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Dr. dr. Farhat, M.Ked(ORL-HNS), Sp.T.H.T.K.L(K)
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Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara (PUI KNF USU), Hospital of Universitas Sumatera Utara, 4th floor, JL. Dr. Mansyur No. 66 Kampus USU Medan 20154, Sumatera Utara
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International Journal of Nasopharyngeal Carcinoma
Published by Universitas Sumatera Utara
ISSN : 26569027     EISSN : 26569035     DOI : https://doi.org/10.32734/ijnpc
Core Subject : Health,
Health Professions Medicine & Pharmacology
The International Journal of Nasopharyngeal Carcinoma (IJNPC) is an open access journal that publishes research findings from disciplines related to nasopharyngeal carcinoma. This journal was published by the Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara, collaborated with TALENTA Publisher Universitas Sumatera Utara. The publication of papers is quarter yearly, published in March, June, September, and December within 10 articles per issue. The journal is purposed to provide international sources of information to doctors and other health professionals who are interested in nasopharyngeal carcinoma. This journal is expected to improve communication between researchers so that it has an impact on the development of knowledge regarding nasopharyngeal carcinoma and stimulates further research related to head and neck surgical oncology, diagnosis, and clinical management.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 94 Documents
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Covid-19 Vaccination in Nasopharyngeal Carcinoma Patients during COVID-19 Pandemic Irnanda Warda Rizki Nasution; Farhat Farhat; Elvita Rahmi Daulay
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 3 No. 02 (2021): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v3i02.6323

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is one kind of cancer that is the most common type of head and neck malignancy, arising from the posterior and lateral parts of the nasopharynx especially from torus tubarius or pharyngeal recess or the other name is Rosenmüller fossa. This shows significant differences from other head and neck cancers, clinical behavior, cause, epidemiology, treatment, as well as prognosis. Clinical trials of COVID-19 vaccines with better follow-up will provide useful data on vaccine advantages in patients receiving cancer treatment, due to the absence of complete data to determine the relationship between active oncology treatment and the power to induce immunity to COVID-19 using the vaccine. Discussion: The primary aim of vaccines is to produce stimulation by the antigen we desire in the presence of sufficient infection to elicit memory immunity with tolerable protection.[15] Due to the increasing frailty of cancer patients with infection as well as deaths from COVID-19, there is an urgent need to vaccinate patients with COVID-19 cancer. Various considerations for the protection and benefits that are expected to have an effect with treatment due to their standart management and changes in the immune system of patients with malignancies. Conclusion The COVID-19 vaccine, granted approved or permitted, will be considered the basic of prevention of this COVID-19 pandemic for patients with nasopharyngeal carcinoma. There are advantages and disadvantages about Covid-19 vaccine. Then, a quality direction on clinical trials of patients with cancer and COVID-19 vaccines becomes very attractive. Finally, comprehensive oncological care requires cancer patients to be prioritized for the COVID-19 vaccine
Radiotherapy Management of Nasopharyngeal Carcinoma Patient in General Hospital Haji Adam Malik Medan: A Case Report
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 3 No. 02 (2021): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v3i02.6324

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is a head and neck malignancy with a high incidence especially in Asian region. NPC has highly prevalence in head and neck cancer with most of the type is squamous cell type with three different histologic subtypes, namely squamous cell carcinoma, nonkeratinizing carcinoma, and undifferentiated carcinoma. Principle of management NPC is radiotherapy because of this kind of carcinoma highly radiosensitive and is the mainstay of treatment for all stages. Case report: A 33-year-old woman came to the ENT-Head and Neck Surgery Outpatient clinic of General Hospital Haji Adam Malik Medan on March, 2021. The patient was diagnosed with Nasopharynx carcinoma, with complaints of nose bleeds and, nasal congestion. History of consuming salted fish was found. History of cooking food with flavoring was found. The patient then performed a non-contrast-enhanced nasopharyngeal MSCT scan on February 17th, 2021 with the result: Left nasopharyngeal mass that extends to the left torus tobarius, left rossenmuller fossa crossing to the right nasopharyngeal midline (T1N0M0). The histopathological results were carried out at the Vina Estetika Hospital: Keratinizing Squamous Cell Carcinoma. The patient then performed a contrast-enhanced nasopharyngeal MSCT scan on March 3rd 2021 with the result: a left-sided nasopharyngeal mass with a rosenmuller fossa and an obliterated Tobarius torus was seen. Nasopharyngeal mass (T1N0M0). The patient was given 70 gy of Radiotherapy on March 18th 2021. After radiation 35 times on May 18th 2021, the patient was evaluated on the next 8 weeks. Conclusion: Using radiotherapy alone in this patient is the best therapy for this patient. Beside that, early diagnosis in NPC was giving better result of this management
Effects of Cisplatin on Superoxide Anion, Sod, Apoptosis and Cytoplasmic p21Expression in C666-1 Cell Lines Undifferentiated Nasopharyngeal Cancer Imam Prabowo; Edi Widjajanto; Aris Widodo; Karisma Prameswari Patria Mahatmi; Handoko Nugroho Yossarsongko; Pudji Rahaju
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 3 No. 02 (2021): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v3i02.6343

Abstract

Introduction: ROS, a mechanism in CIS pathogenesis, causes toxicity when cisplatin is administered. Superoxide anion (O2-), a radical anion, part of ROS that is initially triggered after a part of oxygen enters a living cell. The main principle of this enzyme is to work as a protection against oxygen toxicity and plays a role as body catalyst. The p21 has a main function in the regulation of cell cycle progression. It is able to regulate cell proliferation through its association with PCNA and DNA polymerase accessory factor as a part of cell regulation and apoptosis. Objective: To study the effects of cisplatin on the increase or decrease of O2-, SOD, proliferation (MTT), apoptosis and cytoplasmic p21 expression in C666-1 cell lines. Methods: An experimental study with a post control group design and cisplatin in group dosages of 7.86 µg/mL, 15.36 µg/mL and 30.72 µg/mL. Results: The mean difference of O2- in C666-1 cell lines between cisplatin groups was not significant (P value 0.871, P>0.05). The mean difference of SOD in C666-1 cell lines was highly significant (P value 0.001, P<0.05) showing a significant increase of SOD. The mean difference of C666-1 cell lines proliferation (MTT) between cisplatin groups was not significant (P value 0.094, P>0.05). The mean difference of C666-1 cell lines apoptosis between cisplatin groups was not significant (P value 0.104, P>0.05). Cytoplasmic p21 highest expression was found at the 30.72 dosage obtained from 24 hours observation. Conclusion: Increase of SOD after a high dose of cisplatin administration, due to the balance between ROS production and detoxification process caused by antioxidants (SOD), will affect cancer cells to proliferate and survive. Increase of apoptosis at the highest dose found in this study, showed that apoptosis was induced by cisplatin. Therefore, antioxidant administration may be considered for nasopharyngeal cancer patients.
Chemotherapy Management of Nasopharyngeal Carcinoma Patient in General Hospital Haji Adam Malik Medan : A Case Report Saurma Otri Sonya Simanjuntak; Farhat Farhat; Elvita Rahmi Daulay
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 3 No. 02 (2021): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v3i02.6344

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is in the fourth place according to the most most common malignancies in Indonesians. Three types of nasopharyngeal carcinoma are squamous cell, non-keratinizing, and undifferentiated carcinoma. Case report: A 51-year-old man came to the ENT-Head and Neck Surgery Outpatient clinic of General Hospital Haji Adam Malik Medan on November 2, 2020 with main complaint of lump on the neck and nasal congestion. The patient underwent a contrast-enhanced nasopharyngeal MSCT scan with the result: T2N0M0. The histopathology results: Non-Keratinizing Squamous Cell Carcinoma. The patient was given 70 gy of Chemoradiation (CRT) followed by adjuvant chemotherapy with Cisplatin + 5 Fu.  Conclusion: There was no visible mass on the nasopharynx after using this combination therapy

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