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Journal of Pharmaceutical and Medicinal Sciences
Published by Sekolah Tinggi Ilmu Farmasi Makassar
ISSN : 25282824     EISSN : 2580328X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Journal of Pharmaceutical and Medicinal Sciences (JPMS) pISSN 2528-2824; eISSN 2580-328X dedicated to publish original research papers, original research notes, invited topical reviews, mini-reviews, editorial commentary and news. Medicinal resources about exchange of information and understandings about people's use of plants, fungi, animals, microorganisms, minerals, their biological and pharmacological effects based on the principles established through international conventions. Pharmaceutical including drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology and targeted drug delivery.
Arjuna Subject : -
Articles 2 Documents
 1 
Search results for , issue "Vol 7 No 2 (2022): JPMS Vol 7 Issue 2" : 2 Documents clear
Formulation and Evaluation Lozenges of Angkak Powder as supportive therapy candidate for DHF Nurul Hikma; Andi Arjuna; Radhia Riski; Jainer Pasca Siampa
Jurnal Farmasi dan Ilmu Pengobatan Vol 7 No 2 (2022): JPMS Vol 7 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v7i1.140

Abstract

Angkak contains monacolin-K compounds which are identical to lovastatin and B complex vitamins (vitamin B12 and folic acid) are believed to play a role in increasing blood platelet levels in DHF. This study aims to determine the optimum formula of angkak powder lozenges with variations of sucrose-mannitol-aspartame sweetener that meet the physical requirements. In this study lozenges were made in 5 formulas with sucrose-mannitol sweetener (F1 14%; without mannitol, F2 10;4%, F3 7;7%, F4 4;10% and F5 without sucrose;14%), while the concentration The aspartame used in the 5 formulas is 1%. The method used is the wet granulation method with the resulting tablet weight is 1000 mg. The lozenges were tested for physical properties including weight uniformity, size uniformity, catch up, and disintegration time. The results showed that the use of sucrose-mannitol-aspartame sweetener produced lozenges that met the requirements for uniformity of weight, uniformity of size, and disintegration time. So, it can be said that F5 is the optimal formula with an average value of 0.042% and a disintegration time of 20.22 minutes.
Studi Penambatan Senyawa Dari Tanaman Kembang Bulan (Tithonia Diversifolia (Hemsley) A.Gray) Terhadap Peroxisome Proliferator-Activated Receptor-Gamma (PPARɣ) Untuk Penyakit Diabetes Melitus Nur Rahma Rumata; Nursamsiar Nursamsiar; Maghfirah Putri Arifin
Jurnal Farmasi dan Ilmu Pengobatan Vol 7 No 2 (2022): JPMS Vol 7 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v7i2.141

Abstract

Diabetes mellitus is a disease whose prevalence continues to increase both in the world and developing countries, so it is said that diabetes mellitus is a problem for global public health. One of the receptors that play a role in stimulating insulin storage so that resistance does not occur is the PPARƔ receptor. The purpose of this study was to simulate the interaction of moonflower compounds with several proteins at the PPARƔ receptor in the design of antidiabetic drugs by molecular docking method. The docking results showed that all moonflower compounds could interact with the active site of PPARƔ. The ligands with the best interactions were indicated by compounds with the best interactions shown by compounds 27, compounds 29 and compounds 31 with binding energy values, respectively, namely, -8.03 kcal/mol, -6.85 kcal/mol, -8.20 kcal/mol. Meanwhile, Thiazolidinediones as a positive control showed G value of -9.71 kcal/mol. These results indicate that the compound T. diversifolia is predicted to have potential as antidiabetic therapy.

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