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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

Arjuna Subject : -

Articles 1,760 Documents

84 85 86 87 88

Maternal Cystatin C Serum is Higher in Women with Severe Preeclampsia Isasari, Kurnia M.; Pangemanan, Wim T; Zulqarnain, Iskandar; Rahadiyanto, Kemas
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the comparison between maternal cystatin C serum in severe preeclampsia and normal pregnancy. Method: This was an observational study with cross sectional analytic approach. The subjects are sixty women with severe preeclampsia and normal pregnancy who met inclusion criteria. The maternal serum level of cystatin C was automatically measured with Particle Enhanced Nephelometric Assay (PENIA). Result: Mean serum level of cystatin C in severe preeclampsia was 1.169 ± 0.311 mg/l. Mean serum level of cystatin C in normal pregnancy was 0.929 ± 0.166. There was a significant differences between maternal serum levels of cystatin C in women with severe preeclampsia compared with women with normal pregnancy. Conclusion: There was a significant differences between maternal serum levels of cystatin C in severe preeclampsia compared with normal pregnancy. Keywords: cystatin C, endotheliosis glomerulus, severe preeclamp

The Level of Heat Shock Protein 70 is Lower in Postterm Pregnancy Soetrisno, Soetrisno
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To analyze whether there are differences between the levels of HSP70 of Postterm pregnancy and aterm pregnancy in Dr. Moewardi Hospital, Surakarta, Central Java. Method: This was a cross-sectional study. The independent variable was the level of Heat Shock Protein 70 (HSP70), and the dependent variable was the incidence of postterm pregnancy. The data was then analyzed by t test. Result: The subjects were 45 women, who were divided into 2 groups of women with postterm pregnancies (15 women) and aterm pregnancies (30 women). The mean levels of HSP70 in the serum of women with postterm pregnancy is lower (0.40 ng/ml) compared to the level of the normal pregnant group (3.94 ng/ml) and this difference was statistically significant (p<0.001). Conclusion: The mean level of HSP70 in postterm pregnancy is lower than in normal full-term pregnancy.  Keywords: Heat Shock Protein 70, Maternal Stress, postterm pregnancy

Expression of B-Cell Lymphoma Protein-2 (Bcl-2) and Caspase-3 are Related with Ovarian Cancer Budiana, I Nyoman G.
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: To determine the expression of Bcl-2 and caspase-3 and their relationship with ovarian cancer. Method: This study was a cross-sectional study. Speciment was tissue sample from ovarian cancer patients collected from parafinblock to determine the Bcl-2 and caspase-3 expression and demographic data obtained secondary from patients medical records. Expression of Bcl-2 and caspase-3 was examined by immunohistochemistry under light microscope with 400x light power field. The result was recorded as negative when the protein was expressed in 10% or less of cells and as a positive when the protein was expressed in more than 10% of cells. Result: A total of 45 samples was included as research subjects. 31 of 45 subjects showed the expression of Bcl-2 positive (68.9%), while the positive expression of caspase-3 was presented in 20 subjects (44.4%). There was a relationship between the expression of Bcl-2 with the expression of caspase-3 in ovarian cancer patients (p=0.002; Lambda=0.4). There was also a negative relationship, where the subjects with positive expression of Bcl-2 showed negative expression of caspase-3. In contrast, subjects with negative expression of Bcl-2 showed positive expression of caspase-3. Conclusion: There was a significance relationship between the expression of Bcl-2 with the expression of caspase-3 in ovarian cancer patients. Keywords: Bcl-2 expression, caspase-3 expression, ovarian cancer

Serum Level of Vascular Endothelial Growth Factor (VEGF) can be used to Assess Response of Radiation Therapy in Cervical Cancer Armanza, Ferry; Andrijono, Andrijono; Sutrisna, Bambang
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare the sensitivity and specificity of Squamous Cell Carcinoma (SCC) and Vascular Endothelial Growth Factor (VEGF) levels to assess the response of radiation therapy. Method: The study was conducted by the method of analytic observational cohort study in 24 patients with cervical cancer stage II-B and III-B in RSCM that met inclusion criteria. Examination of VEGF and SCC in serum samples was performed in the Prodia Laboratory Jakarta. The examination was conducted twice before and after radiation therapy. The subjects were treated by radiation therapy/chemoradiation according to standard procedures. After the completion of radiation was declared, the response of radiation therapy was conducted by clinical assessment. Result: Of the 24 subjects, we obtained a mean level of SCC pre-radiation was 23.43 ± 5.84 ng/ml and post-radiation was 2.19 ± 0.68 ng/ml. The mean VEGF pre-radiation was 790.41 ± 111.06 pg/ml and post-radiation was 497.47 ± 79.26 pg/ml. ROC curves of each tumor marker obtained SCC pre-radiation AUC 40%, p 0.53 (CI 0.18-0.68) and SCC post-radiation AUC 48.1%, p 0.91 (CI 0.21-0,75) can not be used as a diagnostic and prognostic factors of response to radiation therapy. VEGF pre-radiation produced an AUC of 17.5%, p 0.04 (CI 0.00-0.36), thus cannot be used as a prognostic factor for response to radiation therapy. VEGF after radiation produced an AUC of 92.5%, p 0.01 (CI 0.81-1.00), thus can be a diagnostic factor for response to radiation therapy. VEGF post-radiation with cut-off point 614.75 pg/ml had a sensitivity 80%, specificity 75%, NDP 94.12%, NDN 42.86%; RKP 3.2; RKN 0.26 and accuracy 79.16%. There is a significant correlation between the decrease of serum VEGF level post-radiation and a positive response of radiation therapy (p 0.01, CI 1.00-3.23). Conclusion: Examination of VEGF levels can be used to assess the response of radiation therapy with a sensitivity of 80% and specificity of 75%.  Keywords: cervical cancer, SCC, therapeutic response, VEGF

HER2/Neu Expression was Different between Benign, Borderline and Malignant Epithelial Ovarian Tumors Hadisubroto, Yona S.; Suwiyoga, Ketut
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the difference of HER2/neu expression in benign, borderline and malignant epithelial ovarian tumor. Method: An analytic cross-sectional study was performed on 49 samples of epithelial ovarian cases which were divided into three groups: twelve cases of benign epithelial ovarian tumor, 9 cases of borderline epithelial ovarian tumor and 28 cases of malignant epithelial ovarian tumor. Paraffin embedded tissue samples was cut, stained with HER2/neu imunohistochemistry and examined in Pathology Laboratory at Sanglah Hospital. The other data was collected from medical record samples. The data was analysed using One Way Anova test and Chi-square test with level of confidence α = 0.05. Result: There were 13 cases (46.43%) of the HER2/neu over expression in malignant epithelial ovarian tumors, 2 cases (22.22%) of the HER2/neu over expression in borderline epithelial ovarian tumors and 1 case (9.09%) of the HER2/neu over expression in benign epithelial ovarian tumors. With p = 0.048 (p < 0.05), there are differentiation of HER2/neu expression in benign, borderline and malignant epithelial ovarian tumors. Conclusion: In this study HER2/neu expression was different between benign, borderline and malignant epithelial ovarian tumors. Keywords: benign epithelial ovarian tumor, borderline epithelial ovarian tumor, HER2/neu, malignant epithelial ovarian tumor, ovarian cancer.

Risk of Malignancy Index is not accurate as a Triage Tool for Ovarian Cancer Tanamas, Gregorius; Iskandar, Jasmine; Utami, Tofan W; Anggraeni, Tricia D; Nuryanto, Kartiwa H
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate Risk of Malignancy Index (RMI) as a triage tool for ovarian cancer in Dr. Cipto Mangunkusumo Hospital. Method: This is a retrospective study conducted from January 2008-December 2012 in patients diagnosed with ovarian mass. Patients admitted for surgery due to ovarian masses were included to this study. RMI 3 score was calculated based on ultrasonography examination in Dr. Cipto Mangunkusumo Hospital, CA-125 test and menopausal status. Patients without final pathological report and incomplete data were excluded from study. Data were analysed using SPSS 20 to evaluate RMI result and final pathlogical report in benign and malignant case. Result: From 882 patients identified with ovarian masses from cancer registry, only 99 patients aged 17-70 y.o were included in this study. Most of the patients were nully-parity (28.3%), non-menopausal women (60.6%), normal body mass index (40.4%), and with stage IIIC ovarian cancer (33.3%). Ultrasonography examination showed that most of patients had solid mass and ascites (19.2%). Meanwhile, CA-125 showed that patients with <35 U/ml were 10.1% and ≥ 35 U/ml were 89.9%. Patients with RMI scores <200 (benign cases) were 19 cases (19.2%) and ≥ 200 (malignant cases) were 80 cases (80.8%). Meanwhile, patients with benign final pathological report were 23 cases (23.2%) and malignant cases were 76 cases (76.8%). There was no statistical difference in RMI between benign and malignant cases based on final pathological report. Conclusion: Our study showed that RMI was not accurate as triage tool for ovarian cancer in our hospital. Further investigation and more patients are needed to confirm this study. Keywords: CA-125, menopausal status, ovarian cancer, risk of malignancy index (RMI), ultrasonography.

Prevention of Recurrent Urinary Tract Infections in Postmenopausal Women Fernando, Darrell; Santoso, Budi I
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the most effective and applicable methods to reduce recurrence of urinary tract infections in postmenopausal women. Method: A search was conducted on Pubmed, NEJM, BMJ, and Google. After screening and selection, six articles were considered useful; comprising of two original research articles, one systematic review, and three society guidelines. Result: Society guidelines recommended continuous antimicrobial prophylaxis, with postcoital antimicrobial prophylaxis as an alternative. The first research article found similar results in continous antimicrobial prophylaxis group and intermittent antimicrobial prophylaxis group. The second research article found no significant difference in cranberry and trimethoprim group. The systematic review revealed vaginal estrogens are effective in preventing recurrent UTI, but the type of estrogen is less clear. Oral estrogens are not effective. Conclusion: Prevention of recurrent urinary tract infections in postmenopausal women include risk factor identification, non-antimicrobial prophylaxis with cranberry and vaginal estrogen preparations, and antimicrobial prophylaxis (continuous or intermittent). Keywords: postmenopausal, prevention, recurrent urinary tract infection.

The Prevalence and Risk Factors of Stress Urinary Incontinence in Postpartum Pratiwi, Renny; Suparman, Eddy; Lengkong, Rudy A
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To know the incidence of stress urinary incontinence in postpartum and determine the relationship among age, parity, infant birth weight, mode of delivery, episiotomy and perineum rupture. Method: This study used cross sectional analytic design. Qualified subjects from inclusion criteria were interviewed by researchers using pre-defined MESA questioner. Subjects with stress urinary incontinence were found from the questionnaire result. The acquired data was measured and analyzed using SPSS v. 22.0 software and discussed using available literature. Result: From 162 subjects, 36 cases (22.22%) had stress urinary incontinence, 47.22% aging ? 35 years old, 72.22% had multiple pregnancies, 88.89% had per vaginal delivery. Using multivariate logistic regression test, we found there was a relationship between stress urinary incontinence with age and parity (p 35 years old and multiple parities. Keywords: multiple parities, post-partum, stress urinary incontinence

Estradiol Level and Psychosocial Stress in Perimenopausal Women Levita, Lucia L; Hadiprodjo, Hadiprodjo; Abdullah, Nusratuddin; Pelupessy, Nugraha U
Indonesian Journal of Obstetrics and Gynecology Volume 7 No. 2 April 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective : To determine the relationship between estradiol levels and psychosocial stress in the perimenopausal women. Methods : Sixty perimenopausal included in a cross-sectional study from July to December 2016. Blood samples obtained from the women to measure the estradiol and the cortisol levels. Stress level measured with visual. Data presented as the mean and standard deviation (mean±SD) with p-value <.05 was considered statistically significant.  Results : There was no significant difference between the estradiol levels and the stress level (p=0.27) during perimenopause period. The estradiol levels were higher compared with the cortisol levels. The non parametrik correlations analysis show the estradiol levels were not correlated with the cortisol levels (p=0.352). However, the cortisol levels were correlated with the stress levels (p<0.05). Conclusion : Estradiol does not cause psychosocial stress during perimenopause period in our study population Keywords : Estradiol, psychosocial stress, perimenopause

Factors Associated with Reproductive Age Couples’ Selection of Sterilization in the Era of the National Health Insurance Program Nugroho, Achmadi S; Azhari, Azhari; Nurtjahyo, Awan; Theodorus, Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 7 No. 2 April 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective:To assess factors associated withselection of contraceptive sterilization in reproductive age couples in Dr. Mohammad Hoesin Palembang hospital in the era of BPJS. Methods: This cross sectional study was conducted between January - December 2017. Study sample was reproductive age couples (RAC) who were married and came to P2 UGD, maternity room and midwifery ward of Dr. Mohammad Hoesin Palembang hospital and metour inclusion criteria. All study participants were given a questionnaire to assess factors that influence selection of contraceptive methods in women. Data were analyzed using SPSS software version 17. Results: We found a significant relationship between number of children (PR = 3,988; p = 0.016), knowledge level (PR = 3,893; p = 0,024) and husband support (PR = 5,233; p = 0.009) with sterilization contraceptive selection. In addition, there were no significant correlation between age (PR = 2,311, p = 0,210), education level (PR = 1,893, p = 0,331), woman attitude (PR = 1,567, p = 0,758), availability of contraception ( (PR = 1,969, p = 0,342), officer attitude (PR = 1,088, p = 0,000) and information given by officer (PR = 1,378; p = 0,719) 1,310; p = 0.802) with selection of sterilization. With logistic regression test, we found that husband support was the most important factor to selection of sterilization contraception (PR = 4,266, p = 0,040) followed by knowledge (PR = 3,620, p = 0,041). Conclusion:Sterilization selection in reproductive age couples at Dr. Mohammad Hoesin Palembang Hospitalis influenced by female knowledge and husband support. Keywords:sterilization, tubal ligation, vasectomy, reproductive age couple

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Contact Name
eko subaktiansyah

Contact Email
eko.subaktiansyah@gmail.com

Phone
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Journal Mail Official
support@inajog.com

Editorial Address
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Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA