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Amin Fatoni
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Molekul: Jurnal Ilmiah Kimia
Published by Universitas Jenderal Soedirman
ISSN : 19079761     EISSN : 25030310     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.
Arjuna Subject : -
Articles 13 Documents
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Search results for , issue "Vol 14, No 2 (2019)" : 13 Documents clear
β- Sitosterol and Betulonic Acid from n-Hexane Extract the Stem Bark of Tetracera indica Muharni, Muharni; elfita, elfita; Julunar, Julinar; Yohandini, Heni; oktaviani, muthia
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (615.289 KB) | DOI: 10.20884/1.jm.2019.14.2.507

Abstract

The Tetraceraindicahasbeen used traditionally to treat various diseases including skin medications, lower blood pressure, fever, headache, wound andgout medicine.   The objective of the research was isolatedand characterizedthe ?-sitosterol (1) and betulonicacid (2) fromn-hexaneextract of the stem bark of Tetraceraindica.  The dry powder thestembark (550 g)wasmaceration with n-hexane for 24 hrs.Thisextraction process was repeated three times.  The n-hexane extract was separated and purified by chromatographytechnique. The structure of isolatedcompound wasdetermined by spectroscopy data UV, IR, NMR and compared with reported data.  Two compounds have been isolated and base on spectroscopy data thecompounds is ?-sitosterol (1) andbetulonic acid (2).   Betulonic acid is being reported for the first time from T.indica,meanwhile the?-sitosterolpreviously reported from MeOHextractof leaves of T. indicabut  is being reported for the first time from the stembarkof  T.indica.
Computational Approach to Evaluate Eugenol Affinity and Derivatives Empirical Against Cu(II) Muhammad Cholid Djunaidi; Tantri Nevi Astuti; Parsaoran Siahaan
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.821 KB) | DOI: 10.20884/1.jm.2019.14.2.499

Abstract

A computational approach to assess the emperical results of eugenol affinity, eugenoxy acetate (EOA), and pyridine methyl eugenoxy acetate (PMEOA) against Cu2+has been done. This research aims to determine the effects of the functional groups (−OH, −COOH, and −N) on eugenol and their derivatives on the selectivity of Cu2+adsorption experimentally and to calculate the energy interaction between eugenol compounds and derivatives with Cu2+. The experimental approach was carried out by solvent extraction method, using 10 mL of Cu2+10 ppm solution along with 0.3089 mmol of eugenol, EOA and PMEOA. The remaining concentration of Cu2+metal after extraction in the water phase was measured using an Atomic Absorption Spectrophotometer (AAS). Assessments of the Cu2+metal interaction with eugenol, EOA and PMEOA compounds were carried out using the ab initio method with 6-31G** basis set to predict the interaction energy. The results showed that pyridine methyl eugenoxy acetate (PMEOA) can separate Cu2+better than eugenol and EOA with extraction efficiency (% E) = 78.76%. The calculation results of Cu2+metal interactions with eugenol, EOA, and PMEOA compounds found that PMEOA has the lowest energy of interaction compared to eugenol and EOA with Cu2+metal.
Effectiveness of Leaves Extract Fractions of Archidendron jiringa (Jack) I.C Nielsen Against Microbes Oom Komala; Sri Wardatun; Lia Puspita Sari
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.568 KB) | DOI: 10.20884/1.jm.2019.14.2.538

Abstract

Archidendron jiringa(Jack) I.C Nielsen) contains a lot of essential oils, saponins, alkaloids, terpenoids, steroids, tannins, glycosides, and flavonoids. Flavonoid is a secondary metabolite compound in a plant as antimicrobial. This study aims to determine the antimicrobial activity of fractions of ethanol 96%, n-hexan, ethyl acetate, and ethanol-water leaves extractand determine levels of favonoids.  A. jiringaleaves extract were tested against Streptococus mutans, Pseudomonas aeruginosa, and Candida albicans.  The research using agar disc diffusion technique for antimicrobial  activity and colorimetric method to know the total of flavonoid. Chloramphenicol and ketoconazole were used as a reference standard. The result of this study shows fractions of ethanol 96%,  n-hexane,  ethyl acetate, and  ethanol-water A. jiringaleaves extract  can inhibit microbial growth of S. mutans, P. aeruginosa, and C. albicans.Total of flavonoids on the extract respectively are 1.13%, 0.494%, 2.337%, and 0.549%. determined with complementary colorimetry to each leaf extract fractionA. jiringawith aluminum chloride method. Absorption spectrum measurement using a spectrophotometer.  The higher  percent of flavonoids would cause greater    bacteriainhibitory  zone but  only  0.090 for  pearson correlation value. Conclusions ethyl acetate leaves extract most effective inhibit microbial growth from the other fractions.

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