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Dr. dr. Farhat, M.Ked(ORL-HNS), Sp.T.H.T.K.L(K)
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Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara (PUI KNF USU), Hospital of Universitas Sumatera Utara, 4th floor, JL. Dr. Mansyur No. 66 Kampus USU Medan 20154, Sumatera Utara
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International Journal of Nasopharyngeal Carcinoma
Published by Universitas Sumatera Utara
ISSN : 26569027     EISSN : 26569035     DOI : https://doi.org/10.32734/ijnpc
Core Subject : Health,
Health Professions Medicine & Pharmacology
The International Journal of Nasopharyngeal Carcinoma (IJNPC) is an open access journal that publishes research findings from disciplines related to nasopharyngeal carcinoma. This journal was published by the Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara, collaborated with TALENTA Publisher Universitas Sumatera Utara. The publication of papers is quarter yearly, published in March, June, September, and December within 10 articles per issue. The journal is purposed to provide international sources of information to doctors and other health professionals who are interested in nasopharyngeal carcinoma. This journal is expected to improve communication between researchers so that it has an impact on the development of knowledge regarding nasopharyngeal carcinoma and stimulates further research related to head and neck surgical oncology, diagnosis, and clinical management.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 9 Documents
 1 
Search results for , issue "Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma" : 9 Documents clear
Profile of Mean Platelet Volume (MPV) in Patients with Nasopharyngeal Carcinoma before Undergoing Therapy in Sanglah General Hospital Denpasar I Gde Ardika Nuaba
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4763

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is a head and neck malignancy that is endemic in Southern China and Southeast Asia, including Indonesia. Currently, the TNM classification based on anatomical information is the most commonly used staging system. However, large variations were reported in clinical outcomes from one patient to another, even though they were at the same stage and had the same management strategy. MPV is an indicator of increased platelet activation and can easily be detected from peripheral blood through complete blood count analysis. MPV can be used as a marker of angiogenesis in patients with malignancy because of the role of platelets as angiogenic, metastatic and proteolytic in the inflammatory process of malignancy. Objective: To investigate the Mean Platelet Volume (MPV) profile in Nasopharyngeal Carcinoma patients before undergoing therapy at Sanglah General Hospital, Denpasar. Methods: This study was a cross-sectional descriptive study with 77 samples from April to June 2020 by performing a complete blood count in patients who had recently been diagnosed with nasopharyngeal carcinoma and had never undergone other treatment related to malignancy such as radiotherapy and chemotherapy. Results: The MPV value increased the most in male group compared to the female group (87.5% : 71.4%). MPV value is also have increased the most in the age group >50 years compared to other age groups (83.6%). Clinical stage IV is known to have increased the MPV value the most compared to other clinical stage groups (100%). There was an increase in the MPV value most in the histopathological type group of NKSCC compared to the other histopathological type groups (83.7%). Conclusion: The MPV value most increased in the male group, the age group >50 years, clinical stage IV group, and the histopathological type group of NKSCC.
Management of Recurrent Nasopharyngeal Carcinoma Yussy Afriani Dewi; Edwina Driyan Anindya; Bambang Purwanto
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4764

Abstract

Introduction: Recurrent nasopharyngeal carcinoma is a tumor that relapse after remission is completed whose treatment is still a challenge in the medical field because it has a set of medical properties a truly unique pathway. It is very important to understand the recurrence of nasopharyngeal carcinoma including the importance of improving individual management guidelines as well as a complete evaluation of the quality of life of patients. Objective: Statements of purpose of the study. Methods: The method carried out in this study is  retrospective descriptive research retrieval from patient’s medical record with recurrent nasopharyngeal carcinoma at Oncology Head Neck Surgery of ORL-HNS outpatient clinic, Hasan Sadikin General Hospital Bandung from 2017 to 2019. Results: Between 2017-2019 period, there were 1.727 outpatient NPC with recurrent NPC were 135 patients (7.8%). Most of them were treated by chemotherapy (45%) followed by combination therapy (30%), and radiotherapy (25%). Conclusion: Most recurrent NCP patients in this study were treated by chemotherapy (45%). Treatment techniques should be highly individualized and depend on the site and extent of recurrence, previous treatment, and the availability of equipment and expertise.
Characteristic of Nasopharyngeal Carcinoma Patients in Mangusada General Hospital in January-December 2019 I Gusti Ketut Nurada; I Gusti Ayu Putu Wahyu Widiantari
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4766

Abstract

Introduction: Nasopharyngeal carcinoma is the most common head and neck malignancy worldwide, with a unique geographic distribution pattern. The incidence of NPC in Indonesia is 6.2 per 100,000 with 13,084 new cases and 7,391 deaths due to this disease in 2012, which places Indonesia as one of countries with numerous case of nasopharyngeal carcinoma and highest deaths in the world. Objective: The purpose of this study was to assess the characteristics of nasopharyngeal carcinoma patients at Mangusada General Hospital including histopathological classification, distribution according to age and sex, as well as clinical signs and symptoms. Methods: The descriptive study with a retrospective cross-sectional approach to assessing the entire population of nasopharyngeal carcinoma in Mangusada General Hospital based on gender, age, symptoms, and histopathological classification from January to December 2019. The data was obtained from medical records and processed into frequency and distribution table. Results: The number of cases that obtained was 40 cases. There were more male than female nasopharyngeal carcinoma patients with a sex ratio of 1.66, and found mostly in the age group 45-64 years (67.5%). Most of the patients presented with advanced complaints such as nasal congestion (60%), bleeding from the nose (57.5%), and lumps in the neck (55%). The most histopathologic type of nasopharyngeal carcinoma found was the non-keratinizing squamous cell carcinoma undifferentiated subtype (100%). Conclusion: All patients with nasopharyngeal carcinoma who came to the Mangusada General Hospital were histopathologically included non-keratinizing squamous cell carcinoma undifferentiated subtype, with the largest age distribution in the early elderly group, the most affected patients were male, and most patients who attended already showing advanced clinical signs.
Association of Waiting Time for Diagnosis with Quality of Life (QoL) in Nasopharyngeal Carcinoma: A Survey in Dharmais Cancer Hospital Fifi Dwijayanti; Nuryanti Samosir; Cita Herawati
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4768

Abstract

Introduction: Cancer patients experience many symptoms. The symptoms have a major impact on Quality of Life (QoL) among patients with nasopharyngeal carcinoma. Diagnostic and treatment delays can be reduced to improve the prognoses of the cancer patients. Cancer waiting time may still be important as indicators of overall performance of a health service. Objective: The aim of this study was to investigate the association of waiting time for diagnosis with quality of life in nasopharyngeal carcinoma. Methods: A cohort survey was done in six months from July to December 2019. We conducted new patients whom never had any therapy from other care centers. Data were collected two times using the structured interview technique by using EORTC QLQ-C30 and QLQ-H&N43 questionnaires. We counted the time for diagnosis from the first time the patient came for diagnostic until the first therapy for the cancer. Results: The eligible samples were 24 patients. Their mean (SD) and median ages were 46.71 (10.1) and 49.0 years respectively and waiting time for diagnosis was 34.2 (10.4) and 31.0 days. The patient’s scored <33.3 for global health status in first came to the hospital (pre-test) was 66.7%. In pre-test, diarrhea and constipation were the most disturbing symptoms and the post-test were loss of appetite and dyspnea. Time for diagnosis was statistically significant with global health (P<0.05). Global health has significant differences in the pre-test and post-test. Conclusion: The nasopharyngeal carcinoma patients in our institution had a worse quality of life regarding overall status. Waiting time for diagnosis has association with global health score in quality of life (QoL). Further research is required to investigate the clinical patient during waiting period for diagnosis.
A 58-Year-Old Male with Nasopharyngeal Papillary Adenocarcinoma: A Case Report Dewi Susilowati; Dwi Antono; Nur Iman Nugroho
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4795

Abstract

Introduction: Nasopharyngeal Papillary Adenocarcinoma (NPAC) is a very rare type of nasopharyngeal cancer. NPAC was distinguished from common nasopharyngeal cancer due to its specific histological type. Case Report: We reported a case of a 58-year-old male patient with complaints of headache, mass in the nasopharynx, and lumps on both sides of the neck. Based on his history of illness, physical examination, imaging, and histopathology, we concluded that he was diagnosed with Nasopharyngeal Papillary Adenocarcinoma (NPAC). Six cycles of paclitaxel-cisplatin chemotherapy regimen were planned for the patient. The patient was currently undergoing his fifth cycle of chemotherapy and showed a good response. Conclusion: The chemotherapy management of this patient was given according to the general management of nasopharyngeal carcinoma to increase the good response of the patient.
Correlation of Cigarette Smoking and Salted Fish Consumption with Nasopharyngeal Carcinoma and Its Clinical Stage in ORL-HNS Outpatient, Sanglah General Hospital I Gde Ardika Nuaba; Tince Sarlin Nalle; I Wayan Weta
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4806

Abstract

Introduction: Nasopharyngeal carcinoma (NPC), which is located behind the nose, is the most common cancer. The causal of NPC is multifactorial including cigarette smoking and salted fish consumption. Objective: To determine the correlation between cigarette smoking and salted fish consumption with NPC and its clinical stage in the ENT-HNS outpatient, Sanglah General Hospital Denpasar. Methods: A case control study design in ENT clinic of Sanglah Hospital Denpasar. NPC is diagnosed by histopathology laboratory, and the stage of NPC using AJCC 8th, control criteria using policlinic ENT outpatient without cancer. Data were collected by interview method using a questionnaire on 46 patients who were confirmed NPC and 46 control groups. Then investigated the risk factors for cigarette smoking and consumption of salted fish. Results: The mean age of the NPC patient was 47.35±11.89 year old and the control group was 48.04 ±10.28 year old (P=0.130), likewise the composition of gender no statistically different between both groups (P=0.21. The risk (OR) of cigarette smoking and salted fish consumption on nasopharyngeal carcinoma patient was 4.7 (P<0.01) and 2.4(P=0.036), respectively. The results of multivariate analysis showed that there was a significant relationship between cigarette smoking to clinical stage of nasopharyngeal carcinoma (P=0.020 and AOR 3.364). Otherwise, there was no significant correlation between the consumption of salted fish, clinical stage of nasopharyngeal carcinoma (P=0.148 and AOR 2.288). Conclusion: It was found a significant association between cigarette smoking to nasopharyngeal carcinoma and its clinical stage, but not found any significant correlation between the consumption of salted fish with nasopharyngeal carcinoma.
Hemoglobin Levels before and after Chemotherapy (Cisplatin-Paclitaxel) of Nasopharyngeal Cancer Patients at Prof. Dr. Margono Soekarjo Hospital
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4818

Abstract

Introduction: The National Comprehensive Cancer Network recommends induction chemotherapy and concurrent chemoradiotherapy as one of the standard therapy for stage II-IVA nasopharyngeal cancer. The use of induction chemotherapy given before radiotherapy is an effective treatment strategy because it has a better level of adherence and facilitates early eradication of micro metastasis. Chemotherapy has a direct side effect of disruption of erythrocyte formation in the bone marrow and reduces the erythropoietin hormone in the kidney. Decreased hemoglobin levels exacerbate oxygen deficiency in tumours thereby increasing hypoxic cells and contributing to the development of radiotherapy resistance. Objective: This research was conducted to find out the hemoglobin levels before and after chemotherapy (cisplatin-paclita An analytical observational studies with cross sectional method. The subjects were 36 nasopharyngeal cancer patients that gone through 6 cycles of chemotherapy and meets the research criteria.xel) in nasopharyngeal cancer patients. Methods: An analytical observational studies with  cross sectional method. The subjects were 36 nasopharyngeal cancer patients that gone through 6 cycles of chemotherapy and meets the research criteria. Results: The results of the bivariate analysis showed differences in the average of hemoglobin levels before and after chemotherapy, the average hemoglobin levels before chemotherapy which were 13.39 g/dL and after chemotherapy which were 11.35 g /dL in nasopharyngeal cancer patients at Prof. Dr. Margono Soekarjo Hospital (P=0,001). Conclusion: There is a significant difference between hemoglobin levels before and after chemotherapy (cisplatin-paclitaxel) in nasopharyngeal cancer patients in Prof. Dr. Margono Soekarjo Hospital.
Probability of Anti PDGF/R as Antiangiogenic Nasopharyngeal Carcinoma: A Review Oke Kadarullah
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4892

Abstract

Introduction: Nasopharyngeal Carcinoma (NPC) is frequently found in Southeast Asia, especially in Indonesia, with a higher incidence rate compared to global numbers. The mortality rate of NPC in Indonesia is also higher than the standardized mortality rate. Radiotherapy and chemotherapy are the first line treatment, but still has 5 – 10% chance of recurrence. NPC is mostly persistence and recurrence, and this itself is a challenge in achieving effective treatment. Patients in Indonesia commonly search for treatment at an advanced stage. Review: Advanced stage NPC requires an additional combination therapy such as chemotherapy and targeted therapy. Targeted therapy in the past 10 years have not shown a significant improvement in recurrent NPC. Cetuximab is the empiric choice for head and neck squamous cell carcinoma. EGFR and VEGFR are target molecules tyrosine kinase, including PDGF/R, which plays a role in angiogenesis and cancer progressivity. PDGF and its receptors shows an important role in certain cancers including head and neck cancer. PDGF/R in NPC has been researched in vitro and in vivo but more clinical data is still needed. Conclusion: The role of PDGF/PDGFR in targeted therapy development is still being used. This is to push the anti angiogenic combination strategy as an option for NPC with radio-chemotherapy resistance, or for stable, progressive and recurrent NPC while considering its unwanted effects.
Several Biomolecular Parameters as Prognostic, Therapeutic and Preventive Factors of Nasopharyngeal Carcinoma Farhat Farhat
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4984

Abstract

Introduction: Polymorphism of the enzyme in metabolyzing carcinogen such as CYP2E1 and GSTs are the genetic factor contributing for NPC. NPC also is related with several proteins that induce the growth and progression of tumor. Identification of the genetic variation and protein are beneficial for clinical use. Review: CYP2E1 polymorphisms are associated with increased activity and enzyme transcription, thereby increasing the activation of nitrosamines as carcinogens in NPC. In addition, polymorphism of GSTs as the phase II enzyme decrease the act to detoxify carcinogen and inhibit oxidative stress. Several studies showed the relation of those polymorphism with the risk factor of NPC. The protein expression in NPC was also studied by several researchers. Several proteins in NPC such as p38 MPAK, TNF-α, NF- κB, PPAR-gamma, LMP-1, VEGF, COX-2, and MMP-9 are related with tumor growth, prognosis and also help in treatment of NPC. Conclusion: Identifying GSTs and CYP2E1 polymorphism may be help in determining risk factor for NPC due to the association of those with increased susceptibility for NPC. Analyzing the protein expression by immunohistochemistry also help the clinician to identify the prognosis and considering therapy for NPC.

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