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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

Arjuna Subject : -

Articles 1,760 Documents

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KRAS and BRAF Mutation in Borderline Epithelial Type Ovarian Tumor Suardi, Dodi
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (99.322 KB)

Objective: To understand the molecular profile by identifying the mutation of KRAS and BRAF in borderline type ovarian tumor. Method: In the study, we examined paraffin tissue sample from Department of Pathology Anatomy, University of Indonesia/Dr. Cipto Mangunkususmo Hospital, Jakarta, that was diagnosed as borderline epithelial ovarian tumor. Seventeen samples were taken to Sandya Laboratory in Bandung for examination of PCR BRAF exon 15 codon 600, and KRAS in exon 2 codon 12 and 13, as well as exon 3 codon 61. Result: Mutation of KRAS occurred in 94% of subjects (serous borderline 62.5%, mucinous bordeline 37.5%), of which 70.6% mutation happened in exon 2 codon 12 (serous borderline 33.3%, mucinous borderline 66.7%), 52.9% mutation in exon 2 codon 13 (serous borderline 33.3%, mucinous borderline 66.7%), and 76.5% mutation in exon 3 codon 61 (serous borderline 30.8%, mucinous borderline 69.2%). Mutation of BRAF occurred only in 47% of subjects, but the results of Exact Fisher test showed that mutation in BRAF gave significant result, while other variables did not give significant result (p=0.009). Conclusion: Molecular pathology in borderline ovarian tumor related with BRAF mutation is more likely to occur in serous borderline type, while KRAS mutation is more likely to occur in mucinous borderline type. [Indones J Obstet Gynecol 2013; 37-2: 107-12] Keywords: borderline ovarian tumor, BRAF, KRAS

Modified Gatot Score has a better Specificity in Predicting Ovarian Malignancies Compared to Risk Malignancy Index Mansur, Shirley
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (91.403 KB)

Objective: The study was designed to evaluate the sensitivity and specificity of several methods in detecting ovarian epithelial malignancy by comparing Gatot Score and Risk Malignancy Index, and also proposing the modification of Gatot Score. Methods: Four hundred and one subjects with suspected epithelial ovarian malignancy were subjected to the study and had anamnesis, physical examinations, laboratories studies and ultrasonography performed. From the data, we took the variables according to Gatot Score and Risk Malignancy Index. We performed statistic analysis in term of sensitivity, specificity, ROC and optimal cut-off-point. Result: From 401 observation subjects, revealed that Gatot Score possess the sensitivity of 73.7% and specificity of 45.6% (p = 0.000; LR 28.830), while RMI possess the sensitivity of 72.4% and specificity of 35.94% (p = 0.02, LR 9.588) for RMI 1, and the sensitivity of 76% and specificity of 30.9% (p = 0.05; LR 7.984) for RMI 2. Modification to Gatot Score was performed by re-weighting to its all variables, which resulted in Gatot Score Modification 1 with cut-off point of 28.5, sensitivity of 60.4% and specificity of 35.94% (p= 0.000, LR 44.228) and Gatot Score Modification 2 with cut-off point of 5.75, sensitivity range between 49.3-69.6% and specificity range between 51.6-65.2% (p = 0.000; LR 36.806). Conclusion: Both Gatot Score and RMI gave unsatisfactory output in predicting the malignancy of ovary. By reassigning the weighting of all variables in Gatot Score, the sensitivity and especially the specificity was improved in detecting the malignancy of epithelial type ovary. This measure was directed for patients in reproductive ages, thus increasing the possibility of true malignancy. [Indones J Obstet Gynecol 2013; 37-2: 113-6] Keywords: Ca-125, epithelial ovary tumor, Gatot score, risk malignancy index

Serum Adiponectin Level is Lower in Patients with Endometriotic Cyst Fahdiansyah, Fahdiansyah; Anwar, Ruswana; Irianti, setyorini
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To analyse the difference of serum adiponectin level between patients with endometriotic cyst and those with non-endometriotic cyst, and its difference between endometriosis stages. Methods: This is a cross-sectional comparative analytical study involving 25 women with endometriotic cyst and 25 women with nonendometriotic cyst, which had undergone laparoscopy or laparotomy surgery. Blood samples were withdrawn and checked for serum adiponectin level in PRODIA laboratory in Jakarta. Serum adiponectin level of both groups were then measured and compared. The study was conducted in Dr. Hasan Sadikin Hospital in September- December 2012. Results: Shows no significant difference in subjects’ characteristic which are age (p = 0.994) and BMI (p = 0.267). There is a significant difference (p < 0.0001) between serum adiponectin level in endometriosis group (mean = 3.91 ± 1.976) with level of which in nonendometriosis group (mean = 8.59 ± 1.977). There is no significant difference (p = 0.384) of serum adiponectin level between stage III endometriosis (mean = 4.24 ± 1.8168) and stage IV endometriosis (mean = 3.54 ± 2.1531). Conclusion: Serum adiponectin level in patients with endometriotic cyst is significantly lower compared to level of which in patients with non-endometriotic cyst. There is no significant difference of serum adiponectin level between endometriosis stages. [Indones J Obstet Gynecol 2013; 1-3: 119-23] Keywords: adiponectin, endometriotic cyst, non-endometriotic cyst, endometriosis stage

Ki-67 Expression is Correlated with Cyst Size and Stage of Endometriosis Alif, Muhammad; Anwar, Ruswana; Pribadi, Adhi
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To analyze the association between Ki-67 expression with the cyst size and stage of endometriosis, and the correlation strength between them. Methods: A cross-sectional analytic observational study involving 56 paraffin blocks from subjects diagnosed with endometriosis, who had undergone laparotomy or laparoscopic surgery. The study is conducted in Dr. Hasan Sadikin Hospital in September-November 2012. Results: Shows a significant association between Ki-67 expression and the size of endometriotic cyst (p < 0.0001), also with a strong correlation (r = 0.55) according to Guilford criteria. There is also a significant association between Ki-67 expression and the endometriosis stage (p < 0.0001), with a strong correlation (r = 0.564) according to Guilford criteria. Conclusion: Ki-67 expression is correlated with the cyst size and stage of endometriosis. [Indones J Obstet Gynecol 2013; 1-3: 124-8] Keywords: endometriosis stage, endometriotic cyst size, Ki-67

Total Testosterone Level is Lower in Women Consuming Combined Oral Contraception with Impaired Sexual Function Amra, Yuniarty; Tumeida, Joseph L; Hartono, Edi
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: The aim of this research was to assess the relationship between total testosterone level and female sexual function based on Female Sexual Function Index (FSFI) among the acceptors of combined oral contraceptive pill. Methods: The research was conducted in BLU of Dr. Wahidin Sudirohusodo Hospital and several teaching hospitals in obstetrics and gynecology sections of Medical faculty, Hasanuddin University from October to December 2012. This study assessed sexual function among 60 women as the acceptors of combined oral contraceptive pill. Sexual function was assessed using FSFI questionnaire which had been validated in several countries. This research used cross sectional design and the sample was selected using consecutive sampling method. The data were processed using SPSS with independent t test of the significant level of 0.05. Results: The results of the research reveal that total testosterone level among the acceptors of combined oral contraceptive pill who have impaired sexual function is low. The result of the correlation test between testosterone level and FSFI score indicates a significant level (p<0.05) with a correlation coefficient of (r) = 0.737. The testosterone level of female who have impaired sexual function is significantly different (p<0.05) from women who have normal sexual function. The cut off testosterone level that could indicate the occurrence of sexual dysfunction is 12.4 ng/dl. Conclusion: The total testosterone level among the acceptors of combined oral contraceptive pill who have impaired sexual function is lower than others who have no impaired sexual function. [Indones J Obstet Gynecol 2013; 1-3: 129-33] Keywords: combined oral contraceptive pill, FSFI, sexual function, total testosterone level

Levels of Thyroid Peroxidase Antibodies is Higher in Threatened Abortion Sanjaya, I Nyoman A.; Hidayat, Syarif T
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To assess the relationship between the incidence of threatened abortion with serum levels of TPO antibodies. Methods: This was cross-sectional study involving subjects 40 cases and 40 controls. The study was conducted September 2012 to November 2012. The difference in the levels of thyroid peroxidase antibody was tested by Mann-Whitney test. Result: In this study, hypothyroidism was found only in the abortion group, as many as 6 subjects (15%) and subclinical hypothyroidism was more prevalent in threatened abortion group, found in 2 people (5%), compared to normal pregnant group, found in only 1 person (2.5%). This study revealed a significant difference in the mean levels of TPO antibodies in the threatened abortion and normal pregnancy group. The mean levels of TPO antibodies in threatened abortion group was 91.76 ± 133.18 IU/ml with the lowest level of 14.41 IU/ml and the highest levels of 534.47 IU/ml while in the normal pregnancy group found an average 12.97 ± 3.91 IU/ml with the lowest value 2.02 IU/ml and the highest value of 20.78 IU/ml. In this study, subjects with TPO antibody levels ≥ 125 IU/ml, all of them experienced threatened abortion (n = 7) and found the risk of miscarriage by 2.212-fold compared with subjects with TPO levels < 125 IU/ml. Conclusion: There are differences in the levels of TPO antibodies in patients with threatened abortion and in normal pregnancies, with average levels of TPO antibodies in imminent abortion group is higher than normal pregnancy group. There is a relationship between TPO antibody levels ≥ 125 IU/ml with the incidence of threatened abortion, with the risk of threatened abortion increasing 2.212 times. [Indones J Obstet Gynecol 2013; 1-3: 134-8] Keywords: threatened abortion, thyroid peroxidase antibody (TPO)

The Hemoglobin Levels and Hematocrit Decrement is less in Severe Preeclampsia Patients Undergoing Caesarean Section with B-Lynch as Prophylaxis Parwis, Ahmad; Anwar, Anita D; Irianti, Setyorini
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To analyze the differences between the reduction in hemoglobin and hematocrit level in severe preeclampsia patients who have had Caesarean section with and without B-Lynch prophylaxis. Method: The design of the study was an experimental analytic with Randomized Control Trial (RCT). Thirty patients who came to Dr. Hasan Sadikin Hospital, Soreang Hospital, and Cibabat Hospital during 11 July - 25 September 2012 and met inclusion criteria were selected and divided into two groups. The first group were caesarean section with B-Lynch prophylaxis, the second one were without BLynch prophylaxis. The sample were taken with simple random sampling. Each patient were examined for hemoglobin and hematocrit level before and 6 hour after C section. The data was analyzed by t-test and Mann Whitney test. Result: There were significant differences (p <0.05) on the decrease of hemoglobin and hematocrit level between patient who were performed B-Lynch prophylaxis and those who were not (7.98% vs 19.75%; p = 0.001 and 9.02% vs 18.28%, p = 0.013, respectively). Conclusion: The decreasing hemoglobin and hematocrit level before and 6 hour after C section is less in patient with severe preeclampsia who had caesarean section with B-Lynch prophylaxis compared to cesarean section without B-Lynch prophylaxis. [Indones J Obstet Gynecol 2013; 1-3: 139-44] Keywords: B-Lynch, postpartum haemorrhage, preeclampsia

Total Serum Level of Calcium and Ion Calcium is Lower in Hypotonic Uterine Inertia Wattimury, Josef; Permadi, Wiryawan; Armawan, Edwin
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To know the correlation between total and ion serum calcium level with the uterine contractility of laboring patient. Methods: This is a cross-sectional analytic correlative study measuring the strength of correlation of total and ion calcium serum level between groups with hypotonic uterine inertia - and normal labor. Each group consists of 20 subjects who met inclusion criteria and presented to Dr. Hasan Sadikin Hospital in August - September 2012. Statistical analysis was performed by using Eta (η) coefficient. Results: Mean total calcium serum level on hypotonic uterine inertia is 6.66 mg/dl, while mean of total calcium serum level on normal labor is 8.56 mg/dl, with Eta (η) correlation coefficient 0.721. Mean ion calcium serum level on hypotonic uterine inertia is 4.14 mg/dl, while mean of total calcium serum level on normal labor is 4.92 mg/dl, with Eta (η) correlation coefficient 0.802. Conclusion: Total serum level of calcium and ion calcium in hypotonic uterine inertia is lower than the level of which in normal labor. There is a strong correlation between total and ion serum calcium level with uterine contractility, the Eta (η) correlation coefficient are 0.721 and 0.802 respectively. [Indones J Obstet Gynecol 2013; 1-3: 145-8] Keywords: hypotonic uterine inertia, ion serum calcium level, normal labor, total serum calcium level

Risanto’s Formulas is more Accurate in Determining Estimated Fetal Weight Based on Maternal Fundal Height Titisar, Hanifah I; Siswosudarmo, Risanto
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To compare the accuracy of Johnson’s and Risanto’s formulas in determining estimated fetal weight based on maternal fundal height (FH). Methods: This was a cross sectional study, consisting of 655 pregnant women from Dr. Sardjito Hospital and affiliated hospital sat 37-42 weeks of gestation. Fundal height was measured from the symphisis to the top of uterine fundus, using inverted unelastic flexible tape. EFW based on Johnson’s and Risanto’s formulas were compared with the actualbirth weight. Wilcox on analysis was used for statistical analysis. Results: Mean EFW of Johnson’s formula was 3136 ± 392.2 grams and EFW of Risanto’s formula was 3056 ± 322.5 grams and mean actual birth weight was 3021 ± 341.1 grams. The mean difference between EFW of Johnson’s formula and the actual birth weight was 156.1 ± 107.3 grams, and mean difference between EFW of Risanto’s formula and the actual birth weight was 100.8 ± 86.1 grams. Those two differences was statistically significant (p=0.001). Conclusion: This study showed that Risanto’s formula was more accurate than Johnson’s in predicting birth weight based on the maternal’s fundal height. [Indones J Obstet Gynecol 2013; 1-3: 149-51] Keywords: actual birth weight, fundal height, Johnson’s formula, Risanto’s formula

The Risk of Urinary Tract Infection in Post-Operative Pelvic Organ Prolapse is Increasing in Patients with Shorter Urethral-Anal Distance Fakhrudit, Emir; Fauzit, Amir; Effendy, Kms Yusuf; Theodorus, Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives : The purpose of our study was to find the correlation between urethral-anal distance and urinary tract infection (UTI) after surgery for grade III and IV uterine prolapse. Methods : Cross sectional study of 57 consecutive women who underwent surgery for grade III and IV uterine prolapse Fisher exact test was used to determine independent risk factors. Results : Eight (14%) women developed a UTI. The risk of UTI was significantly increased in women whose distance between the urethra and the anus was less than 50.27 mm, with PR: (95%Cl): 43.75 (6.05-303.61) and p: 0.001. Conclusion: There is correlation between urethral-anal distance and urinary tract infention (UTI) after surgery for grade III and IV uterine prolapse. [Indones J Obstet Gynecol 2013; 1-3: 152-5] Keywords: cystocele, pelvic organ prolapse, rectocele, urinary tract infection, uterine prolapse

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Contact Name
eko subaktiansyah

Contact Email
eko.subaktiansyah@gmail.com

Phone
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Journal Mail Official
support@inajog.com

Editorial Address
-

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA