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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 17 Documents
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Search results for , issue "Vol 5, No 2 (2023): Volume 5 Edisi 2 2023" : 17 Documents clear
Kajian Literatur: Etnomedisin sebagai Analgesik di Indonesia Mahacita Andanalusia; Neneng Rachmalia Izzatul Mukhlishah
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21477

Abstract

Ethnomedicine has a major role in the development of new drugs. Based on ethnomedicine studies, it is known that some plants’ biological activity has potential as a therapy. One of its activities is as an analgesic, which can help to deal with frequent pain incidents in the world. The purpose of this literature review was to collect information on the use of ethnomedicine as an analgesic in several regions in Indonesia. The method used was narrative review using the Google Scholar database with publication limits from 2019 to 2023. There were nine studies that meet the criteria and represent the western, central and eastern parts of Indonesia. A total of four studies show that Zingiber officinale is used as an analgesic with UV 0.02-1.0. Three studies show Alpinia galanga and Piper betle are used as analgesic with UV 0.4-1.77 and 0.06-1.20, respectively. Two studies show that Oriza sativa and Curcuma longa are used by the local people as analgesics with a UV of 0.04-1.40 and 0.13-0.45, respectively. Other plants that have high UV in several regions include Orthosiphon aristatus (0.80); Curcuma viridiflora (4.00); Ficus septica (0.43), and Emelia ribes (0.60) Based on the results, it is known that Zingiber officinale, Alpinia galanga, Piper betle, Oriza sativa, and Curcuma longa are the plants most widely used as analgesics in several regions in Indonesia. This literature review can be used as a consideration in finding analgesic support therapy using ethnomedicine.
Deteksi Bakteri Salmonella sp. dengan Kultur Darah Pada Pasien Widal Positif di Laboratorium Klinik X Nurul Istiqomah; Novia Agustina; Salsa Bellamilenia Putri
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21497

Abstract

Until now, the gold standard test for diagnosing typhoid fever is a bacterial culture or also known as a gall culture examination. Blood cultures have the best sensitivity (40–60%) when performed in the first-early second week. Purpose: this study aims to identify the presence of Salmonella sp. in the blood of Widal positive patients. Method: this research is a descriptive study with a cross-sectional approach. This study used the blood culture method. The media used in this study were oxgall, SSA, KIA and IMViC media. The results showed that 20% of Salmonella typhi bacteria were found, 7% of other bacteria and 73% of bacteria did not grow on the media. The macroscopic characteristics of salmonella bacteria found were round colonies, clear in color, convex surface, flat colony edges, semi mucoid consistency, no reduction of tellurit. The microscopic characteristics are rod-shaped, spread arrangement, red in color and are Gram negative. Cultivation on IMViC media showed Indole -, MR +, VP -, Citrate -, KIA medium alkaline slope, acid base, H2S +, gas -. Conclusion: Salmonella thypi was found in the blood cultures of positive widal patients.
Analisis Kandungan Formalin dan Boraks Pada Bakso dan Tahu di Wilayah Kota Malang Lukky Jayadi; Dwipajati Dwipajati; Nurma Sabila
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.17998

Abstract

The main danger posed by formalin and boric acid or often called borcas if exposed continuously is that it can irritate the respiratory tract if inhaled, cause skin blisters if in contact with skin, nausea, vomiting, diarrhea, possible bleeding, abdominal pain, headache, hypotension, fainting. to coma. In addition, formalin can cause degenerative changes in the liver, heart, brain, other organs and can trigger genetic mutations resulting in cell damage or cell death which can result in the growth of cancer cells. This study aims to identify the content of formalin and boric acid or borkas in food samples of meatballs and tofu. The method used in this research is to test for boric acid or borcass by using AgNO3 and Paper Test Kit and for testing Formalin using KMnO4 and Reagent Test Kit. This method is used as a qualitative test for the presence of formalin and borax or boric acid in the sample. A positive result for the presence of borax or boric acid with AgNO3 with the occurrence of a white precipitate and using a paper test kit will turn brown. To identify formalin, a positive result with KMnO4 is indicated by a change in color to brown and using a test kit reagent is indicated by a change in the color of the positive sample to purple. The samples tested were 3 meatball samples and 3 tofu samples. The results of the identification of formalin and borax or boric acid in all meatball and tofu samples were obtained using qualitative tests, no meatball and tofu samples containing formalin and borax or boric acid were found.
Gambaran Interaksi Obat Pada Pasien Diabetes Mellitus Tipe 2 di Rumah Sakit X Fajrin Noviyanto; Rita Mintarsih; Farahdina Chairani
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21578

Abstract

Diabetes mellitus is a chronic condition characterized by higher than normal blood glucose levels and problems with protein, carbohydrate, and lipid metabolism caused by a relative or total lack of the hormone insulin. In addition, as a result of more prescriptions being written, the danger of drug interactions increases due to potential interactions among diabetic inpatients. The purpose of this study was to describe drug interactions in patients with Type 2 Diabetes Mellitus at X Hospital in the period January-March 2023. Data taken retrospectively from medical records were used in this kind of study, and Lexicomp Interact Online was used to evaluate drug interaction data. The results of this study showed that females 46-55 experienced. Most drug interactions in the hospital. Based on lexicomp interact online, drug interactions were categorized into 3 categories, B minor (23.6%), C moderate (62.5%) and D major (13.9%). This study may encourage healthcare workers to increase their awareness to counteract drug interactions in diabetic patients with complications to improve their clinical outcomes.
Potensi Ekstrak Enzim Daun Pepaya (Carica papaya L.) Sebagai Agen Fibrinolitik Dengan Metode Clot Lysis in Vitro Hervina Warninghiyun; Ana Indrayati; Pudiastuti RSP
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21326

Abstract

Stroke is a disease caused due to blockage of blood vessels. Health department in 2013 stated that 15,4% of people died from strokes. One of the treatment therapies that can be used is fibrinolytic. Fibrinolytic agents have a role in lysing blood clots, these agents can be obtained from microbes, plants and animals. This study aims to determine the protein content contained in papaya leaf enzyme extract (Carica papaya L.), and to determine the potential of the enzyme extract at certain concentrations as an alternative to natural fibrinolytic drugs. The study began with plant determination, sampling, enzyme extraction using a blender, purification of the extract by precipitation using ammonium sulphate, protein content determination using the Lowry method, and testing the fibrinolytic activity of the clot lysis method in vitro. Three series of test concentrations were made, namely 20, 40, and 80%. The results of the research on papaya leaf extract showed that the protein content in purification pellet 1 was 196,22 µg/ml and purification pellet 2 was 306,33 µg/ml. In papaya leaves, fibrinolytic activity was proven with the optimal percentage of blood clot lysis in purification pellet 2 with a concentration of 80% which was 79%.
Evaluasi Kepatuhan Pengobatan Menggunakan Google Form Pasien Pneumonia di Wilayah Kota Pontianak Robby Najini; Shoma Rizkifani; M. Akib Yuswar; Yeni Utari Ningsih; Ade Ferdinan
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21945

Abstract

Pneumonia is an acute infection with the first line of treatment is antibiotics, so it is necessary to study patient adherence in undergoing treatment using the Medication Adherence Rating Scale (MARS) questionnaire through the Google Form. This study aims to determine the percentage of characteristic descriptions including age, gender, and treatment regimen, know the percentage level of patient adherence in undergoing treatment, as well as knowing the significant difference between monotherapy and combination therapy groups on treatment adherence to pneumonia patients under five in Pontianak City. The method used is an observational method with a cross sectional research design that is analytic. The data was collected by filling out the MARS questionnaire through the Google Form and the data were analyzed using the Chi-Square test method. The results showed that patients aged 4 years (56.1%), male patients (73.7%), monotherapy (70.2%), and high adherence (80.7%). The results of the Chi-Square test showed that there was no significant difference between the monotherapy and combination therapy groups on compliance with pneumonia patients, with values (RR = 0.354; 95% CI = 0.125-1.004). The conclusion of this study the use of Google Form as a survey medium is the percentage of pneumonia sufferers is greater in patients aged 4 years, male, the most commonly prescribed therapy regimen is monotherapy, and patient adherence falls into the high adherence category. There was no significant difference between monotherapy and combination therapy groups on compliance with pneumonia patients in Pontianak City.
Aktivitas Kombinasi Krim Daun Pare (Momordica charantia L) dan Kulit Jeruk (Citrus nobilis) dalam Penyembuhan Luka Bakar I Made Agus Sunadi Putra; Made Dwik Lestari; Ni Nyoman Wahyu Udayani; Ketut Agus Adrianta; Nyoman Budiartha Siada
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21269

Abstract

Burns are injuries to the skin caused by heat, fire, hot steam, exposure to chemicals, solar radiation, or electric shock. Burns need to be treated immediately because they can cause infection in the skin. Healing burns can be done by utilizing several types of existing plants, namely bitter melon leaves and orange peels which are known to be able to help heal burns because they contain secondary metabolites such as flavonoids, tannins, saponins, steroids, alkaloids, and terpenoids which can be used for wound healing. The purpose of this study was to determine the effect of a combination of bitter melon leaf extract cream and orange peel as healing burns in white rats. This research is a quantitative study using laboratory experimental methods with a post test only control group design. In this study, male white rats were made with wounds on the back skin. Using 20 white rats divided into 5 different treatment groups. The negative control was given a cream base, the positive control was given Burnazin cream, F1 3% : 5%, F2 ie 4% : 4%, F3 ie 5% : 3%. The wound was smeared with preparations according to group division and carried out for 14 days. Based on the results of observations of the effect of a combination of bitter melon leaf extract and orange peel cream at F1 concentrations with a concentration ratio of 3%: 5%, it has a faster healing effect on burn area. Based on the results of the Kruskal wallis test on the healing of second degree burns in male white rats, there was a significant difference. The p value or sig is 0.014, so it can be concluded that there is a significant difference between the healing areas of burns in white rats.

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