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All Journal Medicina E-Jurnal Medika Udayana Oto Rhino Laryngologica Indonesiana International Journal of Nasopharyngeal Carcinoma Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Jurnal Sehat Indonesia (JUSINDO)
I Gde Ardika Nuaba
Department Of Otorhinolaryngology-Head And Neck Surgery, Faculty Of Medicine Udayana University/Sanglah General Hospital Denpasar, Bali, Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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DIAGNOSIS DAN PENATALAKSANAAN KISTA DUKTUS TIROGLOSUS Mustika, I Made; Nuaba, I Gde Ardika
Medicina Vol 46 No 1 (2015): Januari 2015
Publisher : Medicina

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Abstract

Kista duktus tiroglosus merupakan massa leher kongenital yang paling sering dijumpai pada anak-anak namun dapat  juga dijumpai pada orang dewasa. Kelainan  ini  terjadi oleh karena kegagalanobliterasi  duktus  tiroglosus  selama masa  embriologi. Pada  laporan  kasus  ini  dilaporkan  seorangperempuan berusia 35  tahun dengan kista duktustiroglosus. Keluhan disadari sejak 2 bulan yanglalu. Pemeriksaan  sitologi  aspirasi  jarum halus  preoperasi  suatu  lesi  kistik,  gambaran morfologisesuai  untuk  kista  duktus  tiroglosus.Hasil  tes  fungsi  tiroid  dalam  batas  normal  dan  hasil  ultrasonografi  leher menunjukkan  kesan  suspek  kista  duktus  tiroglosus,  tiroid  kanandankiri normal.Penatalaksanaan kasus ini adalah eksisi seluruh kista dan saluran duktus tiroglosus sampai foramensekum  pada  dasar  lidah  yang  dikenal  dengan  teknik  Sistrunk.Hasil  histopatologi  spesimenpembedahan menunjukkan  kista  duktus  tiroglosus. Perkembang  kasus  ini menunjukkan  hasilpenyembuhan yang baik dan 6 bulan pasca-tindakan eksisi tidak ditemukan adanya kekambuhan.[MEDICINA 2015;46:52-55].Thyroglossal duct cyst (TDC) is common congenital neck mass usually present in young children althoughcan be found in adult. TDC results from a failure in obliteration of the embryogenic duct formationduring thyroid migration. We report a case of a35 year-adult woman with TDC since 2 months ago. Fineneedle  aspiration  citologypreoperative  shows  cystic  lesion, morphological  views  appropriate  asthyroglossal  duct  cyst.  Thyroid  fuction  test was  normal  and  neck  ultrasonography  showedsucpectthyroglossal duct cyst, both of thyroid was normal.Management of this case wascomplete cystexcision until base of hyoid bone, removal of the central portion of the hyoid bone and excision of anyproximal thyroglossal duct as known as Sistrunk procedure.Histopathology finding of post operativespecimen  showed  thyroglossal  duct  cyst. Healing  processinthiscasehas  been  shown  goodresultsand6monthsafter excision there was norecurrences. [MEDICINA 2015;46:52-55].
ANGIOFIBROMA NASOFARING PADA PASIEN USIA LANJUT Yudianto A, Sony; Tjekeg, M; Ardika Nuaba, G
Medicina Vol 44 No 2 (2013): Mei 2013
Publisher : Medicina

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Abstract

Angiofibroma nasofaring adalah tumor jinak nasofaring yang secara histopatologis merupakan tumor jinak, tetapi secara klinis bersifat destruktif. Tumor ini sering terjadi pada laki-laki prepubertas dan remaja, jarang ditemukan pada pasien usia di atas 25 tahun. Pada kasus ini dilaporkan angiofibroma nasofaring pada laki-laki usia lanjut dengan keluhan hidung tersumbat dan epistaksis berulang, dilakukan operasi ekstirpasi tumor dengan pendekatan transpalatal. Prognosis pasien ini baik, karena pada evaluasi 3 bulan setelah operasi tidak tampak pertumbuhan tumor baru.[MEDICINA 2013;44:105-108].
KARAKTERISTIK PASIEN KARSINOMA NASOFARING DI RSUP SANGLAH DENPASAR TAHUN 2014-2016 I G A Wira Saraswati; I Gde Ardika Nuaba; I Ketut Suanda
E-Jurnal Medika Udayana Vol 8 No 1 (2019): Vol 8 No 1 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

Karsinoma nasofaring (KNF) merupakan kanker yang terdapat pada sel-sel epitel mukosa nasofaring. Penelitian ini dilakukan untuk mengetahui faktor-faktor apa saja yang berhubungan dengan kejadian KNF serta karakterstik pasien KNF di RSUP Sanglah Denpasar tahun 2014-2016. Penelitian ini bersifat deskriptif retrospektif dengan mengumpulkan data rekam medis pasien KNF di RSUP Sanglah Denpasar. Hasil penelitian ini, penderita awal terdiagnosis KNF tertinggi tahun 2016 sebanyak 114 orang. Berdasarkan umur dijumpai selama tiga periode tertinggi terdapat pada kelompok umur usia produktif (36-55 tahun). Jenis kelamin tertinggi pada laki-laki tahun 2016 sebanyak 75 orang (65,79%). Berdasarkan status pekerjaan paling tinggi pada pekerja aktif sebanyak 113 orang (66,08%). Stadium penyakit paling tinggi pada stadium IVA tahun 2016 sebanyak 46 orang (40,35%) dari total 69 orang (40,35%). Berdasarkan paparan asap rokok terbanyak di jumpai pada tahun 2016 sebanyak 58 orang (50,88%) dari total 90 orang (52,63%) yang mengenai laki-laki. Histopatolgi (WHO) paling banyak dijumpai selama tiga periode pada who tipe 3 sebanyak 163 orang (95,32%). Disimpulkan bahwa kejadian KNF di RSUP Sanglah Denpasar meningkat tiap tahunnya serta lebih sering diketahui pada stadium lanjut. Hasil penelitian ini diharapkan dapat digunakan sebagai dasar penelitian lebih lanjut untuk mengetahui karakterstik pasien KNF tiap tahunnya di RSUP Sanglah Denpasar. Kata Kunci: KNF, Karakteristik, RSUP Sanglah Denpasar
KARAKTERISTIK PASIEN KARSINOMA NASOFARING DI POLIKLINIK TELINGA HIDUNG TENGGOROKKAN-KEPALA LEHER RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR PADA BULAN NOVEMBER-DESEMBER 2014 Ferdinand Maubere; I Gde Ardika Nuaba
E-Jurnal Medika Udayana vol 4 no 2 (2015):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Karsinoma nasofaring (KNF) merupakan tumor ganas kepala leher yang paling banyak di Indonesia. Prognosis pasien KNF sangat bergantung pada diagnosis dan terapi pada stadium dini. Namun demikian, perhatian dan pengetahuan dokter umum di Indonesia mengenai KNF masih kurang memadai untuk mendukung penapisan dan pendeteksian sedini mungkin. Penelitian ini bertujuan meninjau karakteristik khusus pada pasien KNF yang nantinya dapat dijadikan dasar penelitian selanjutnya sebagai salah satu alat bantu penapisan dan deteksi dini. Rancangan penelitian ini adalah deskriptif kuantitatif dan dilaksanakan di poliklinik THT-KL RSUP Sanglah Denpasar pada bulan November hingga Desember 2014. Jumlah sampel 68 pasien dengan diagnosis karsinoma nasofaring yang sudah ditentukan stadiumnya, baik pasien yang baru terdaftar ataupun pasien lama.  Hasil penelitian ini menunjukkan rasio pasien KNF laki-laki berbanding perempuan adalah 2,78 : 1. Rerata umur responden adalah 50,01 ± 10,10 tahun dan sebanyak 51,5% responden berusia 30-50 tahun. Sebanyak 63,3% responden mulai berobat pada stadium IV dan 20,6% pada stadium III. Pada variabel host, sebanyak 13,2% memiliki riwayat penyakit kanker pada keluarga, 22,1% memiliki riwayat penyakit THT kronik selama lebih dari 3 minggu, dan 67,6% memiliki ?1 gigi yang bermasalah. Pada variabel perilaku, 57,4% mengkonsumsi ikan asin ?3 kali per bulan, 47.1% adalah perokok, dan 10,3% jarang menyikat gigi. Pada variabel lingkungan, 75,0% terpapar asap kayu bakar selama >10 tahun, 42,6% terpapar zat kimia inhalasi, dan 30,9% terpapar debu kayu.    
KARAKTERISTIK PASIEN KARSINOMA NASOFARING DI POLIKLINIK TELINGA HIDUNG TENGGOROKKAN-KEPALA LEHER RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR PADA BULAN NOVEMBER-DESEMBER 2014 Ferdinand Maubere; I Gde Ardika Nuaba
E-Jurnal Medika Udayana vol 4 no 5(2015):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Karsinoma nasofaring (KNF) merupakan tumor ganas kepala leher yang paling banyak di Indonesia.Prognosis pasien KNF sangat bergantung pada diagnosis dan terapi pada stadium dini.Namun demikian, perhatian dan pengetahuan dokter umum di Indonesia mengenaiKNFmasih kurang memadai untuk mendukung penapisan dan pendeteksian sedini mungkin. Penelitian ini bertujuan meninjau karakteristik khusus pada pasien KNF yang nantinya dapat dijadikan dasar penelitian selanjutnya sebagai salah satu alat bantu penapisan dan deteksi dini. Rancangan penelitian ini adalah deskriptif kuantitatif dan dilaksanakan di poliklinik THT-KL RSUP Sanglah Denpasar pada bulan November hingga Desember 2014.Jumlah sampel 68 pasien dengan diagnosis karsinoma nasofaring yang sudah ditentukan stadiumnya, baik pasien yang baru terdaftar ataupun pasien lama. Hasil penelitian ini menunjukkan rasio pasien KNF laki-laki berbanding perempuan adalah 2,78 : 1. Rerata umur responden adalah 50,01 ± 10,10tahun dan sebanyak 51,5% responden berusia 30-50 tahun.Sebanyak 63,3%responden mulai berobat pada stadium IV dan 20,6% pada stadium III. Pada variabel host, sebanyak 13,2% memiliki riwayat penyakit kanker pada keluarga, 22,1% memiliki riwayat penyakit THT kronik selama lebih dari 3 minggu,dan 67,6% memiliki ?1 gigi yang bermasalah. Pada variabel perilaku, 57,4% mengkonsumsi ikan asin ?3kali per bulan, 47.1% adalah perokok, dan 10,3% jarang menyikat gigi. Pada variabel lingkungan, 75,0% terpapar asap kayu bakar selama >10 tahun, 42,6%terpapar zat kimia inhalasi, dan 30,9% terpapar debu kayu.    
Tumor Dabska sinonasal Suriya Suwanto; Gde Ardika Nuaba; Wayan Sucipta
Oto Rhino Laryngologica Indonesiana Vol 43, No 2 (2013): Volume 43, No. 2 July - December 2013
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.116 KB) | DOI: 10.32637/orli.v43i2.72

Abstract

Latar belakang: Tumor Dabska adalah salah satu jenis tumor pembuluh darah dengan keganasan intermediate dan dikenal sebagai angiosarkoma derajat rendah. Tumor ini merupakan neoplasma yang sangat jarang dan hanya 31 kasus dilaporkan di seluruh dunia.Tujuan: Memperkenalkan tumor Dabska berikut tatalaksana dalam bidang THT-KL. Kasus: Satu kasus tumor Dabska sinonasal pada seorang wanita berusia 35 tahun. Penatalaksanaan: Penatalaksanaan sesuai literatur adalah eksisi luas dan radioterapi. Pada pasien ini, eksisi luas tidak dapat dilaksanakan karena besarnya ukuran massa tumor sehingga radioterapi dipilih sebagai modalitas terapi. Pasien meninggal dunia pascaradioterapi.Kesimpulan: Tumor Dabska adalah tumor pembuluh darah yang jarang ditemukan. Penatalaksanaan adalah dengan eksisi luas dan radioterapi. Kata kunci: Tumor Dabska, endovascular papillary hemangioendothelioma, tumor vaskular.
COMPARISON OF CYTHOCROME P450 FAMILY 2 SUBFAMILY A POLYPEPTYDE 6 (CYP2A6) GENE POLYMORPHISM PROPORTION ON EARLY AND ADVANCED STAGE OF UNDIFFERENTIATED TYPE NASOPHARYNGEAL CARCINOMA IN BALINESE I Gde Ardika Nuaba; Komang Andi Dwi Saputra; I Ketut Suanda; I Gusti Ayu Trisna Dewi
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2066

Abstract

Introduction Nasopharyngeal carcinoma (NPC) is a malignancy derived from epithelial cells lining the nasopharynx. The etiology of nasopharyngeal carcinoma is multifactorial. One of the risk factors is CYP2A6 gene polymorphism which causes nitrosamines are not metabolized, leading to DNA change that could trigger cancer. Objectives The purpose of this study is to know the association of CYP2A6 gene polymorphism and clinical stage of undifferentiated type of NPC Material and Method This is a cross sectional analytic study. The sample in this study were 80 nasopharyngeal carcinoma patients whose treated in ENT-HN department of Sanglah General Hospital between 2017 - 2018. The collected data consist of subject’s characteristic and CYP2A6 gene polymorphisms identified by the PCR-RFLP technique. Results The probability of CYP2A6 gene polymorphism in the undifferentiated type of NPC in the Balinese tribe is 3.125 times greater in advanced stage than early stage. Based on multivariate analysis, there was a statistically significant association between CYP2A6 gene polymorphism and clinical stage of undifferentiated type NPC in Balinese with p value = 0,0048 (p < 0,05). Conclusion There is association between CYP2A6 gene polymorphism and clinical stage of undifferentiated type NPC in Balinese tribe.
COMPARISON OF POLYMORPHISM rs2070672 CYP2E1 GENE PROPORTION IN EARLY AND ADVANCED STAGE OF UNDIFFERENTIATED TYPE NASOPHARYNGEAL CARCINOMA IN BALINESE I Ketut Suanda; I Gde Ardika Nuaba; Ni Putu Ayu Wiarni Susanthi
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.2652

Abstract

Introduction: Nasopharyngeal carcinoma is the most common malignancy in the ENT field. The cause of nasopharyngeal carcinoma is multifactorial. One of the risk factors for an increase in nasopharyngeal carcinoma is the rs2070672 polymorphism of the CYP2E1gene. Purpose: To determine the rs2070672 CYP2E1gene polymorphism proportion in early and advanced stage undifferentiated type NPC subjects in Balinese. Method: This research is a cross sectional comparative study. The case population were all subjects with undifferentiated type NPC in the ENT outpatient clinic at Sanglah General Hospital Denpasar. This study uses 65 samples. Data collected in the form of subject characteristics and rs2070672 CYP2E1gene polymorphisms which examined by ARMS-PCR technique. Results: The average age of the sample was 48.1 years, the most were male as many as 48 subjects (73.8%), and the highest was advanced stage as many as 56 subjects (86.2%). In the chi square test the proportion of polymorphisms in the advanced stage was 2.357 times higher than the early stages. The results of multivariate analysis using logistic regression proved that the rs2070672 CYP2E1gene polymorphism at advanced stage was 7.469 times higher than early stage. Conclusion: There is a difference in the proportion of rs2070672 CYP2E1gene polymorphism in undifferentiated type NPC of Balinese, where advanced stage is higher than early stage.
Profile of Mean Platelet Volume (MPV) in Patients with Nasopharyngeal Carcinoma before Undergoing Therapy in Sanglah General Hospital Denpasar I Gde Ardika Nuaba
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4763

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is a head and neck malignancy that is endemic in Southern China and Southeast Asia, including Indonesia. Currently, the TNM classification based on anatomical information is the most commonly used staging system. However, large variations were reported in clinical outcomes from one patient to another, even though they were at the same stage and had the same management strategy. MPV is an indicator of increased platelet activation and can easily be detected from peripheral blood through complete blood count analysis. MPV can be used as a marker of angiogenesis in patients with malignancy because of the role of platelets as angiogenic, metastatic and proteolytic in the inflammatory process of malignancy. Objective: To investigate the Mean Platelet Volume (MPV) profile in Nasopharyngeal Carcinoma patients before undergoing therapy at Sanglah General Hospital, Denpasar. Methods: This study was a cross-sectional descriptive study with 77 samples from April to June 2020 by performing a complete blood count in patients who had recently been diagnosed with nasopharyngeal carcinoma and had never undergone other treatment related to malignancy such as radiotherapy and chemotherapy. Results: The MPV value increased the most in male group compared to the female group (87.5% : 71.4%). MPV value is also have increased the most in the age group >50 years compared to other age groups (83.6%). Clinical stage IV is known to have increased the MPV value the most compared to other clinical stage groups (100%). There was an increase in the MPV value most in the histopathological type group of NKSCC compared to the other histopathological type groups (83.7%). Conclusion: The MPV value most increased in the male group, the age group >50 years, clinical stage IV group, and the histopathological type group of NKSCC.
Correlation of Cigarette Smoking and Salted Fish Consumption with Nasopharyngeal Carcinoma and Its Clinical Stage in ORL-HNS Outpatient, Sanglah General Hospital I Gde Ardika Nuaba; Tince Sarlin Nalle; I Wayan Weta
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4806

Abstract

Introduction: Nasopharyngeal carcinoma (NPC), which is located behind the nose, is the most common cancer. The causal of NPC is multifactorial including cigarette smoking and salted fish consumption. Objective: To determine the correlation between cigarette smoking and salted fish consumption with NPC and its clinical stage in the ENT-HNS outpatient, Sanglah General Hospital Denpasar. Methods: A case control study design in ENT clinic of Sanglah Hospital Denpasar. NPC is diagnosed by histopathology laboratory, and the stage of NPC using AJCC 8th, control criteria using policlinic ENT outpatient without cancer. Data were collected by interview method using a questionnaire on 46 patients who were confirmed NPC and 46 control groups. Then investigated the risk factors for cigarette smoking and consumption of salted fish. Results: The mean age of the NPC patient was 47.35±11.89 year old and the control group was 48.04 ±10.28 year old (P=0.130), likewise the composition of gender no statistically different between both groups (P=0.21. The risk (OR) of cigarette smoking and salted fish consumption on nasopharyngeal carcinoma patient was 4.7 (P<0.01) and 2.4(P=0.036), respectively. The results of multivariate analysis showed that there was a significant relationship between cigarette smoking to clinical stage of nasopharyngeal carcinoma (P=0.020 and AOR 3.364). Otherwise, there was no significant correlation between the consumption of salted fish, clinical stage of nasopharyngeal carcinoma (P=0.148 and AOR 2.288). Conclusion: It was found a significant association between cigarette smoking to nasopharyngeal carcinoma and its clinical stage, but not found any significant correlation between the consumption of salted fish with nasopharyngeal carcinoma.
Co-Authors Damayanthi, M. Ayu Dwi Eka Putra Setiawan Ferdinand Maubere Herman Saputra I G A Wira Saraswati I Gusti Ayu Trisna Dewi I Ketut Suanda I Made Arimbawa I Made Mustika, I Made I Wayan Lolik Lesmana I Wayan Weta Ida Ayu Alit Widiantari Jessica Filbertine Komang Andi Dwi Saputra Komang Soniananda Pradnyana Putri M Tjekeg Made Lely Rahayu Ni Putu Ayu Wiarni Susanthi Ni Putu Deby Rathasari Paramita, Ayu Diah Perdana Renata Timoty Pasaribu Sony Yudianto A Steven Yohanis Latupeirissa Suanda, I Ketut Suriya Suwanto Tince Sarlin Nalle Wayan Sucipta Widiantari, Ida Ayu Alit