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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,760 Documents
Progesterone Receptor Gene Polymorphism Promoter Region +331G/A Increases Risk of Endometriosis Alkaf, Syifa; Chakra, Aerul; Said, Usman; Saleh, Irsan
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 1, January 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.419 KB) | DOI: 10.32771/inajog.v4i1.73

Abstract

Objective: To identify relationship between progesterone receptor gene polymorphism promoter region +331G/A with the risk of endometriosis. Method: An observational case-control study. Population are women with endometriosis and/or adenomyosis who have been performed laparotomy/laparoscopy at Obstetrics and Gynecology Department Dr. Mohammad Hoesin General Hospital Palembang, January-November 2013. Subjects fulfilled inclusion criteria, given informed consent and performed blood sampling continued by PCRRFLP. Results were divided into A/A genotype (homozygote mutant), G/A (heterozygote mutant), and G/G (homozygote wild type). Data were analyzed by SPSS 21.0 version. Result: PCR-RFLP results for+331G/A genotype were 26 (54.1%) in case group and 14 (26.4%) in control. +331A/A genotype was not found in both groups. There was significant increase risk of endometriosis in women carrying genotype +331G/A to those with genotype +331G/G with OR 3.29 (p
Acute Toxicity and Outcomes of Radiation Alone Versus Concurrent Chemoradiation for Locoregional Advanced Stage Cervical Cancer Gunawan, Rudy
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 1, January 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.156 KB) | DOI: 10.32771/inajog.v36i1.284

Abstract

Objective: To evaluate and determine the toxicity and outcomes in patient receiving radiation (RT) alone versus concurrent chemoradiation (CRT) using cisplatin for locoregional advanced cervical cancer in Dr. Cipto Mangunkusumo Hospital (RSCM). Methods: Simple randomized single-blind clinical study, done during the period of November 2010-April 2011, in 32 patients with locoregional advanced cervical cancer (16 were treated RT alone and the rest is treated with CRT). Teletherapy was administrated using 60Co Gamma Rays 1.3 MV and photon beam linear accelerator 4-10 MV. The radiation was administered as much as 2.0 Gy per fraction daily for 5 days/week, for the total of 25 fractions. Brachytherapy was performed using HDR after-loading method, with Microselectron plane radiation source 129I, as much as 3x7 Gy doses to point A. CRT using cisplatin 30 mg/m2 were given for 5 series during the radiotherapy course. The toxicity assessments were carried out each week, up until 3 months after the therapy was deemed completed based on the RTOG and ECOG criteria. Results: We acquired 100% complete response in both the CRT and RT groups. In the CRT group, we found acute gastrointestinal toxicity grade 3 (18.75%) and grade 2 (43.75%); acute genitourinary toxicity grade 3 (25%), grade 2 (31.25%); and acute hematological toxicity grade 3 (12.50%) and grade 2 (25%). It is contrasted with the RT group, in which we did not found any cases of acute gastrointestinal toxicity, genitourinary or acute hematologic toxicity. The overall time treatment (OTT) of 56-58 days in CRT and RT group were 25% vs. 81.25% respectively, and the OTT of 59-70 days in CRT and RT group were 75% vs. 18.75%, respectively. Conclusion:The response to CRT and RT for locoregional advanced cervical cancer was not different in 3 month evaluation. Acute gastrointestinal, genitourinary, and hematologic toxicities found in CRT were higher than in RT (p=0.000; p=0.000; p=0.002). [Indones J Obstet Gynecol 2012; 36-1:37-42] Keywords: acute toxicity, concurrent chemoradiation, locoregional advanced stage cervical cancer, response therapy
Analysis of Oocyte and Embryo Numbers, and Pregnancy Rate in Patients Undergone In Vitro Fertilization with Long and Short Protocols Shafira, Nadia
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 2, April 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.984 KB) | DOI: 10.32771/inajog.v36i2.294

Abstract

Objectives: To compare the oocyte count, embryo count, pregnancy rate, and the presence of OHSS in patients undergoing In Vitro Fertilization (IVF) with long and short protocols at Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta. Methods: A cross sectional study was done at Yasmin Reproductive Clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Data was collected from the medical records of 200 infertile women undergoing IVF, 100 women with long protocols and the other 100 with short protocols. Variables compared in these 2 groups are the oocyte count, embryo count, the pregnancy rate, and presence OHSS using Mann-Whitney U Test with SPSS 11 Program. Result: From 200 women undergoing IVF procedure, 45.5% of them aged between 35-40 years old, with the youngest is 22 years old and the oldest is 48 years old (average age=35 years, SD=4.7), and almost half of them (45%) have BMI between 18.01-23.00 kg/m2. 185 women has primary infertility. These subjects came to the clinic mostly due to male factor (23.5%), idiopathic cause (19%), and ovulation disturbance (13%), whilst endometriosis, tubal factor, and other factors take just little percentage. When compared between long and short protocols, the number of oocyte retrieved is significantly different (p=0.007, CI=5.84-7.11), whereas embryo numbers (p=0.054, CI=1.80-2.39) and the pregnancy rate (p=0.525, CI=0.21-0.33) found to be not significantly different. There were 2 cases of moderate OHSS developed in the long protocol group. Conclusion: Although the number of embryo produced and the pregnancy rate are found to be not significantly different between the two groups, long protocol of IVF is found to produce more oocyte to be retrieved and develop more OHSS events compared to short protocol. Due to this result, GnRH antagonist can be considered when planning an IVF procedure. However, a longitudinal multicenter study with larger sample size is needed to validate the current data. [Indones J Obstet Gynecol 2012; 36-2: 95-9] Keywords: in vitro fertilization, long protocol, pregnancy rate, short protocol
Depo Medroxyprogesterone Acetate Injection was Associated with a Greater Risk of Diabetes Mellitus: a Study at East Jakarta Public Health Centres Bonaville, Edwin
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 2, April 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.687 KB) | DOI: 10.32771/inajog.v36i2.295

Abstract

Objective: To study the relationship between the history of contraceptive injection depo medroxyprogesterone acetate (DMPA) exposure with incidence of diabetes mellitus and the associated risk factors. Methods: This is a case-control study conducted in 6 Public Health Centers in East Jakarta involving 30 cases of diabetes mellitus and 61 controls. Body mass index (BMI), parity, type of contraception, duration of contraceptive use, history of gestational diabetes and breastfeeding were assessed in each group. Data were analyzed with Chi Square or Fisher’s test, and logistic regression. Results: The mean age of the subjects was 45.00 (35-67) years, with a median number of parity of 3.00 (0-7), and the median of BMI was 27.31 (15.24 to 40.27). The number of DMPA injections users was 31.9% and the mean duration of contraception usage was 5.36 ± 4.42 years. There was a correlation between the history of DMPA injections with incidence of diabetes mellitus, with an odds ratio of 3.36 95% CI [1.098 to 10.469]. The risk persisted after adjustment of age and BMI. Conclusion: DMPA exposure was associated with a greater risk of diabetes mellitus. Risk was associated with length of use and persisted after adjusment with age and BMI. [Indones J Obstet Gynecol 2012; 36-2: 100-4 Keywords: depo medroxyprogesterone acetate (DMPA), diabetes mellitus
The Serum Level of Vascular Endothelial Growth Factor (VEGF) is Declined after Paclitaxel-Carboplatin Combined Chemotherapy Treatment on Epithelial Ovarian Cancer Abdullah, Amelia
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.129 KB) | DOI: 10.32771/inajog.v36i3.313

Abstract

Objective: To assess the effect of Paclitaxel-Carboplatin combination on epithelial ovarian cancer by studying the changes in VEGF serum levels after receiving 3 series of chemotherapy. Methods: This was a cohort study conducted at several teaching hospitals in Obstetrics and Gynecology Department of the Faculty of Medicine, Hasanuddin University from April 2011 to March 2012. The subjects were patients with ovarian cancer who met the inclusion criteria and had undergone surgery. The clinical staging was determined with 2009 FIGO criteria. They went through histopathology examination to determine the histological type and cell differentiation of the lesion. They also went through combined chemotherapy of Paclitaxel and Carboplatin. The data were analyzed with paired t-test. Results: The study reveals that out of 30 cases of ovarian cancer who received a combination chemotherapy, most were < 45 years of age (53.33%), nulliparous (46.7%), serosum type (53.3%), with moderate differentiation (36.7%), and in advanced stage (73.3%). The VEGF serum level after 3 series of chemotherapy was lower than before (the average value: 294.67 vs 572.77 ng/ml). There was a significant change in VEGF serum level after receiving chemotherapy (p=0.000). The VEGF serum level of advanced-stage and early stage epithelial ovarian cancer after chemotherapy decreases significantly (p=0.000 and p=0.011). The advanced-stage cases showed more responses to chemotherapy than the early-stage did. There was a tendency that adenocarcinoma serosum type was more responsive to the therapy than mucinosum type (p=0.000 vs 0.003). Conclusion: There is no difference in VEGF serum level based on cell differentiation but there is a tendency that well and moderate differentiated cells have a greater change than the poor differentiated cells (p=0.003, p=0.003 vs p=0.019). [Indones J Obstet Gynecol 2012; 36-3: 135-9] Keywords: carboplatin, epithelial ovarian cancer, paclitaxel, VEGF
A Comparison between the Level of Interleukin 10 (IL-10) in Aterm and Preterm Labor Lisangan, Yusri
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.914 KB) | DOI: 10.32771/inajog.v36i4.318

Abstract

Objective: To compare the level of interleukin 10 in aterm and preterm labor. Method: The research was conducted from November 1st 2011 until January 31st 2012. The subjects were pregnant women underwent labor during the period who had agreed to participate in this study. The study was conducted in the Obstetrics and Gynecology departments of several teaching hospitals of Hasanuddin University in Makassar. The study design was cross sectional with 48 samples. The data were analysed by using the Mann Whithney test. Results: The result revealed that there was an increase of interleukin 10 level in mothers with preterm labor, in comparison with the control group (p < 0.05). Conclusion: The level of interleukin 10 in mothers with preterm labor are higher than aterm labors less than espective. [Indones J Obstet Gynecol 2012; 36-4: 163-6] Keywords: interleukin 10, preterm labor
The Role of Hospitals in Cervical Cancer Prevention Susilawati, Susie; Ocviyanti, Dwiana
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.216 KB) | DOI: 10.32771/inajog.v2i1.371

Abstract

Objective: To evaluate the role of hospitals in DKI Jakarta on primary and secondary cervical cancer prevention. Method: This was a survey conducted to 25 hospitals, chosen with simple random sampling from 109 hospitals in DKI Jakarta. Questionnaire used for interview contained statements regarding knowledge, attitude and behavior of 117 health care professionals along with identification of facility preparedness for cervical cancer prevention within those 25 hospitals. Result: The assessment of knowledge shows that all health care professionals (100%) knew that HPV vaccination is used as a primary prevention for cervical cancer. About 98.3% respondent knew HPV vaccine injected intramuscularly. As much as 91.5% of the respondent knew HPV vaccine is given three times either at month 0, 1, 6 or at month 0, 2, 6. About 71.8% respondent knew deltoid as site for vaccine injection. Most of health care professionals (99.1%) knew VIA (visual inspection with acetic acid) can be used for early detection of cervical cancer. About 76.9% respondent knew how to interpret positive VIA results and 60.7% respondent knew how to do VIA test. As much as 93.2% health care professional knew the purpose of Pap test and about 82.1% knew how to do it. From attitude aspect, most of health care professionals (96.6%) agreed in giving HPV vaccination. About 94% of them agreed to do VIA test and about 98.3% agreed in conducting Pap test. From behavioral aspect, most of the respondent (76.9%) offered HPV vaccination to their clients/patients and 62.4% respondent did HPV vaccination. VIA test was offered and conducted by 52.1% and 30.8% of them, respectively. About 86.3% respondent offered Pap test and 71.8% did the Pap test. As many as 75% of female health care professionals who meet the qualification already had a Pap test for themselves, but only 32.5% ever been vaccinated for HPV. From facility aspect, twenty hospitals (80%) in DKI Jakarta offered HPV vaccination with Pap test can be done in all of them. VIA test and colposcopy were only available in eleven (44%) and ten (40%) hospitals respectively. Conclusion: Most hospitals in DKI Jakarta have health care professionals with good knowledge and attitude in cervical cancer prevention. However, not many have shown expected behavior in the primary prevention. Most hospitals in DKI Jakarta provide facilities for HPV vaccination and Pap test, but only few have VIA facilities and colposcopy. Keywords: cervical cancer prevention, health care professional, hospital
Complication on Teenage Pregnancy and Related Factors Madjid, Omo A; Roesman, Nanda I S
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.908 KB) | DOI: 10.32771/inajog.v2i1.372

Abstract

Objective: To evaluate related factors, which contribute to complication of teenage pregnancy. Method: A cross-sectional research by consecutive sampling method was held upon teenager who was having her first pregnancy or had just been having her first child. This research took place at dr. Zainoel Abidin Public Hospital, Banda Aceh, in period of June until November 2012. Result: By demographic characteristic, we obtained that the majority of complication of teenage pregnancy occur in the age range of 17-19 years old and most are within Sex maturation Rate grade 5. The most common complications are caesarean section, premature rupture of membranes and cephalo-pelvic disproportion. There is a significant relation between antenatal visit conducted in accordance with WHO criteria and economic level with the incidence of complication. Conclusion: We found significant relation between antenatal visit conducted in accordance with WHO criteria and economic level with the incidence of complication. Keywords: complications, teenage pregnancy.
Intracervical Lidocaine Block is more Effective for Pain Management of Curettage in Incomplete Abortion Saranga, Oktovianus; Hartono, Eddy; Sunarno, Isharyah
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.316 KB) | DOI: 10.32771/inajog.v2i1.373

Abstract

Objective: To compare the effects of Intra cervical and paracervical block with 1% lidocaine for pain management in curettage of incomplete abortion. Method: This study is a prospective study with Randomized Control Trial approach. The samples were 52 pregnant women with gestational age of less than 20 weeks, which diagnosed as having an incomplete abortion and a procedure using any local anesthetic technique. T test was used to calculate the mean VAS score and standard deviation for each group. Fisher Exact test was used to assess the relationship between variable characteristics and the local anesthetic technique. Result: The use of local anesthesia using intra cervical block technique for pain management in incomplete abortion with curettage proved to be more effective in lowering degree of pain than paracervical block techniques. Conclusion: Intracervical block technique as a local anesthetic technique is simpler and relatively safer than paracervical block. This technique can be used extensively in Department of Obstetrics and Gynecology Medical Faculty, Hasanuddin University for pain management in curettage. Keywords: pain, Intracervical anesthesia, paracervical anesthesia, Visual Analogue Scale (VAS)
The Level of 8-OHdG Serum was Higher in Women with Blighted Ovum Putra, I Made Mahadinata; Surya, I Gede P
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.995 KB) | DOI: 10.32771/inajog.v2i1.374

Abstract

Objective: To determine the difference of 8-hydroxy-2-deoxyguanocyne (8-OHdG) serum level in women experiencing blighted ovum and women with normal pregnancy. Method: This was a cross sectional study with 82 samples, divided into two groups. Thirty two cases of blighted ovum and 51 cases of normal pregnancies, with 7-12 weeks gestational age. The examination of 8-OHdG serum level, was performed with the venous blood taken from the cubiti veins, and its 8-OHdG serum quantities were than examined at the Pathology Lab. at Sanglah General Hospital. Data was analyzed with the Shapiro Wilk Test and the t independent test with alpha 0.05. Result: The average 8-OHdG serum level in women with blighted ovum and normal pregnancies were 0.177 (SD 0.06) ng/ml and 0.111 (SD 0.01)ng/ml, and significantly different (p&lt;0.05). The cut off value of 8-OHdG serum level was 0.138 ng/ml with sensitivity of 96.1% and specificity of 80.6%. Conclusion: The level of 8-OHdG serum was higher in women with blighted ovum than in women with normal pregnancies.&nbsp; Keywords: 8-OHdG serum level, blighted ovum, and normal pregnancy.

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