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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

Arjuna Subject : -

Articles 1,760 Documents

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Caspase-3 can not be Used to Predict the Response to Neoadjuvant Chemotherapy Regiment PVB in Cervical Cancer Stage IB-IIA Ambari, Ediwibowo; Winarto, Hariyono; Sutrisna, Bambang; Siregar, Budiningsih
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To determine the factors that may be used as the prognostic parameter for the therapeutic efficacy of neoadjuvant chemotherapy, which can be used to revising the management of early stage cervical cancer patients with large lesions. Methods: This was a retrospective cohort study. The study was conducted in the Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia. The subjects were 15 cervical cancer stage IB2 and IIA patients with lesions’ size of > 4 cm, who would be treated with neoadjuvant chemotherapy, consisted of cisplatin 50 mg/m2, vincristine 2 mg/m2 and bleomycin 15 mg regiment. The patients’ response would be evaluated after completing 3 series of chemotherapy. Data was retrieved from medical records and cervical biopsy paraffin blocks and examined histopathologically using IHC staining to see expression of caspase-3 with histoscore assessment score. Data was analyzed by univariate, bivariate analysis. Results: Response to PVB neoadjuvant chemotherapy was found in 5 out of 15 patients. None of the clinicopathology variables can be used to predict response to therapy. Expression of caspase-3 as a marker of apoptosis, can not predict the response of the therapy before administrating neoadjuvant chemotherapy either. There is a significant difference between the levels of caspase-3 in epidermoid carcinoma with adenocarcinoma, with p value of 0.02 (RR 6;95% CI 1.69-21.26). Conclusion: Clinicopathologic factors and the expression of caspase-3 before getting chemotherapy neoadjuvant can not predict the succeed of the therapy. [Indones J Obstet Gynecol 2013; 1-3: 156-60] Keywords: caspase -3, clinicopathologic, early-stage cervical cancer lession in large, neoadjuvant chemotherapy response to therapy

Management of Pseudomyxoma Peritonei Syndrome during Pregnancy Aditanzil, Hanny; Mahendra, Bayu; Suwiyoga, Ketut
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To improve skill in making a diagnosis and management of pseudomyxoma peritoneum originating borderline mucinous ovarian tumor during pregnancy. Methods: Case report. Conclusion: Diagnosis of pseudomyxoma peritoneum during pregnancy is difficult before surgery. Management is based on grade of malignancy and gestational age of pregnancy. [Indones J Obstet Gynecol 2013; 1-3: 161-5] Keywords: mucinous tumor, pregnancy, pseudomyxoma peritoneum

Management of Abnormal Cervical Cytology: Atypical Squamous Cells of Undetermined Significance (ASC-US) and Atypical Squamous Cells cannot exclude High Grade Intraepithelial Lesion (ASC-H) Kusuma, Fitriyadi; Liedapraja, Mediana s.
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To review for the management of abnormal cervical cytology: atypical squamous cells of undetermined significance (ASCUS) and atypical squamous cells cannot exclude high-grade intraepithelial lesion (ASC-H) as a treatment of cervical precancerous lesions in order to avoidexcessive treatment, reduce of unnecessary examinations and to provide cost effectively. Method: Literature study on published literatures and studies about the management of cervical cytology. Conclusion: The results of ASC-US cervical cytology and ASC-H is aninitial screening to detect precancerous cervical lesions. Definitive therapy should be done when finding a low-grade lesions (LSIL) and high degree of lesion(HSIL) squamous intraepithelial. A clinician expected to understand the natural history of HPV infection and the management of precancerous cervical lesions properly. [Indones J Obstet Gynecol 2013; 37-3: 166-170] Keywords: ASC-H, ASC-US, cervical cytology abnormalities, cervical precancerous lesion.

Motivation is the Strongest Influence in Choosing Delivery Place Astuti, Indria
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 4, October 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To analyze the factors that correlated with decision to choose the most appropriate delivery place of mothers’ delivery attended by health personnel, in West Bandung District. Method: This was a case-control study with consecutive sampling method on the mothers who gave birth at two health centers: Cikalong Wetan and Cipongkor, West Bandung District. There were two groups of mothers. First, the case group consisted of 52 mothers at non-healthcare facilities. Second, control group consisted of 52 mothers at healthcare facilities. There were sociodemographic (culture, educational), contextual (income, transportation, distance, availability health facilities) and characteristics of needs (counseling, prenatal care, motivation) factors and dependent variable was decision in choosing the place of delivery. The data was analyzed using chi square test to determine the correlation factors, whereas multiple logistic regression was used to determine the strongest correlating factors. Result: The results showed that there were correlation between various factors with the decision selection of delivery place of the mothers by health care in: cultural factor (OR = 23; p < 0.001; CI 95% : 7.99-66.20), educational factor (OR = 4.86; p < 0.001; CI 95% : 1.35- 19.09), income factor (OR = 2.36; p = 0.031; CI 95%: 6.51-57.49), transportation factor (OR = 19.35; p < 0.001; CI 95%: 6.51 to 57.49), distance factor (OR = 3.19, p = 0.007; 95% CI: 1.67-37.69), availability health facilities factor (OR = 7.94, p = 0.007; CI 95% 1.67-37.69 and OR = 3.97; CI 95% : 0.40-39.75), counseling factor (OR = 23, p < 0.001; CI 95%: 7.99-66.20), prenatal care factor (OR = 5.21, p < 0.001; 95%: 2.24-12.12), motivational factor (OR = 196, p < 0.001; CI 95 % : 41.64-922.48). The strongest factor was the motivational factor (OR = 103.33; p < 0.001; CI 95%: 10.00-1065.72). Conclusion: This study concluded that there was correlation between sociodemographic, contextual, and characteristics of needs with the decision in choosing place of delivery that attended by health personnel. Motivation was the strongest factor correlated to the mothers’ decision to deliver at public health center. [Indones J Obstet Gynecol 2013; 1-4:173-8] Keywords: characteristics of demand, contextual, delivery place, socio-demographic

Contraceptive User’s Profile Gunardi, Eka R
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 4, October 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To obtain informations regarding the profile of contraceptive users in Raden Saleh Clinic, Jakarta. Method: A cross-sectional study was conducted in June 2012, at Raden Saleh Clinic, Jakarta. The study population was the patient who came to Raden Saleh Clinic from 2008 until 2011. Results: The mean age of the contraception users was 34.06 and the mean of their husband’s age was 38.91 years old. Most of the patients were graduated from senior high school (43.2%) and university (37.9%). More than half of the patients (55.2%) were not working and more than a half of their husband (53.2%) were private employee. Almost all (92.6%) of the patient were married. Most of the patient (38.8%) came with no prior contraception. After consultation, all patients had chosen their preferred contraceptive methods, namely IUD (61.4%), injectable contraception (20.9%), pill (13.7%), sterilization (3.4%), and implant (0.6%). Conclusion: Family planning reduces maternal mortality and the best method is different for each patient because of the difference in their own condition and the consideration of the cost and benefit. [Indones J Obstet Gynecol 2013; 1-4:179-82] Keywords: contraception, contraceptive users profile

The Number of LH Receptor could Predict the Success of Oocyte Maturity in the Process of In Vitro Maturation Amansyah, Adek
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 4, October 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v1i4.363

Objective: To evaluate the relationship between the number of LH receptor and the success of oocyte maturity in the process of in vitro maturation (IVM). Method: This experimental study was conducted in the Permata Hati Infertility Clinical Laboratory, Dr. Sardjito General Hospital, Yogyakarta, with the samples of 300 oocytes obtained through collecting immature cow’s oocytes from the abattoir and grouped the oocytes into 3 (three) groups based on the pattern of oocyte cumulus cells on the vesicle germinal stage 2 - 8 mm with three layers of cumulus cell. The sample of the cumulus cells from these three groups were taken and the LH receptor examination was done with immunohistochemistry. After that, the IVM process was performed to the three groups and its development for 24 hours was evaluated. Its maturation quality was evaluated with the emergence of the first polar body (1PB) and compared to the other groups and related to the number of LH receptor in the three groups. Result: The result of this study indicated that the oocyte cumulus cells showed a difference of function during IVM process. The maturity rate in this study showed that the number of LH receptor was related to the morphological pattern of oocyte cumulus cells with oocyte maturity. The maturity of the cumulus cells which 100% covered the oocyte was higher than that of the cumulus cells which > 50% and < 30% covered the oocytes, namely, 74% compared to 60% and 12%. The result of this study also showed that the average number of LH receptors in the three groups (A, B, and C) was 183.4, 78.8, and 24.0 respectively. A significant difference was found in the three groups (p < 0.0001). When related to IVM maturity, this difference showed that the bigger number of oocyte cumulus cells influenced the oocyte maturity. Conclusion: The number of LH receptor can be used as a prediction to determine the success of oocyte maturation in the process of in vitro maturation. [Indones J Obstet Gynecol 2013; 1-4:183-7] Keywords: IVM, LH receptor, oocyte cumulus cell

Tenascin-C is Strongly Expressed in the Anterior Vaginal Walls of Women with Pelvic Organ Prolapse Sulham, Risma N.; Irianta, Trika; Malinta, Umar
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 4, October 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To compare the expression of tenascin in the anterior vaginal wall in women with pelvic organ prolapse and without pelvic organ prolapse (POP). Method: This study was a cross sectional study. The study was conducted in RS Dr. Wahidin Sudirohusodo and other network hospitals of Obstetrics and Gynecology Department of Hasanuddin University, Makassar, from 1st January 2011 to 1st April 2012. This study assessed the expression of tenascin in 35 women with pelvic organ prolapse grade III and IV and the controls were 35 women without pelvic organ prolapse. Tenascin expression was assessed by immunohistochemical examination using tenascin antibody staining (mouse monoclonal antibody Novacastratenascin C, code NCLTenasC). Sampling was done by consecutive sampling. Data processed by the chi-square. The significance level used was 0.05. Result: The result of this research shows that with exception of history of bearing baby > 4000 gr weight (p=0.572); age, parity, menopausal status, and body mass index were significantly different between the group. This indicates that the variable does not affect the calculation of research data. While parity, menopausal status and body mass index (BMI), from an analysis of risk factors for POP were associated with increased intensity of tenascin is significant in postmenopausal status, and BMI > 25 (overweight) (p <0.05). Expression of tenascin in a sample of moderate (+ +) as many as 18 cases (51.5%) compared with controls expression of tenascin weaker (+) 25 cases (71.5%). Conclusion: Expression of tenascin robust anterior vaginal wall in women with POP and weak women without POP. Keywords: pelvic organ prolaps, risk factors, tenascin-C

Probiotic Supplements do not Increase the Effectiveness of Antibiotics in the Treatment of Bacterial Vaginosis Hamid, Ratnah
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 4, October 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective : This study aims to assess the effect of the addition of probiotic supplement to the standard therapy on the recovery of Bacterial vaginosis infection. Methods: The research was conducted by taking samples from Obstetrics and Gynecology Department in several teaching hospitals of Faculty of Medicine, Hasanuddin University. This study was an experimental study. Consecutive sampling was conducted on 50 samples, which were then divided into two groups. Group 1 received Metronidazol therapy 2 times a day for 7 days, while group 2 received Metronidazol therapy 2 times a day supplemented with oral Probiotic of once a day for 7 days. The data were analysed by using the chi-square test. Results: There is no significant difference in the recovery of bacterial vaginosis infection between the group that received the probiotic supplementation and the group that did not. Conclusion: The addition of probiotic supplement to the standard therapy of BV infection does not show any signifcant effect. [Indones J Obstet Gynecol 2013; 1-4: 194-8] Keyword: bacterial vaginosis, probiotic supplement, recovery, standard therapy

Expression of Tenascin in the Uterosacral Ligament is Stronger in Women with Pelvic Organ Prolapse Lusiadewi, Eny
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 4, October 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: This study aimed to compare the expression of tenascin uterosacral ligament in women with and without pelvic organ prolapsen (POP). Methods: The research was carried out in Dr. Wahidin Sudirohusodo Hospital and other educational hospitals of obstetrics and gynecology division UNHAS Faculty of Medicine, which began on January 1st, 2011 until April 2012. This study assessed the expression of tenascin in 35 women with POP levels III and IV, and the controls were 35 women without POP. Tenascin expression was assessed by immunohistochemical examination using tenascin antibody staining (mouse monoclonal antibody Novacastra tenascin C, code NCL-Tenas C). The research was carried out cross sectional. Sampling was done by consecutive sampling. Data processed by the chi-square. The significance level used was 0.05. Results: The results showed that the characteristics of research subjects based on age, education, parity, labor history, history of big babies, not statistically significant. This indicates that the variable does not affect the calculation of the research data. While the characteristics of menopausal status and body mass index (BMI), from the analysis of risk factors for POP is associated significantly with a higher intensity of tenascin in post-menopausal status and BMI> 25 (overweight) (p

HE4 has a High Diagnostic Value to Detect Epithelial Ovarian Cancer Laihad, Bismarck J.
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 4, October 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To find out the diagnostic value of CA125 and HE4 as a tumor marker, and also RMI and ROMA as a malignancy predictor in patients with ovarian tumors. Methods: This study was a diagnostic study using cross-sectional design.This study was performed in Jakarta from November 2010 to May 2011. One hundred and twenty eight serum samples of patients diagnosed with ovarian tumors were collected before undergoing surgery in Dr. Cipto Mangunkusumo General Hospital. The CA125 and HE4 levels were then examined. The histopathological examination of tissue specimens were performed in Department of Pathology Anatomy in RSCM. For statistical analysis, we used a 2x2 table to produce ROC-AUC curve. Results: The median value of HE4 and CA125 serum concentrations was higher and more significant on patients with ovarian malignancy than patients with benign ovarian tumor (p

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Home Page

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Location Kota adm. jakarta pusat, Dki jakarta INDONESIA

Abstract

Abstract

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Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
eko subaktiansyah

Contact Email
eko.subaktiansyah@gmail.com

Phone
-

Journal Mail Official
support@inajog.com

Editorial Address
-

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA