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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
  • Website
Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 450 Documents
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Association Between Fabella and Clinical Factors with Knee Osteoarthritis Severity Based on X-Ray Findings According to the Kellgren-Lawrence Classification at Royal Prima General Hospital Medan Ricky Suryamin; Faisal Reza; Ica Y Pulungan
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11622

Abstract

Background: Knee osteoarthritis is a common degenerative joint disease associated with pain, functional limitation, and radiographic progression. The fabella, a sesamoid bone located in the lateral head of the gastrocnemius tendon, has been proposed as a possible contributor to knee biomechanics and osteoarthritis severity. Methods: This retrospective cohort study evaluated 274 patients who underwent knee radiographic examination at Royal Prima General Hospital Medan. The presence and condition of fabella, age, sex, and body mass index (BMI) were analyzed against knee osteoarthritis severity based on the Kellgren-Lawrence classification. Data were analyzed using univariate analysis and multiple linear regression. Result: Most patients were older than 56 years (74.8%), female (78.8%), and obese (91.2%). Fabella was non-degenerative in 47.4% of patients, degenerative in 17.9%, and not visible in 34.7%. Osteoarthritis severity was Grade II in 38.3%, Grade III in 39.4%, and Grade IV in 22.3%. Fabella (B=0.391; p<0.001) and age (B=0.337; p=0.003) were significantly associated with osteoarthritis severity, whereas sex (p=0.952) and BMI (p=0.126) were not. The overall regression model was significant (F=19.955; p<0.001; R2=0.229). Conclusions: Fabella and age were significantly associated with higher knee osteoarthritis severity, while sex and BMI were not significant predictors in this cohort. Radiographic assessment of fabella may provide additional information in evaluating patients with knee osteoarthritis.
Purulent Cellulitis In A 50-Year-Old Patient With A History Of Hypertension Devin Alexander; Muhammad Rivandio A. S.
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11623

Abstract

Background: Cellulitis is an acute diffuse bacterial infection involving the dermis and subcutaneous tissue. It may be classified as purulent or non-purulent cellulitis. Lower-extremity involvement is common, and comorbid vascular disease or impaired circulation may increase the risk of infection. Case Description: A 50-year-old woman presented to the emergency department with left leg pain, fever, swelling, erythema, and purulent ulcers. She had a history of hypertension and was not taking medication regularly. Physical examination revealed blood pressure of 181/86 mmHg, left crural ulcers with slough and necrotic tissue, and pitting edema. Laboratory examination showed leukocytosis, while chest radiography showed cardiomegaly with aortic calcification. The patient was diagnosed with suspected peripheral arterial disease accompanied by purulent cellulitis. She received intravenous antibiotics, analgesics, supportive therapy, wound care, and incision of bullae during hospitalization, with clinical improvement. Conclusions: Purulent cellulitis requires prompt recognition and treatment. Ulcers may serve as a portal of entry for skin flora, while hypertension and vascular compromise may contribute to impaired tissue perfusion and edema. Antibiotic therapy, drainage when indicated, wound care, and bacterial culture for definitive therapy are important components of management.
Perioperative Management of Craniotomy for Clipping Aneurysm: A Case Report Damatus Try Hartanto Taopan; I Putu Pramana Suarjaya
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11624

Abstract

Background: Ruptured aneurysm is the most common cause of spontaneous subarachnoid hemorrhages. The clinical manifestations of aneurysmal subarachnoid hemorrhage are rapid onset of severe headache, loss of consciousness, nausea and/or vomiting, nuchal rigidity, or photophobia. The definitive treatment of the aneurysm is craniotomy and clipping or endovascular coiling. Several pathophysiological consequences of subarachnoid hemorrhage have been reported in previous studies. The role of the anesthesiologist is to acknowledge these sequelae in order to conduct a thorough pre anesthesia evaluation and to prepare perioperative management. However, case reports that discussed perioperative management of craniotomy for clipping aneurysm are still lacking. Case Description: We present a case of a 66-year-old woman diagnosed with acute non-communicating hydrocephalus, intraventricular hemorrhage pan-ventricle and subarachnoid hemorrhage in basal cistern, right and left sylvian fissure, right and left temporal due to aneurysm rupture post VP. Craniotomy for aneurysm clipping was planned and the surgery was done under general anesthesia. Intraoperatively, the patient’s hemodynamic was successfully maintained stable. Conclusion: Postoperatively, patient was closely monitored in the intensive care unit and no neurological deficits or other complications were found. This case report aims to further discuss the importance and concerns regarding the perioperative management of craniotomy for clipping aneurysm.
Apical Leakage of Bioceramic versus Epoxy Resin–Based Sealers in Single-Cone Obturation: A Systematic Review and Meta-Analysis Vikri Sandya Dhika; Veriantara Satya Dhika
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11625

Abstract

Background: Bioceramic sealers paired with the single-cone obturation technique represent an evolving clinical paradigm, yet no systematic review has exclusively evaluated their apical sealing performance against epoxy resin–based sealers within this specific technique. This study aimed to systematically compare the in vitro apical leakage of bioceramic versus epoxy resin–based sealers used with single-cone obturation in extracted human teeth. Methods: A systematic search of PubMed, Embase, and Scopus was conducted from inception to 1 April 2026, following PRISMA 2020 guidelines. Only English-language publications were included. In vitro and ex vivo studies comparing apical leakage between bioceramic and epoxy resin sealers with at least one single-cone obturation group were included. Risk of bias was assessed using the QUIN tool. Standardized mean differences were pooled using a random-effects model for studies reporting comparable continuous leakage data. Result: Eight studies met the inclusion criteria. Five were rated as low risk of bias and three as medium risk. Meta-analysis of four studies with continuous leakage data (n = 77 per group) yielded a pooled SMD of −1.75 (95% CI: −3.92 to 0.42), favoring bioceramic sealers, though heterogeneity was considerable (I² = 88.1%). Narrative synthesis of the remaining four studies showed directionally consistent trends supporting bioceramic sealers across bacterial leakage and nanoleakage methodologies. Conclusions: Bioceramic sealers demonstrated a trend toward less apical leakage than epoxy resin–based sealers with single-cone obturation; however, evidence certainty remains low due to high heterogeneity and limited study numbers. Standardized multicenter in vitro studies and long-term clinical trials are warranted.
Vital Pulp Therapy Using Resin-Modified Calcium Silicate for Permanent Teeth with Reversible Pulpitis: A Systematic Review Vikri Sandya Dhika; Veriantara Satya Dhika
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11626

Abstract

Background: Resin-modified calcium silicate (RMCS) cements combine the bioactivity of traditional calcium silicates with the superior handling properties of resins. This systematic review and meta-analysis evaluate the clinical and radiographic success of RMCS compared to established capping materials in permanent teeth diagnosed with reversible pulpitis. Methods: Following PRISMA 2020 guidelines, comprehensive searches were conducted across PubMed, EMBASE, Scopus, and Web of Science from inception through April 11, 2026. We included randomized controlled trials assessing vital pulp therapy (indirect and direct pulp capping) using RMCS against active comparators (calcium hydroxide, Biodentine) with at least six months of follow-up. Risk ratios were pooled utilizing the inverse variance method with a DerSimonian-Laird random-effects model. Result: Six randomized controlled trials met the criteria for quantitative synthesis. Pooled data indicated that RMCS materials demonstrated robust overall clinical and radiographic success rates across diverse vital pulp therapy procedures at 12- to 36-month follow-ups. Subgroup analyses revealed that while RMCS performed equivalently to calcium hydroxide in indirect pulp capping, it exhibited slightly varied success rates when compared to pure calcium silicate cements like Biodentine during direct pulp capping, though statistical heterogeneity was observed across these subsets. Conclusions: RMCS serves as a highly effective and clinically pragmatic biomaterial for vital pulp therapy in teeth with reversible pulpitis. While providing excellent outcomes for indirect treatments, clinicians should weigh subtle performance differences against pure calcium silicates when managing direct pulp exposures.
Regenerative Approaches Using Platelet-Rich Plasma (PRP) and Stem Cells for Pelvic Floor Disorders: A Systematic Review Devanti Octavia Ellyamurti; Griffin Mia Inggita Kusno; Tuti Khairani Rahman; Putri Dhiya Prameswari Woyono
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11627

Abstract

Background: Pelvic floor disorders, including stress urinary incontinence, pelvic organ prolapse, fecal incontinence, and vulvovaginal atrophy, represent a major burden on quality of life. Platelet-rich plasma and platelet-rich fibrin have emerged as autologous regenerative therapies with potential applications across these conditions. This systematic review synthesized the clinical evidence from human trials of platelet-rich plasma and platelet-rich fibrin for pelvic floor disorders to evaluate efficacy, safety, and methodological quality. Methods: PubMed, EMBASE, and Scopus were searched from inception through 15 May 2026. Eligible studies were human clinical trials of platelet-rich plasma or platelet-rich fibrin injection for pelvic floor disorders or closely related urogynecologic conditions reporting continence, functional, quality-of-life, or safety outcomes. Study selection was performed independently by all authors, with discrepancies resolved through discussion. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool for randomized trials and the Risk of Bias in Non-Randomized Studies of Interventions tool for observational studies. Result: Fourteen studies (663 participants) were included, comprising six randomized trials and eight prospective nonrandomized or single-arm studies. The majority addressed female stress urinary incontinence. Randomized controlled trials demonstrated significant improvements in continence questionnaires and pad tests favoring platelet-rich plasma over sham or pelvic floor muscle training. However, one placebo-controlled trial found no significant difference. Safety profiles were favorable across all studies. Risk of bias was high in single-arm studies and ranged from some concerns to low in randomized trials. Conclusions: Platelet-rich plasma and platelet-rich fibrin demonstrate preliminary safety and efficacy signals for pelvic floor disorders, particularly stress urinary incontinence. However, the evidence base remains limited by small sample sizes, heterogeneous protocols, and a predominance of uncontrolled studies, warranting larger, well-designed randomized controlled trials.
Mitochondrial DNA Mutations and Pediatric Neurological Disorders: A Systematic Review Putu Rika Anjani; Erika Aini Putri S; dr. Iffa Maulida Wiedy Astari; dr. Yudi Wahyudi; Veriantara Satya Dhika
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11628

Abstract

Background: Mitochondrial DNA mutations are increasingly recognized as a significant cause of neurological disease in the pediatric population, yet the breadth of genotype–phenotype associations, diagnostic yield, and clinical spectrum across different study designs and populations have not been systematically synthesized. Methods: A systematic search of PubMed, EMBASE, and Scopus was conducted from inception until 10 May 2026 to identify studies evaluating mitochondrial DNA mutations in pediatric patients with neurological or neurodevelopmental disorders. All authors independently performed study selection; discrepancies were resolved through discussion. Data extraction and risk-of-bias assessment were performed using standardized tools adapted for observational study designs. Narrative synthesis was conducted. Result: Twenty-one studies met inclusion criteria, encompassing cohort, case-control, and diagnostic studies from twelve countries. Leigh syndrome and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes were the most frequently reported phenotypes. Recurrent mutations in MT-ATP6, MT-TL1, MT-ND3, MT-ND5, and MT-ND6 were identified across studies. Autism spectrum disorder studies yielded mixed results regarding mitochondrial DNA involvement. Overall risk of bias ranged from low–moderate to high. Conclusions: Mitochondrial DNA mutations contribute to a wide spectrum of pediatric neurological disease, with Leigh syndrome and mitochondrial encephalomyopathy predominating. Standardized phenotyping and comprehensive sequencing approaches are needed for future multicenter studies.
Graded Eccentric Rehabilitation After Adipose-Derived Stem Cell Injection for Knee Osteoarthritis: A Systematic Review Faulina Yosia Panjaitan; Himawan Widyatmiko; Farkhana Dwi Ariyani; Aisyah Muthia Rasyida
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11629

Abstract

Background: Knee osteoarthritis is a leading cause of disability worldwide, and adipose-derived cell therapies have emerged as potential disease-modifying interventions. However, no direct evidence exists for graded eccentric rehabilitation following adipose-derived cell injection. This systematic review synthesized the indirect clinical evidence from adipose-derived mesenchymal stem cell, stromal vascular fraction, and microfragmented adipose tissue injection trials for knee osteoarthritis to characterize post-injection rehabilitation practices, efficacy, and safety. Methods: PubMed, EMBASE, and Scopus were searched from inception through 15 May 2026. Eligible studies were human clinical trials of intra-articular adipose-derived cell or stromal vascular fraction injection for knee osteoarthritis reporting pain, function, imaging, or safety outcomes. Study selection was performed independently by all authors, with discrepancies resolved through discussion. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool for randomized trials and the Risk of Bias in Non-Randomized Studies of Interventions tool for observational studies. Result: Eighteen studies (811 participants) were included. No study directly examined graded eccentric rehabilitation after adipose-derived cell injection. Post-injection protocols ranged from simple rest to conventional physiotherapy. Most randomized controlled trials demonstrated significant improvements in pain and function scores, with favorable safety profiles. Risk of bias ranged from low-to-some concerns in placebo-controlled trials to serious in uncontrolled cohort studies. Conclusions: Adipose-derived cell therapies for knee osteoarthritis demonstrate promising short-to-medium-term clinical benefits with acceptable safety. However, the complete absence of graded eccentric rehabilitation protocols in the existing literature represents a critical evidence gap warranting future investigation.
The Effectiveness of Quadratus Lumborum Block Compared to Transversus Abdominis Plane Block in Treating Acute Pain Post Abdominal Surgery: A Systematic Review Devina Martina Bumi; I Gusti Ngurah Mahaalit Aribawa; I Made Gede Widnyana; Tjokorda Gde Agung Senapathi
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11630

Abstract

Background: Parameters of successful anesthesia and surgery include postoperative pain management. Abdominal surgery can cause severe pain, affect recovery, and trigger pathophysiological reactions. Quadratus lumborum block (QLB) and transversus abdominis plane (TAP) block are commonly used peripheral nerve blocks for postoperative analgesia. Methods: This systematic review aimed to compare the effectiveness of QLB and TAP block, including postoperative opioid consumption, in adults aged 18 to 65 years undergoing abdominal surgery. The review followed PRISMA guidelines and searched studies assessing QLB and TAP block for acute postoperative pain management. Result: A total of 475 records were identified, and four randomized controlled trials met the inclusion criteria for further analysis. Outcomes were synthesized descriptively using pain scores (VAS, NPIS, and NRS) and total opioid consumption. Conclusions: QLB showed more favorable primary and secondary outcomes compared with TAP block in the included studies, suggesting better postoperative analgesic effectiveness after abdominal surgery.
Apolipoprotein B Discordance with Low-Density Lipoprotein Cholesterol and Risk of Atherosclerotic Cardiovascular Events and Mortality: A Systematic Review and Meta-Analysis Adinda Wafdani Putri; Jessica Adrya; Srigita Varsha; Muhammad Ferhat; Stella Pangestika; Natania Eliadi; Alan Dharmasaputra
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11631

Abstract

Background: Apolipoprotein B (apoB) reflects the burden of atherogenic lipoprotein particles and may identify residual cardiovascular risk when low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol appears controlled. This review evaluated whether elevated apoB discordance is associated with cardiovascular events and mortality. Methods: PubMed, Scopus, ScienceDirect, and Google Scholar were searched through 23 May 2026. Eligible studies enrolled adults, assessed apoB discordance using residual-, percentile-, or median-based definitions, and reported adjusted estimates for clinical outcomes. Risk of bias was assessed using the Newcastle-Ottawa Scale. Random-effects meta-analysis used restricted maximum likelihood estimation with Hartung-Knapp-Sidik-Jonkman adjustment. Result: Four studies (128,103 participants) were included. In the cohort-only analysis, the pooled estimate was HR 1.28 (95% CI 0.31-5.25; I² = 67.7%). For all-cause mortality, the pooled estimate was HR 1.12 (95% CI 1.02-1.23; I² = 0%). The residual-based excess apoB-only analysis showed HR 1.11 (95% CI 1.04-1.17; I² = 0%). Conclusions: ApoB discordance may identify residual risk beyond LDL-C, with the most consistent evidence observed for all-cause mortality. Evidence for atherosclerotic cardiovascular events and cardiovascular mortality remains suggestive but limited by heterogeneity and few eligible studies.

Page 45 of 45 | Total Record : 450

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