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ANALISIS NMR 2D DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA DIHIDROKSISANTON DAN TRIHIDROKSISANTON DARI KULIT BATANG KANDIS GAJAH (Garcina griffithii T. Anders) Elfita, Elfita; Supriyatna, Supriyatna; Bahti, Husein H; Dachriyanus, Dachriyanus
Alchemy Jurnal Penelitian Kimia Vol 6, No 2 (2007)
Publisher : Alchemy Jurnal Penelitian Kimia

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Abstract

Senyawa dihidroksisanton dan trihidroksisanton telah diisolasi dari kulit batang kandis gajah (G. Griffithii). Senyawa dihidroksisanton diisolasi dari fraksi diklorometan dan trihidroksisanton dari fraksi metanol. Senyawa trihidroksisanton memiliki aktivitas antibakteri yang lebih tinggi dibanding senyawa dihidroksisanton terhadap bakteri uji Escherichia coli, Shigella disentriae, Staphylococcus aureus, dan Bacillus subtilis dengan standar antibiotik amoksisillin. Penentuan struktur molekul kedua senyawa tersebut dilakukan dengan analisis NMR 2D.
UJI AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN SENYAWA DERIVAT PIRANON DARI MIKROBA ENDOFITIK Penicillium sp PADA TUMBUHAN KUNYIT PUTIH (Curcuma zedoaria (Berg.) Roscoe) Muharni, Muharni; Fitrya, Fitrya; oktaruliza, Milanti; Elfita, Elfita
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (859.669 KB) | DOI: 10.14499/mot-TradMedJ19iss3pp107-112

Abstract

Pencarian senyawa bioaktif terus menerus dilakukan seiring dengan makin banyaknya penyakit-penyakit baru yang bermunculan, mulai dari penyakit infeksi, kanker, dan berbagai penyakit degeneratif lainnya. Penemuan senyawa antibiotoik baru dan senyawa yang bersifat antioksidan sangat diperlukan untuk mengatasi hal ini.  Mikroba endofitik merupakan mikroba yang tumbuh dalam jaringan tumbuhan yang dapat menghasilkan metabolit sekunder yang aktif.  Pada penelitian sebelumnya telah berhasil diisolasi dua senyawa dari mikroba endofitik Penicillium sp pada tumbuhan kunyit putih dan diidentifikasi sebagai Di-(2-etilheksil)phthalat dan derivat piranon yaitu5 (4’-etoksi-2’-hidroksi-5’-metil-2’,3’-dihidrofuran-3’-il (hidroksi) metil-4-isopropil-3-metil-2-piran-2-on). Tujuan penelitian ini adalah menguji aktivitas antibakteri dan antioksidan dari senyawa derivat piranon yang dihasilkan dari mikroba endofitik Penicillium sp pada tumbuhan kunyit putih (Curcuma zeodaria). Aktivitas antibakteri  dilakukan  dengan metode difusi cakram dengan bakteri uji E.coli, S. dysenteriae, S. aureus, dan B.  subtilis  dengan variasi konsentrasi uji  250, 500, 1000, dan 2000 μg/ml, dan  aktivitas antioksidan dengan metode 1,1-difenil-2-pikrilhidrazil (DPPH) dengan variasi konsentrasi 1000, 500, 250, 125, 62,5, 31,25, 15,625, dan 7,8125µg/mL. Hasil penelitian menunjukkan aktivitas antibakteri paling kuat pada bakteri S. aureus dengan zona hambat 11mm pada konsentrasi 250µg/mL. Senyawa derivat piranon juga bersifat aktif anti oksidan dengan IC5016,05µg/mL.
β- Sitosterol and Betulonic Acid from n-Hexane Extract the Stem Bark of Tetracera indica Muharni, Muharni; elfita, elfita; Julunar, Julinar; Yohandini, Heni; oktaviani, muthia
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (615.289 KB) | DOI: 10.20884/1.jm.2019.14.2.507

Abstract

The Tetraceraindicahasbeen used traditionally to treat various diseases including skin medications, lower blood pressure, fever, headache, wound andgout medicine.   The objective of the research was isolatedand characterizedthe ?-sitosterol (1) and betulonicacid (2) fromn-hexaneextract of the stem bark of Tetraceraindica.  The dry powder thestembark (550 g)wasmaceration with n-hexane for 24 hrs.Thisextraction process was repeated three times.  The n-hexane extract was separated and purified by chromatographytechnique. The structure of isolatedcompound wasdetermined by spectroscopy data UV, IR, NMR and compared with reported data.  Two compounds have been isolated and base on spectroscopy data thecompounds is ?-sitosterol (1) andbetulonic acid (2).   Betulonic acid is being reported for the first time from T.indica,meanwhile the?-sitosterolpreviously reported from MeOHextractof leaves of T. indicabut  is being reported for the first time from the stembarkof  T.indica.
Senyawa Antimalaria dari Jamur Endofitik Tumbuhan Sambiloto (Andographis paniculata Nees) Elfita, Elfita; Muharni, Muharni; Munawar, Munawar; Salni, Salni; Oktasari, Ade
Jurnal Natur Indonesia Vol 13, No 2 (2011)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (85.93 KB) | DOI: 10.31258/jnat.13.2.123-129

Abstract

Plants have been the chief source of compounds of medicine for thousand of years. Plants are also the source ofmany medicines for the majority of the world’s population. The role of biotechnology is very important for multiplying,conserving the spesies, and enhancing the production of secondary metabolites. Endophytic are microbes thatinhabit plants are currently considered to be a wellspring of novel secondary metabolites offering the potensial formedical and industrial exploitation. Plants with ethnobotanical history, for example sambiloto (Andographispaniculata Nees) are likely candidates for finding bioactive compounds. Isolation begin with cultivation of Aspergillusflavus fungi in 2 liter of Potato Dextrose Broth media for four weeks. Media is extracted into the solvent n-hexaneand ethylacetate following by evaporation. Ethylacetate extracts were separated by chromatography techniquesin order to get pure compound in the form of white crystal. Phytochemical tests showed that the isolated compoundis alkaloid. The molecular structure of the isolated compound was determined based on spectroscopic data,including UV, IR, 1H-NMR, 13C-NMR, HMQC, and HMBC spectrum. The compound was determined as7-hydroxypiranopiridin-4-on with molecule formula C8H7NO2 (Mr=149). The compound has antimalarial activityagainst Plasmodium falciparum 3D7, with IC50 values 0,201 μM.
Isolation of Antioxidant Compound from Endophytic Fungi Acremonium sp. from the Twigs of Kandis Gajah Elfita, Elfita; Muharni, Muharni; Munawar, Munawar
Makara Journal of Science Vol. 16, No. 1
Publisher : UI Scholars Hub

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Abstract

SECONDARY METABOLITE OF Aspergillus fumigatus, ENDOPHYTIC FUNGI OF THE MEDICINAL PLANT Garcinia griffithii Elfita, Elfita; Muharni, Muharni; Indah, Tri
Makara Journal of Science Vol. 15, No. 2
Publisher : UI Scholars Hub

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Abstract

Potential Endophytic Fungi from the Leaves of Syzygium zeylanicum (L.) and Their Secondary Metabolite Elfita, Elfita; Syarifah, Syarifah; Widjajanty, Hary; Setiawan, Arum; Kurniawati, Alfia Rahma
Molekul Vol 18 No 3 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.3.7881

Abstract

Endophytic fungi coexist without harms in the host in some parts or all parts of its lifecycle. Endophytic fungi excrete specialized bioactive compounds beneficial for of its host; the compound itself can be different from what can be found on their host. Endophytic fungi are capable to excrete biologically significant secondary metabolites acting as antidiabetic, antioxidant, antimicrobial, and cytostatic agents. Endophytic fungi existence are common across different plants; including Syzygium zeylanicum that can be found in Indonesia. This study aims to isolate endophytic fungi found in leaves of Syzygium zeylanicum, L., to elucidate their characterized morphologically, and to examine its antimicrobial and antioxidant properties in addition to their chemical structures. Characterization of endophytic fungi was conducted by their macroscopic and microscopic features, followed by molecular characterization of highly bioactive metabolites. Antimicrobial activities were measured by disc diffusion method. Antioxidant properties were measured with DPPH. Secondary metabolites were chromatographically isolated and identified with spectroscopy techniques (NMR ID and 2D). Four endophytic fungi isolates were obtained: Penicillium citrinum (SZ1), Colletotrichum lindemuthianum (SZ2), Aspergillus nidulan (SZ3), Scopulariopsis asperula (SZ4). Penicillium citrinum (SZ1) showed antimicrobial activities against four different bacteria (71.3% against E. coli; 74.1% against S. aureus; 76.2% against S. typhi; and dan76.9% against B. subtilis). Antioxidant activity ini all ekstrak of endophytic fungi showed very activity (IC50 SZ3 extract = 3.85 µg/mL). Potential endophytic fungi SZ1 was molecularly identified as Penicillium citrinum. Extracts from SZ1 fungi contains bioactive 4-hydroxy-2-(4-hydroxyphenyl)-ɣ-butyrolactone-3-yl) methyl acetate. The newly obtained substance could be developed into antimicrobial and antioxidant agents in further studies.
Mengembangkan Bahasa Indonesia Anak Usia Dini Melalui Permainan Kotak Ajaib Di Raudhatul Athfal Munzhiroh 3 Kulim Kota Pekanbaru Nikmah, Nikmah; Inmaryanto, Inmaryanto; Elfita, Elfita
Ar-Raihanah: Jurnal Pendidikan Islam Anak Usia Dini Vol. 2 No. 2 (2022): Ar-Raihanah: Jurnal Pendidikan Islam Anak Usia Dini
Publisher : Sekolah Tinggi Agama Islam Al- Kifayah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.207 KB) | DOI: 10.53398/jr.v2i2.199

Abstract

This research is motivated by the lack of children's Indonesian language development, some children have not been able to recognize simple words and some children are less active in learning. The purpose of this study was to determine the improvement of children's Indonesian language skills by using the magic box game through the CAR research method (Classroom Action Research). This research was conducted in two cycles and each cycle was conducted in two meetings. In order for this classroom action research to be successful without any obstacles that interfere with the smooth running of the research, the researcher arranges the stages that are passed in classroom action research, namely: 1) Action planning/preparation, 2) Action implementation, 3) Observation, and 4) Reflection. The subjects in this study were B1 class students with 16 students, namely in the first semester of the 2022/2023 academic year at RA Munzhiroh 3 Kulim Pekanbaru City. Meanwhile, the object of this research is the use of the magic box game to improve the development of Indonesian in children. The research data were collected through teacher observation techniques and children's activities and documentation. After the data is collected through observation, the data is processed using the percentage formula. The results of this study are an increase in the learning process carried out by the teacher and the children's Indonesian language skills. Observation of children's activities also increased, this can be seen from the initial data to cycle II meeting 2. Initial data 41.27%, Cycle II meeting 2 obtained an average percentage of 85.28%. So that the overall increase in teacher activity obtained an average percentage of 44.01%
Pelatihan Pembuatan Salep Untuk Infeksi Kulit dari Ekstrak Daun Karamunting (Rhodomyrtus Tomentosa) Di Desa Tanjung Baru, Ogan Ilir Ferlinahayati, Ferlinahayati; Rachmat, Addy; Hermansyah, Hermansyah; Elfita, Elfita; Hariani, Poedji Loekitowati
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 4 No. 1 (2024): Januari 2024 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59395/altifani.v4i1.518

Abstract

Kulit memiliki fungsi sebagai pertahanan pertama untuk melindungi tubuh dari penyakit. Infeksi kulit dapat disebabkan oleh mikroorganisme, seperti bakteri, virus, jamur, atau parasit. Tanaman karamunting (Rhodomyrtus tomentosa) secara tradisional telah digunakan masyarakat untuk pengobatan termasuk pengobatan luka. Kegiatan pengabdian masyarakat ini bertujuan memberikan pelatihan pembuatan salep untuk pengobatan infeksi kulit dari ekstrak etanol daun karamunting berbasis vaselin.  Kegiatan pengabdian masyarakat dilakukan di desa Tanjung Baru, kecamatan Indralaya Utara, kabupaten Ogan Ilir. Khalayak sasaran adalah ibu-ibu PKK dan remaja putri sebanyak 30 orang. Tahapan kegiatan yaitu (i) penyuluhan tentang penyakit infeksi kulit, penyebab infeksi kulit, penularan dan pengobatan, (ii) pelatihan pembuatan ekstrak etanol dari daun karamunting, pembuatan salep berbasis vaselin dan (iii) evaluasi hasil kegiatan. Hasil evaluasi kegiatan dengan memberikan berbagai pertanyaan setelah kegiatan menunjukkan 97,62 % peserta menjawab tepat dan sangat tepat materi yang diberikan. Hasil uji tingkat kesukaan dan kenyamanan penggunaan salep menunjukkan sebanyak 82,64 % peserta menyatakan sangat suka terhadap aroma, bentuk, warna, kenyamanan dan daya lekat ketika salep digunakan. Hal ini mengindikasikan bahwa salep untuk infeksi kulit ini diterima dengan baik oleh masyarakat sebagai alternatif pengobatan penyakit infeksi kulit.
Fabrication of NiFe2O4/SiO2/TiO2 Magnetic Composite for Effective Photodegradation of Congo Red Dye Hariani, Poedji Loekitowati; Salni, Salni; Kimur, Melviana Violetta; Hidayati, Nurlisa; Elfita, Elfita
Indonesian Journal of Chemistry Vol 25, No 3 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.94143

Abstract

This study aims to fabricate a NiFe2O4/SiO2/TiO2 magnetic composite to serve as a photocatalyst for the degradation of Congo red dye. The catalyst characterization involved XRD, FTIR, UV-vis DRS, BET, VSM, SEM-EDS, and pHpzc analyses. The performance in degradation was determined by the effect of various variables, including solution pH, dye concentration, and irradiation time. Results revealed that the NiFe2O4/SiO2/TiO2 composite exhibited a crystallite size of 24.56 nm and a bandgap of 2.1 eV. The surface area of NiFe2O4/SiO2/TiO2 was measured at 154 m2/g, exceeding that of NiFe2O4/SiO2 and NiFe2O4, which were observed at 122 and 51 m2/g, respectively. NiFe2O4/SiO2/TiO2 exhibited magnetic properties with a magnetic saturation of 18.55 emu/g. Under optimal conditions (pH 5, initial dye concentration of 20 mg/L, and 90 min of visible irradiation), the degradation efficiency reached 96.86%. It was concluded that the photodegradation was effective, as its efficiency decreased from 96.86 to 92.45% after five reuse cycles. The presence of mineralization was evaluated using total organic carbon analysis, which revealed an 84.60% reduction in carbon content.