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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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Articles 5 Documents
 1 
Search results for , issue "Vol 7, No 3 (2022)" : 5 Documents clear
An Evaluation of Causality, Severity, and Preventability of Adverse Drug Reactions Reported by Undergraduate Medical Students in a Tertiary Care Hospital Mohammad Y. Bhat; Samina Farhat; Urfan Nabi
Pharmacology and Clinical Pharmacy Research Vol 7, No 3 (2022)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v7i3.40945

Abstract

Adverse drug reactions (ADRs) have become a major clinical problem that causes mortality and morbidity, besides causing an additional burden on the total cost of patient treatment worldwide. Therefore, this study aimed to assess ADRs’ causality, severity, and prevent- ability and sensitize undergraduate medical students to reduce underreporting cases. A ret- rospective observational study in J&K tertiary teaching hospital in India. We conducted the study after sensitizing the students about pharmacovigilance and guiding them to submit individual case safety reports (ICSRs) of ADRs during their clinical stages. The study was conducted for ten months, from May 2020 to February 2021, as a part of their internal assess- ment, followed by evaluating the data using simple descriptive statistics. We analyzed a total of 124 reports over the stipulated time. The most common ADRs reported were related to skin and appendages, and antibiotics accounted for a maximum number of cases. Causality assessment showed that most ADRs were possible (61.1%) and probable (38.8%). Severity and preventability assessment revealed that most reported ADRs were moderate (67.9%) and mild (32.0%), while most ADRs were preventable, with only 30.0% of them not preventable. Students reported valuable and clinically relevant ADRs. This study will foster the culture of reporting and analyzing the impact of ADRs among undergraduate students. Furthermore, since most ADRs in this study were preventable, managing such ADRs through therapeutic intervention would benefit better patient care.
Adverse Reaction Monitoring following Coronavirus Disease (COVID-19) Immunization among Health Care Workers of a Tertiary Care Hospital in India Suraj B. Panchal; Latha Shivanand; Rakesh Navale; Somashekara S. Chikkannasetty; Amrutha D. Torvi; Rameez Ahmed; Satish Ghatage
Pharmacology and Clinical Pharmacy Research Vol 7, No 3 (2022)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v7i3.38415

Abstract

With the unprecedented and devastating impact of Corona Virus Disease (COVID-19) pandemic on public health, high coverage of safe and efficacious vaccines against COVID-19 disease could contribute to the control of the COVID-19 pandemic. However, in India vaccination strategy against COVID-19 was implemented to overcome this catastrophe as early as January 2021. Considering the novelty in adverse events and the dearth of research studies about the adverse event following immunization (AEFI) associated with COVID-19 vaccine, the present study aimed to determine the incidence and types of adverse events following COVID-19 vaccination among healthcare workers (HCWs). It was a prospective, observational study conducted among the HCWs of a tertiary care hospital who received the first dose of the ChAdOx1 nCoV-19 vaccine between January-March 2021. Systemic and local adverse events experienced up to the first 24 hours of vaccination were surveyed using Google Forms. Of the total 1045 HCWs who were vaccinated, 666 HCWs responded completely to the Google form. The majority (79.3%) of the participants were 18-30 years old. The most commonly reported AEFI were pain at the injection site (68.8%), fatigue (40.1%), myalgia (35.4), and malaise (35.0%). Among the systemic adverse events, the incidence of fatigue, and local adverse events, the pain at the injection site was considerably greater in the 18-30 years age group than in the other HCWs group (P < 0.001). The severity of most AEFI was mild-to-moderate in nature. Hence, this study concludes that AEFI associated with the ChAdOx1 nCoV-19 vaccine after a single dose was safe and tolerable. The maximum number of participants accepted AEFI because minor reactions would be common and treatable
Evaluation of Knowledge, Attitude, and Practice about the Rational Use of Medicines among Junior Residents in a Tertiary Hare hospital in India Sakshi Singh; Arvind K. Yadav; Meenu Pichholiya; Sandeep K. Kamlekar; Sangita Gupta
Pharmacology and Clinical Pharmacy Research Vol 7, No 3 (2022)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v7i3.38647

Abstract

Rational use of medicine is an integral part of the health care system, which has become the weakest part due to various contributors like prescribers, producers, controllers, and consumers that have led to irrationality and increased the patient’s socio-economic burden. This study aimed to assess junior residents’ knowledge, attitude, and practice of rational medicine of medicine in a tertiary care teaching hospital. This cross-sectional observational study was conducted in the Department of Pharmacology at the tertiary care teaching hospital in Rajasthan, India, for a period of six months, from February 2021 to June 2021. All first- and second-year hospital residents, except those unwilling to participate, were included in the study. The first part of the questionnaire was about knowledge, and the second part was about the attitude and practice of junior residents regarding the rational use of medicines. The data was presented in the form of figures and percentages. Most residents (98%) were aware of the term rationality and rational use of medicines. Maximum numbers of residents (97%) were aware of the term essential medicines. The residents who were aware of drugs included in the National Essential of Medicine and term P-drug were 55% and 69%, respectively. Nearly 21% of residents prescribe drugs by generic names, while the majority (65%) prescribe both generic and brand names. Almost all (98%) of residents agreed that regular training is needed about the rational use of medicines to improve rational prescribing and 89% of residents think regular prescription auditing should be done. This study concludes that most residents were aware of the rational use of medicines, essential medicines, and the P drug concept. But they should receive regular training on the rational use of medications. This will prevent serious problems related to the inappropriate prescribing of medicines during their medical practice.
Study to Evaluate the Efficacy and Safety of Topical Lipid-based Amphotericin B Gel 0.1% in Patients with Cutaneous Mycosis Resistant to Conventional Therapy Mamatha Kamarthi; Raghav M V; Laxminarayana Kamath; Revathi T N
Pharmacology and Clinical Pharmacy Research Vol 7, No 3 (2022)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v7i3.38892

Abstract

The last few years have seen a significant rise in the incidence of cutaneous mycosis infections resistant to conventional therapy. Topical nanostructured lipid formulations of Amphotericin B have emerged as a novel system to tackle this menace. The present study is an open-label, single-arm, prospective study to analyze the efficacy and safety of topical nanostructured lipid-based Amphotericin B gel in treating patients attending Dermatology OPD, Victoria hospital, with cutaneous mycosis resistant to conventional therapy. Thirty patients diagnosed with tinea corporis/cruris resistant to conventional therapy were included in the study.  Patients were advised to apply amphotericin B gel 0.1% on the affected area twice daily for four weeks. Outcome parameters like pruritus, erythema, vesicles, desquamation, and KOH mount were noted weekly for the assessment of efficacy and safety.  One-way ANOVA was used for statistical analysis. After treatment with Amphotericin B gel, patients showed a statistically significant reduction in pruritus, erythema, vesicles, and desquamation from baseline across time towards the end of 4 weeks (p<0.05).  Also, the Mean total score of all symptoms, which was 8.3±3.1 at baseline, was reduced to 0.9±0.7 at the end of the 4th week (p<0.05). All the patients treated were mycologically negative for KOH mount at the end of the study period. No serious adverse drug reactions were reported to treatment. To conclude, topical nanostructured lipid-based amphotericin B gel in patients with cutaneous mycosis resistant to conventional treatment was efficacious and safe.
Prebiotic Activity of Pectin from Ambon Lumut Banana (Musa acuminata AAA) Peel Bertha Rusdi; Onoy Rohaeni; Miski A. Khairinisa; Umi Yuniarni
Pharmacology and Clinical Pharmacy Research Vol 7, No 3 (2022)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v7i3.41598

Abstract

Banana peel is an agricultural waste that contains pectin. Ambon lumut banana (Musa acuminata AAA) is often consumed in Indonesia, but its peel is rarely utilized thus the availability of Ambon lumut banana peel in Indonesia is high. Pectin selectively increases beneficial gut bacteria, and this is commonly known as prebiotic. This study aims to evaluate the prebiotic activity of Ambon lumut banana peel by observing the growth of a beneficial gut bacteria, Lactobacillus acidophilus, and pathogen enteric bacteria, Escherichia coli, in media (MRSB) enriched with the pectin. The result showed that 1% of Ambon lumut banana peel pectin significantly increased the number of L. acidophilus and decreased the number of E. coli compared to bacteria culture without carbon source (glucose-free MRSB) and bacteria culture with glucose as carbon source. The prebiotic index of Ambon lumut banana peel pectin was 0.53. In addition to that, the short chain fatty acid (SCFA) which is beneficial metabolite of L. acidophilus for human health was also measured using HPLC.  The HPLC analysis results showed that L. acidophilus culture enriched with pectin contains SCFA, including acetic acid, butyric acid, and propionic acid at the concentration of 10.22 µg/mL, 5.38 µg/mL and 0.55 µg/mL respectively.

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