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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 450 Documents
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The Relationship Between Sleep Hygiene and Sleep Quality in Non-Shift Worker Khonsa Sefa Wicaksono; Pricilla Yani Gunawan
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.10501

Abstract

Background: Impaired sleep quality is the most frequently encountered problem. The prevalence of sleep quality disorders in Indonesia reaches 10% of the population. Sleep quality can occur due to many things, one of which is poor sleep hygiene behavior. The level of sleep hygiene behavior and poor sleep quality will reduce productivity in permanent employees.   Methods: This research used a cross-sectional study with a sample size of 109 employees using a purposive sampling technique. This research will be carried out by filling out a questionnaire.   Result: Of the 109 subjects, 24 people (22.0%) had moderate-severe sleep hygiene, while 85 people (78.0%) had good sleep hygiene. Based on PSQI, 102 people (93.6%) experienced bad sleep disorders and 7 people (6.4%) did not experience sleep disorders. There was no statistically significant relationship (P = 0.648).   Conclusions: There is no statistically significant relationship between sleep hygiene and sleep quality.
The Association Between Combined Oral Contraceptive Use and the Incidence of High-Density Lesions on Digital Mammography Carissa Faustina; Nina ISH Supit; Nungky Kusumaningtyas; Alvin Setiawan; Ratna Sari Wijaya
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11079

Abstract

Background: High mammographic density (MD) is an independent breast cancer risk factor that hinders early detection through the "masking effect." Global literature on the impact of combined oral contraceptives (COCs) remains inconsistent, with limited data available for the Indonesian population. This research aims to investigate the association between COC use and high-density lesions on digital mammography while evaluating the influence of family history.   Methods: This cross-sectional study analysed 158 subjects at Siloam MRCCC Hospital (Dec 2025–Jan 2026) using purposive sampling. Statistical associations were assessed using Chi-square and Fisher’s exact tests.   Result: Long-term COC use (≥5 years) was significantly associated with a reduced risk of high-density lesions (OR=0.28; 95% CI: 0.14–0.55; p<0.001) in perimenopausal women (median age 53). In contrast, family history was a potent risk factor, with a 100% prevalence of high-density lesions (p=0.003). After adjusting for family history, the protective association of COC use persisted (aOR=0.43). BMI and reproductive history showed no statistically significant associations.   Conclusion: Long-term COC use correlates with lower mammographic density in perimenopausal women, potentially mitigating diagnostic masking. However, family history remains a dominant factor that overrides these hormonal associations. These findings highlight the need for multifaceted screening strategies that integrate genetic predisposition and physiological tissue involution.
Relationship Between the Length and Depth of Myocardial Bridging and the Degree of Proximal Coronary Artery Stenosis Using Coronary Computed Tomography Angiography Teodorus Alfons Pratama; Rusli Muljadi; Koesbandono Koesbandono; Antonia Anna Lukito; Andree Kurniawan
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11154

Abstract

Background: Myocardial bridging (MB) is a congenital anomaly of the coronary arteries that results in dynamic compression during the cardiac cycle. This condition accelerates the development of atherosclerosis, particularly in the proximal coronary segment. Evidence regarding the relationship between MB morphology and the degree of stenosis based on coronary CT angiography (CCTA) remains limited and inconsistent. This study aimed to evaluate the association between MB length and depth and the degree of proximal coronary artery stenosis using CCTA at Siloam Lippo Village Hospital.   Methods: This was an observational analytic study with a cross-sectional design. Samples were obtained through consecutive sampling of patients aged ≥18 years who underwent CCTA between 2024 and 2025. Data were analysed using the Mann-Whitney U test for comparison of means, with a p-value <0.05 considered statistically significant.   Result: A total of 144 patients met the inclusion criteria. MB was most commonly found in the mid-left anterior descending (mid-LAD) segment, with a mean depth of 1.18 mm and a mean length of 14.67 mm. Most proximal stenosis cases were categorized as non-significant (<50%). Mann-Whitney U analysis showed that MB depth was significantly associated with the degree of proximal stenosis (p = 0.006), whereas MB length was not (p = 0.345). The interaction between these variables, represented as MB area, showed a stronger correlation with the degree of stenosis (p = 0.004).   Conclusion: MB is associated with the degree of proximal coronary artery stenosis as assessed by CCTA. These findings may improve risk stratification and support more appropriate clinical management in patients with MB.
The Relationship Between Self-Care and Quality of Life in Patients With Coronary Artery Disease in Siloam Hospital Lippo Village Sunanto Ng; Karin Pratiwi Oktaviani
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11217

Abstract

Background: Coronary artery disease not only contributes to high mortality but also substantially impairs quality of life. Although self-care is recognized as a key component of chronic disease management, empirical evidence integrating disease-specific self-care assessment and symptom-based quality of life measurement in Indonesian populations remains limited.   Methods: This analytical observational study employed a cross-sectional design involving 50 outpatients with CAD at Siloam Lippo Village Hospital (June–September 2023). Self-care was assessed using the Self-Care of Coronary Heart Disease Inventory (SC-CHDI), while quality of life was measured using the Seattle Angina Questionnaire (SAQ). Data were analyzed using the Chi-square test with a significance level of p<0.05.   Result: A total of 60% of participants demonstrated good self-care and quality of life. A significant association was observed between self-care and quality of life (p=0.038; OR=4.125; 95% CI: 1.235–13.782). Clinical factors including hypertension (p=0.007), diabetes mellitus (p<0.001), and angina severity grade (p=0.002) were also significantly associated with quality of life.   Conclusion: Self-care is a key determinant of quality of life in patients with CAD. Notably, the use of disease-specific instruments (SC-CHDI and SAQ) provided a more sensitive and clinically relevant assessment of the relationship between self-care behaviors and patient-reported outcomes, supporting the implementation of patient-centered care strategies in clinical practice.
Effectiveness and Safety of Bleomycin Sclerotherapy in Pediatric Low-Flow Vascular Malformations: A Retrospective Cross-Sectional Study Rio Hermawan; Koesbandono Koesbandono; Raditya Utomo; Hardini Intan S. Mahdi; Ade Nurlina; Ratna Sari Wijaya
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11227

Abstract

Background: Low-flow vascular malformations (LFVMs) are congenital vascular anomalies commonly managed using sclerotherapy. Among available sclerosant agents, bleomycin has demonstrated favorable therapeutic efficacy and safety profiles in pediatric vascular malformations, although treatment responses remain variable across different lesion types and morphologies.   Methods: This retrospective cross-sectional study evaluated pediatric patients with LFVMs who underwent bleomycin sclerotherapy at Dharmais Cancer Hospital between January 2019 and May 2025. Demographic characteristics, lesion profiles, treatment sessions, cumulative bleomycin doses, therapeutic outcomes, and treatment-related adverse events were analyzed. Therapeutic responses were categorized into Grade 0-3 outcomes.   Result: A total of 41 pediatric patients with LFVMs were included in the study. Patients aged 0-5 years represented the largest age group (51.2%), while the head and neck region was the most common lesion location (41.4%). Venolymphatic malformations (51.2%) and microcystic lesions (65.8%) were the predominant lesion subtypes. Grade 2 clinical response was the most frequently observed therapeutic outcome (58.5%), whereas Grade 3 response was identified in 17.1% of patients. The mean number of treatment sessions was 5.80 +/- 2.42. Treatment-related adverse events were minimal, with pain and edema observed in one patient each (2.4%), and no cases of pulmonary injury or major systemic complications identified. No significant association was found between treatment sessions or cumulative bleomycin dose and therapeutic outcomes (p>0.05).   Conclusions: Bleomycin sclerotherapy demonstrated favorable effectiveness and safety profiles in pediatric patients with LFVMs. Therapeutic outcomes appeared to be influenced more strongly by lesion characteristics than by treatment intensity or cumulative bleomycin dose.
Late Relapse of Diffuse Large B-Cell Lymphoma in a Patient with Minor Thalassemia: A Diagnostic Challenge Stephanie Marisca; Jennifer Jesse Limanto
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11447

Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) commonly responds to chemoimmunotherapy, and relapse risk usually decreases after prolonged remission. Thalassemia has been associated with increased risk of hematologic malignancy, although its relationship with late DLBCL relapse remains unclear.   Case Description: A 68-year-old woman with minor thalassemia and a history of primary mediastinal B-cell lymphoma in complete remission for 15 years presented with fever and fatigue. Laboratory findings showed pancytopenia and elevated lactate dehydrogenase. FDG-PET/CT demonstrated increased uptake in the spleen and bone marrow. Bone marrow biopsy showed large B-lymphoid cells positive for CD20 and MUM1, establishing relapsed DLBCL with extranodal involvement. Complete remission was achieved after two cycles of R-COP chemotherapy, but the patient later died from severe infection, metabolic complications, and cardiomyopathy during the fourth cycle.   Conclusions: Late relapse of DLBCL in patients with thalassemia is diagnostically challenging because cytopenia and systemic symptoms may overlap with hematologic complications. Long-term surveillance and prompt evaluation of new pancytopenia, splenomegaly, or systemic symptoms are essential in lymphoma survivors with thalassemia.
The Impact of Introductory Anatomy Laboratory Videos on Medical Students’ Laboratory Quiz Performance Stefanus Satria Sumali; Mona Marlina
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11453

Abstract

Background: This study examined the association between viewing introductory anatomy laboratory videos and quiz performance among medical students at the Faculty of Medicine, Universitas Pelita Harapan.   Methods: Using observational design with a cross-sectional approach of secondary data from 180 students in the Skin and Special Senses course.   Result: Students who watched the introductory video were significantly more likely to achieve quiz scores of ≥60 than those who did not. Chi-square analysis demonstrated a significant association between video viewing status and quiz performance (χ²(1)=40.36, p<0.001), with a moderate relationship strength (Cramér’s V=0.474). Students who watched the video were nearly eight times more likely to achieve passing scores (OR=7.91, 95% CI: 4.06–15.42).   Conclusions: Watching introductory anatomy laboratory videos was significantly associated with better laboratory quiz performance. It may support self-directed learning and enhance the academic performance.
Association Between LDL-to-HDL Cholesterol Ratio and Albuminuria in Patients With Type 2 Diabetes Mellitus: A Cross- Sectional Study Jeremia Siregar; Michelle Audrey Widuri Hutapea; Angeline Tancherla; Andree Kurniawan; Stephanie Marisca
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11493

Abstract

Background: Dyslipidemia plays a role in the pathogenesis of diabetic kidney disease, yet the clinical utility of the LDL/HDL ratio for detecting early renal involvement remains uncertain. This study evaluated the association between LDL/HDL ratio and albuminuria in type 2 diabetes mellitus (T2DM) patients.   Methods: A cross-sectional study was conducted using medical records of adults with T2DM at Siloam Hospital Lippo Village, Indonesia. Patients with complete lipid profiles and urine albumin–creatinine ratio (ACR) data were included. The LDL/HDL ratio was analyzed in relation to albuminuria. Receiver operating characteristic (ROC) analysis determined the optimal cutoff. The ratio was dichotomized using this cutoff, and associations with albuminuria were evaluated using chi-square tests and Poisson regression with robust variance to estimate adjusted prevalence ratios (aPRs).   Result: A total of 95 patients were analyzed, of whom 46.3% had albuminuria. The LDL/HDL ratio correlated with ACR (ρ=0.528, p<0.001). ROC analysis showed good discrimination for albuminuria (AUC 0.796; 95%CI 0.704–0.888), with a bootstrap 95%CI 0.700–0.881. The optimal cutoff was 2.435, yielding 77.3% sensitivity and 74.5% specificity. Albuminuria was more frequent in patients with LDL/HDL ≥2.435 than in those below the cutoff (72.3% vs. 20.8%; p<0.001). LDL/HDL ≥2.435 was independently associated with albuminuria (aPR 3.03; 95%CI 1.82–5.26; p<0.001). Hypertension, older age, and higher HbA1c were also significant predictors.   Conclusion: The LDL/HDL ratio showed acceptable discriminatory performance and was independently associated with albuminuria in patients with T2DM. This simple index may serve as an adjunctive marker for renal risk stratification, pending external validation in larger prospective studies.
Risk Factor Profile of Children With Cerebral Palsy at Sambang Lihum Psychiatric Hospital Adelia Hanny Tiara; Wahyu Bagus Handoko; Bambang Dwiputranto; Haerati Haerati; Ramadiana Ramadiana
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11620

Abstract

Background: Cerebral palsy is a common childhood motor disorder caused by non-progressive disturbances in the developing brain. Local descriptions of risk factors are needed to support prevention, early detection, and rehabilitation planning. Methods: This descriptive cross-sectional study was conducted at Sambang Lihum Psychiatric Hospital from 1-31 March 2025. Fourteen children with cerebral palsy who underwent therapy or care during the study period were included. Data were obtained from medical records and parent or guardian interviews using a structured questionnaire and were analyzed descriptively. Result: Most children were aged 1-5 years (8/14; 57.2%). Maternal age during pregnancy was mostly 18-35 years (10/14; 71.4%). Nine children (64.3%) were born at <=37 weeks of gestation, and six (42.9%) had birth weight <2500 g. Most children had no history of head trauma (78.6%), febrile seizure (57.1%), or brain infection (92.9%). Conclusions: The most prominent risk factors identified in this sample were prematurity and low birth weight. Strengthening antenatal monitoring, neonatal care, and early rehabilitation remains important for children at risk of cerebral palsy.
Association of Dorsal Subcutaneous Fat Thickness, Paraspinal Muscle Fat Infiltration, Modic Changes, and Demographic Factors with Lumbar Disc Degeneration on Magnetic Resonance Imaging Audrina Ernes; Inda Kania M; Nyi Raden Siti Vissy Puspa Dewi Muharam
Medicinus Vol. 15 No. 3 (2026): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i3.11621

Abstract

Background: Lumbar disc degeneration is a common contributor to chronic low back pain. Magnetic resonance imaging enables assessment of disc degeneration and related factors, including dorsal subcutaneous fat thickness, paraspinal muscle fat infiltration, Modic changes, age, and sex. Methods: This quantitative cross-sectional study used consecutive sampling of patients who underwent non-contrast lumbar MRI at Royal Prima General Hospital, Medan, from September to November 2025. A total of 253 samples were analyzed. Lumbar disc degeneration was graded using the modified Pfirrmann system, paraspinal fat infiltration using the Goutallier classification, and Modic changes using standard MRI criteria. Statistical analysis was performed using SPSS. Result: Lumbar disc degeneration tended to be more severe in the lower lumbar levels, particularly L4-L5 and L5-S1. Paraspinal muscle fat infiltration, Modic changes, and age showed significant associations with lumbar disc degeneration. Dorsal subcutaneous fat thickness and sex did not show significant associations with degeneration across the analyzed levels. Conclusions: Paraspinal muscle fat infiltration, Modic changes, and age were significantly associated with lumbar disc degeneration on MRI, whereas dorsal subcutaneous fat thickness and sex were not. These findings support careful MRI evaluation of paraspinal muscle quality and endplate changes in patients with lumbar degeneration.

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