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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,760 Documents
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A Randomized FiveYear Comparative Study of Two LevonorgestrelReleasing Implant Systems: Norplant® Capsules and Jadena® Rods Affandi, Biran; Ridwan, Rusdi S; Hoesni, R Hasan M; Tandjung, Thamrin; Ichsan, TM; Amran, Rizani; Manan, Heriyadi; Gunardi, Eka R; Pramana, Noor; Hadiyono, Suryo; Widohariadi, Widohariadi; Farid, Retno B; Taher, Mardiah
Indonesian Journal of Obstetrics and Gynecology Volume 4, No. 4, October 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.478 KB) | DOI: 10.32771/inajog.v4i4.447

Abstract

Objective: To provide a randomized comparison between Jadena® and Norplant® in terms of efficacy and acceptability among Indonesian women. Method: This study was a phase IV, open label, randomized, multicenter study throughout Indonesia. Subjects were Indonesian adult women who were randomized to receive Jadena® or Norplant® as their contraceptive method. The subjects were recruited from 6 large cities in Indonesia, such as Medan, Palembang, Jakarta, Semarang, Surabaya, and Makassar. Result: Of 600 subjects, 301 women getting to Jadena® and 299 women to Norplant® were enrolled between August 1998 and February 1999. The mean age was 29.8 (SD 5.3) years old, ranging from 18 to 40 years old. We did not find the pregnancy during the study. Non-pregnancy probability at the end of one year was similar between Jadena® (0.920 (SD 0.016)) and Norplant® users (0.916 (SD 0.084)). The continuation rates of Jadena® at one and three-year were 95.3% and 66.8%; whereas, the continuation rates of Norplant® was 94.3% at year-1 and 70.2% at year-3. Conclusion: The new two rod levonorgestrel subdermal system (Jadena®) showed similar efficacy with the old six capsule levonorgestrel subdermal system (Norplant®) in term of birth control. Both implant systems also have similar tolerability profile. Jadena® is easier to insert and remove than Norplant®. Keywords: birth control, efficacy, implant
Pemeriksaan Antigen pp65 dan mRNA pp67 Cytomegalovirus (CMV) Pada Wanita Hamil dengan IgG anti-CMV positif di RSUPN Dr. Cipto Mangunkusumo, Jakarta UTAMI, T. W.; HESTIANTORO, A.; BUSTAMI, A.; SURJANA, E. J.
Indonesian Journal of Obstetrics and Gynecology Volume. 30, No. 4, October 2006
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.854 KB)

Abstract

Tujuan: Mengetahui proporsi seropositif CMV pada wanita hamil dengan riwayat abortus dan gambaran hasil pemeriksaan antigen pp65 CMV, mRNA pp67 CMV, serta kesesuaiannya pada wanita hamil dengan IgG anti-CMV yang positif. Rancangan/rumusan data: Studi deskriptif. Kesesuaian hasil pemeriksaan antara antigen pp65 dan mRNA pp67 CMV dinilai dengan menghitung nilai kappa (k). Tempat: (1) IGD lantai III dan Poliklinik kebidanan dan kandungan RSUPN Dr. Cipto Mangunkusumo Jakarta, (2) Bagian Mikrobiologi dan (3) Makmal Terpadu Imunoendokrinologi Fakultas Kedokteran Universitas Indonesia, Jakarta. Bahan dan cara kerja: Sampel berasal dari darah wanita hamil dengan riwayat abortus dan darah tali pusat janin yang dilahirkan. Pemeriksaan IgM dan IgG CMV dilakukan dengan metode ELISA, pemeriksaan antigen pp65 CMV dengan teknik imunohistokimia, dan pemeriksaan mRNA pp67 CMV dengan teknik NASBA. Hasil: Selama kurun Januari - Juni 2005, terkumpul 50 sampel yang berasal dari 25 subjek; terdiri dari 25 darah ibu dan 25 darah janin. Seluruh (100%) wanita hamil dengan riwayat abortus dalam penelitian ini memberikan hasil IgG antiCMV yang positif. Tidak ada subjek dengan IgM anti-CMV yang positif. Pada pemeriksaan antigen pp65 CMV terdapat 6% hasil yang positif, yaitu 2% dari sampel ibu dan 4% sampel tali pusat. Tidak terdapat hasil yang positif pada pemeriksaan NASBA mRNA pp67 CMV. Terdapat 26% sampel, yaitu 12% sampel ibu dan 14% sampel janin dengan hasil mRNA pp67 CMV tidak dapat ditentukan. Kesimpulan: Proporsi seropositif IgG anti-CMV pada wanita hamil dengan riwayat abortus dalam penelitian ini adalah sangat tinggi. Pada pemeriksaan antigen pp65 CMV terdapat 6% hasil yang positif. Tidak ada hasil mRNA pp67 CMV yang positif. Penelitian ini menunjukkan bahwa pada individu yang imunokompeten, jarang sekali terjadi reaktivasi sehingga risiko infeksi CMV kongenital adalah kecil. Dalam penelitian ini tidak terdapat kesesuaian hasil antara pemeriksaan antigen pp65 dan NASBA mRNA pp67 CMV, dengan nilai kappa 0%. [Maj Obstet Ginekol Indones 2006; 30-4: 203-12] Kata kunci: antigen pp65, mRNA pp67 CMV, IgG anti-CMV, wanita hamil, riwayat abortus.
The Number of Vaginal Epithellial and Neutrophil Strongly Correlates with the Occurrence of Premature Delivery Sandra, Alia
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.487 KB)

Abstract

Objective: To investigate the relationship of the amount of vagina epithelia and neutrophil with premature delivery. The study was carried out in several hospitals at Obstetrics and Gynecology Department of the Faculty of Medicine Hasanuddin University, from September 2011 to January 2012. Methods: The study was cross-sectional study involving two groups of sample: premature delivery group fulfilling inclusive criteria and a control group of normal delivery. The total samples are 48 persons, comprising of 16 premature deliveries, and 32 normal pregnancy. Result: The study revealed that there was a significant correlation between ≥1 parity and premature delivery (p
Identifying Causes of Vaginal Discharge: The Role of Gynecologic Symptoms and Signs Hasan, Farhan D; Ocviyanti, Dwiana
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 1, January 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.529 KB) | DOI: 10.32771/inajog.v3i1.17

Abstract

Abstract Objective: To attain diagnostic accuracy of various gynecologic symptoms and signs in identifying causes of vaginal discharge. Method: Eighty-two subjects were included in this cross sectional study. Gynecologic symptoms and signs were inquired from each subject and further laboratory examinations were carried out to identify the etiology. Diagnostic accuracy for each symptom and sign was compared to the laboratory examination as the standard reference. Symptoms and signs with positive predictive value (PPV) of more than 50% were considered to have good diagnostic accuracy. Result: For bacterial vaginosis, excessive wetness in genital area; vulvar maceration; and thin, turbid, yellowish vaginal discharge had PPVs of 53%; 52%; and 52%, respectively. For candidal vaginitis, vulvar maceration; and white, curd-like vaginal discharge had PPVs of 58% and 100%, respectively. For trichomoniasis, thin, turbid, frothy, yellowish vaginal discharge; and strawberry-cervix appearance had PPVs of 60% and 100%, respectively. There were no symptoms or signs with PPV of more than 50% for chlamydial cervicitis. Diagnostic accuracy for clinical findings in gonorrheal cervicitis could not be calculated due to the small number of subjects. Conclusion: Various gynecologic symptoms and signs were found to be accurate in diagnosing bacterial vaginosis, candidal vaginitis, and trichomoniasis. No symptoms or signs were considered accurate to aid etiological diagnosis for chlamydial and gonorrheal cervicitis. Keywords: bacterial vaginosis, Candida sp, Chlamydia trachomatis, gynecologic symptoms and signs, Neisseria gonorrhoeae, Trichomonas vaginalis
Antioxidant Milk Supplementation in Pregnancy: A Study of Retinol Binding Protein and Angiogenic Factors in Preeclampsia Hutabarat, Martina
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 3, July 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.919 KB)

Abstract

Objectives: To assess the role of retinol supplementation in the process of angiogenesis in preeclampsia. Methods: The research was a double blind randomized clinical trial conducted Dr. Cipto Mangunkusumo Hospital outpatient clinic since January 2009 - December 2010. Samples were analyzed in Prodia Laboratory and Showa University in Tokyo, Japan. Subjects were tested in trimester 1, 2 and 2 weeks after delivery. During pregnancy subjects were given pregnancy milk supplements available on the market which had and that has been retinol fortified. Bivariate and multivariate analysis were performed of which retinol milk feeding, retinol binding protein (RBP) level, and level of angiogenic factors as independent variables and preeclampsia acted as the dependent one. Results: One hundred four study subjects were divided into a control group of 55 and treatment of 49. Incidence of preeclampsia in this study was is 8.7% from which 8 persons (14.5%) came from the control group and 1 person (2%) from the treatment group. Characteristics of the two groups were equivalent. RBP levels obtained in the treatment group was lower than the control group, while in the subjects with preeclampsia the RBP level was higher than the group without preeclampsia. Correlation between the level of RBP with angiogenic factors showed no significant relationship except for the level of PlGF (p=0.036) which had a weak correlation (r=0.206). The level of angiogenic factors in the treatment group showed lower result than the control group whereas among the subjects with preeclampsia angiogenic factor levels were always higher than without preeclampsia. With multivariate analysis we found that significant factors associated with preeclampsia was sFlt-1 levels (p=0.004) and sFlt-1/PlGF ratio (p=0.017). Conclusions: Providing milk supplements can reduce the levels of retinol (RBP), and antiangiogenic factors, but does not significantly increase proangiogenic factor level. Assuming there is no problem with the process of angiogenesis provision of retinol-fortified milk can reduce the incidence of preeclampsia. However, further research with a larger scale is needed. [Indones J Obstet Gynecol 2011; 35-3:100-4] Keywords: retinol-fortified milk, RBP level, sFlt-1 level, sEng level, PlGF level, preeclampsia
Deteksi human papilloma virus (HPV) tipe 16 dan tipe 18 dengan teknik polymerase chain reaction (PCR) dan hibridisasi dot blot dengan pelacak DNA berlabel biotin ROSILAWATI, M. L.; BELA, B.; INDARTI, J.
Indonesian Journal of Obstetrics and Gynecology Volume. 31, No. 4, October 2007
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.024 KB)

Abstract

Tujuan: Menerapkan teknik PCR-hibridisasi dot blot dengan pelacak DNA berlabel biotin untuk mendeteksi HPV tipe 16 dan 18 pada spesimen swab dan biopsi jaringan serviks. Rancangan/rumusan data: Penelitian ini bersifat deskriptif. Bahan dan cara kerja: Sampel yang digunakan dalam penelitian ini adalah spesimen swab dan biopsi serviks berjumlah 124 spesimen. Ekstraksi DNA sampel dilakukan dengan metode Boom dan QIAAmp DNA Mini Kit (Qiagen). Amplifikasi DNA dengan teknik PCR menggunakan primer PGMY11 dan PGMY09, dilaksanakan untuk mendeteksi infeksi HPV. Tipe HPV-16 dan tipe 18 dideteksi dengan teknik hibridisasi dot blot dari produk PCR dengan pelacak DNA berlabel biotin. Hasil: Dari 124 spesimen, 18 spesimen (15%), menunjukkan hasil PCR positif HPV dan dari hasil positif PCR tersebut, 7 spesimen menunjukkan hasil hibridisasi dot blot negatif sehingga dapat dinyatakan spesimen tersebut terinfeksi dengan tipe HPV risiko tinggi lainnya atau risiko rendah. Hasil positif hibridisasi dot blot terlihat pada 24 spesimen (19%) yaitu 20 spesimen (16%) terinfeksi HPV-16 dan 4 spesimen (3%) terinfeksi HPV-18. Dari 20 spesimen positif HPV-16, 9 spesimen memperlihatkan hasil PCR negatif sedangkan dari 4 spesimen positif HPV- 18, 1 spesimen menunjukkan hasil negatif PCR. Hal ini membuktikan teknik PCR-hibridisasi dot blot lebih sensitif dibanding PCR-elektroforesis gel agarosa. Beberapa spesimen swab maupun biopsi pasien prakanker atau kanker memperlihatkan hasil negatif HPV-16 maupun 18. Kemungkinan faktor penyebabnya adalah selain adanya infeksi tipe HPV risiko tinggi dan virus lain juga terintegrasinya DNA HPV ke dalam DNA genom host. Berdasarkan kelompok umur, pasien dengan umur di atas 30 tahun lebih banyak terinfeksi HPV-16 maupun HPV-18. Kesimpulan: HPV dari spesimen alat genitalia dapat dideteksi dengan teknik PCR menggunakan primer PGMY11 dan PGMY09. Deteksi tipe HPV terutama HPV-16 dan HPV-18 dapat dilakukan dengan teknik PCR yang dilanjutkan dengan hibridisasi dot blot dengan pelacak DNA berlabel biotin yang merupakan metode cepat, sensitif , spesifik dan sangat efisien digunakan pada spesimen dengan jumlah banyak. Teknik ini dapat diterapkan sebagai metode deteksi dini kanker serviks secara molekuler. [Maj Obstet Ginekol Indones 2007; 31-4: 218-25] Kata kunci: PCR, hibridisasi dot blot, HPV-16, HPV-18
The Level of 8-OHdG Serum was Higher in Women with Blighted Ovum Putra, I Made Mahadinata
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.995 KB)

Abstract

Objective: To determine the difference of 8-hydroxy-2-deoxyguanocyne (8-OHdG) serum level in women experiencing blighted ovum and women with normal pregnancy. Method: This was a cross sectional study with 82 samples, divided into two groups. Thirty two cases of blighted ovum and 51 cases of normal pregnancies, with 7-12 weeks gestational age. The examination of 8-OHdG serum level, was performed with the venous blood taken from the cubiti veins, and its 8-OHdG serum quantities were than examined at the Pathology Lab. at Sanglah General Hospital. Data was analyzed with the Shapiro Wilk Test and the t independent test with alpha 0.05. Result: The average 8-OHdG serum level in women with blighted ovum and normal pregnancies were 0.177 (SD 0.06) ng/ml and 0.111 (SD 0.01)ng/ml, and significantly different (p
Husband’s Support is a Main Factor Associated with Contraceptive Practices Fernando, Darrell; Dediat, Rachmat
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 3, July 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.385 KB) | DOI: 10.32771/inajog.v3i3.40

Abstract

Objective: To determine factors associated with contraceptive practices in Palabuhanratu, West Java. Method: We conducted a cross-sectional study at the Obstetrics and Gynecologic ward of Local General Hospital of Palabuhanratu District, between March and June 2012. Data was collected using directed interview method by investigators and midwives, using non-validated questionnaires. Statistical analysis was performed using SPSS 20.0, utilizing Chi-Square test for nominal data and Kruskal-Wallis test for numerical data. Result: We obtained 71 samples. The only factors which are significant were age group of 20-35 years old (OR=3.5, 95%CI=1.1-11.1, p=0.025) and husband’s support (OR=14.67, 95%CI=1.52-141.18, p=0.012). The most recognized contraceptive methods familiar to our respondents were injection (94.4%) and pills (93.0%), and the most useful source of information on contraception was medical personnel (73.2%). Conclusion: Husband’s support is a main factor associated with contraceptive practice. The choice of contraceptive method should be adjusted according to the ability and desire of patients to prevent failures in family planning. Keywords: associated factors, contraception, husband’s support
Changes in Quality of Life Score of Patients with Pelvic Organ Prolapse after Vaginal Surgery Measured by Pelvic Floor Distress Inventory (PFDI20) and Pelvic Floor Impact Questionnaire (PFIQ7) Questionnaires Hakim, Surahman; Maharani, Cut R
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 3, July 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (91.624 KB) | DOI: 10.32771/inajog.v5i3.545

Abstract

Objective: To determine changes in the quality of life in patients with pelvic organ prolapse who had undergone vaginal surgery. Methods: Prospective cohort study, carried out in Dr. Cipto Mangunkusumo and Fatmawati during the period of July 2015 to October 2016. The quality of life of the subjects was followed up three months after undergoing vaginal surgery. We used the Indonesian version of Pelvic Floor Distress Inventory (PFDI-20) and Pelvic Floor Impact Questionnaire (PFIQ-7). Results: In this study, 25 subjects were involved. The results showed significant score reduction in the quality of life in patients treated with vaginal surgery with p < 0.05 in almost all scales except CRAIQ-7. Conclusion: There is a reduction in quality of life scores in patients treated with vaginal surgery at all scales except CRAIQ-7 with a value of p <0.05. [Indones J Obstet Gynecol 2017; 5-3: 164-167] Keywords: PFDI-20, PFIQ-7, POP, vaginal surgery
Maternal Mortality and Contributing Risk Factors Bazar, Abi
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.946 KB)

Abstract

Objectives: Maternal mortality is one indicator to assess a nation’s health care quality. This research was conducted to determine the determinant risk factors for maternal mortality. Methods: A retrospective case control study at Dr. Mohammad Hoesin General Hospital for 5 years, with 200 samples consists of 50 cases of maternal mortality and 150 physiological labor cases as control group. Results: For 5 years, there was 109 cases of maternal mortaliy. Of the 50 samples of maternal mortality cases, the most common cause were preeclampsia/eclampsia (50%), followed by hemorrhage (28%). The risk factors were categorized as distant, intermediate, and outcome factors, as stated by McCarthy et al. On bivariate analysis, we found the significance on maternal education and husband’s occupation (distant factors), residence, referral status, numbers of ANC visits, first attendant, labor facility and history of prior medical history (intermediate factors), and also modes of delivery and complications (outcome factors). On the multivariate analysis to determine the most contributing risks factors for maternal mortality, it was found that maternal education and residence were the most influencing factors for maternal mortality (OR 5.74 and 4.65 respectively; p=0.001). Conclusions: The most contributing risks factors for maternal mortality were maternal education and residence. [Indones J Obstet Gynecol 2012; 36-1:8-13] Keywords: case control study, maternal mortality, risk factors.

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