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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 12 Documents
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Search results for , issue "Vol. 7 No. 4 (2022)" : 12 Documents clear
Neurological Abnormalities in Congenital Rubella Syndrome and Possible Pathophysiology Erny, Erny; Prasetyo, Okky; Soekanto, Ayli
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2022.7.4.585

Abstract

Background: Congenital rubella syndrome is a disease that is a relative severe health problem because it causes multiorgan disability. The purpose of the study was to describe the neurological abnormallities that occur in congenital rubella syndrome and its pathophysiology.Case Presentation: A descriptive study with the subjects of the study of infants and children with congenital rubella syndrome found in the private practice of pediatricians for 10 years aged 15 years with the most complaints of developmental and growth delays, recurrent seizures and behavioral disorders. most are first children with mothers without Measles, Mumps, and Rubella (MMR) vaccination. Inclusion criteria: infants and children with clinical manifestations of at least 2 of all major clinical signs (hearing loss, congenital cataracts and congenital heart defects) accompanied by evidence of infection in the form of rubellaspecific serum IgM and a history of the mother experiencing infection during pregnancy as evidenced by IgG results and or IgM rubella antibodies.Results: 13 cases were obtained, 92.3% of the case population with multiorgan disability and only 1 case (7.69%) with neurological disorders alone. 84.6% of cases of neurological disability occurred as a result of infection in the 1st trimester.Conclusion: Neurological abnormalities were acquired in the entire study population and were mostly due to infections in the 1st trimester of pregnancy.Keywords: neurological abnormalities, congenital rubella syndrome.Correspondence: Erny. Pediatric Department Medical Faculty Wijayakusuma University. Jl. Dukuh Kupang XXV no 54 Surabaya, East Java, Indonesia. Email: drernyspa@gmail.com. Mobile: 0818381740.Indonesian Journal of Medicine (2022), 07(04): 449-455https://doi.org/10.26911/theijmed.2022.07.04.10
Meta-Analysis the Effect of Chlorhexidine and Povidone Iodine Mouthwashes on Viral Load SARS-CoV-2-Saliva Narulita, Danti; Rahardjo, Setyo Sri; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2022.7.4.589

Abstract

Background: The strategy to reduce the risk of transmission of COVID-19 is to reduce the salivary SARS-CoV-2 viral load. Chlorhexidine and povidone iodine mouthwash are common active ingredients in oral antiseptics that have efficient viral activity against salivary SARS-CoV-2. This study aims to combine the results of several effect sizes regarding the effect of using chlorhexidine and povidone iodine mouthwash on the salivary SARS-CoV-2 viral load from various countries.Subject and Method: This study is a meta-analysis with the following PICO model, P: COVID-19 patients. I: use of chlorhexidine and povidone iodine mouthwash. C: no mouthwash. O: salivary SARS-CoV-2 viral load. A search for the articles used in this study was carried out using the keywords “COVID-19” OR “SARS-CoV-2” OR “viral load” OR “SARS-Cov-2 viral load” OR “Chlorhexidine mouthrinse” OR “Povidone Iodine mouthrinse ” OR “Randomized Controlled Trial” OR “RCT” between 2012-2022 from the PubMed, Springerlink, Elsevier, Google Scholar and Wiley Online Library databases. The inclusion criteria used in this study were full-text articles using a Randomized Controlled Trial (RCT) design. The analysis used was multivariate with Standardized Mean Difference (SMD). The articles collected were then critically reviewed using the PRISMA checklist, then the data were analyzed using the Review Manager 5.4 tool.Results: This meta-analysis examined 10 articles with a Randomized Controlled Trial (RCT) study design originating from Singapore, Saudi Arabia, Iran, Brazil, Italy, South Korea and Malaysia. A meta-analysis of 7 articles showed that the use of chlorhexidine mouthwash could reduce salivary SARS-CoV-2 viral load by 0.12 units lower than without the use of mouthwash (SMD= -0.12; 95% CI= -0.33 to 0.09; p=0.250). Meanwhile, 7 articles showed that the use of povidone iodine mouthwash could reduce the salivary SARS-CoV-2 viral load by 0.64 units lower than without the use of mouthwash (SMD= -0.64; 95% CI= -1.51 to 0.23; p=0.150).Conclusion: The use of chlorhexidine and povidone iodine mouthwashes can reduce the amount of salivary SARS-CoV-2 viral Keywords: mouthwash, chlorhexidine, povidone iodine, COVID-19, salivary SARS-CoV-2 viral load.Correspondence: Danti Narulita. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah. Email: dantinarulita@yahoo.co.id. Mobile: +6282158818400.Indonesian Journal of Medicine (2022), 07(04): 387-400https://doi.org/10.26911/theijmed.2022.07.04.04

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