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Molekul: Jurnal Ilmiah Kimia
Published by Universitas Jenderal Soedirman
ISSN : 19079761     EISSN : 25030310     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.
Arjuna Subject : -
Articles 14 Documents
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Search results for , issue "Vol 16, No 3 (2021)" : 14 Documents clear
Bioactive Compound Contents and Antioxidant Activity of of Fermented Lead Tree (Leucaena leucocephala (lmk.) de Wit) Seeds Suryanti, Venty; Marliyana, Soerya Dewi; Rohana, Gracia Lasma; Trisnawati, Elyna Wahyu; Widiyanti, Widiyanti
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.768 KB) | DOI: 10.20884/1.jm.2021.16.3.756

Abstract

Leucaena leucocephala (lmk.) de Wit) (leed tree) seeds have been fermented by Indonesian as a traditional food which is called tempeh. The fermentation products of legume seeds are good functional foods, since they contain many bioactive compounds. The objective of this study was to determine the bioactive compound contents of fermented lead tree seed, such as total phenolic, ascorbic acid, β-carotene and a-tocopherol. Antioxidant activity testing was carried out using the thiobarbituric acid reactive substances (TBARS) method. Analysis of total phenolics, ascorbic acid, β-carotene and a-tocopherol were carried out using the folin-ciocalteu method, iodine titration, spectrophotometry and iron (III) chloride-thiocyanate, respectively. Rhizopus oligosporus was used to ferment lead tree seeds for 0, 1, 2, 3 and 4 days. Fermented leed tree seed powder was extracted with petroleum ether followed by ethanol. In comparison to unfermented leed tree seed powder, the β-carotene and a-tocopherol of the fermented seed powder increased. The greatest enhancement of β-carotene and a-tocopherol contents were observed at day 2 of fermentation. The highest antioxidant activities of fermented leed tree seeds were also obained at day 2 of fermentation with 55.55±4.59 and 74.46±3.49% inhibition in petroleum ether and ethanol extracts, respectively. The results show that lead tree seed tempeh has high antioxidant activity due to the bioactive compounds contains, such as  phenolics, β-carotene and a-tocopherol. Therefore, leed tree seed tempeh could be used for possible commercial production of functional food to alleviate oxidative stress.
Backmatter (Instruction for author and back cover) Amin Fatoni
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (70.381 KB) | DOI: 10.20884/1.jm.2021.16.3.876

Abstract

Backmatter (Instruction for author and back cover)
Comparison of Cr/C and Cr2O3/Z Catalysts on Hydrocracking of Bio Oil from Pyrolysis of Palm Empty Fruit Bunches Zainal Fanani; Hasanuddin hasanuddin; Addy Rachmat; Muhammad Said
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (386.645 KB) | DOI: 10.20884/1.jm.2021.16.3.812

Abstract

Bio-oil derived from palm empty fruit bunch is not suitable for fuel purpose due to high acidity and low heating. Cr2O3/Zeolite and Cr/C catalysts was developed to upgrade bio-oil through hydrocracking. The catalyst prepared via impregnation method followed by oxidation-reduction. Ammonia and pyridine adsorption used to evaluate acidity as well as crystallinity assessment by using XRD. Hydrocracking reaction conducted in hydrogen gas flow rates 0.5-3.0 L/min, the surface area of Cr/C catalyst found out 1,497.07-1,652.58 m2/g, whilst the temperatures 450 to 700 ℃ and the catalyst weights between 0.5 to 2.5 g. Acidity calculated from ammonia and pyridine adsorption shows Cr2O3/Zeolite has higher value compare to pristine Zeolite. XRD pattern shows Cr2O3/Zeolite has high crystallinity as indicated by sharp and pointed diffraction peaks. The optimum condition of hydrocracking confirmed by lower density of liquid product. The variables obtained by a separate experiments shows that H2 gas flow rate best at 2.5 L/min, temperature of hydrocracking 500 ℃ for Cr2O3/Zeolite and 600oC for Cr/C whereas weight of Cr2O3/Zeolite catalyst is 1.5 g. The Cr/C catalyst that gave low density product possess 1,554.48 m2/g surface area. GCMS data shows increase on the number of straight chain compounds within the hydrocracking product.
Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium Hernayanti Hernayanti; Sri Lestari; Saryono Saryono; Puji Lestari
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.654 KB) | DOI: 10.20884/1.jm.2021.16.3.775

Abstract

Cadmium is  a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into six groups  with four replications, i.e group of healthy control (C1), negative control induced by CdSO4 with dosage 56 mg/kg for 14 days and treatment (C3-C6) with dosage of 100, 200 ,300 and 400 mg/kg of C. asiatica. The blood Cd, GST, GSH, TNF- α and COx2 were measured after a 21 days administration of C. asiatica. The data were analyzed by ANOVA test followed by Duncan test with a significance level of 5%. The result showed that administrating C.asiatica can neutralized cadmium, improve inflammation in liver.The conclusion of our research that C.asiatica extract can decrease Cd level, TNF-α and COx2 levels and increase GST and GSH level in rat induced by cadmium. A 200 mg/kg was the effective dosage to reduce Cd, TNF-α and COx2 levels and increase GST and GSH levels. Key words : anti inflammatory, Cd, Centella asiatica, GST, COX2

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