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Eksakta : Berkala Ilmiah Bidang MIPA
Published by Universitas Negeri Padang
ISSN : -     EISSN : 25497464     DOI : https://doi.org/10.24036/eksakta/
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering
Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) is an open access journal and peer-reviewed that publishes either original article or reviews. The journal is dedicated towards dissemination of knowledge related to the advancement in scientific research. The prestigious interdisciplinary editorial board reflects the diversity of subjects covered in this journal. Under the realm of science and technology, the coverage includes environmental science, pure and applied mathematics, agricultural research and engineering, biology, biotechnology, bioinformatics, Healthcare sciences (including clinical medicine, preventive medicine & public health), physics, biophysics, computer science, chemistry and bioengineering, to name a few. This Journal Is Published at 3 Month intervals on January-Marc, April-June, July-September and October-December
Arjuna Subject : Umum - Umum
Articles 402 Documents
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Evaluation of Straw Mushroom Color Stability during Storage: The Role of Nano Edible Coating, Packaging, and Temperature Kiki Nuratni Sitompul; Syariful Mubarok; Kusumiyati Kusumiyati
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/619

Abstract

Straw mushrooms are one of the nutritious edible mushrooms with high economic value. However, color changes during storage are one of the problems that impact the marketability. Post-harvest treatment in the form of the use of nano edible coatings, packaging, and storage temperatures can prevent gas exchange, control humidity and anti-browning agents in straw mushrooms. This study aims to evaluate the effect of nano edible coatings, packaging types, and different storage temperatures on the color stability of straw mushrooms. This study used a Completely Randomized Design consisting of a combination of nano edible coating treatments (nano sodium alginate and nano aloe vera), packaging types (vacuum, biodegradable, wrap packaging), and storage temperatures (room temperature (±25°C), 10°C, and 5°C), so that there are 18 treatment combinations. Each treatment was repeated twice so there were 36 experimental units. Each experimental unit consisted of two samples so that there were 72 samples at each observation time (1, 3, 5 days after storage), so that the total samples were 216. The results of the study showed that the combination treatment of nano sodium alginate with wrap packaging at a temperature of 10°C showed the best L*, a*, and hue values during 5 days of storage.
Metric Dimension of Maple Leaf Graph Des Welyyanti; Susi Mulyani Putri; Ikhlas Pratama Sandy
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 01 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss01/622

Abstract

This study determines the metric dimension of the Maple Leaf Graph (Mₚ) for 2 ≤ p ≤ 9 using the concepts of vertex distance and resolving sets. By analyzing the distance representation of each vertex with respect to a resolving set, the minimum resolving set is identified, defining the metric dimension of the graph. Calculations were performed manually to ensure consistency and accuracy.The analysis reveals a tiered linear reduction pattern, where the metric dimension does not increase linearly with p. The main findings are summarized in three theorems: for p = 2 and p = 3, the metric dimension of the Maple Leaf Graph equals p; for p = 4, 5, and 6, it equals p – 1; and for p = 7, 8, and 9, it equals p – 2. These results introduce a new class of graphs and provide theoretical insights into the behavior of metric dimension in multi-cycle constructions, thereby contributing to the development of combinatorial graph theory.
Hydrogeological Evaluation Based on Water Quality Parameters and Groundwater Level Conditions in Kolaka and Tangketada Basins, Southeast Sulawesi Muhammad Abdul Rahman Salim; Dasapta Erwin Irawan; Imam Achmad Sadisun; Bonanza Herlambang Fredomeseliano; Kurniawan
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/623

Abstract

This study aims to evaluate the hydrogeological conditions of Pomalaa through analysis of groundwater flow patterns, groundwater level fluctuations, and water quality parameters. The methods used include geological and hydrogeological mapping, groundwater level measurements, and delineation of groundwater basins based on regional topography and lithological data. Water quality analysis was conducted by measuring temperature, Total Dissolved Solids (TDS), electrical conductivity (EC), and pH parameters. The study area consists of five main rock units, with three types of aquifers based on lithological characteristics, namely intergranular and fractured aquifers, low-yield aquifers, and rare aquifers. The results of the study show that groundwater flow patterns follow natural hydraulic gradients, but fluctuate due to environmental changes and mining activities. Several points show significant water quality degradation, with pH, TDS, and EC values exceeding drinking water thresholds. The water quality index shows variations from very good (57), good (49), poor (23), very poor (22), to unfit for drinking (48). The solution offered by this study is the need for mitigation strategies and sustainable water resource management, which is of utmost urgency to maintain ecosystem balance and ensure the availability of clean water for the community and industry in the future.
Flavonoid Role as Autophagy Modulators in Breast Cancer Treatment Strategy Frans Dany; Ade Arsianti; Linda Erlina; Ratih Rinendyaputri
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/624

Abstract

Autophagy is a tightly regulated catabolic process that enables cancer cells to survive under metabolic stress and contributes to the development of chemoresistance. Targeting autophagy has therefore emerged as a promising strategy to enhance cancer therapy efficacy. Flavonoids, a diverse class of polyphenolic compounds abundantly found in plants, have gained considerable attention due to their broad-spectrum biological activities, including anticancer effects. Recent studies highlight their ability to modulate key signaling pathways involved in cell proliferation, apoptosis, and autophagy. Several flavonoids, such as fisetin, apigenin, and quercetin, exhibit roles as autophagy modulators depending on the cellular context, offering therapeutic flexibility. Their low toxicity and synergistic potential with conventional drugs underscore their relevance as adjuvant agents. This review discusses the critical role of autophagy in cancer progression and drug resistance, and examines current evidence supporting the integration of flavonoids as autophagy modulators in the design of more effective and targeted anticancer strategies, particularly in breast cancer therapy.
Serological and Non-Sputum Biomarkers for Tuberculosis Diagnosis: A Systematic Review of Host- and Pathogen-Derived Signatures Wa Ode Diah Erwati; Andriansjah Rukmana
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/626

Abstract

Tuberculosis (TB) remains a major global health concern, with more than 10 million new cases reported annually. Conventional sputum-based diagnostics such as microscopy, culture, and GeneXpert MTB/RIF show limited sensitivity in children, individuals with HIV, and extrapulmonary TB, highlighting the need for accurate non-sputum alternatives. This systematic review evaluates the diagnostic performance of serological and other non-sputum biomarkers for active TB, focusing on both host and pathogen derived targets. Eleven eligible studies (2016–2024) involving 2,548 participants were analyzed. The reviewed studies employed multiplex immunoassays and protein microarrays to assess immune markers and M. tuberculosis antigens. Key findings indicate that several cytokines (e.g., IFN-γ, IP-10, IL-27) and antibodies to ESAT-6, CFP-10, and Ag85B differentiated active from latent infection. Multi-antigen panels achieved sensitivity and specificity above 85%, while saliva, serum, and skin-based assays showed potential for non-invasive and field-applicable diagnosis. The novelty of this review lies in its integrative approach analyzing both host and pathogen biomarkers, which are often studied separately. Such multi-marker, non-sputum serological strategies could complement current TB diagnostics and provide reliable, accessible tools for use in resource-limited and high HIV prevalence settings
Synthesis and Characterization of Sodium Aluminate from Aluminum and Sodium Hydroxide Dinalia Dinalia; Syamsi Aini; Jon Efendi
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/627

Abstract

The synthesis of sodium aluminate from aluminum and sodium hydroxide was successfully conducted to optimize its potential as a precursor for zeolite production. Aluminum was reacted with NaOH solution under continuous stirring for five hours, with variations in pH and Al-to-NaOH molar ratio to determine optimal synthesis conditions. The highest aluminum conversion (94.33%) was achieved at pH 13.6 and an Al-to-NaOH molar ratio of 1:4. Fourier-transform infrared (FTIR) spectroscopy confirmed the formation of tetrahedral [AlO₄]⁻ units through characteristic aluminate vibrational bands at 624 and 727 cm⁻¹. X-ray diffraction (XRD) analysis revealed sharp reflections at 2θ ≈ 34.8°, corresponding to crystalline NaAlO₂ (JCPDS No. 33-1200), indicating high crystallinity and phase purity. Scanning electron microscopy coupled with energy-dispersive X-ray (SEM–EDX) analysis showed irregular plate-like crystalline particles with a near-stoichiometric Na:Al ratio (~1:1), confirming compositional homogeneity. Overall, optimized alkalinity and stoichiometry were found to be critical for producing highly crystalline and compositionally pure sodium aluminate, suggesting its suitability as a high-quality, environmentally friendly precursor for zeolite synthesis.
Production, Characterization, and Application of Palm Fruit (Arenga pinnata Merr.) Flour in Boba Pearls Fauzan Azima; Desniarti Desniarti; Muhammad Iqbal; Bunga Silvana Khaira
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/628

Abstract

Widely consumed food products can be strategically fortified with dietary fiber to enhance population-level fiber intake. This study examined the physicochemical and functional properties of palm fruit flour to determine its potential as a dietary fiber-enhancing substitute in tapioca-based boba. Initially, palm fruit flour was characterized for its physicochemical and functional properties. Afterwards, it was substituted for 20% of the tapioca in tapioca-based boba pearls and compared to a control (100% tapioca). Analyses of both the raw flour and the boba included its physicochemical and functional properties. Characterization of palm fruit flour showed a high water absorption capacity (8.79 mL/g) and whiteness degree (92.12%). Substituting 20% of the tapioca with palm fruit flour resulted in a product with a high dietary fiber content (20.73%), increased moisture content (68.46 ± 1.25), and a lowered caloric value (2.24 kcal). In conclusion, palm fruit flour is an effective ingredient for fortifying boba nutritionally, though it changes the texture, producing a softer product. Thus, it presents a potentially valuable approach for formulating novel functional foods for healthy consumers, offering a redefined sensory experience. This study is the first to evaluate palm fruit flour as a partial tapioca substitute for fiber-enriched boba production.
In Silico Evaluation of Natural Compounds as Dual Inhibitors of Exotoxin A and LasB (Elastase) Virulence Proteins in Pseudomonas aeruginosa Andrias Bayu Fariska; Linda Erlina; Ade Arsianti; Aryo Tedjo
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 04 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss04/631

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen whose virulence is largely mediated by Exotoxin A and LasB (elastase), making them promising anti-virulence drug targets. This study aimed to evaluate the inhibitory potential of natural compounds against these two key proteins using an in silico approach. Pharmacophore-based virtual screening of HerbalDB compounds was performed by LigandScout software, followed by molecular docking using AutoDockTools-1.5.7 against Exotoxin A (PDB ID: 1AER) and LasB (PDB ID: 1U4G). Native ligands and co-crystallized inhibitors were used as docking controls to validate binding accuracy. Among the screened compounds, Epicatechin-(4β-6)-epicatechin-(4β-8)-catechin exhibited the strongest binding affinity to Exotoxin A (ΔG = −10.72 kcal·mol⁻¹), while Carpaine showed the highest affinity for LasB (ΔG = −8.91 kcal·mol⁻¹). The predicted interactions involved hydrogen bonds and hydrophobic interactions with active-site residues, comparable to the native inhibitors. Furthermore, ADMET analysis indicated favorable pharmacokinetic and drug-likeness properties. These findings suggest that selected natural compounds possess potential dual inhibitory activity against Exotoxin A and LasB, warranting further experimental validation as anti-virulence candidates for controlling P. aeruginosa infections.
Cellulolytic Bacteria Isolation from Sugarcane Garden Soil Arief Muammar; Mesha Arjuna; Maria Manullang; Endah Retnaningrum
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 01 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss01/632

Abstract

The soil surrounding the sugar cane garden is a promising habitat for cellulolytic bacteria because it contains a source of cellulose, hemicellulose, and other carbon sources derived from the sugar canes remaining organic matter.  This study attempts to determine the presence of cellulolytic bacteria isolated from sugar cane garden soil, as well as the ability of cellulolytic bacteria to degrade cellulose based on optical density and sugar reduction values isolated from sugarcane garden soil.  We collected soil samples from five points (T1, T2, T3, T4, T5), isolating the bacteria in CMC (Carboxyl Methyl Cellulose) medium, qualitatively testing the cellulase enzyme activity with Congo Red and Iodine Assays, and quantitatively using the DNS Assay. The results of the qualitative test with the Congo Red assay revealed that there were three positive isolates with a clearly visible clear zone, namely TII C4, TII C1, and TIV C4, and after quantitative supernatant tests, the OD values of all isolates were higher than the negative control in supernatant samples using 540nm wave length using spectrophotometer, by using synthetic cellulose called Carboxy Methyl cellulase (CMC) as a substrate in the cellulase enzyme test.
Compound Profile of Methanol Extract of Katang-Katang Leaves (Ipomoea pes-caprae) and Evaluation of Its Antibacterial and Antioxidant Activities Dessy Rosye Rooy; Imanuel Berly Delvis Kapelle; Rosmawaty
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 01 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss01/633

Abstract

 Increasing antibiotic resistance has prompted the search for safer and more sustainable natural alternatives. Ipomoea pes-caprae, a coastal plant traditionally used for the treatment of wounds and inflammation, is known to be rich in secondary metabolites such as flavonoids, terpenoids, alkaloids, and phenolic acids that have potential antioxidant and antibacterial properties. This study aimed to map the metabolite profile of the methanolic extract of I. pes-caprae leaves using LC-HRMS, to analyze its relationship with antioxidant activity measured by the DPPH method, and to evaluate its antibacterial activity against Staphylococcus aureus and Escherichia coli. LC-HRMS analysis identified 406 compounds with Palmitic Acid as the dominant component (24.503%), including primary and secondary metabolite groups such as flavonoids (quercetin, rutin, kaempferol), phenolic acids (caffeic, ferulic, chlorogenic acid), terpenoids (caryophyllene oxide, lupeol), alkaloids, and phytohormones. The methanol extract showed moderate antioxidant activity (IC₅₀ = 136.71 ppm) and antibacterial activity against E. coli (inhibition zone 9.5 mm), which is thought to originate from the synergy of various secondary metabolites through free radical scavenging mechanisms and bacterial membrane damage. These findings strengthen the scientific basis for I. pes-caprae as a natural source of antioxidant and antibacterial agents for the development of natural pharmaceutical products.

Page 38 of 41 | Total Record : 402

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