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Efta Triastuti
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Pharmaceutical Journal of Indonesia Department of Pharmacy, Faculty of Medicine, Brawijaya University Jalan Veteran (Kampus Sumbersari) Malang 65145 Tel. (0341) 569117ext 156, 173 ; Fax. (0341) 564755 Website : http://www.pji.ub.ac.id Email :pji@ub.ac.id
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INDONESIA
Pharmaceutical Journal of Indonesia
Published by Universitas Brawijaya
ISSN : 2461114X     EISSN : 2461114X     DOI : https://doi.org/10.21776/ub.pji
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Pharmaceutical Journal of Indonesia (PJI) is an online journal which is published twice a year by Department of Pharmacy, Faculty of Medicine, Brawijaya University. The articles published in PJI cover the themes of Clinical and Community Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Technology, and Natural Product Pharmacy/Chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol 3, No 2 (2018)" : 5 Documents clear
ANTIOXIDANT TEST OF ETHOSOME KAFFIR LIME LEAVES (Citrus hystrix D.C.) EXTRACT AS SKIN ANTI-AGING WITH DPPH METHOD Dody Muzuka, Muhammad Okta
Pharmaceutical Journal of Indonesia Vol 3, No 2 (2018)
Publisher : Brawijaya University

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Abstract

The main processes causing aging skin can be divided into two types, that are intrinsic and extrinsic. Intrinsic aging is caused by genetic factors and increasing age. Extrinsic aging is caused by environmental factors such as sunlight exposure, air pollution, smoking, and malnutrition. Kaffir lime leaf's extract contains alkaloids, flavonoids (hesperidin and naringenin), terpenoids and phenols that have antioxidant activity. Ethosome is a drug delivery system primarily composed of phospholipids, ethanol, and water as a solvent. The presence of ethanol can decrease temperature transition of stratum corneum lipid and increase fluidity. Method used to determine antioxidant activity as antiaging was α-diphenyl-β-picrylhydrazyl (DPPH). The ethosome formula was differentiated with three different concentrations of soya lecithin phospholipid with 1,5%; 2,5% and 3%. The kaffir lime leaves ethosome was tested with an organoleptic test, phytochemical screening, pH test, vesicles measurement, morphology test, antioxidant value, and stability test. The extract's yield was obtained 9.85% with ethanol 96% as a solvent and contained phenol, terpenoids, alkaloids and flavonoids on phytochemical screening. The stability test was conducted on day 0, day 15th, and day 30th at 25oC ± 2oC and relative humidity 60% ± 5%. The pH test of the ethosome complied the specifications of skin's pH. The vesicles' size of each formula did not comply the specification goal of dermis. Antioxidants test showed that kaffir lime leaves ethosome had a very powerful antioxidant. It could be concluded that kaffir lime leaves extract was a potentially powerful antioxidants.
Pendekatan Struktur Aktivitas dan Penambatan Molekul Senyawa 2-iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl)acetate Hasil Isolasi Fungi Endofit Genus Fusarium sp pada Enzim β-ketoasil-ACP KasA Sintase Rollando, Rollando
Pharmaceutical Journal of Indonesia Vol 3, No 2 (2018)
Publisher : Brawijaya University

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Abstract

Fungi endofit dapat memproduksi senyawa yang memiliki aktivitas biologi, diantaranya senyawa flavonoid, alkaloid, fenolik, dan terpenoid. Fungi endofit genus Fusarium sp yang diisolasi dari daun tanaman meniran menghasilkan senyawa 2-iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl)acetate yang mempunyai aktivitas dapat menghambat pertumbuhan bakteri Mycobacterium tuberculosis dengan nilai EC50 sebesar 18,98 µM. Penelitian ini bertujuan untuk mengetahui mekanisme aksi senyawa 2-iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl)acetate pada enzim asam siklopropan mikolik sintase dan β-ketoasil-ACP KasA sintase. Enzim asam siklopropan mikolik sintase dan enzim β-ketoasil-ACP KasA sintase memiliki andil yang besar dalam pembentukan asam mikolat, bila aktivitas kedua enzim terhambat maka pembentukan asam mikolat juga akan terhambat sehingga dapat menyebabkan kematian pada bakteri Mycobacterium tuberculosis. Pendekatan dilakukan dengan metode penambatan molekul (molecular docking) dengan didahului optimasi dan validasi metode. Reseptor yang digunakan adalah 2WGE dan 3HEM yang didapat dari Protein Data Bank. Hasil analisis menunjukan senyawa 2-iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl)acetate mampu berikatan dengan lebih baik terhadap enzim asam mikolik siklopropan sintase dan enzim β-ketoasil-ACP KasA sintase dibandingkan dengan positif dan native ligand. Dari analsis tersebut disimpulkan bahwa senyawa 2-iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl)acetate mampu bertindak sebagai inhibitor enzim asam mikolik siklopropan sintase dan enzim β-ketoasil-ACP KasA sintase pada bakteri Mycobacterium tuberculosis secara in-silico.
The Perceived Waiting Time versus the Actual Drug Waiting Time in the Outpatient Pharmacy at Persada Hospital Setiawati, Lisa
Pharmaceutical Journal of Indonesia Vol 3, No 2 (2018)
Publisher : Brawijaya University

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Abstract

The target of quality service for Persada Hospital outpatient pharmacy has been achieved in which the average time spent on waiting for the non-compounded drug is 11 minutes and for the compounded drug is 25 minutes. That achievement has not been able to alter the perceived length of the drug waiting time at the outpatient pharmacy evidenced by the number of losses resulting from unattended prescriptions due to the long wait. This study is aimed to find out and analyze the main factors leading to the perceived length of drug waiting time at the outpatient pharmacy and come up with alternative solutions thereto. The employed method in this study is descriptive qualitative research comprising the observation, interview and the collection of secondary data. The researchers conducted an observation on the process and flow of the prescription service of the outpatient pharmacy and proceeded to the focus group discussion to discover the main problems using Fish Bone Diagram.  The uncertain length of the wait time was found to be the major cause. To resolve the issue of the uncertainty of the waiting time, the Time Motion Study was conducted on the service response time as a follow up by providing the estimated waiting duration guide (information)  for the outpatient pharmacy. This guide comprises 3 categories of the service waiting time of 10-15 minutes, 25-45 minutes, and 25-60 minutes. 
HUBUNGAN ANTARA WAKTU TUNGGU PELAYANAN DENGAN TINGKAT KEPUASAN PASIEN RAWAT JALAN BPJS TERHADAP PELAYANAN RESEP (PENELITIAN DILAKUKAN DI INSTALASI FARMASI RUMAH SAKIT MUHAMMADIYAH MALANG) Ihsan, Muhammad; Illahi, Ratna Kurnia; Pramestutie, Hananditia Rachma
Pharmaceutical Journal of Indonesia Vol 3, No 2 (2018)
Publisher : Brawijaya University

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Abstract

Pelayanan kefarmasian di Instalasi Farmasi Rumah Sakit merupakan salah satu unit pelayanan yang wajib disediakan di rumah sakit. Terdapat beberapa indikator yang harus dipenuhi oleh Instalasi Farmasi Rumah Sakit, salah satunya adalah kepuasan pasien dan waktu tunggu pelayanan resep, yang dianggap dapat mempengaruhi ekspektasi pasien terhadap pelayanan rumah sakit, khususnya pelayanan di Instalasi Farmasi Rumah Sakit. Penelitian ini bertujuan untuk mengetahui hubungan antara waktu tunggu pelayanan resep dengan tingkat kepuasan pasien pada pelayanan resep di Instalasi Farmasi Rumah Sakit, dengan pendekatan observasional analitik pada 150 orang pasien rawat jalan BPJS atau pengantarnya yang sedang menebus resep. Kuesioner dan stopwatch masing-masing digunakan sebagai instrumen untuk mengukur kepuasan pasien dan waktu tunggu pelayanan resep. Analisis data dilakukan dengan 2 metode, yaitu metode Pearson untuk pelayanan resep obat racikan dan Spearman untuk pelayanan resep obat jadi. Penelitian ini juga telah mendapatkan kelayakan etik dari Komisi Etik Penelitian Kesehatan Fakultas Kedokteran Universitas Brawijaya No. 263/EC/KEPK-S1-FARM/07/2017. Dari penelitian ini, tidak terdapat hubungan antara waktu tunggu pelayanan resep dengan tingkat kepuasan pasien pada pelayanan resep obat racikan (p = 0,516), tetapi terdapat hubungan antar kedua variabel pada pelayanan resep obat jadi (p = 0,049). Selain itu, didapatkan rata-rata waktu tunggu pelayanan resep sekitar 39 menit 34 detik untuk pelayanan resep obat racikan dan 29 menit 0 detik untuk pelayanan resep obat jadi. Secara umum, pasien merasa puas terhadap pelayanan di Instalasi Farmasi Rumah Sakit Universitas Muhammadiyah Malang dan tidak memerlukan waktu melebihi yang ditentukan oleh peraturan perundangan untuk memperoleh obat.
SURVEI TINGKAT PENGETAHUAN TENTANG KEAMANAN PENGGUNAAN OBAT PADA IBU MENYUSUI DI PUSKESMAS SUMBERSARI KABUPATEN JEMBER Norcahyanti, Ika
Pharmaceutical Journal of Indonesia Vol 3, No 2 (2018)
Publisher : Brawijaya University

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Abstract

On lactation a mother can experience a variety of health complaints or disorders that require the use of the medicine, so many mothers who are breastfeeding using drugs that can give undesirable effects on the baby's feedings. Some drugs with certain characteristics can be mixed into the breast milk. The characteristics referred to, among others, is a drug that is easily soluble in fats, a drug that has the weight of small molecules, ionized drugs, and drugs that bind weakly with plasma proteins. The level of knowledge of nursing mothers will drug safety is a crucial factor to safeguard the safety of the baby. When nursing mothers have a good level of knowledge will be drug safety throughout lactation, so baby can escape from the dangers of drug side effects. This research is a survey research with cross-sectional design against 100 people respondents in Sumbersari Clinics at Jember Regency. The sample of respondents is selected using a purposive sampling technique. Before the questionnaires distributed to respondents, first conducted the test validity and reliability tests. Category level of knowledge of nursing mothers about the safety of the drugs are divided into 3 categories, namely low, medium, and high. Reference to that category, taken from the average rating ± SD knowledge of nursing mothers. Descriptive analysis shows average values ± SD i.e of 6.5 ± 2.4, so for a value of between 4.1-8.9 are included in the category of being. Values smaller than 4.1 fall into the low category and values greater than 8.9 fall into the high category. The results showed that breastfeeding mothers who have low knowledge level of 20%, the level of knowledge being of 57% and a high level of knowledge of 23%. Research results also showed that based on the security level of drug use in accordance with the WHO is a year of 2003, drugs consumed by nursing mothers is made up of the drug with a security level of category one (amoxicillin, mefenamic acid, dextromethorphan HBr, ibuprofen, paracetamol, and tetracycline), drugs with a security level of category two (acetylsalicylic acid and ephedrine HCl), as well as a drug with a security level of category three (chlorphenamine).

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