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JPSCR : Journal of Pharmaceutical Science and Clinical Research

jpscr
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Published by Universitas Sebelas Maret

ISSN : - EISSN : 2503331x DOI : -

Core Subject : Health, Social,

Environmental Science Public Health

Journal of Pharmaceutical Science And Clinical Research (e-ISSN 2503-331x) offers a forum for publishing the original research articles, review articles from contributors, and the novel technology news related to pharmaceutical science and clinical research. Scientific articles dealing with natural products, pharmaceutical science-industry and clinical research, etc. are particularly welcome. The journal encompasses research articles, original research report, reviews, short communications and scientific commentaries pharmaceutical science and clinical research including: bioactive products, chemotaxonomy, chemistry, ecological biochemistry, metabolism, pharmacy management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, pharmaceutical social and pharmaceutical industry.

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Articles 9 Documents

Search results for , issue "Vol 1, No 1 (2016)" : 9 Documents clear

PERBEDAAN KADAR KAFEIN DAUN TEH (Camellia sinensis (L.) Kuntze) BERDASARKAN STATUS KETINGGIAN TEMPAT TANAM DENGAN METODE HPLC Anif Nur Artanti; Wahyu Rohmatin Nikmah; Discus Hendra Setiawan; Fea Prihapsara
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 1 (2016)
Publisher : Universitas Sebelas Maret

Tea is the most widely consumed beverage in the world next to water. Tea leaves contain caffeine compound that has many advantages for health. Generally tea garden is in hill, especially in the mountain area which has difference high place that can influence the secondary metabolic compound in plant. So, it needs to observe about the effect of difference height planting place to tea leaf caffeine contain. This research was experimental research that taken samples from tea leaf TRI 2024 variety from 3 height variations, is 800 m; 1000 m; and 1200 m above sea level. The analytical method used in this research is high performance liquid chromatography (HPLC). The HPLC instrument is Lab Alliance brand, LC-10AT VP pump, coulomb ACE 5 C18 and UV-Vis detector at 275 nm length. The difference of caffeine content was analyzed using ANOVA.The result showed that any influence between height planting and caffeine content. Caffeine content in height 800 m above sea level is 562,20782 mg/gram sample, in height 1000 m above sea level is 239,80893 mg/gram sample and caffeine content in 1200 m above sea level is 185,93200 mg/gram. The highest caffeine contain is in height 800 m above sea level is 562,20782 mg/gram sample.

APLIKASI TEORI PERILAKU BERALASAN PADA KONSUMEN PRODUK HAND SANITIZER Prihapsara, Fea; Kustati, Fatimah Dwi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 1 (2016)
Publisher : Universitas Sebelas Maret

Mencuci tangan merupakan ritual yang sederhana dan dapat mengurangi risiko penularan penyakit infeksi hingga 50%. Namun, karena tidak selalu mudah menemukan air bersih dan sabun maka diperkenalkanlah produk hand sanitizer untuk mempermudah aktivitas seseorang dalam urusan cuci tangan. Penelitian ini dilakukan untuk mengetahui pengaruh dari sikap dan norma subyektif baik secara parsial maupun bersamaan terhadap niat beli mahasiswa pada produk hand sanitizer.Penelitian ini termasuk penelitian deskriptif, berupa penelitian survey dengan responden sebanyak 120 mahasiswa yang diambil dengan metode judgemental sampling. Data primer dikumpulkan dengan kuesioner dan dianalisis dengan menggunakan uji validitas dan reliabilitas, uji asumsi klasik, uji F, uji t, koefisien determinasi, dan analisis regresi berganda.Hasil penelitian menunjukkan bahwa variabel sikap secara parsial berpengaruh positif dan signifikan terhadap niat beli dengan nilai signifikasi (Pvalue) 0,000<0,05. Norma subyektif secara parsial tidak berpengaruh signifikan terhadap niat beli dengan nilai signifikasi (Pvalue) 0,996>0,05. Secara bersama-sama sikap dan norma subyektif berpengaruh positif dan signifikan terhadap niat beli dengan Fhitung sebesar 13,547 dan signifikasi (Pvalue) 0,000<0,05. Selain itu juga diperoleh nilai koefisien determinasi sebesar 0,174 yang artinya 17,4% perubahan variabel niat dapat dijelaskan oleh variabel sikap dan norma subyektif.

PERBANDINGAN PENGGUNAAN BAHAN PENGHANCUR SECARA INTRAGRANULAR, EKSTRAGRANULAR, DAN KOMBINASINYA Ahmad Ainurofiq; Nailatul Azizah
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 1 (2016)
Publisher : Universitas Sebelas Maret

Rate of disintegration the tablet is determined by disintegrant position in intragranular or extragranular. Intragranulary granules were disintegrant into their constituent particles, while in extragranulary tablets were disintegrant into granules.This study aims to determine the effectiveness of the addition of materials disintegrant intragranulary, extragranulary, and combination on the disintegration of the tablet with the parameters of physical properties of tablets produced. The tablets were prepared in three formulas based on comparative materials disintegrant variations intragranular and extragranular. Comparison of the three formulas in intragranular and extragranular: F1 (100%: 0%), F2 (75%: 25%), F3 (0%: 100%). Tablet were prepared using wet granulation method with 10% starch binder materials. The resulting granule tested physical properties of granule include: flow time, angle of repose, and tapping. Furthermore, compressed with a constantdepth of punch. The tablets tested the physical properties include: uniformity of weight, hardness, friability, and disintegration time.Statistical results with oneway ANOVA test showed that between tablets formula have difference disintegration time tablet was significant difference with the addition of disintegrant. Data base obtain showed that all formulas parasetamol tablets fulfilled the requirements of granular physical test but only F2 fulfilled the requirements of tablets physical test. The most effective formula tablet is F2 (75%:25%) was disintegration time (8.05 minute).

ANALISIS ABC DALAM PERENCANAAN OBAT ANTIBIOTIK DI RUMAH SAKIT ORTOPEDI SURAKARTA Tina Hari Yanti; Yeni Farida
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 1 (2016)
Publisher : Universitas Sebelas Maret

Planning of drug is an attempt determination of the type of drug, quantity and quality of medicines as needed. Antibiotics are used as primary therapy in cases of bacterial infection, so it needs a good planning for control the supplies. This study aims to classify antibiotics using ABC analysis to help the control of antibiotic drugs at Pharmacy Instalation of Prof. Dr. R. Soeharso Orthopedy Hospital Surakarta.The design of this study is non-experimental research with descriptive analysis by using quantitative data. Data was analyzed using Microsoft Excel 2007. Data was obtained from prescriptions that contain antibiotic drugs at Pharmacy Instalation of Prof. Dr. R. Soeharso Orthopedy Hospital Surakarta during 2013. Data was analyzed using ABC method. The data classified by usingABC method showed that out of 100 antibiotic drug items, 9 (9%) are categorized as group A, 13 (13%) are categorized as group B, and 78 (78%) are categorized as group C.

ANALISIS FAKTOR INTERNAL-EKSTERNAL TERHADAP PENGELOLAAN OBAT DI INSTALASI FARMASI RSUD DR. MOEWARDI SURAKARTA Sholichah Rochmani; Achmad Fudholi; Lukman Hakim
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 1 (2016)
Publisher : Universitas Sebelas Maret

SWOT analysis is first step for formulating the strategic, to analyze the external and internal environmental factors. The purpose of this research is to analyze the external and internal environmental factors which influence pharmacy department, formulating the strategic management of the pharmacy department that can increase good works Pharmacy Department of RSUD Dr. Moewardi Surakarta .The method for the research is realized by collecting secondary data related to drugs management in pharmacy department, and then collect the primary data by conducting direct observation in the form of interview with Chief Pharmacy Department and distribute questionnaires to the doctor, officials, and patients. To determine the management of drug using the drug management indicators and to determine strengths, weaknesses, opportunities, and threats using SWOT analysis. The result showed that the internal environmental factor such as drug management in selection phase, selected drugs by DOEN is 6%. Procurement phase, the percentage of capital available along with all the used fund can only absorbs the average of 95,6% of the real total, percentage according to between planning with the fact to inappropriate drug 105,01%, and the average availability of medicine of 35 days. On distribution phase, the expired or damaged medicine out of the supported 0%. Use phase, showed by the waiting time for outpatient uncompounding prescription is 30,47 minutes and compounding prescription is 60,01 minutes. External environmental factors in pharmacy department such as opportunity: human resources in pharmacy department need to practical training, a good service in pharmacy department, drugs is complete; threats focused on existing hospitals in Surakarta, good services for customers quality, long waiting time for drug in pharmacy department. Pharmacy Department of RSUD Dr. Moewardi Surakarta was on the first quadrant. The strategy which can be used by Pharmacy Department of RSUD Dr. Moewardi Surakarta in this condition is to support the aggressive growing policy (growth oriented strategy).

EFEK PENGGUNAAN SIMVASTATIN TERHADAP KENAIKAN GULA DARAH PUASA PASIEN DIABETES MELITUS TIPE 2 Yeni Farida; Claudia Putri
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 1 (2016)
Publisher : Universitas Sebelas Maret

Simvastatin were given in diabetes mellitus patient to reduce the risk of cardiovascular event. Many studies have shown the effectiveness of statins in improving lipid profile. However, effects of statins on glucose metabolism are still unclear. The study aimed to investigate effect of simvastatin on increasing fasting plasma glucose.This retrospective cohort study using medical records included adult diabetes mellitus patient aged 18-60 years old that inpatient in 2014. We studied profil in fasting plasma glucose (FPG) in this population between before and after simvastatin therapy. Data were limited to patients who had 4 FPG measurements, 2 measurement before and 2 measurement at least a month after medication. Diagnosis of diabetes had to be present before the first FPG measurement.Coefficients kontingency analysis evaluated correlation between simvastatin and increasing of fasting plasma glucose.In this study, 15 patients were eligible. Before simvastatin therapy, 8 patients had normal level of FPG and 7 patients had abnormal level but it were decrease. After a month of simvastatin therapy, level of FPG had increased became abnormal in all patient. Statin use is associated with a rise of FPG in patients with diabetes (p < 0.0001).

OVERVIEW OF DRUG PROCUREMENT MANAGEMENT INDICATORS IN SUKOHARJO CENTRAL JAVA HOSPITAL Heru Sasongko; Okky Mareta Octadevi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 1 (2016)
Publisher : Universitas Sebelas Maret

Drug management in hospital is one of important hospital management especially in the planning and procurement stages. Inefficiency can induce bad condition on hospital, both medically and economically. This study was conducted to describe procurement of drugs for public patients in Sukoharjo Regional General Hospital. These stages were chosen because of the success of the drug planning and procurement will greatly determine the quality of the service at the Pharmacy Installation of Hospital.This is non-experimental research with descriptive designs. Data were collected concurently and retrospectively in Sukoharjo Regional General Hospital, a primary and secondary data. Primary data were obtained at the time of the study by conducting in-depth interviews, and secondary data obtained by tracking the documents prior year. The result of this study showed the percentage of available fund compared on total needed fund 96.16% and the percentage of drug items held with the planned was 82.16%, the procurement frequency of each drug item was 1-6 times in annual, drug invoice failure frequency was four times of 41 samples, and the frequency rate of delayed in payment by the hospital to the time agreed was 36.45 days.

POTENCY OF RADICAL SCAVENGING ACTIVITY FROM ETHYL ACETATE FRACTION OF Phaseolus vulgaris L., N. lappaceum L., and Pleurotus ostreatus Anif Nur Artanti; Nestri Handayani; Nisya Arienda; Rika Triyoga Prasetyo Rini; Astrid Octaviani
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 1 (2016)
Publisher : Universitas Sebelas Maret

Several studied shows that some plants and part of them could protect human body from oxidation of lipid and free radical danger exposure. Various possibilities can occur as a result of the free radical danger exposure, including malfunctioning of cells, damage cell structures, until the occurrence of cancer. One of the compounds found effication as an antioxidant is flavonoid. This study has been done to examine ethyl ascetate fraction from Phaseolus vulgaris L., N. lappaceum L., andPleurotus ostreatus which has potency as radical scavenger. Antiradical activity assay was determined by DPPH method (1,1 difenil-2-pikrilhidrazil). Based on the study the radical scavenging activity respectively from the lowest to the highest activity are vitamin C (5,4 µg/ml) ; fraction from Nephelium lappaceum L (21,81µg/ml) ; fraction from Phaseolus vulgaris L (50,64µg/ml) and Pleurotus ostreatus(80,51µg/ml).

AN OVERVIEW OF HIV TREATMENTS: WHAT TO START Vinci Mizranita
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 1 (2016)
Publisher : Universitas Sebelas Maret

Combinations of HAART using 2 NRTIs plus NNRTIs or PIs (zidovudine, abacavir or tenofovir plus lamivudine, or emtricitabine plus tenofovir) are preferred treatment of HIV infection internationally and in Australia.Some antiretroviral should not be combined due to overlapping toxicities and potential viral antagonism (e.g. Atazanavir + indinavir, didanosine + stavudine). The challenges for treating HIV infection will be to reduce adverse effects, drug resistance, and increased options for treatment-experienced patients (HIV patient with previously treated using ARV).

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