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Papsmear Examination for Diagnosing PreCancer Lesion in Invisible SquamoColumnar Junction
Nuranna, Laila;
Daud, Sulaeman;
Purwoto, Gatot;
Winarto, Hariyono;
Nuryanto, Kartiwa H
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.439
Objective: To know the concealed pre-cancer lesion in women with
invisible squamo-columnar junction (SCJ) by Papsmear examination.
Method: This study was a descriptive cross-sectional design starting
from August 2014 to March 2015 at several Public Health Cares in
Jakarta. A total of 1,682 subjects were screened by Acetoacetate
Visual Inspection (AVI) examination. After the data was collected,
the process was continued by verification, editing, and coding. The
descriptive analysis showed the percentage of SCJ in age distribution,
the percentage of AVI examination based on SCJ, and the percentage
of Papsmear examination in invisible SCJ according to negative
AVI result.
Result: There were 1,484 (88.2%) women with the visible SCJ and
198 (11.8%) women with invisible SCJ. The percentage of invisible
SCJ in the menopausal women group was 122 (61,6%); meanwhile,
in the non-menopausal women group, it was 76 (38.4%). Almost
half of the percentage from visible SCJ was found in menopausal
women group 45.8% (103/225 women). The positive AVI result
was 4 (7.1%) in the menopausal women group and 52 (92.9%) in
non-menopausal women group. The result of Papsmear examination
with invisible SCJ were 197 (100%) normal.
Conclusion: Almost half of visible SCJ was found in menopausal
women group. Most of positive AVI result was found in the nonmenopausal
women group. All women with the invisible SCJ have a
normal Papsmear result.
Keywords: acetoacetate visual inspection, papsmear, pre-cancer lesion,
squamo-columnar junction
Postradical Hysterectomy Survival Rate in Early Stage Cervical Cancer Patients
Yeremia, Wesley;
Rarung, Max;
Laihad, Bismarck J
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.441
Objective: Determining the survival rate of early stage cervical cancer
patients after radical hysterectomy.
Method: A retrospective cohort study was conducted on 24 earlystage
cervical cancer patients who had performed radical hysterectomy
in Prof. dr. R.D. Kandou Hospital Manado during the period
between January 2008 and December 2010. We used Kaplan-Meier
methods to observe the survival rate.
Result: The mean age of patients in this study was 47.8 (33-63)
years old with a median of 45 years old. The largest proportion was
less than 50 years old (66.7%) and stage IIA cervical cancer (66.7%)
as the severity of cancer. Most histopathology type was the squamous
cell carcinoma (50.0%). About 70.8% patients did not have
lymph nodes metastasis and 62.5% patients did not receive adjuvant
therapy. This study revealed that 1-year, 2-year, 3-year, 4-year, and
5-year survival rate were 100.0%, 100.0%, 95.8%, 83.0%, 70.8%;
respectively.
Conclusion: The survival rate of early stage cervical cancer afte[Indones J Obstet Gynecol 2016; 4-3: 164-169]
Keywords: cervical cancer, radical hysterectomy, survival rate
Phosphatase Regenerating Liver3 and ECadherin Expression in Epithelial Ovarian Cancer
Maharani, Risma;
Rauf, Syahrul;
Masadah, Rina
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.442
Objective: To determine the expression of Phosphatase Regenerating
Liver-3 (PRL-3) and E-Cadherin in the epithelial ovarian cancer
on various stages and differentiation grades.
Method: This was a cross-sectional study design conducted at
Obstetrics and Gynecology Department of several teaching hospitals,
Faculty of Medicine Universitas Hasanuddin from January
to June 2015. The expression of PRL-3 and E-cadherin was
assessed immunohistochemically in 40 patients with epithelial
ovarian cancer including 15 patients in early stage and 25 patients
in advanced stage. We used the Fisher’s exact test with the
significance of p0.05). The significant difference was
found in the expression of E-cadherin whereas the high expression
was shown at early stage than advanced stage (p0.05). This study also pointed out no
correlation between the expression of PRL-3 and E-cadherin in
epithelial ovarian cancer (p>0.05).
Conclusion: PRL-3 overexpression does not decrease E-cadherin
expression in epithelial ovarian cancer.
Keywords: E-cadherin, epithelial ovarian cancer, PRL-3
The Prevalence and Risk Factors of Stress Urinary Incontinence in Postpartum
Pratiwi, Renny;
Suparman, Eddy;
Lengkong, Rudy A
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.438
Objective: To know the incidence of stress urinary incontinence in
postpartum and determine the relationship among age, parity, infant
birth weight, mode of delivery, episiotomy and perineum rupture.
Method: This study used cross sectional analytic design. Qualified
subjects from inclusion criteria were interviewed by researchers
using pre-defined MESA questioner. Subjects with stress urinary
incontinence were found from the questionnaire result. The acquired
data was measured and analyzed using SPSS v. 22.0 software and
discussed using available literature.
Result: From 162 subjects, 36 cases (22.22%) had stress urinary
incontinence, 47.22% aging ? 35 years old, 72.22% had multiple
pregnancies, 88.89% had per vaginal delivery. Using multivariate
logistic regression test, we found there was a relationship between
stress urinary incontinence with age and parity (p 35 years old and multiple parities.
Keywords: multiple parities, post-partum, stress urinary incontinence
Characteristics of Maternal Mortality Cases in a Tertiary Hospital
Junita Indarti;
Ferry Y Irawan
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.431
Objective: To identify the characteristics of maternal mortality cases in a tertiary hospital in Jakarta, including socio-demographic characteristics, previous medical and obstetric history, and patient’s clinical condition on arrival at the hospital. Method: This was a survey to identify the descriptive data of maternal mortality cases through medical records during study period. Manual review of 51 medical records was conducted for 2 years from January 2013 to December 2014 in Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital (RSCM). Result: Of 51 cases of maternal deaths, 46 subjects (90.19%) had nine years of minimum education background. There were two subjects less than 21 years old and another was 42 years old. None of these subjects were using intrauterine device (IUD) or implant as the contraceptive methods where 66.6% subjects with underlying disease never used contraception. Ninety-two percent of subjects did antenatal care (ANC) regularly and 80.4% (41 subjects) of them was done in midwives. There were 14 subjects (29.78%) who had ANC in the first trimester of pregnancy. Severe preeclampsia is the most prevalent complication in pregnancy (26 subjects, 65%), which all (100%) patients arrived at RSCM with HELLP Syndrome. Therefore, preeclampsia was the leading cause of death in RSCM. Conclusion: The characteristics of maternal death in RSCM are prevalent in the group of 25-34 years old with the high school as the educational background. Most of them are multiparity and do not use the long-term contraceptive methods. Preeclampsia is the major cause of maternal death in RSCM. Keywords: maternal mortality, risk factors, tertiary hospital
Maternal and Fetal Outcome on Pregnancy in Advanced Maternal Age
Sianty Dewi;
Ferry Ferry;
Eddy Toynbee;
Sandhy Prayudhana
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.432
Objective: Pregnancy in advanced maternal age (AMA) was classified as high risk. The study aims to provide a better description of pregnancy outcome in AMA. Method: The cross sectional study was to review the demography, medical and obstetrics problems, mode of delivery, maternal and fetal outcome in Tangerang General Hospital as a referral center in Banten. The data were taken from medical records of 35-year-old and above women age who delivered on the period of January to December 2014. Result: The total number of delivery and live birth was 6,107 and 5,926 respectively, including 1,548 (25.36%) pregnancies in AMA. The prevalence of grandmultiparities was 11.4%. The average education level was mostly elementary. The prevalence of hypertension in pregnancy was 34.6%. There was increasing trend of miscarriages from 10.8% in 35-40-year-old group to 25% in above 45- year-old group. Pregnancy complications were higher consisting of 3.2% multifetal, 16.6% malpresentation, and 7.1% placenta previa. Cesarean section rate was 33.6%. Maternal near-missed cases were 56 of 1000 and the maternal mortality rate (MMR) was 932 of 100,000 live births. The prevalence of stillbirth and perinatal mortality were 5.3% and 12.9%; respectively. Conclusion: Adverse maternal and fetal outcome were higher in AMA as it takes special attention and multidiscipline-approached care started from preconception, antenatal, preparation of delivery, and also postpartum care. Keywords: advanced maternal age (AMA), fetal outcome, maternal outcome, pregnancy
Heme Oxygenase1 Level in Normotensive Pregnancy and Preeclampsia with Severe Features
Christian Homenta;
John J Wantania;
Juneke J Kaeng
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.433
Objective: To understand the relationship of heme oxygenase-1 (HO-1) level between normotensive pregnancy and preeclampsia with severe features. Method: The cross sectional study was conducted in the Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sam Ratulangi/Prof. Dr. R. D. Kandou General Hospital Manado. The subjects consisted of 26 pregnant women with normal blood pressure and 26 women with severe features of preeclampsia. We took the patients’ history, general physical examination, and laboratory assessment. The blood samples were taken from normotensive women more than 20 weeks of pregnancy and preeclamptic women with severe features more than 20 weeks of pregnancy. The data obtained was processed using SPSS 20.0 software. We did the nonparametric Mann-Whitney test to analyze the relationship between heme oxygenase-1 (HO-1) level in normotensive pregnancy and preeclampsia with severe features. Result: The level of heme oxygenase-1 (HO-1) in normotensive pregnant women was at 3.24 (SD 0.58) ng/ml (95% CI 3.00-3.47), and the level of heme oxygenase-1 (HO-1) of preeclamptic women with severe features was 3.92 (SD 0.73) ng/ml (95% CI 3.62-4.21). The result of Mann-Whitney test showed p value of 0.001 which meant that there was significant difference in the level of heme oxygenase- 1 (HO-1) between normotensive women and pre-eclamptic women with severe features. Conclusion: There was the relationship between the level of heme oxygenase-1 (HO-1) and the incidence of preeclampsia with severe features. Keywords: heme oxygenase-1 (HO-1), normotensive pregnancy, preeclampsia with severe features
Cystatin C Serum Level and the Severity of Preeclampsia
Abraham Winarto;
Eddy Suparman;
John Wantania
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.434
Objective: Determining the cystatin C serum level among normotensive, mild preeclamptic, severe preeclamptic pregnant women and their relationship with the severity of preeclampsia. Method: The study was held using cross sectional design in Prof. Dr. RD Kandou Hospital in Manado and its network hospitals. We did on 51 samples at term pregnant women, consisting of 17 samples for each group in normotensive, mild preeclampsia, and severe preeclampsia. The data were analyzed using SPSS version 22.0 software through ANOVA and Kruskal Wallis statistical test. Result: The mean cystatin C serum concentration in normotensive pregnant women, mild preeclampsia, and severe preeclampsia were 0.82 mg/l, 1.03 mg/l, and 1.32 mg/l; respectively. The ANOVA statistical test showed the significant association between cystatin C level and severity of preeclampsia (p
Classic Antiphospholipid and Antiphosphatidylserine Antibody Profile in Suspected Antiphospholipid Antibody Syndrome Patient
Angga J Suryadi;
Kanadi Sumapradja
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology
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DOI: 10.32771/inajog.v4i3.435
Objective: To compare the classic examination results of antiphospholipid (aPS) and antiphospatidylserine (aPL) antibody profile to establish the diagnosis from suspected antiphospholipid antibody syndrome (APS) patient in order to state the subsequent treatment strategies. Method: This descriptive cross-sectional study design was conducted at outpatient clinics of Dr. Cipto Mangunkusumo Hospital (RSCM) from January to December 2015. The laboratory test was held in Clinical Pathology Laboratory RSCM/Faculty of Medicine Universitas Indonesia (FKUI) and in corporation with Prodia laboratory. Result: All of normal patients did not have positive result in any laboratory examination (Lupus Anti-coagulant (LA), anticardiolipin (aCL), anti-?2 glycoprotein I (anti-?2GPI), and aPS). In patient suspected APS, 11 (37.1%) patients had positive aCL, 7 (25.9%) patients had positive anti-?2GPI, and 11 (37.1%) patients had positive aPS. The most positive cross laboratory examination was between aCL and aPS (25.9%). In this study, we found the most positive test result was aCL and aPS (62.9%). From this study, suspected APS patient who had negative result in classic laboratory examination, but showing the positive result in aPS was in 5 (18.5%) patients. Conclusion: All normal pregnant patients do not have any positive classic examination and aPS. Meanwhile, in patients with suspected APS, less than 20% patients show positive result of aPS with negative result in classic laboratory examination. Keywords: antiphospatidylserine, antiphospolipid syndrome