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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,509 Documents

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Acute Gouty Arthritis with Knee Effusion in a Patient with Chronic Lymphocytic Leukemia: Diagnostic Confirmation and Pre-Chemotherapy Hyperuricemia Management Panji Hadi Permana; Eka Kurniawan; Raveinal; Deka Viotra; Fadrian Fadrian
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1614

Background: Gout and chronic lymphocytic leukemia (CLL) represent distinct hematologic and rheumatologic pathologies; however, their concurrent presentation presents significant diagnostic and therapeutic challenges. Tumor lysis syndrome and chemotherapy-induced hyperuricemia are recognized complications of hematologic malignancies, yet the manifestation of acute gouty arthritis with crystallographic confirmation in CLL patients remains an underreported clinical scenario requiring careful diagnostic stratification. Case presentation: We present a 69-year-old male farmer with newly diagnosed CLL (stage C, Binet classification) admitted for acute left knee arthritis with effusion, left ankle arthritis, and concurrent community-acquired pneumonia (CAP). Clinical examination revealed articular inflammation characterized by pain, swelling, erythema, warmth, and significant joint effusion with documented flexion limitation and positive bulging sign. Musculoskeletal ultrasound demonstrated double contour sign, synovial hypertrophy, and effusion measuring 5.8 cm in the suprapatellar recess with monosodium urate (MSU) crystal deposition confirmed by polarized light microscopy of synovial fluid (5,350 cells/mm³, 40% polymorphonuclear neutrophils, 60% mononuclear cells, positive MSU crystals). Serum uric acid was elevated at 10.6 mg/dL. The patient was successfully managed with colchicine, methylprednisolone, arthrocentesis, and supportive care while maintaining CLL treatment preparedness. Conclusion: This case illustrates the importance of confirmatory synovial fluid analysis and ultrasound imaging in the diagnosis of acute gout in the context of hematologic malignancy. Optimal management requires careful coordination between rheumatology and hematology-oncology services to prevent therapeutic complications and ensure safe chemotherapy initiation in CLL patients with concurrent acute gouty arthritis and hyperuricemia.

Immunomodulatory Effects of Probiotics on Th17-Mediated Immune Responses in Psoriasis: A Systematic Review and Meta-Analysis Rindi Rosalina Fadly; Usman Pato; Maya Savira
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1615

Background: Psoriasis is a chronic inflammatory skin disorder with increasing evidence supporting the role of the gut-skin axis in its pathogenesis. Recent studies suggest that probiotic supplementation may modulate Th17-mediated immune responses and improve clinical outcomes in psoriasis. Methods: A systematic review and random-effects meta-analysis was conducted using PubMed, Scopus, Web of Science, and Cochrane Library databases (through February 2025). Randomised controlled trials evaluating probiotic supplementation in adult patients with psoriasis were included. The primary outcome was change in Psoriasis Area and Severity Index (PASI) score. Secondary outcomes included inflammatory markers (IL-6, CRP, IL-17) and immunological markers (Foxp3+ regulatory T cells, IL-10, TGF-β). Risk of bias was assessed using the Cochrane Risk of Bias tool (RoB 2), and evidence quality was evaluated using GRADE methodology. Results: Five randomised controlled trials encompassing 268 participants (132 intervention, 136 control) were analysed. The pooled effect size for clinical outcomes (PASI) showed significant improvement favouring probiotic supplementation (Hedges' g = −0.8165; 95% confidence interval [CI], −1.6487 to −0.0483; p = 0.048; I² = 92.45%). Substantial heterogeneity was observed, with the Alshihmani 2025 pilot study demonstrating markedly larger effects on immunological markers (Hedges' g = −5.6963). Subgroup analysis revealed single-strain probiotics (pooled Hedges' g = −0.3487) had smaller effect sizes than multi-strain formulations (pooled Hedges' g = −3.6740). Publication bias assessment via funnel plot and Egger's regression showed no statistically significant asymmetry (p = 0.087). Conclusion: Probiotic supplementation demonstrated statistically significant improvements in clinical outcomes and immunological markers in psoriasis. However, substantial heterogeneity and reliance on small trials limit certainty. The mechanistic evidence supporting gut-skin axis modulation warrants further investigation in adequately powered, long-term randomised controlled trials with standardised outcome measures and strain-specific analysis.

Management of Rare Secondary Full-Thickness Macular Hole in Proliferative Diabetic Retinopathy: Inverted ILM Flap Technique with Extended Surgical Follow-up I Gusti Ngurah Dhyana Yoga; Ari Andayani; Ni Made Ari Suryathi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1616

Background: Secondary full-thickness macular hole (FTMH) in proliferative diabetic retinopathy (PDR) is rare, occurring in only 1-4% of PDR cases. Combined with tractional retinal detachment (TRD), this complication presents significant surgical challenges. The inverted internal limiting membrane (ILM) flap technique remains under-utilized in this specific setting. Case presentation: A 61-year-old Indonesian male with type 2 diabetes (>15 years), chronic kidney disease, and cardiovascular disease presented with sudden vision loss (best-corrected visual acuity 1/300). Examination revealed superior TRD (2-11 o'clock) and large FTMH (CMT 249 micrometers). After intravitreal bevacizumab (August 9th, 2024), he underwent 360-degree pars plana vitrectomy with inverted ILM flap and silicone oil tamponade (August 14th, 2024). Inferior redetachment at 2 months necessitated re-vitrectomy with endolaser and silicone oil evacuation (October 23rd, 2024). At final follow-up (12 weeks post-second surgery), the patient achieved complete retinal reattachment with normalized macular anatomy, visual acuity 1/60, and intraocular pressure 10 mmHg. Conclusion: Despite severe baseline disease and comorbidities, stepwise surgical strategy incorporating preoperative anti-VEGF therapy, comprehensive traction release, inverted ILM flap reconstruction, and staged procedures yielded meaningful anatomical recovery. This case supports inverted ILM flap utility in PDR-related secondary FTMH.

Effect of Simulated and Real Aircraft Cabin Environments on Tear Film Parameters in Dry Eye Disease: A Meta-Analysis Jelly Vianti Fransisca Oeitano; I Gusti Ayu Made Juliari; Ida Ayu Ary Pramita; I Made Ady Wirawan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1617

Background: Air travel exposes passengers to environmental stressors, such as reduced cabin pressure and low humidity, which may exacerbate ocular surface conditions, particularly pre-existing dry eye disease (DED). This meta-analysis quantifies the impact of real and simulated aircraft cabin environments on tear film parameters, ocular surface biomarkers, and intraocular pressure (IOP). Methods: Following PRISMA 2020 guidelines, a systematic search (January 2000–March 2026) identified ten eligible studies comprising 445 participants, with two providing complete quantitative data for meta-analytic pooling (10 effect sizes). Results: Using a random-effects model, the overall pooled standardised mean difference (SMD) was 0.97 (95% CI: -0.67 to 2.61), indicating a large but non-significant effect with substantial heterogeneity (I2 = 97.23%). Subgroup analyses revealed a non-significant pooled effect for tear film outcomes (Hedges' g = 0.71), contrasted by a significant elevation in IOP for gas-filled eyes (g = 1.92; p = 0.001). Despite the non-significant overall pooled estimate, individual effect sizes demonstrated large, clinically meaningful reductions in tear break-up time (TBUT) and significant increases in both corneal staining and inflammatory biomarkers (MMP-9 and IL-6). Egger's test showed no publication bias, though GRADE certainty remained low to very low. Conclusion: Aircraft cabin environments induce clinically significant deteriorations in tear film stability, ocular surface integrity, and inflammation, alongside significant IOP elevations in susceptible individuals. These findings underscore the necessity of pre-flight ocular counselling and targeted preventive strategies for at-risk passengers, highlighting the need for future large-scale, standardised investigations.

In-House Virtual Surgical Planning Using 3D Slicer: Outcomes of Free Fibular Flap Mandibular Reconstruction Redo Alif Iszar; Mulyadi; Ozi Rahmat Firdaus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1618

Background: Mandibular reconstruction following tumor resection remains a significant surgical challenge requiring precise restoration of facial symmetry and function. Virtual surgical planning has emerged as a transformative approach, yet its adoption remains limited by the high costs of commercial platforms and proprietary cutting guides. Methods: This proof-of-concept case series evaluated the operative outcomes and cost-effectiveness of an in-house virtual surgical planning workflow using 3D Slicer, a free open-source software platform, for mandibular reconstruction with free fibular flap without fibular cutting guides. Results: Four consecutive patients (three males, one female; mean age 39.0 years; standard deviation 13.1; range 28-58) who underwent mandibular reconstruction between July and December 2024 were included. Three patients presented with ameloblastoma and one with squamous cell carcinoma. Preoperative computed tomography data were processed using 3D Slicer version 5.6.2 to generate three-dimensional mandibular models through thresholding segmentation, followed by mirroring technique reconstruction and polylactic acid three-dimensional printing. The mean ischemic time was 51.0 minutes (standard deviation 10.7; 95% confidence interval 34.0-68.0), representing a 70.4% reduction compared with conventional approaches in published literature. The mean total operative time was 455.0 minutes (standard deviation 136.5; 95% confidence interval 237.8-672.2). Model printing costs of IDR 50,000-100,000 (approximately USD 3-7) represented a 99% reduction compared with commercial cutting guides. Conclusion: All flaps survived without complications. These preliminary findings suggest that simplified in-house virtual surgical planning using free open-source software provides a potentially cost-effective and efficient alternative for mandibular reconstruction, warranting validation in larger prospective studies.

Successful Management of Culture-Negative Fungal Keratitis with Epithelial Keratectomy and Intracameral Fluconazole Injection: A Case Report Kristian Dernitra; I Gusti Ayu Made Juliari; Ida Ayu Ary Pramita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1619

Background: Fungal keratitis is a major cause of corneal blindness in tropical regions. Microbiological culture often yields negative results in up to 40% of clinically suspected cases, creating diagnostic and therapeutic challenges. This report describes successful management of culture-negative suspected fungal keratitis using epithelial keratectomy combined with intracameral fluconazole injection. Case presentation: A 58-year-old male presented with progressive visual loss in the left eye following mud exposure and irrigation with river water. Examination revealed a 3×3 mm paracentral corneal ulcer with stromal infiltration exceeding one-third depth, satellite lesions, and 1.5 mm hypopyon. Gram stain, potassium hydroxide preparation, and culture were all negative. Based on clinical suspicion of fungal etiology, the patient underwent epithelial keratectomy with intracameral fluconazole injection, supplemented by intensive topical and systemic antifungal therapy. Progressive improvement was observed, with complete hypopyon resolution by day 26 and visual acuity improving from 1/300 to 6/30 over four months. Conclusion: This case demonstrates that timely invasive antifungal intervention guided by clinical judgment can achieve favorable outcomes in culture-negative suspected fungal keratitis. The preservation of useful vision without corneal transplantation is particularly significant in resource-limited settings, underscoring the critical role of clinical decision-making when laboratory confirmation is unavailable.

Emergency Bedside Transvenous Pacing Without Fluoroscopic Guidance for Refractory Symptomatic Bradycardia Following Cardiac Arrest in Acute Inferior ST-Elevation Myocardial Infarction: A Case Report Philipus Wiranata; Michael Sebastian Kawilarang
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1620

Background: Symptomatic bradycardia is a recognized complication of acute inferior myocardial infarction due to atrioventricular node ischemia. Temporary transvenous pacemaker insertion traditionally requires fluoroscopic guidance, which may be unavailable in emergency departments. Alternative non-fluoroscopic approaches are essential in time-critical, resource-limited settings. Case presentation: A 62-year-old male with uncontrolled diabetes mellitus presented to the emergency department with respiratory and cardiac arrest. Following cardiopulmonary resuscitation, return of spontaneous circulation was achieved. Electrocardiography revealed inferior ST-elevation myocardial infarction with second-degree atrioventricular block type II. Despite administration of atropine sulfate (cumulative dose 1.25 mg intravenously) and vasopressor support, the patient developed refractory symptomatic bradycardia with heart rate declining to 25-30 beats per minute, culminating in a second cardiac arrest. After achieving return of spontaneous circulation for the second time, a temporary transvenous pacemaker was inserted at the bedside in the emergency department via the femoral vein using a blind technique with electrocardiographic monitoring as the sole guide for successful placement. The pacemaker was set to VVI mode at 70 beats per minute. Subsequent fluoroscopic confirmation in the catheterization laboratory revealed the catheter tip in the right ventricular outflow tract, which was repositioned to the right ventricular apex. Percutaneous coronary intervention was subsequently performed. Conclusion: Bedside blind temporary transvenous pacemaker insertion using electrocardiographic monitoring is a feasible and effective approach in emergency settings where fluoroscopic guidance is unavailable.

Menopausal Status as the Strongest Independent Predictor of Neoadjuvant Chemotherapy Response in Locally Advanced Breast Cancer Stephen William Soeseno; I Wayan Sudarsa; Ni Gusti Ayu Agung Manik Yuniawaty Wetan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1621

Background: Neoadjuvant chemotherapy (NAC) is the standard treatment for locally advanced breast cancer (LABC), yet predicting individual patient response remains challenging. This study investigates menopausal status and other clinicopathological factors as predictors of NAC response in a Southeast Asian population. Methods: This retrospective cohort study analyzed 247 LABC patients treated with NAC between 2022–2023 at the Oncology Surgery Division, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Bali. Variables included menopausal status (premenopausal vs. postmenopausal), histological type, histological grading, molecular subtype, lymphovascular invasion (LVI), tumor-infiltrating lymphocytes (TIL), and age. Bivariate analysis used chi-square tests; multivariate logistic regression identified independent predictors. Results: Among 247 patients (mean age 51.7 ± 9.1 years), 130 (52.6%) achieved positive response. Postmenopausal patients demonstrated significantly higher response rates (79.7% vs. 12.1%, p<0.001). Multivariate analysis revealed menopausal status as the strongest predictor (OR=14.999, 95%CI: 6.045–37.213, p<0.001), followed by molecular subtype (OR=4.182, p=0.006), histological grading (OR=3.596, p=0.010), and histological type (OR=0.367, p=0.017). Age, LVI, and TIL lost statistical significance in the multivariate model. Conclusion: Menopausal status emerged as the strongest independent predictor of NAC response in LABC, suggesting that hormonal factors play a pivotal role in chemotherapy sensitivity. These findings support more aggressive NAC regimens or combined endocrine-cytotoxic strategies for postmenopausal patients and warrant validation in prospective Southeast Asian cohorts.

Emergency Splenectomy for Blunt Splenic Rupture Complicated by Post-Traumatic Acute Kidney Injury and Multiple Organ Dysfunction Syndrome: A Case Report Syifa Firza Aziza; Satrio Teguh Krisyuantoro; Pandu Anggoro; Dia Irawati; Fitria Nurul Hidayah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1622

Background: Multiple organ dysfunction syndrome is a leading cause of mortality after major blunt trauma. The spleen is the most frequently injured intra-abdominal solid organ, and when rupture occurs, it may precipitate haemorrhagic shock, systemic inflammatory response, and cascading failure of the kidneys, lungs, and coagulation system. Early recognition, rapid haemorrhage control, and coordinated multidisciplinary support are essential to limit progression and improve survival. Case presentation: A 30-year-old male motorcyclist presented to the emergency department after a high-velocity road traffic accident without helmet protection. On arrival, he was hypotensive (72/57 mmHg), tachycardic (140 bpm), apathetic with a Glasgow Coma Scale of 12, and had left upper quadrant tenderness with muscular defence. Focused assessment with sonography for trauma demonstrated free intraperitoneal fluid consistent with splenic rupture. Haemoglobin fell from 12.8 to 5.9 g/dL within hours and leukocytes rose to 37.8 ×10³/µL. An emergency splenectomy was performed for haemostasis. During the five-day intensive care course, he developed progressive oliguric acute kidney injury (peak creatinine 5.6 mg/dL, urea 114 mg/dL) requiring intermittent haemodialysis, hypercapnic respiratory failure (pH 6.969; pCO₂ 124.6 mmHg) requiring mechanical ventilation, stress hyperglycaemia (441 mg/dL) managed with insulin, and transient thrombocytopenia. Multidisciplinary care by trauma surgery, critical care, nephrology, and internal medicine resulted in haemodynamic stabilisation, recovery of renal function, and successful weaning from ventilation. Conclusion: Prompt haemorrhage control through emergency splenectomy, goal-directed resuscitation, early initiation of renal replacement therapy, metabolic support, and coordinated multidisciplinary intervention were decisive in mitigating trauma-induced multiple organ dysfunction syndrome in this patient and are proposed as pillars of management in similar presentations.

Comparative Efficacy of Intra-articular Platelet-Rich Plasma Versus Dextrose Prolotherapy for Pain Reduction and Functional Recovery in Knee Osteoarthritis: A Meta-Analysis of Randomised Controlled Trials Bagus Bayu Pradnyana; Bagus Diva Indra Dharma
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 7 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i7.1623

Background: Knee osteoarthritis (OA) is a primary cause of chronic pain and disability. Intra-articular platelet-rich plasma (PRP) and hypertonic dextrose prolotherapy are emerging regenerative therapies, yet their comparative and long-term effectiveness remain incompletely characterized. This meta-analysis quantifies their pooled effect on pain and function, prioritizing the head-to-head comparison of PRP versus prolotherapy. Methods: A systematic search of PubMed, Scopus, and Google Scholar (to July 2025) identified randomized and prospective comparative trials evaluating intra-articular PRP and/or prolotherapy in adults with Kellgren–Lawrence grade I–III knee OA. Pain and functional outcomes were extracted, and risk of bias was assessed using the Cochrane RoB 2 framework. Standardized mean differences (Hedges' g) were pooled using a restricted maximum likelihood random-effects model, alongside subgroup and small-study effect analyses. Results: Ten studies (n=855) were included. The mixed-comparator pooled estimate significantly favored the active therapies (Hedges' g = −0.948, 95% CI −1.725 to −0.171; p=0.022; I²=94.9%). Subgroup analyses revealed an effect size of g = −1.302 for PRP versus prolotherapy, g = −1.049 for prolotherapy versus inactive comparators, and g = −0.412 for PRP versus saline placebo. Differences between subgroups were not statistically significant (p=0.627). Egger regression indicated small-study effects (p=0.016). Conclusion: Both PRP and prolotherapy yield clinically meaningful improvements in knee OA pain and function. PRP demonstrates larger, more durable effects in direct comparisons, positioning it as the preferred regenerative option for sustained benefit beyond six months. Prolotherapy remains a practical alternative for shorter-term relief. However, substantial heterogeneity, small-study effects, and modest advantages over blinded saline necessitate cautious translational interpretation.

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Rachmat Hidayat

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dr.rachmat.hidayat@gmail.com

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Journal Mail Official
dr.rachmat.hidayat@gmail.com

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Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA