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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
Arjuna Subject : -
Articles 12 Documents
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Search results for , issue " Vol 8, No 1 (2016)" : 12 Documents clear
Validasi Metode Penetapan Kadar Lisinopril dalam Spiked Plasma Secara Ultra Performance Liquid Chromatography Melalui Derivatisasi dengan 1-Fluoro 2,4 Dinitrobenzen Sumiyani, Ririn; Martono, Sudibyo; Sugiyanto, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

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Abstract

ABSTRACT: A rapid, accurate, and sensitive method for determining lisinopril in spiked plasma was developed by means using an Ultra Performance Liquid Chromatography (UPLC) with 1-fluoro 2,4 dinitrobenzen (FDNB) derivatization. Lisinopril was precolumn derivatized with FDNB at optimum condition, i.e. room temperature and borate buffer at pH 11, subsequently analyzed with UPLC. Isocratic condition of acetate buffer (0.01 M, pH 3.50) : acetonitrile : metanol = 70 : 10 : 20 (v/v/v) as mobile phase, 0.3 mL/min of flow rate at λ 296 nm were applied at Acquity BEH C18 column, resulting a linearity of lisinopril at range of concentration of 5,0-100 ng/mL (Y = 410,59x + 211,91, r = 0.93). The accuration of the established method was achieved by 88,59±6,01 to 101,70± 2,56% recovery, while the precision was shown with RSD value of 2,57- 8,16 %, limit of detection (LOD) instrument of 0,73 ng/mL and limit of quatification (LOQ) 2,44 ng/mL, dwith R2 = 0,9987 dan r = 0,9993. In addition, the resulted LOD and LOQ more or less similar with the published HPLC-MS-MS method (1.03-10.0 ng/mL). Hence, it could be concluded that the developed UPLC method can be used as an alternative method for determining lisinopril in plasma.Keywords: Lisinopril, FDNB, derivatization, UPLCABSTRAK: Penetapan kadar lisinopril dalam spiked plasma secara Ultra Performance Liquid Chromatography (UPLC) melalui derivatisasi dengan 1-fluoro 2,4 dinitrobenzen (FDNB) merupakan metode yang cepat, sensitif dan akurat. Derivatisasi precolumn lisinopril dan FDNB optimum pada suhu kamar, suasana dapar borat pH 11,0, dilanjutkan analisis secara UPLC isokratis menggunakan kolom Acquity BEH C dan fase gerak dapar asetat (0,01 M pH 3,50): asetonitril:metanol (70: 10: 20, v/v/v), laju alir 0,3 mL/menit pada λ 296 nm, menghasilkan linieritas kadar lisinopril dalam spiked plasma pada rentang 5,0 -100 ng/mL terhadap luas area lisinopril-DNB dengan persamaan Y = 410,59x + 211,91 dengan R2 = 0,9987 dan r = 0,9993 Akurasi metode ditunjukkan dengan nilai % rekoveri sebesar 88,59±6,01 smpai dengan 101,70± 2,56 %. Ketelitian ditunjukkan dengan nilai RSD 2,57- 8,16 %, sedangkan Batas Deteksi Instrumen = 0,73 ng/ mL dan Batas Kuantitasi = 2,44 ng/mL. Hasil Batas Deteksi penelitian ini relatif sama dengan Batas Deteksi penetapan kadar lisinopril secara HPLC-MS (1,03- 10,0 ng/mL). Dengan demikian dapat disimpulkan bahwa metode ini berpotensi dikembangkan sebagai metode alternatif pengganti HPLC-MS untuk penetapan lisinopril dalam plasma.Kata kunci: Lisinopril, FDNB, derivatisasi, UPLC
Kesinambungan Pendanaan JKN-BPJS Kesehatan Situmorang, Chazali H
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

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Abstract

ABSTRACT: Jaminan Kesehatan Nasional (JKN) is one of five social security programmes in Indonesia, under the Sistem Jaminan Sosial Nasional (SJSN) scheme. So far, there has been a significant improvement in JKN programme’s operation. However, there is a concern of maintaining financial sustainability, as the key factor to attain the programme’s long-term objective. In order to study the financing of JKN, an actuarial analysis has been done. The data used in this analysis were obtained from two main sources, i.e. BPJS Kesehatan and Ministry of Health RI. Other data used were the JKN premium revenues and health care costs (capitation, non-capitation, CBGs and non-CBGs). Based on the analysis, there is a clear evidence that shows a large mismatch in JKN financing. The health care costs of JKN is projected to increase from 6.1 Billion IDR in year 2014, to approximately 23.8 Billion IDR in year 2019, an increase of more than 58% each year. Based on these findings, it can be concluded that the JKN financing is not sustainable, at least at existing conditions. However, there are solutions for the policy makers to increase the sustainability, i.e. by revising the premium nominal value through the amendment of Perpres No. 111/2013, by rasionalising the health care costs standard tariff through the amendment of Permenkes No. 59/2014, and by implementing cost control and cost efficiency in every operational aspects. Keywords: Indonesia, National Health Security, National Social Security System, JKN, SJSN ABSTRAK: Jaminan Kesehatan Nasional (JKN) merupakan satu dari lima program Sistem Jaminan Sosial Nasional (SJSN) di Indonesia. Kemajuan besar telah dicapai dalam pelaksanaan program JKN. Namun demikian kesinambungan keuangan merupakan faktor kunci yang perlu dipertimbangkan untuk mencapai tujuan JKN jangka panjang. Oleh karena itu, dalam rangka menentukan keberlanjutan pendanaan JKN, sebuah analisis aktuaria telah dilakukan. Data yang digunakan dalam analisis aktuaria ini diperoleh dari dua sumber utama, yaitu BPJS Kesehatan dan Kementerian Kesehatan RI. Data lain yang digunakan juga mencakup data pendapatan JKN (premium) dan biaya kesehatan (kapitasi, non-kapitasi, CBGs dan non- CBGs). Hasil kajian menunjukkan bukti jelas adanya kesenjangan pendanaan program JKN. Meskipun hanya untuk membiayai manfaat JKN, kesenjangan pendanaan JKN naik dari 6,1 triliun rupiah pada tahun 2014 menjadi 23,8 triliun rupiah pada tahun 2019, atau naik lebih dari 58% per tahun. Sehubungan dengan hasil kajian ini disimpulkan bahwa kondisi keuangan JKN tidak mampu berkelanjutan, setidaknya dalam kondisi seperti sekarang ini. Namun demikian ada beberapa cara dimana para pembuat kebijakan dapat membuat kebijakan agar sistem keuangan JKN lebih berkelanjutan. Cara tersebut meliputi revisi nilai premi yang kini diatur dalam Peraturan Presiden Nomor 111/2013, rasionalisasi tarif pelayanan kesehatan yang kini diatur dalam PerMenkes 59/2014, serta meluncurkan serangkaian program pengendalian biaya dan mempromosikan efisiensi. Kata kunci: Jaminan Kesehatan Nasional, Sistem Jaminan Sosial Nasional, JKN, SJSN, aktuaria, pendanaan kesehatan

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