2 level examination was performed on 50 biopsy and surgery result on cervical cancer cases through immunohistochemistry. Data were analyzed using chi-square test with significant level of 95%. Results: Study result indicated that significant correlation is found between COX-2 expression and cervical cancer stage with p value < 0.05. No significant correlation is found between COX-2 expression and Lymphovascular Space Invasion and inflammatory cell inflation with p value > 0.05. No correlation also is found between COX-2 expression and parity, education, profession, combination oral contraception uses  5 years, sexual partner and smoking history with p value > 0.05. Conclusion: Based on our results it can be concluded that the higher the stage of cervical cancer in line with the expression of COX-2 and examination of COX-2 expression can be used as a marker of cervical malignancy, besides that LVSI and inflammatory cell infiltration not affected on COX-2 expression.Key words: Cyclooxygenase-2, Cervical Cancer, Stage.
Perbandingan Kadar Reactive Oxygen Species (ROS) sebagai Penanda Stres Oksidatif pada Ibu Hamil Dengan dan Tanpa Vaginosis Bakterial Dwicky Limbersia Aries; Maisuri T. Chalid; Rina Previana Amiruddin; Rizalinda Sjahril; Efendi Lukas; Susiawaty Mustafa
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.529

Abstract

Tujuan: Menganalisis perbandingan antara kadar reactive oxygen species pada ibu hamil dengan dan tanpa vaginosis bakterial.Metode: Penelitian cross sectional dilakukan pada ibu hamil yang datang berobat ke Poliklinik RSUP Dr. Wahidin Sudirohusodo, Rumah Sakit jejaring serta Puskesmas di Makassar, Indonesia, pada Juli 2021 sampai Juli 2022. Pengambilan sampel dilakukan dengan consecutive sampling. Subjek penelitian dengan dan tanpa vaginosis bakterial dikelompokkan berdasarkan hasil dari kriteria Amsel kemudian  kadar reactive oxygen species diukur dengan ROS ELISA Kit. Data dianalisis dengan uji chi-square, uji Mann-Whitney dan uji Kruskal Wallis.Hasil: Diperoleh 85 subyek penelitian yang terdiri dari 41 ibu hamil dengan vaginosis bakterial positif dan 44 ibu hamil dengan vaginosis bakterial negatif. Ibu hamil dengan vaginosis bakterial positif mempunyai kadar reactive oxygen species lebih rendah dibandingkan ibu hamil dengan vaginosis bakterial negatif (p=0.001*). Faktor lain yang berhubungan signifikan dengan kadar reactive oxygen species adalah lama keputihan >1 bulan. Umur, paritas, status gizi, diet fast food dan usia kehamilan tidak berhubungan signifikan dengan kadar reactive oxygen species (p>0,05).Kesimpulan: Kadar reactive oxygen species pada ibu hamil dengan vaginosis bakterial lebih rendah dari pada ibu hamil tanpa vaginosis bakterial. Diperlukan studi lanjut dengan skala penelitian yang lebih besar dengan lebih mengendalikan faktor-faktor yang dapat memengaruhi bias penelitian serta penelitian lebih lanjut mengenai kadar ROS dengan pendekatan sampel cairan vaginaComparison of Reactive Oxygen Species (ROS) Levels as Marker Of Oxidative Stress in Pregnant Women With and Without Bacterial VaginosisAbstractObjective: To analyze the comparison between levels of reactive oxygen species in pregnant women with and without bacterial vaginosis. Method: This study used a cross-sectional method that was conducted on pregnant women who came for treatment at Dr. Wahidin Sudirohusodo Hospital Polyclinic, a network hospital and public health center in Makassar, Indonesia, in July 2021-July 2022. Sampling was carried out using consecutive sampling. Research subjects with and without bacterial vaginosis were grouped based on the results of Amsel criteria and then ROS levels were measured by ROS ELISA kit. Data were analyzed by chi-square test, Mann-Whitney test, and Kruskal Wallis test. Results: There were 85 research subjects consisting of 41 pregnant women with positive bacterial vaginosis and 44 pregnant women with negative bacterial vaginosis. Pregnant women with positive bacterial vaginosis had lower levels of reactive oxygen species than pregnant women with negative bacterial vaginosis (p=0.001*). Another factor significantly related to reactive oxygen species levels  is vaginal discharge for > 1 month. Age, parity, nutritional status, fast food diet, and gestational age were not significantly related to levels of reactive oxygen species (p>0.05).Conclusion: The level of reactive oxygen species in pregnant women with bacterial vaginosis is lower than in pregnant women without bacterial vaginosis. Further studies are needed with a larger research scale with better control over factors that can influence research bias and further research on ROS levels with a vaginal fluid sample approach.Key words: bacterial vaginosis, pregnant women, reactive oxygen species
The Correlation Between CYP19 Levels, VAS of Dysmenorrhea, and the Grading Score ASRM of Endometriosis Fatimah Usman; Muhammad Komarul Hakim; Heriyadi Manan; Mgs. Irsan Saleh
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.503

Abstract

Objective: We aim to assess the correlation between the CYP19 level, the visual analogue scale (VAS) pain and endometriosis American Society for Reproductive Medicine (ASRM)  grading scale.Method: An observational analytic study with a cross–sectional design was conducted at the Obstetrics/Gynecology Department, RSUP Dr. Moh Hoesin Palembang, Laboratory of Biomedical and Biomolecular of the Faculty of Medicine, Universitas Sriwijaya from July–December 2022. Subjects who were diagnosed with endometriosis and met the inclusion and exclusion criteria underwent a histopathological examination to measure the degree of disease according to ASRM. Using the same sample, the CYP19 levels were assessed by enzyme linked immunosorbent assay (ELISA). Univariate and bivariate statistical analyses were performed to see the correlation.Results: This study involved 37 subjects aged 20–48 (Mean: 32 years). We found there was a significant correlation between the degree of VAS score and ASRM grading (p<0.001). In addition, although CYP19 expression was found in ectopic endometrial tissue, there was no significant correlation between the level of CYP19 expression in the tissue and the VAS score dysmenorrhea (p= 0,618) and ASRM grading (p=0.604).Conclusion: There is no significant correlation between CYP19 levels and the degree of pain in VAS or ASRM grading in patients.Hubungan Kadar CYP19, Visual Analogue Score (VAS) Dismenorea, dan Grading Score American Society for Reproductive Medicine (ASRM) Endometriosis Abstrak    Tujuan: Penelitian ini bertujuan untuk menilai hubungan kadar CYP19, skala nyeri visual analogue scale (VAS) dan grading berdasarkan American Society for Reproductive Medicine (ASRM) pada pasien endometriosis.Metode: Sebuah studi analitik observasional dengan rancangan cross–sectional dilakukan di Bagian/KSM Obstetri Ginekologi, RSUP Dr. Moh Hoesin Palembang dan Laboratorium Biomedis dan Biomolekuler Fakultas Kedokteran Universitas Sriwijaya, pada periode Juli–Desember 2022. Subjek penelitian yang terdiagnosis endometriosis dan memenuhi kriteria inklusi dan eksklusi, dilanjutkan pemeriksaan histopatologis untuk mengukur derajat penyakit sesuai rASRM. Dengan menggunakan sampel yang sama dilakukan penilaian kadar CYP19 melalui pemeriksaan enzyme linked immunosorbent assay (ELISA). Analisis statistik univariat dan bivariat dilakukan untuk melihat hubungan tersebut. Hasil: Penelitian ini melibatkan 37 subjek dengan rentang usia 20–48 (Median: 32 tahun). Pada penelitian, terdapat hubungan yang bermakna antara derajat nyeri VAS endometriosis terhadap derajat endometriosis (p<0,001). Selain itu, walaupun ditemukan adanya ekspresi CYP19 pada jaringan endometrium ektopik, namun tidak terdapat hubungan yang bermakna antara tingkat kadar CYP19 pada jaringan dengan derajat VAS score dismenorea (p=0,618) dan derajat ASRM endometriosis (p=0,604).Kesimpulan: Tidak terdapat hubungan bermakna antara kadar CYP19 dengan derajat nyeri VAS maupun derajat ASRM endometriosis pada pasien.Kata kunci: ASRM, Kadar CYP19, Endometriosis
CA-125 sebagai Prediktor Sitoreduksi pada Pasien Kanker Ovarium Tipe Epitel Bagja Dumas Darwizar; Gatot Nyarumenteng Adipurnawan Winarno; Jusuf Sulaeman Effendi
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.266

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui apakah CA-125 dapat menjadi prediktor yang baik untuk sitoreduksi pada kanker ovarium tipe epitel.Metode: Desain penelitian ini adalah cross sectional dengan pemeriksaan pasien yang diduga memiliki tumor ganas ovarium, pemeriksaan kadar CA-125 pre operasi dan jenis sitoreduksi pasca operasi. Sitoreduksi optimal dipertimbangkan jika sisa tumor terbesar berdiameter <1 cm. Nilai p numerik diuji dengan uji T tidak berpasangan jika data berdistribusi normal dengan uji alternatif Mann Whitney jika data tidak berdistribusi normal. Data kategorik nilai p dihitung berdasarkan uji Chi-Square dengan alternatif Kolmogorov Smirnov dan uji Exact Fisher jika persyaratan Chi-Square tidak terpenuhi. Nilai diagnostik CA-125 dievaluasi dan nilai cut-off optimal ditentukan. Analisis ROC digunakan untuk menentukan nilai cut-off CA-125 yang optimal. Data yang diperoleh direkam dalam bentuk khusus kemudian diolah dengan SPSS versi 25.0 for windows. Pasien yang dikumpulkan sesuai dengan kriteria selama masa penelitian adalah 109 pasien.Hasil: Ditemukan bahwa nilai rata-rata CA-125 untuk kelompok sitoreduksi suboptimal lebih tinggi dibandingkan dengan kelompok sitoreduksi optimal (1157,63±2105,196 vs 237,53±319,432), yang signifikan secara statistik, p=0,0001 (nilai p<0,05). Cut off point CA-125 dalam penelitian ini adalah 248,55 dengan nilai sensitivitas 73,2%, nilai spesifisitas 73,6%, nilai prediksi positif 74,5%, nilai prediksi negatif 72,2%, dan akurasi 73,3%. Kesimpulan: Data kami menunjukkan bahwa CA-125 pre-operasi adalah prediktor sedang untuk sitoreduksi yang optimal.CA-125 as A Cyoreduction Predictor in Patient with Epithelial Ovarian CarcinomaAbstract Objective: This study aims to determine whether CA-125 can be a good predictor of cytoreduction in epithelial ovarian carcinoma.Method: Cross sectional study by examining patients suspected of ovarian malignancy, checking for their preoperative CA-125 levels and post operative type of cytoreduction. Optimal cytoreduction was considered if the largest residual tumor was <1 cm in diameter. Numerical p value is tested by unpaired T test if the data is normally distributed with the alternative Mann Whitney test if the data is not normally distributed. The p value categorical data is calculated based on the Chi-Square test with the alternative Kolmogorov Smirnov and Exact Fisher tests if the requirements of the Chi-Square are not met. The diagnostic value of the CA-125 is evaluated and the optimal cut-off value is determined. The ROC analysis was plotted to determine the optimal cut-off of CA-125. The data obtained is recorded in a special form and then processed with SPSS version 25.0 for windows. Patients collected during the study period were 109 patients. Results: It was found that mean value of CA-125 for suboptimal cytoreduction group was higher than optimal cytoreduction (1157.63±2105.196 vs 237.53±319.432), which is statistically significant, p = 0.0001 (p value <0.05). CA-125 cut off point in this research was 248.55 with sensitivity value of 73.2%, specificity value of 73.6%, the positive predictive value 74.5%, the negative predictive value 72.2% and its accuracy 73.3%. Conclusion: Our data indicate that preoperative CA-125 is moderate predictor for optimal cytoreduction.Key words: CA-125, cytoreduction, Epithelial Ovarian Carcinoma, Predictor
Correlation of Leucine-Rich-α-2-Glycoprotein- 1 (LRG-1) Level in Urine with Cervical Cancer Stage, Histology Type and Histology Grading Prilly Astari; Syahrul Rauf; Elizabet C. Jusuf; St. Maisuri T Chalid; Sharvianty Arifuddin; Retno B Farid
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.489

Abstract

Objective: To determine if the level of LRG-1 in urine correlates with cervical cancer stage, histology type and histology gradingMethod: This cross-sectional study using ELISA to test urinary LRG-1 of 59 cervical cancer patients. Data were analyzed using Kruskal-Wallis test.Results: From the total of 59 samples, LRG-1 in urine ranged from 0.48 ng/mL to 170.43 ng/mL, with median value 58.42 ng/mL. A median value of 21.42±52.29 ng/mL was found in the urine at early stage and 115.32±59.36 ng/mL at advanced stage. Most patients had cervical cancer at advanced stage (69.4%), squamous cell carcinoma (66.1%), and grade cannot be assessed (45.8%). Median LRG-1 levels were highest in squamous cell carcinoma (66.42±60.89 ng/mL) and poorly differentiated (127.74 ±54.13 ng/mL). LRG-1 levels were significantly correlated with cervical cancer stage (p-value=0.045) but not histological type (p-value=0.940) or histopathological grade (p-value=0.488).Conclusion: The more advanced the cervical cancer stage, the more elevated urinary LRG-1 levels. LRG-1 contributes to angiogenesis and antiapoptotic processes in cancer. Further studies are required to identify and evaluate LRG-1 in urine as an important biomarker for making clinical decisions and developing potential treatments.Hubungan Kadar Protein Leucine-Rich-α-2-Glycoprotein-1 (LRG-1) Urine dengan Stadium, Tipe Histologis, dan Derajat Diferensiasi Kanker ServiksAbstrakTujuan: Untuk mengetahui hubungan kadar LRG-1 dalam urine dengan stadium, tipe histologis, dan derajat diferensiasi kanker serviks.Metode: Studi ini menggunakan desain penelitian cross-sectional pada 59 perempuan yang telah didiagnosis kanker serviks, kemudian diperiksa kadar protein LRG-1 dalam urine dengan metode ELISA. Uji statistik menggunakan Kruskal Wallis. Hasil: Dari total 59 sampel didapatkan kadar LRG-1 dalam urine terendah 0,48 ng/mL dan tertinggi 170,43 ng/mL, nilai median 58,42 ng/mL. Nilai median pada stadium awal 21,42±52,29 ng/mL dan stadium lanjut 115,32±59,36 ng/mL. Lebih banyak penderita mengalami kanker serviks pada stadium lanjut (69,4%), tipe histopatologis Squamous Cell Carcinoma (66,1%), derajat diferensiasi tidak dapat ditentukan (45,8%). Median tertinggi kadar LRG-1 pada tipe Squamous Cell Carcinoma (66,42±60,89 ng/mL), dan derajat diferensiasi yang buruk (127,74±54,13 ng/mL). Terdapat hubungan yang signifikan antara kadar LRG-1 dan stadium kanker serviks (nilai p = 0,045), tetapi tidak dengan tipe histologis (nilai p=0,940) dan derajat diferensiasi (nilai p=0,488).Kesimpulan: Semakin tinggi stadium maka semakin tinggi kadar protein LRG-1 dalam urine. LRG-1 berperan dalam proses angiogenesis dan antiapoptosis pada kanker. Diperlukan penelitian lebih lanjut agar identifikasi dan evaluasi biomarker LRG-1 urine dapat menjadi penanda penting yang membantu dalam pengambilan keputusan klinis, serta pengembangan terapi.Kata Kunci: Derajat diferensiasi, Kanker serviks, LRG-1, Stadium, Tipe histologis
COVID-19 Infection in Pregnancy Increases Length of Hospitalization and Need for Postpartum Intermediate Care Slamet Susanto; Zulvayanti Zulvayanti; Windi Nurdiawan; Djamhoer Martaadisoebrata; Hadi Susiarno
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.528

Abstract

Objective: To find the prevalence and the outcomes of pregnant women with COVID-19 infection. Method: This was a cross-sectional study. The subjects were selected by total sampling. All pregnant women with COVID-19 infection and without COVID-19 infection who gave birth at Harapan Mulia Hospital from June 1, 2020 to August 31, 2021 with complete medical record data were recruited.Results: The average age of the patients with COVID-19 was 29.10 ± 7.325 years and the average age of the patients without COVID-19 was 29.24 ± 7.021 years. The average gestational age of pregnant women with COVID-19 was 37.52 ± 1.978 weeks and without COVID-19 was 38.14 ± 1.718 weeks. From the results of the statistical test of maternal outcomes, it was obtained that the P value for the length of hospitalization and type of treatment room after delivery was < 0.05, while the other variables were >0.05. For perinatal outcome analysis, from the results of statistical tests, it was obtained that P values for all variables were >0.05. Conclusion: There are differences in maternal outcomes and no differences in perinatal outcomes between pregnant women with COVID-19 and pregnant women without COVID-19 infection.Infeksi COVID-19 pada Kehamilan Meningkatkan Lama Rawat Inap dan Kebutuhan Ruang Intermediate Pasca PersalinanAbstrakTujuan: Mengetahui besarnya prevalensi dari ibu hamil dengan infeksi COVID-19 serta luarannya di RS Harapan Mulia BekasiMetode: analitik cross-sectionalHasil: Perbandingan demografi kelompok Ibu hamil dengan COVID-19, rata-rata usia pasien adalah 29,10 ± 7,325 tahun dan non COVID-19 29,24 ± 7,021 tahun. Rata-rata usia kehamilan ibu hamil dengan COVID-19 adalah 37,52 ± 1,978 minggu dan non COVID-19 adalah 38,14 ± 1,718 minggu. Dari hasil uji statistik luaran maternal, diperoleh nilai P pada lama perawatan dan jenis perawatan setelah persalinan lebih kecil dari 0,05 (nilai p < 0,05), sementara variabel lainnya lebih besar dari 0,05 (nilai p>0,05). Untuk analisis luaran perinatal, dari hasil uji statistik diperoleh nilai P pada semua variabel lebih besar dari 0,05 (nilai  >0,05). Kesimpulan: Terdapat perbedaan luaran maternal dan tidak didapatkan perbedaan luaran perinatal antara kelompok ibu hamil dengan COVID-19 dan non COVID-19.Kata kunci: infeksi COVID-19, luaran maternal, luaran perinatal
Hubungan antara Kisspeptin-10 dan Preeklamsia Berat Dwi Arry Wibowo; Nusratuddin Abdullah; Isharyah Sunarno; Andi Nursanty Padjalangi; Upik A. Miskad
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.487

Abstract

Tujuan: Menganalisis perbandingan ekspresi KISSPEPTIN-10 antara pasien tidak preeklamsia, preeklamsia berat, dan preeklamsia berat dengan komplikasi.Metode: Penelitian ini menggunakan desain kontrol kasus yang dilakukan pada ibu hamil preeklamsia berat dengan dan tanpa komplikasi sebagai kelompok kasus dan ibu hamil tidak preeklamsia berat sebagai kontrol di RSUP dr. Wahidin Sudirohusodo dan rumah sakit jejaring Fakultas Kedokteran Universitas Hasanuddin. Pengambilan sampel dilakukan dengan consecutive sampling. Kriteria inklusi yaitu ibu hamil dengan preeklamsia berat dan preeklamsia berat dengan komplikasi. Kriteria eksklusi yaitu pasien dengan hipertensi kronik, penyakit tiroid, dan penyakit ginjal sebelum kehamilan dan plasenta previa. Ekspresi KISSPEPTIN-10 diukur secara imunohistokimia dari plasenta saat melahirkan. Data dianalisis dengan uji chi square dan uji Kruskal Wallis. Data dianalisis dengan program SPSS.Hasil: Hasil ini diperoleh 88 subyek penelitian yang terdiri atas 30 pasien kelompok tidak preeklamsia, 30 pasien kelompok preeklamsia berat dan 28 pasien kelompok preeklamsia berat dengan komplikasi. Ekspresi KISSPEPTIN-10 berbeda signifikan antara kelompok tidak preeklamsia berat, preeklamsia berat, dan preeklamsia berat dengan komplikasi (p<0,05).Kesimpulan: Semakin tinggi ekspresi KISSPEPTIN-10 sejalan dengan semakin beratnya derajat preeklamsia berat. Relationship between Kisspeptin-10 and Severe PreeclampsiaAbstractObjective: To analyze the comparison of KISSPEPTIN-10 expression between severe preeclampsia and severe preeclampsia with complications.Method: This study used a case control design which was carried out in pregnant women with severe preeclampsia with and without complications as the case group and pregnant women without severe preeclampsia as a control at Dr. Wahidin Sudirohusodo and the Hasanuddin University Faculty of Medicine network hospital. Sampling was done by consecutive sampling. The inclusion criteria were pregnant women with severe preeclampsia and severe preeclampsia with complications. Exclusion criteria were patients with chronic hypertension, thyroid disease and kidney disease before pregnancy and placenta previa. KISSPEPTIN-10 expression was measured immunohistochemically from the placenta at delivery. Data were analyzed with the chi square test and the Kruskal Wallis test. Data were analyzed with the SPSS program.Results: This result founded 88 subjects consisting of 30 patients in the non-preeclampsia group, 30 patients in the severe preeclampsia group and 28 patients in the severe preeclampsia group with complications. KISSPEPTIN-10 expression differed significantly between groups without severe preeclampsia, severe preeclampsia and severe preeclampsia with complications (p<0.05). Conclusion: The higher the KISSPEPTIN-10 expression is in line with the more severe the degree of preeclampsia. Key words: Complications, KISSPEPTIN, Severe Preeclampsia
Karakteristik Karsinoma Ovarium Pra-Menopause dengan Kadar CA 125 ≤200 U/mL di RSUP Dr. Hasan Sadikin Bandung dari Tahun 2019–2021 Yudi Mulyana Hidayat; Eunike Febe Febriani; Ali Budi Harsono; Gatot N. A. Winarno; Andi Kurniadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.491

Abstract

Tujuan: Mendeskripsikan karakteristik karsinoma ovarium pra-menopause dengan kadar CA 125 ≤ 200 U/mL di RSUP Dr. Hasan Sadikin Bandung dari tahun 2019 sampai 2021.Metode: Penelitian deskriptif ini menggunakan metode total sampling dari data sekunder pasien kanker ovarium yang memenuhi kriteria inklusi dan memiliki variabel lengkap.Hasil: Penelitian yang melibatkan 32 sampel ini, menunjukkan nilai rata-rata CA 125 sebesar 82,63 U/mL dengan interval 3,3–194,8 U/mL. Mayoritas pasien berada pada rentang usia 40–49 tahun (40,6%), sudah menikah (87,5%), berprofesi sebagai ibu rumah tangga (81,3%), dan tinggal di Kawasan Pembangunan Bandung Raya (34,4%). Sebanyak 37,5% pasien adalah nullipara dan memiliki tipe histopatologis tumor epitel mucinous. Stadium tumor terbanyak adalah stadium I (56,3%). Kebanyakan pasien menjalani surgical staging komplit sebagai terapi penyakitnya (46,8%). Kesimpulan: Sebagian besar pasien karsinoma ovarium pra-menopause dengan kadar CA 125 ≤ 200 U/mL pada tahun 2019–2021 berada pada rentang usia 40–49 tahun, sudah menikah, bekerja sebagai ibu rumah tangga, dan berdomisili di Kawasan Pengembangan Bandung Raya. Kebanyakan pasien berstatus nullipara, memiliki tumor dengan tipe histopatologis epitel mucinous, dan terdiagnosis pada stadium I. Tipe pengobatan yang paling umum ditemui adalah surgical staging komplit.Characteristics of Pre-Menopausal Ovarian Carcinoma with CA 125 Level ≤ 200 U/mL in Dr. Hasan Sadikin General Hospital Bandung From 2019–2021Abstract Objective: To describe the characteristics of pre-menopausal ovarian carcinoma patients with CA 125 Level ≤ 200 U/mL in Dr. Hasan Sadikin General Hospital Bandung from 2019 until 2021.Method: This descriptive study used the total sampling method of secondary data on ovarian cancer patients that have met the inclusion criterias and have complete variables.Results: This study involving 32 samples showed the average level of CA 125 was 82,63 U/mL with the interval of 3,3 – 194,8 U/mL. Majority of the patients were in the age range of 40 – 49 years old (40,6%), has been married (87,5%), were housewifes (81,3%), and lived in Development Area of Bandung Raya (34,4%). About 37,5% patients were nullipara and had mucinous epithelial histopatology type of tumor. The most abundant tumor stage were stage I (56,3%). Most patients had undergoing complete surgical staging for their therapy (46,8%). Conclusion: Most of pre-menopausal ovarian carcinoma patients with CA 125 level ≤ 200 U/mL  in 2019–2021 were in the age range of 40 – 49 years old, has been married, had profession as housewifes, and domiciled in Development Area of Bandung Raya. Majority of patients were nullipara, had tumor with mucinous epithelial histopatology type, and were diagnosed at the stage I. The most found therapy were complete surgical staging.Key words: ovarian cancer, CA 125, cancer antigen 125, characteristic
Achondroplasia Berulang pada Orangtua dengan Perawakan Normal: Laporan Kasus Fatima Zahra; Adhi Pribadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.479

Abstract

Achondroplasia adalah penyebab paling umum dari perawakan pendek yang tidak proporsional. Individu yang terkena memiliki pemendekan rhizomelia pada anggota badan, makrosefali, dan fitur wajah yang khas. Diagnosis achondroplasia dapat ditegakkan dengan temuan klinis dan radiografi yang khas pada sebagian besar individu yang terkena. Identifikasi varian patogen heterozigot pada FGFR3 dapat membantu menegakkan diagnosis. Kejadian rekurensi achondroplasia pada orangtua dengan perawakan normal sangat jarang terjadi. Pada presentasi kasus ini, kami melaporkan achondroplasia berulang pada orangtua dengan perawakan normal, dengan ditemukan mutasi pada gen FGFR3.Recurrent Achondroplasia in Average Stature Parents : A Case ReportAbstractAchondroplasia is the most common cause of disproportionate short stature. Affected individuals have rhizomelic shortening of the limbs, macrocephaly, and characteristic facial features. Achondroplasia can be diagnosed by characteristic clinical and radiographic findings in most affected individuals. Identification of a heterozygous pathogenic variant in FGFR3 can establish the diagnosis. Recurrent achondroplasia in average stature parents is a very rare case. In this case presentation, we report recurrent achondroplasia in average stature parents with proven mutation of FGFR3 gene mutation.Keyword: recurrent achondroplasia, FGFR3 mutation

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