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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 409 Documents
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Isolated Abducens Nerve Palsy: A Case Report of Cerebral Pseudocyst of Dorello’s Canal Puspitasari, Vivien; Japutri, Josephine; Solansa, Tracy; Cenweikiawan, Anderson
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10768

Abstract

Background: Abducens nerve is the second longest intracranial path out of all of the cranial nerves. Abducens nerve pasly had a prevalence 11.3/100.000 and mostly seen in adults. Isolated abducens nerve palsy due to neoplastic lesion are rare and mostly related to skull base tumor. Case Description: We present a case of 57 years old woman with complaints of red right eye and worsening headache associates with diplopia on the right lateral gaze for three days prior admission. She was later diagnosed with isolated abducens nerve palsy associated to neoplasm cause in Dorello’s canal. Patient was then discharged with symptomatic therapy and educated for head posturing and avoid triggers. Conclusions: Abducens nerve palsy is the most common isolated ocular nerve palsy. The incidence of mass formation such as neoplastic lesion or cyst are rare.
A Rare Manifestation of ‘Complex’ Post Streptococcus Infection Movement Disorder in Paediatric Patient a Case Report Lalisang, Lilie; Khairani, Arie; Chairy, Abdul; Djuanda, Gerald
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10769

Abstract

Background: Post Streptococcal Movement Disorder (PSMD) is a rare disease. One of the PSMD diagnosis is Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS). Case Description: 10 year old female with involuntary movement including myoclonic jerks, chorea and stereotype. Movement duration is 5 minutes, repetitive and sensitive to loud noise. Patient has history of respiratory infection 2 weeks ago with Positive ASTO test. Patients showed improvement after treatment with antibiotics, corticosteroids and antipsychotics. Conclusion: The pathophysiology of PANDAS begins with Group A beta-hemolytic infection that causes cross reaction in cortical structures and basal ganglia due to molecular mimicry. Currently there is no definitive test for PANDAS,where diagnosis is primarly confirmed by identifying signs, symptoms and physical neurological examination.
Investigating the Prognostic Value of Serum Albumin Levels in Patients Undergoing Hemodialysis: A Systematic Review and Meta-analysis Adrya, Jessica; Sasongko, Calvin; Andrean, Melvin; Kartadinata, Muhammad Faishal; Theis, Aveline Maisie; Putri, Syafira Ayudiah Syah; Mukti, A. Muh. Yasser; Moelyadi, Felly; Varsha, Srigita; Dhika, Veriantara Satya
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10770

Abstract

Background: Hypoalbuminemia, characterized by low serum albumin levels, is frequently observed in patients undergoing hemodialysis and has been identified as a potential predictor of increased mortality risk. This systematic review aims to evaluate the relationship between hypoalbuminemia and mortality in hemodialysis patients, assessing the prognostic value of serum albumin levels as an indicator for patient outcomes. Methods: A comprehensive search was conducted in databases including PubMed, Europe PMC, and Scopus to identify relevant studies. Studies were included if they investigated the association between serum albumin levels and mortality outcomes in adult patients undergoing hemodialysis. Data extraction was performed independently by two reviewers, focusing on study characteristics, patient demographics, albumin levels, and mortality outcomes. Quality assessment of studies was conducted using the Newcastle-Ottawa Scale (NOS). Result: A total of eight studies, encompassing 45,178 hemodialysis patients with a mean age in the 50s, met the inclusion criteria. The studies had a combined male cohort of 22,501 individuals. The definition of hypoalbuminemia varied across studies, with cutoff values ranging from 3.0 to 3.9 g/dL. Follow-up durations spanned from as early as 3 months to a maximum of 6.1 years. The meta-analysis revealed a pooled hazard ratio (HR) of 1.08 (95% CI: 0.94–1.25), suggesting a non-significant association between hypoalbuminemia and increased mortality risk (P = 0.28). However, substantial heterogeneity was present (I² = 79%), indicating variability across studies. Conclusions: Hypoalbuminemia showed a non-significant association with mortality in hemodialysis patients, though variability across studies suggests further research is needed for clarity.
The Role of Glycemic Load, Dairy, and Fatty Acids in Acne Disorders: A Systematic Review and Meta-Analysis Limanda, Claudia Felicia; Mathlubaa, Asya; Istikanto, Ferdian Harum; Sisca; Nabila, Yusra; Amalia, Shania Rizky; Putri, Syafira Ayudiah Syah; Ilmiani, Tasya Khalis; Hartanto, Ericko; Nurfadhila, Melinda
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10771

Abstract

Background: Modern dietary patterns characterized by high glycemic load, dairy consumption, and imbalanced fatty acid profiles may aggravate acne through insulin, IGF-1, and inflammatory pathways. However, findings across studies remain inconsistent. This systematic review and meta-analysis aimed to evaluate the associations between dietary glycemic load, glycemic index, dairy intake, and fatty acid composition with acne disorders. Methods: Following PRISMA 2020 guidelines, PubMed, EMBASE, and Scopus were systematically searched to September 2025. Eligible human studies assessing quantitative relationships between these dietary exposures and acne risk or severity were included. Random-effects meta-analyses were performed using the Hartung–Knapp–Sidik–Jonkman method, with effect sizes expressed as standardized mean differences (SMD) or risk ratios (RR). Result: Five studies encompassing 716 participants (426 acne, 290 controls) met the inclusion criteria. Pooled estimates indicated no significant associations for glycemic load (SMD = 0.09; 95% CI −0.30 to 0.49), glycemic index (SMD = 0.09; 95% CI −0.30 to 0.49), fatty acids/adiponectin (SMD = 0.11; 95% CI −0.74 to 0.97), or dairy consumption (RR = 1.04; 95% CI 0.25 to 4.25). Heterogeneity ranged from moderate to high (I² = 65–90%). Certainty of evidence was moderate for glycemic and dairy outcomes, and low for fatty acids. Conclusions: No significant pooled associations were observed between dietary glycemic load, dairy intake, or fatty acids and acne risk. Despite biological plausibility linking diet to acne via hormonal and inflammatory mechanisms, evidence remains inconsistent. Larger, controlled trials are warranted to define the role of nutritional interventions in acne management.
Procedural Success and Safety of Cryoablation Versus Radiofrequency Ablation in Atrioventricular Nodal Reentrant Tachycardia: A Systematic Review and Meta-Analysis Putri, Evira Agustina; Tunisa, Izza; Suciati, Putri Ayu
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.10775

Abstract

Background: This meta-analysis compares cryoablation and radiofrequency ablation efficacy, safety, and procedural outcomes in atrioventricular nodal reentrant tachycardia (AVNRT). This meta-analysis aims to compare procedural success, long-term recurrence, and complication rates of cryoablation versus radiofrequency ablation in the treatment of AVNRT. Methods: Following PRISMA 2020, PubMed, EMBASE, and Scopus were searched (25 September 2025). Eligible randomized or observational studies directly compared CRYO versus RFA for AVNRT and reported procedural success, recurrence, and/or complications. Risk of bias was assessed (ROBINS-I for non-randomized studies). Pooled effects were calculated in RevMan 5.4 using random-effects models; risk ratios (RR) were used for dichotomous outcomes and standardized mean differences (SMD) for continuous outcomes. Estimates used the Wald-type method with REML; heterogeneity was summarized with I². Result: Sixteen studies were included. Acute procedural success was equivalent between CRYO and RFA (RR 1.00, 95% CI 0.99–1.02; p=0.47; I²=0%). CRYO showed higher recurrence during follow-up (RR 2.29, 95% CI 1.49–3.53; p=0.0002; I²=39%). Complications favored CRYO (RR 0.51, 95% CI 0.28–0.92; p=0.03; I²=0%). Fluoroscopy time was shorter with CRYO (SMD −0.42, 95% CI −0.66 to −0.19; p=0.0004; I²=87%), while overall procedure duration was similar (SMD 0.12, 95% CI −0.06 to 0.31; p=0.19; I²=79%). Overall risk of bias was predominantly low. Conclusions: CRYO and RFA achieve comparable acute success in AVNRT. CRYO confers fewer complications and lower fluoroscopy exposure but a higher recurrence risk, highlighting a safety–durability trade-off.
The Relationship Between Parental Knowledge, Attitudes, and Preventive Efforts Toward the Risk of Diabetes Mellitus in Overweight and Obese Elementary School Children Priyantika, Afifah; Farah, Fransiska
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.10776

Abstract

Background: Childhood obesity is a growing public health problem globally, strongly linked to the early onset of type 2 diabetes mellitus (T2DM). In Indonesia, the prevalence of obesity in children aged 5–12 years has reached 9.2%, with higher rates in urban areas. Parental knowledge, attitudes, and preventive efforts are considered important determinants in shaping children’s lifestyle behaviors and may influence their risk of T2DM. Methods: This study employed a descriptive-analytic cross-sectional design at SDN Jelambar 08, including parents and students from grades 1 to 6. A purposive sampling method was used, resulting in 190 respondents. Independent variables were parental knowledge, attitudes, and preventive efforts, while dependent variables included risk of T2DM and overweight/obesity status. Data were collected using self-administered questionnaires for parents and anthropometric measurements for children. Data analysis was performed with SPSS, using descriptive statistics and chi-square tests. Results: The study showed that 63.7% of parents were aware of diabetes risk factors, 71.1% demonstrated good attitudes, and 74.2% reported preventive efforts. Of the 190 children, 29.5% were classified as overweight or obese. Chi-square tests revealed no statistically significant association between parental knowledge (p=0.911), attitudes (p=0.140), or preventive efforts (p=0.872) and children’s diabetes risk in the context of overweight and obesity. Conclusions: Parental knowledge, attitudes, and preventive efforts were not significantly related to the risk of diabetes mellitus in overweight and obese children. A multifactorial approach that combines parental education, school-based programs, and pediatric monitoring is needed to address childhood obesity and prevent diabetes onset.
Applications of Artificial Intelligence in Peripheral Neuropathy: A Systematic Review Sutha, Anak Agung Ngurah Agung Bayu; Sharon; Rahman, Dea Nabila; Amanah, Salma Rizqi; Wicaksono, Teguh Budi; Sofiana, Dina; Hermawan, Galih Muchlis
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i1.10778

Abstract

Background: Peripheral neuropathy (PN) is a common complication of metabolic and systemic diseases, particularly diabetes mellitus, resulting in sensory loss, pain, and motor impairment. Conventional diagnostic tools often detect PN only after irreversible nerve injury. Artificial intelligence (AI), especially machine learning (ML), has emerged as a promising tool for early diagnosis and risk prediction by integrating clinical, imaging, and genetic data. Methods: Following PRISMA 2020 guidelines, PubMed, EMBASE, IEEE Xplore, and Scopus were systematically searched up to September 2025. Studies applying ML or deep learning algorithms to PN were included, while reviews, grey literature, and studies lacking methodological details or performance metrics were excluded. Result: Our study included participants with diabetic, chemotherapy-induced, or pain-related neuropathies. Deep learning models, such as multilayer perceptrons and neural networks, achieved diagnostic accuracies of 87–93%, while classical algorithms including random forest, XGBoost, and SVM reported AUCs of 0.80–0.93. Radiomics-based SVMs using ultrasound showed external validation AUCs of 0.70–0.90. Key predictors included HbA1c, diabetes duration, lipid profile, and BMI. Conclusions: Machine learning demonstrates strong potential for improving the prediction, diagnosis, and phenotypic classification of PN. However, heterogeneity in datasets and limited external validation restrict clinical translation. Future work should focus on standardized data, multicenter validation, and interpretable AI models to facilitate integration into clinical practice.
Recent Therapies for Endometriosis: A Systematic Review Putra, Ananda; Winata, Raymond Malvin; Berlianzsa, El-Varel Baby; Chandra, Angelica Isabella Monica; Manubulu, Charles Pauris; Tarigan, Tiara Namora; Ellyamurti, Devanti Octavia; Firdaus, Najmarani Devi; Risdiana, Dilla Alfinda
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i1.10779

Abstract

Background: Endometriosis is a chronic gynecological disorder characterized by the growth of endometrial tissue outside the uterine cavity. It commonly affects women of reproductive age and is associated with chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. The disease significantly impacts productivity, social functioning, and sexual health, making it one of the leading causes of disability and reduced quality of life among women. Methods: This review was conducted through a literature search using databases such as PubMed, ScienceDirect, Google Scholar, and ResearchGate. Articles published between 2016 and 2025 were selected using the keywords endometriosis, hormonal therapy, and non-hormonal therapy. Relevant studies were analyzed, cross-referenced, and evaluated to identify current therapeutic strategies for endometriosis management. Result: The management of endometriosis currently includes both hormonal and non-hormonal therapies. Hormonal treatments involve the use of aromatase inhibitors, gonadotropin-releasing hormone (GnRH) analogues, selective estrogen receptor modulators (SERMs), selective progesterone receptor modulators (SPRMs), and dienogest, all aimed at suppressing estrogen production and endometrial growth. Non-hormonal therapies, on the other hand, utilize anti-inflammatory, anti-angiogenic, and pro-apoptotic mechanisms to target the inflammatory cascade that contributes to the pathogenesis of endometriosis. These therapies aim to reduce chronic inflammation, cell proliferation, and pain without interfering with ovulation or fertility. Conclusions: Both hormonal and non-hormonal therapies play a crucial role in managing endometriosis. While hormonal therapy remains the mainstay of treatment, non-hormonal approaches show promising results with fewer side effects and greater patient tolerability. However, further clinical studies are required to evaluate their long-term efficacy and safety before they can be widely implemented in clinical settings.
The Role of Dermatovenereology in the Diagnosis and Management of Bacterial Vaginosis: A Systematic Review Eldy; Amalia, Shania Rizky; Wardianti, Flora Asri; Sitanggang, Mega Rahmani; Hakiki, Nadhira Permata
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i1.10784

Abstract

Background: Bacterial vaginosis (BV) is a prevalent, recurrent cause of abnormal vaginal discharge with important sexual and reproductive health implications. Because symptoms overlap with candidiasis, trichomoniasis, cervicitis/STIs, and vulvar dermatoses, dermatovenereology services are central to accurate diagnosis and comprehensive care. Methods: A PRISMA-compliant systematic review searched PubMed, EMBASE, and Scopus from inception to September 1, 2023, using controlled vocabulary and keywords related to BV, diagnostic modalities (Amsel, Nugent/Gram stain, microscopy, molecular assays), and dermatovenereology/sexual health services. Screening, full-text eligibility, and narrative synthesis were performed; risk of bias was assessed using the Newcastle–Ottawa Scale. Result: From 729 records, 8 studies were included after deduplication, screening, and eligibility assessment. Studies consistently highlighted the value of objective diagnosis particularly in recurrent, atypical, or post-treatment presentations. NAAT-based testing was used mainly in referral settings and facilitated concurrent STI testing. First-line antibiotics (metronidazole or clindamycin) achieved short-term response, but recurrence was common; suppressive intravaginal metronidazole and newer recurrence-prevention approaches (e.g., astodrimer gel, Lactin-V) reduced relapse in selected populations. Conclusions: Dermatovenereology-led pathways that integrate objective testing, careful differential diagnosis, STI screening, and counseling can improve diagnostic precision and reduce BV recurrence.

Page 41 of 41 | Total Record : 409

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